Journal of Movement Disorders最新文献_第2页

Feasibility and Preliminary Efficacy of Digital Cognitive Training in Parkinson's Disease with Mild Cognitive Impairment: A Pilot Study. 数字认知训练治疗帕金森病伴轻度认知障碍的可行性及初步疗效：一项初步研究。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-26 DOI: 10.14802/jmd.25135

Dongje Lee, Hang-Rai Kim, Yu Jeong Park, Yisuh Ahn, Daeho Lee, Jungyeun Lee, Su Jin Chung, Seung Yeon Kim, Yeji Hwang, Ji Young Yun, Jin Whan Cho, Kyum-Yil Kwon, Seong-Beom Koh, Sung Hoon Kang

{"title":"Feasibility and Preliminary Efficacy of Digital Cognitive Training in Parkinson's Disease with Mild Cognitive Impairment: A Pilot Study.","authors":"Dongje Lee, Hang-Rai Kim, Yu Jeong Park, Yisuh Ahn, Daeho Lee, Jungyeun Lee, Su Jin Chung, Seung Yeon Kim, Yeji Hwang, Ji Young Yun, Jin Whan Cho, Kyum-Yil Kwon, Seong-Beom Koh, Sung Hoon Kang","doi":"10.14802/jmd.25135","DOIUrl":"https://doi.org/10.14802/jmd.25135","url":null,"abstract":"Objective: Cognitive impairment is common in Parkinson's disease (PD), with few pharmacological options. We evaluated the effects of a digital cognitive training program (SUPERBRAIN), previously effective in Alzheimer's risk populations, on cognitive function in PD.Methods: Twenty-nine patients with PD and mild cognitive impairment (PD-MCI) from four clinics were randomized to intervention (n=16) or control (n=7). The intervention group completed a 12-week, home-based, tablet cognitive training program (25-30 min/day, 7 days/week). Cognitive outcomes were assessed using the Seoul Neuropsychological Screening Battery pre- and post-intervention.Results: Adherence was 79.4%. The intervention group showed significant improvements in the Seoul Verbal Learning Test (SVLT) delayed recall and controlled oral word association test, with no changes in controls. ANCOVA confirmed a greater SVLT improvement in the intervention group ((F-statistics = 7.15, P-value = 0.015, partial η² = 0.28).Conclusions: SUPERBRAIN is feasible and improves cognitive function in PD-MCI.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting the triglyceride-glucose index in Parkinson's disease: Risk factor or disease marker? 重新审视帕金森病的甘油三酯-葡萄糖指数：危险因素还是疾病标志物？

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-25 DOI: 10.14802/jmd.25222

Shweta Prasad, Tarunya Nagaraj, Shubha Gs Bhat, Mahima Bhardwaj, Pooja Mailankody, Rohan R Mahale, Nitish Kamble, Vikram V Holla, Ravi Yadav, Pramod Kumar Pal

引用次数: 0

Muscle Ultrasonography as a Diagnostic Tool for Assessing Sarcopenia in Parkinson's Disease. 肌肉超声作为帕金森病肌肉减少症的诊断工具。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-19 DOI: 10.14802/jmd.25072

Lay San Lim, Cheng-Hsien Lu, Yun-Ru Lai, Na-Ning Kan, Chien-Chang Liao, Sieh Yang Lee

