Journal of Movement Disorders最新文献

{"title":"Successful Immunosuppressive Treatment of Spinal Segmental Myoclonus in GlyR Antibody-Associated Stiff-Person Spectrum Disorder/PERM Spectrum.","authors":"Yi Yang, Yuanhe Zhang, Pei Xiao, Ting Zeng, Xianwen Zhang, Yufeng Tang","doi":"10.14802/jmd.25331","DOIUrl":"10.14802/jmd.25331","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"334-336"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between the Vestibulo-Ocular Reflex and Cognitive Function in de novo Parkinson's Disease.","authors":"Mincheol Park, Hyun Joo Kim, Chan-Nyoung Lee, Kun-Woo Park, Sun-Uk Lee, Kyoungwon Baik","doi":"10.14802/jmd.25230","DOIUrl":"10.14802/jmd.25230","url":null,"abstract":"<p><strong>Objective: </strong>Vestibulo-ocular reflex (VOR) impairment has been reported in Parkinson's disease (PD). However, its clinical implications, particularly with respect to cognition, remain unclear. We investigated canal-specific VOR changes and their associations with cognitive function, motor symptoms, gaits, and dopamine transporter (DAT) uptake in de novo PD patients.</p><p><strong>Methods: </strong>We prospectively enrolled 127 patients with de novo PD who underwent video head-impulse tests (video-HITs), comprehensive neuropsychological assessments, gait analysis, and 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography. Associations between VOR gains and the clinical characteristics of PD were evaluated using general linear models adjusted for age, sex, and education level. Cognitive analyses were performed after the patients were stratified into PD with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI) groups. Partial correlation analyses were performed to assess the relationships between VOR gains and regional DAT uptake.</p><p><strong>Results: </strong>Decreased VOR gain in at least one canal was observed in 22 patients (17.32%). Horizontal canal (HC) gain was positively associated with the Korean version of Montreal Cognitive Assessment score (p=0.040), and anterior canal (AC) gain was negatively associated with the base of support (p=0.018). The patterns of association between VOR gains and neuropsychological measures differed between the PD-NC and PD-MCI groups. In addition, VOR-cognition relationships were canal-specific: HC gain was positively related to visuospatial function, whereas AC and posterior canal gains were negatively related to language and frontal-executive functions. DAT uptake in the locus coeruleus was positively correlated with HC gain (p=0.020).</p><p><strong>Conclusion: </strong>VOR integrity is associated with cognitive and gait function in patients with PD. Video-HITs may serve as potential biomarkers for disease monitoring in PD patients.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"275-283"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of Refractory Restless Legs Syndrome in a Parkinson's Disease Patient After Semaglutide Treatment: A Novel Clinical Observation.","authors":"Pasquale Maria Pecoraro, Silvia Lodico, Francesco Bugamelli, Martina Di Carluccio, Lazzaro di Biase","doi":"10.14802/jmd.26097","DOIUrl":"10.14802/jmd.26097","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"353-355"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148225968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematopoietic Stem Cell Transplantation for CSF1R-Related Disorder: A Longitudinal Study of Efficacy and Safety.","authors":"Tomasz Chmiela, Kamila Żur-Wyrozumska, Patrycja Mensah-Glanowska, Audrey J Strongosky, Erik H Middlebrooks, Ernesto Ayala, Zbigniew K Wszolek","doi":"10.14802/jmd.26005","DOIUrl":"10.14802/jmd.26005","url":null,"abstract":"<p><strong>Objective: </strong>This longitudinal study evaluated the long-term efficacy and safety of hematopoietic stem cell transplantation (HSCT) in slowing the progression of CSF1R-related disorder (CSF1R-RD).</p><p><strong>Methods: </strong>Six symptomatic patients (mean follow-up, 6.6 years) were compared with six matched, untreated controls. The CSF1R Clinical Severity Score (CCSS), Montreal Cognitive Assessment, and Sundal radiological score were used for evaluation.</p><p><strong>Results: </strong>Post-HSCT clinical progression slowed significantly from 14.1 to 3.7 CCSS/year, compared with 15.2 CCSS/year in the control group (p<0.01). Cognitive decline was substantially reduced (-1.5 points/year vs. -7.6 points/year), and radiological deterioration slowed (0.4 per year vs. 3.9 per year). Notably, during the observation period, all HSCT patients survived, whereas 50% of the patients in the control group died. No serious transplant-related complications were observed.