Journal of Movement Disorders最新文献

{"title":"Cognitive Impairment Alters Cortical Adaptation and Gait Regulation During Obstacle Walking in Parkinson's Disease: Evidence from Temporal fNIRS and Gait Dynamics.","authors":"Pei-Ling Wong, Yea-Ru Yang, Chen-Wei Hung, Nai-Chen Yeh, Shih-Jung Cheng, Ray-Yau Wang","doi":"10.14802/jmd.25346","DOIUrl":"https://doi.org/10.14802/jmd.25346","url":null,"abstract":"<p><strong>Background: </strong>Obstacle crossing during walking poses a major fall risk in individuals with Parkinson's disease (PD), particularly those with cognitive impairment. Although cognitive decline worsens gait, its specific effects on gait performance and cortical activation during obstacle walking remain unclear. The dynamic interaction between brain activity and gait across different walking phases is especially understudied in PD with mild cognitive impairment (PD-MCI) compared to those without cognitive impairment (PD-nonMCI).</p><p><strong>Methods: </strong>Nineteen PD-nonMCI and fifteen PD-MCI participants performed obstacle walking while functional near-infrared spectroscopy (fNIRS) measured activation in the prefrontal cortex (PFC), supplementary motor area (SMA), and premotor cortex (PMC). Gait parameters (speed, cadence, stride length, stride time) and obstacle crossing metrics (crossing speed, stride length, stride time, step width) were analyzed across early (5-20 s) and late (20-40 s) phases. Generalized estimating equations examined group, phase, and interaction effects. Brain-gait associations were assessed using Spearman's correlations.</p><p><strong>Results: </strong>PD-MCI participants exhibited poorer obstacle walking performance but no significant phase-related behavioral change. Both groups showed higher PFC, SMA, and PMC activation during the early phase, reflecting greater neural engagement at task onset. However, SMA and PMC activation declined more steeply across phases in the PD-MCI group. In PD-MCI, obstacle walking performance correlated negatively with early-phase PMC and late-phase PFC activation.</p><p><strong>Conclusions: </strong>PD-MCI participants showed poorer gait and higher cortical activation, indicating increased neural effort and reduced efficiency. These results highlight altered brain-gait coupling in PD-MCI and emphasize the need for interventions enhancing neural efficiency during complex walking.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematopoietic Stem Cell Transplantation for CSF1R-Related Disorder: A Longitudinal Study of Efficacy and Safety.","authors":"Tomasz Tomasz, Kamila Żur-Wyrozumska, Patrycja Mensah-Glanowska, Audrey J Strongosky, Erik H Middlebrooks, Ernesto Ayala, Zbigniew K Wszolek","doi":"10.14802/jmd.26005","DOIUrl":"https://doi.org/10.14802/jmd.26005","url":null,"abstract":"<p><strong>Objective and design: </strong>This longitudinal study evaluated the long-term efficacy and safety of hematopoietic stem cell transplantation (HSCT) in slowing CSF1R-RD progression. Researchers compared six symptomatic patients (mean follow-up 6.59 years) to six matched untreated controls. Evaluation utilized the CSF1R-Clinical Severity Score (CCSS), Montreal Cognitive Assessment (MoCA), and Sundal radiological scores.</p><p><strong>Results: </strong>Post-HSCT clinical progression slowed significantly from 14.1 to 3.7 CCSS/year, compared to 15.2 in the control group ($p<0.01$). Cognitive decline was substantially reduced (-1.5 vs. -7.6 points/year), and radiological deterioration slowed (0.37 vs. 3.9 per year). Remarkably, all HSCT patients survived, while 50% of the control group died during the observation period. No serious transplant-related complications were observed.</p><p><strong>Conclusion: </strong>HSCT is a potent disease-modifying therapy for CSF1R-RD, drastically improving survival and slowing deterioration. The findings underscore the necessity of early intervention during the symptomatic phase to maximize the preservation of quality of life for affected individuals.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Socioeconomic Status on the Risk of Disability Registration and Cognitive Decline in Patients with Parkinson's Disease: A Nationwide Cohort Study.","authors":"Myung Jun Lee, Dong Wook Kim, Kyoungjune Pak, Minkyeong Kim, Jae-Hyeok Lee","doi":"10.14802/jmd.25330","DOIUrl":"https://doi.org/10.14802/jmd.25330","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between vestibulo-ocular reflex and cognitive function in de novo Parkinson's disease.","authors":"Hyun Joo Kim, Mincheol Park, Chan-Nyoung Lee, Kun-Woo Park, Sun-Uk Lee, Kyoungwon Baik","doi":"10.14802/jmd.25230","DOIUrl":"https://doi.org/10.14802/jmd.25230","url":null,"abstract":"<p><strong>Objective: </strong>Vestibulo-ocular reflex (VOR) impairment has been reported in Parkinson's disease (PD). However, the clinical implications, particularly for cognition remains unclear. We investigated canal-specific VOR changes and their associations with cognitive function, motor symptoms, gaits, and dopamine transporter (DAT) uptake in de-novo PD.