{"title":"Muscle Ultrasonography as a Diagnostic Tool for Assessing Sarcopenia in Parkinson's Disease.","authors":"Lay San Lim, Cheng-Hsien Lu, Yun-Ru Lai, Na-Ning Kan, Chien-Chang Liao, Sieh Yang Lee","doi":"10.14802/jmd.25072","DOIUrl":"10.14802/jmd.25072","url":null,"abstract":"Objectives: This study aimed to evaluate the feasibility of muscle ultrasonography (US) as a diagnostic tool for assessing sarcopenia in patients with Parkinson's disease (PD), addressing the challenge of early detection to prevent falls and enhance quality of life.Materials & methods: This prospective single-center study evaluated the diagnostic accuracy of US for identifying sarcopenia, using the Asian Working Group for Sarcopenia 2019 criteria as the reference. A total of 85 patients with Parkinson's disease (PD) were recruited between June 2022 and August 2024, comprising 31 individuals in the sarcopenic group and 54 in the non-sarcopenia group. We compared muscle thickness (MT), cross-sectional area (CSA), and shear wave velocity of the rectus femoris (RF), anterior tibialis (AT), and biceps brachii (BB) between the two groups. Statistical analyses included univariate analysis, correlation analysis, and binary logistic regression to develop a prediction model for sarcopenia.Results: The sarcopenia group exhibited lower MTBB, MTAT, and CSAAT compared to the non-sarcopenia group (all p < 0.05). MTBB, CSABB, and CSAAT were significantly correlated with the appendicular skeletal muscle mass index and functional measures (all p < 0.05). The prediction model, which included age, BMI, and MTBB as predictors, achieved an area under the curve of 0.857 (95% CI: 0.782, 0.932; p < 0.001) with a sensitivity of 80.6% and specificity of 79.6%.Conclusion: US is a reliable and effective diagnostic tool for assessing sarcopenia in patients with PD, providing a practical approach for early identification of this condition.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical profile and Genetic Composition of patients with Juvenile Parkinsonism from a single tertiary care center in India. 来自印度单一三级保健中心的青少年帕金森症患者的临床概况和遗传组成。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-19 DOI: 10.14802/jmd.25132

M K Farsana, Vikram V Holla, Prashant Phulpagar, Nitish Kamble, Babylakshmi Muthusamy, Ravi Yadav, Pramod Kumar Pal

{"title":"Clinical profile and Genetic Composition of patients with Juvenile Parkinsonism from a single tertiary care center in India.","authors":"M K Farsana, Vikram V Holla, Prashant Phulpagar, Nitish Kamble, Babylakshmi Muthusamy, Ravi Yadav, Pramod Kumar Pal","doi":"10.14802/jmd.25132","DOIUrl":"10.14802/jmd.25132","url":null,"abstract":"Introduction: Studies outlining the genetic architecture of Parkinson's disease in India are sparse, and juvenile parkinsonism is underrepresented in the literature. The objective was to study the clinical, therapeutic, and genetic profile of patients with juvenile parkinsonism and to correlate phenotypic-genotypic characteristics.Methods: This retrospective chart review was conducted in patients with suspected genetically mediated juvenile parkinsonism (onset≤21 years), who have undergone genetic testing at a tertiary care center in India from 2015-2024. The available phenotypic-genotypic characteristics were evaluated and compared between gene(+) and gene(-) patients.Results: Forty patients (22 males, 55%) with juvenile parkinsonism were included with mean age at onset and presentation of 15.85±4.96 years and 26.37±10.11 years respectively. The mean duration of illness was 10.43±10.49 years. A positive family history was present in 40% and consanguinity in 45%. Bradykinesia was the most common motor symptom (95%) and cognitive impairment was the commonest non-motor symptom (17.5%). Pathogenic/likely pathogenic variants were identified in 27 patients (67.5 %), with variants in PRKN being the most common (n=8) followed by PLA2G6 (n=7). Gene(+) cases had significantly more severe disease with better levodopa response, more frequent familial consanguinity, oculomotor abnormality, motor fluctuations and dyskinesia. PARK-PLA2G6 patients had significantly more dystonia, gaze restriction, pyramidal signs, severe disease at presentation, with lesser LEDD and motor fluctuations compared to PARK-PRKN patients.Conclusion: More than two-thirds (67.5%) of the juvenile parkinsonism patients in our cohort had an underlying monogenetic cause. PARK-PRKN, PARK-PLA2G6, and PARK-SYNJ1 are the common causes of genetically mediated juvenile parkinsonism in India.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Safinamide in Early-Stage Parkinson's Disease: A Pilot Evaluation of Motor Symptom Improvement. 沙非胺治疗早期帕金森病的疗效：运动症状改善的初步评估。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-19 DOI: 10.14802/jmd.25176

Yun Su Hwang, Han Uk Ryu, Sang Yeon Kim, Hyun Goo Kang

引用次数: 0

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-11 DOI: 10.14802/jmd.25121

Shivani Rath, P Arjun Chandrashekar, Aravind Gunasekaran, Vikram V Holla, Nitish Kamble, Pramod Kumar Pal, Ravi Yadav