</p><p><strong>Conclusion: </strong>HSCT is a potent disease-modifying therapy for CSF1R-RD that drastically improves survival and slows deterioration. These findings underscore the necessity of early intervention during the symptomatic phase to maximize the preservation of quality of life for affected individuals.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"322-326"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive Brain Stimulation for Parkinson's Disease: Therapeutic Applications and Clinical Perspectives.","authors":"Hae-Won Shin, Zoltan Mari","doi":"10.14802/jmd.26168","DOIUrl":"10.14802/jmd.26168","url":null,"abstract":"<p><p>Noninvasive brain stimulation (NIBS), including repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), and transcranial alternating current stimulation (tACS), has been investigated as an adjunctive therapeutic approach for neurological and psychiatric disorders. In Parkinson's disease (PD), NIBS is of particular interest because several motor and nonmotor symptoms remain insufficiently controlled by pharmacological or surgical treatments. This review summarizes the mechanisms and clinical applications of NIBS in PD, with emphasis on cortical excitability, synaptic plasticity, and network oscillations. These physiological effects may contribute to therapeutic benefit, although clinical responses vary according to stimulation parameters, disease stage, and concurrent task or rehabilitation context. Among NIBS modalities, rTMS has the most consistent clinical evidence, particularly for improving motor symptoms, gait disturbance, depression, and selected cognitive outcomes when applied to the motor cortex, supplementary motor area, or dorsolateral prefrontal cortex. tDCS has shown limited and inconsistent efficacy as a monotherapy for motor symptoms but may have potential benefits for cognitive and mood-related outcomes, especially when combined with physical rehabilitation or cognitive training. tACS remains at an earlier stage of clinical investigation, with preliminary evidence suggesting that frequency-specific stimulation may modulate abnormal oscillatory activity and improve selected motor outcomes, such as tremor or motor stability. Safety, tolerability, and biomarker-guided personalization are important considerations for clinical translation. Further studies are needed to standardize stimulation protocols, assess long-term efficacy, and identify predictors of treatment response. Overall, NIBS represents a generally safe and noninvasive approach that may complement existing treatments for PD. This review summarizes the current evidence and future directions for NIBS-based interventions.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"249-260"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downbeat Nystagmus and Slow Orthostatic Tremor: Expanding the Clinical Spectrum of PNPLA6-Related Disorders.","authors":"Madathum Kuzhiyil Farsana, Vikram V Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal","doi":"10.14802/jmd.26013","DOIUrl":"10.14802/jmd.26013","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"327-329"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attentional or Non-Tactile Sensory Tricks in Idiopathic Cervical Dystonia: A Phenomenological Observation.","authors":"Tara Khoeini, Gholam Ali Shahidi, Mohammad Rohani","doi":"10.14802/jmd.26034","DOIUrl":"10.14802/jmd.26034","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"346-348"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosis After Weight Loss During Continuous Subcutaneous Foslevodopa/Foscarbidopa Therapy.","authors":"Laura Hartmann, Klaus Seppi, Lukas Gattermeyer-Kell, Petra Katschnig-Winter, Daniela Kern, Mariella Kögl, Elisabeth Sokol, Christian Enzinger, Petra Schwingenschuh","doi":"10.14802/jmd.26058","DOIUrl":"10.14802/jmd.26058","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"349-352"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Cognitive Function in Complex Gait Patterns.","authors":"Seong-Beom Koh","doi":"10.14802/jmd.26192","DOIUrl":"10.14802/jmd.26192","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":"19 3","pages":"247-248"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myoclonus and Gaze Palsy in Childhood-Onset SQSTM1-Related Neurodegeneration.","authors":"Jacky Ganguly, Sayoni Roychowdhury, Rohit Keshav, Debayan Dutta, Soumava Mukherjee, Purba Basu, Hrishikesh Kumar","doi":"10.14802/jmd.26164","DOIUrl":"10.14802/jmd.26164","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"363-364"},"PeriodicalIF":4.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}