</p><p><strong>Methods: </strong>We prospectively enrolled 127 patients with de- novo PD who underwent video head-impulse tests (video-HITs), comprehensive neuropsychological assessment, gait analysis, and FP-CIT PET. Associations between VOR gains and clinical characteristics of PD were evaluated using general linear models adjusted for age, sex, and education. Cognitive analyses were performed after stratifying patients into PD with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI). Partial correlation analyses assessed relationships between VOR gains and regional DAT uptake.</p><p><strong>Results: </strong>Decreased VOR gain in at least one canal was observed in 22 patients (17.3%). Horizontal canal (HC) gain was positively associated with the Montreal Cognitive Assessment (p=0.040), anterior canal (AC) gain had negative association with the base of support (p=0.018). Patterns of association between VOR gains and neuropsychological measures differed between PD-NC and PD-MCI. In addition, VOR-cognition relationships were canal-specific: HC gain was positively related to visuospatial function, whereas AC and posterior canal gains were negatively related to language and frontal-executive functions. DAT uptake in the locus coeruleus was positively correlated with HC gain (p=0.020). Conclusion: VOR integrity is associated with cognitive and gait function in patients with PD. Video-HITs may serve as a potential biomarker for disease monitoring in PD.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Downbeat nystagmus and slow orthostatic tremor - Expanding the clinical spectrum of PNPLA6-related disorder.","authors":"M K Farsana, Vikram V Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal","doi":"10.14802/jmd.26013","DOIUrl":"https://doi.org/10.14802/jmd.26013","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potassium calcium-activated Channel subfamily M Alpha1 (KCNMA1) Channelopathy: First case report from India.","authors":"M K Farsana, Vikram V Holla, Mit Ankur Raval, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal","doi":"10.14802/jmd.25336","DOIUrl":"https://doi.org/10.14802/jmd.25336","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Taltirelin Hydrate in Patients With Ataxia Due to Spinocerebellar Degeneration.","authors":"Jin Whan Cho, Jee-Young Lee, Han-Joon Kim, Joong-Seok Kim, Kun-Woo Park, Seong-Min Choi, Chul Hyoung Lyoo, Seong-Beom Koh","doi":"10.14802/jmd.24127e","DOIUrl":"https://doi.org/10.14802/jmd.24127e","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146227077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Amnesia Light and Brief Assessment (ALBA) and the door PICture Naming and Immediate Recall (PICNIR) brief tests for identifying mild cognitive impairment in Parkinson's disease.","authors":"Kateřina Stolaríková, Aleš Bartoš, Kateřina Menšíková, Helena Kisvetrová, Jana Zapletalová, Sandra Kurčová, Raymond Rosales, Petr Kaňovský","doi":"10.14802/jmd.25271","DOIUrl":"https://doi.org/10.14802/jmd.25271","url":null,"abstract":"<p><strong>Objective: </strong>To identify mild cognitive impairment (MCI) in Parkinson's disease (PD) using two brief tests the Amnesia Light and Brief Asssment (ALBA) and the door Picture Naming and Immediate Recall (dPICNIR) in 6-8 minutes.</p><p><strong>Methods: </strong>The ALBA, the dPICNIR and the third version of the Addenbrooke's Cognitive Examination III (ACE-III) were administered to 124 participants, equally divided into PD patients and socio-demographically matched normal controls (NC). The PD group was divided into those with normal cognitive functions (PD-CN) and with MCI (PD-MCI) using neuropsychological tests.</p><p><strong>Results: </strong>Cognitive impairment in the PD group was mild, with significantly lower ACE-III scores than in NC (91 vs. 96 points). Despite these subtle deficits, gesture recall in the ALBA was significantly lower even in the PD-CN group compared to the NC. PD-MCI patients had other significant deficits in the ALBA and PICNIR tests. In the PD group, the gesture recall in the ALBA and correctly recalled pictures in the dPICNIR correlated with the results of verbal fluency and trail making tests, followed by memory tests and all ACE-III scores except visuospatial one. In contrast, correctly recalled sentence words in the ALBA correlated with the memory and language scores in the ACE-III test and memory test scores.