引用次数: 0

Rescue Right Pallidotomy and Left Thalamotomy in a patient with PLA2G6-associated Refractory Status Dystonicus and Tremor. 挽救右侧和左侧丘脑切开术患者与pla2g6相关的难治性状态肌张力障碍和震颤。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-09 DOI: 10.14802/jmd.25114

M K Farsana, Vikram V Holla, S Swathy, Nitish Kamble, Pramod Kumar Pal, Dwarakanath Srinivas, Ravi Yadav

引用次数: 0

Delayed presentation of Diencephalic-Mesencephalic Junction Dysplasia with Compulsive truncal movements and Blepharospasm: A Case Report from India. 间脑-中脑交界处发育不良伴强迫性躯干运动和眼睑痉挛的延迟表现：印度一例报告。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-05 DOI: 10.14802/jmd.25167

Pavankumar Katragadda, Gorantla Padmasri, Karthik Kulanthaivelu, Ravi Yadav

引用次数: 0

Cardiac 123I-meta-iodobenzylguanidine Imaging as a Biomarker for Body-first Parkinson's Disease: Linking Peripheral α-Synuclein to Clinical Subtyping. 心脏123i -间碘苄基胍成像作为体优先帕金森病的生物标志物：将外周α-突触核蛋白与临床亚型联系起来

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-04 DOI: 10.14802/jmd.25137

Dong-Woo Ryu, Sang-Won Yoo, Yoonsang Oh, Joong-Seok Kim

{"title":"Cardiac 123I-meta-iodobenzylguanidine Imaging as a Biomarker for Body-first Parkinson's Disease: Linking Peripheral α-Synuclein to Clinical Subtyping.","authors":"Dong-Woo Ryu, Sang-Won Yoo, Yoonsang Oh, Joong-Seok Kim","doi":"10.14802/jmd.25137","DOIUrl":"https://doi.org/10.14802/jmd.25137","url":null,"abstract":"Recent neuropathological and imaging studies support the concept of \"brain-first vs. body-first\" Parkinson's disease (PD), based on the α-Synuclein Origin site and Connectome model. The body-first phenotype is characterized by early involvement of the peripheral autonomic nervous system, particularly the cardiac sympathetic nerves and enteric nerves. ¹²³I-meta-iodobenzylguanidine (¹²³I-MIBG) myocardial scintigraphy is a well-established method for evaluating cardiac sympathetic innervation. This review explores the potential of ¹²³I-MIBG scintigraphy as a biomarker to differentiate body-first phenotype from brain-first phenotype. Reduced ¹²³I-MIBG uptake has been observed in idiopathic REM sleep behavior disorder, pure autonomic failure, and incidental Lewy body disease-conditions strongly associated with prodromal or early-stage PD. Postmortem and biopsy evidence indicate α-synuclein accumulation in cardiac nerves and other peripheral sites, consistent with a bottom-up progression. α-Synuclein seed amplification assays further corroborate the association between peripheral α-synuclein burden and reduced ¹²³I-MIBG uptake. While ¹²³I-MIBG myocardial scintigraphy is a promising tool, its limitations include cost, limited availability, and potential confounding from underlying cardiac conditions. Nonetheless, early detection of cardiac sympathetic denervation via ¹²³I-MIBG imaging may enhance diagnosis, support subtype classification, and improve understanding of PD pathogenesis.","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellar Ataxia Due to FGF14 GAA Repeat Expansion: First Southeast Asian Case and Novel Neuroimaging Features. FGF14 GAA重复扩张引起小脑共济失调：东南亚首例病例和新的神经影像学特征。

IF 2.8 4区医学

Journal of Movement Disorders Pub Date : 2025-08-01 DOI: 10.14802/jmd.25163

Akmal Mukhlis, Ai-Huey Tan, Norlisah Ramli, Yi-Wen Tay, Lei-Cheng Lit, Chua Jun Ping, Roberta La Piana, David Pellerin, Shen-Yang Lim

引用次数: 0