</p><p><strong>Conclusions: </strong>Subtle cognitive changes in PD can be detected through gesture recall test, even in those with normal cognition. The ALBA and PICNIR tests are effective in identifying MCI in PD and provide a brief and valid assessment of cognitive functions. They are freely available at www.abadeco.cz.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146180319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropsychiatric and cognitive safety of subcutaneous foslevodopa/foscarbidopa in advanced Parkinson's disease: insights from a real-world cohort.","authors":"Clément Desjardins, Hélène de Saint Vaulry, Quentin Salardaine, Céline Rosset, Jean-Philippe Brandel, Guillaume Baille","doi":"10.14802/jmd.25304","DOIUrl":"https://doi.org/10.14802/jmd.25304","url":null,"abstract":"<p><strong>Background: </strong>Continuous subcutaneous foslevodopa/foscarbidopa infusion (CSFLI) represents a transformative therapy for advanced Parkinson's disease (aPD), but real-world neuropsychiatric safety data remain limited, particularly in populations typically excluded from trials. Objective: To assess the frequency, clinical patterns, and predictors of neuropsychiatric and/or cognitive worsening in a real-world CSFLI-treated cohort.</p><p><strong>Methods: </strong>We performed a retrospective observational study of 36 consecutive aPD patients initiating CSFLI with six-month follow-up. Neuropsychiatric/cognitive worsening was defined as any clinically meaningful increase in MDS-UPDRS Part I or PDQ-8 cognitive/psychiatric subscores. Patients were classified as \"worsening\" versus \"no worsening\" and compared for baseline characteristics. Predictors were identified using univariable and exploratory multivariable analyses.</p><p><strong>Results: </strong>Seventeen patients (47.2%) experienced neuropsychiatric/cognitive worsening within six months. Critically, patients with prior confusion or hallucinations who were managed with baseline clozapine had significantly better outcomes: confusion history 57.9% in stable group versus 11.8% in worsening group (p=0.006); clozapine use 63.2% versus 23.5% (p=0.023). Conversely, COMT inhibitor (COMT-I) use was more frequent in the worsening group (70.6% vs 21.1%, p=0.006). Motor outcomes remained stable at 6 months regardless of neuropsychiatric status.</p><p><strong>Conclusions: </strong>In a vulnerable real-world aPD population, neuropsychiatric/cognitive worsening under CSFLI was more frequent than in pivotal trials (47% vs 7-17%) but generally mild and without motor deterioration. Importantly, proactive clozapine use enabled safe CSFLI treatment in patients with psychiatric histories traditionally considered high-risk. COMT-I emerged as a modifiable risk factor. Findings support broader CSFLI use with structured neuropsychiatric monitoring and proactive clozapine in selected patients.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endurance and Efficiency of Cycling and Manual Wheelchairs in Late-Stage Parkinson's Disease: A Preliminary Study.","authors":"Mayura Konzo, Masaru Narita, Masaki Naito, Ayumi Ide, Taiyo Kai, Dai Wakabayashi, Wataru Fujita, Tomohiro Shibata, Yohei Okada","doi":"10.14802/jmd.25317","DOIUrl":"https://doi.org/10.14802/jmd.25317","url":null,"abstract":"<p><strong>Objective: </strong>In late-stage Parkinson's disease (PD), wheelchair mobility becomes essential, yet little is known about endurance and efficiency. For individuals who struggle with manual wheelchair (MW) propulsion, a cycling wheelchair (CW) may provide an alternative. This study compared endurance and efficiency between MW and CW during continuous driving, including turning tasks in late-stage PD.</p><p><strong>Methods: </strong>Nine participants with late-stage PD performed the 6-Minute Push Test using both MW and CW. Total distance, average speed, and the Physiological Cost Index (PCI) were measured. PCI was calculated from pre- and post-driving heart rates.</p><p><strong>Results: </strong>CW resulted in significantly greater total distance and lower PCI than MW, and similar patterns were observed in participants at Hoehn and Yahr stage V (n = 6).</p><p><strong>Conclusion: </strong>CW use may enable more enduring and efficient mobility than MW use in late-stage PD. Further studies are needed to validate these preliminary findings.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}