Journal of Movement Disorders最新文献

{"title":"Impact of Socioeconomic Status on the Risk of Disability Registration and Cognitive Decline in Patients With Parkinson's Disease: A Nationwide Cohort Study.","authors":"Myung Jun Lee, Dong Wook Kim, Kyoungjune Pak, Minkyeong Kim, Jae-Hyeok Lee","doi":"10.14802/jmd.25330","DOIUrl":"10.14802/jmd.25330","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"232-234"},"PeriodicalIF":4.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13175741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Additional Occipital Involvement in Parkinson's Disease With Posterior Cortical Hypoperfusion.","authors":"Chan Wook Park, Su Hong Kim, Phil Hyu Lee, Yun Joong Kim, Young H Sohn, Yong Jeong, Seok Jong Chung","doi":"10.14802/jmd.25231","DOIUrl":"10.14802/jmd.25231","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the clinical relevance of occipital hypoperfusion in patients with Parkinson's disease (PD) with respect to clinical phenotype and the risk of dementia conversion.</p><p><strong>Methods: </strong>We enrolled 349 patients with newly diagnosed PD and 48 healthy controls who underwent dual-phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) positron emission tomography (PET). Patients with PD were classified into three groups based on posterior cortical perfusion patterns on early-phase 18F-FP-CIT PET images: PD with preserved posterior cortical perfusion (n=186), PD with parieto-temporal hypoperfusion (n=84), and PD with parieto-temporo-occipital hypoperfusion (n=79). Baseline clinical features and dementia conversion risk were compared across PD groups.</p><p><strong>Results: </strong>Patients with preserved posterior cortical perfusion were younger than those in the other PD groups. Compared with the other groups, the parieto-temporo-occipital hypoperfusion group tended to have lower Cross-Cultural Smell Identification Test scores, a higher prevalence of rapid eye movement sleep behavior disorder, higher Unified PD Rating Scale motor scores, and more severe reductions in striatal dopamine transporter availability. The risk of dementia conversion was lower in patients with preserved posterior cortical perfusion than in those with posterior cortical hypoperfusion. However, the risk of dementia conversion did not differ between the parieto-temporal and parieto-temporo-occipital hypoperfusion groups.</p><p><strong>Conclusion: </strong>Additional occipital hypoperfusion was not associated with an imminent risk of dementia conversion in patients with PD with posterior cortical hypoperfusion. Nonetheless, occipital involvement may serve as an indicator of the diffuse malignant subtype of PD.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"58-66"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Typical Freezing of Gait Episodes Reported as Astasia-Abasia in the 19th Century.","authors":"Yasuyuki Okuma, Jorik Nonnekes, Bastiaan R Bloem","doi":"10.14802/jmd.25214","DOIUrl":"10.14802/jmd.25214","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"105-106"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conceptualizing a Personalized Care Pathway for Parkinson's Disease Using Wearable Sensors in Muslim Patients: The Ramadan Regime.","authors":"Vinod Metta, Huzaifa Ibrahim, Haidar Dafsari, Rajinder K Dhamija, Hani T S Benamer, Tom Loney, Mishal Abu Al-Melh, Hasna Hussain, Afsal Nalarekttil, Guy Chung-Faye, Gloria Tanjung, Bushra Alblooshi, Shaikha Almazrouei, Bassam Darwish, Mohamed Al Mheiri, Mohamed Elmahdy, Rukmini Mridula, Sai Sampath Kumar, Vinay Goyal, Karolina Popławska-Domaszewicz, Cristian Falup Pecurariu, Prashanth Kukle, Jacob Chacko, Rupam Borgohain, Kallol Ray Chaudhuri","doi":"10.14802/jmd.25198","DOIUrl":"10.14802/jmd.25198","url":null,"abstract":"<p><strong>Objective: </strong>Parkinson's disease (PD) affects approximately 2% of individuals over the age of 60. With more than two billion Muslims observing Ramadan, individuals with PD encounter specific challenges, such as deteriorating motor skills, sleep disturbances, and an increased risk of falls during fasting.</p><p><strong>Methods: </strong>Our study focused on 75 patients with idiopathic PD divided into two groups: the Ramadan Regime group, which consisted of 50 patients whose medication was adjusted to twice daily at Suhoor and Iftar, and the Nontreatment group, which included 25 patients who abstained from medication for religious reasons. Both groups were instructed to wear a Parkinson's KinetiGraph (PKG) wrist device.</p><p><strong>Results: </strong>The study findings revealed that motor function worsened in the Nontreatment group (p<0.001) but improved in the Ramadan Regime group (p=0.007). Daytime sleepiness also significantly increased in the Nontreatment group (p<0.001).</p><p><strong>Conclusion: </strong>Overall, the findings suggest that the Ramadan regime significantly enhances patient health and quality of life.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"39-48"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Peripheral NLRP3 Inflammasome Expression in Patients With Parkinson's Disease and Patients With Multiple System Atrophy.","authors":"Jeongjae Lee, Han-Joon Kim, Huu Dat Nguyen, Suk Jun Song, Trung Nguyen Thanh, In Hee Kwak, Hye Joung Choi, Hyeo-Il Ma, Young Eun Kim","doi":"10.14802/jmd.25124","DOIUrl":"10.14802/jmd.25124","url":null,"abstract":"<p><strong>Objective: </strong>The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has been proposed to be a downstream mediator of neuroinflammation in individuals with Parkinson's disease (PD). However, its involvement across disease stages and related synucleinopathies, such as multiple system atrophy (MSA), remains unclear. We aimed to analyze the peripheral mRNA expression of NLRP3-related genes and cytokines across individuals with isolated REM sleep behavior disorder (iRBD), early-stage PD, late-stage PD, and MSA.</p><p><strong>Methods: </strong>Peripheral blood mononuclear cells (PBMCs) were collected from 151 participants: 35 healthy controls (HCs), 31 patients with iRBD, 41 patients with early-stage PD, 21 patients with late-stage PD, and 23 patients with MSA. mRNA expression was measured using quantitative real-time polymerase chain reaction. Statistical comparisons were performed using analysis of variance (ANOVA) or Welch's ANOVA, and associations with clinical variables were analyzed through stepwise multiple linear regression.</p><p><strong>Results: </strong>NLRP3 expression was significantly lower in patients with iRBD (p=0.0263) and patients with early-stage PD (p= 0.0101) than in HCs. NIMA-related kinase 7 (NEK7) expression progressively decreased across the disease spectrum (HCs vs. patients with early-stage PD, p=0.0008; vs. patients with late-stage PD, p<0.0001). In contrast, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and caspase-1 were elevated in patients with PD, especially those in the late stages. Levels of patients with MSA resembled those of HCs but differed from those of patients with PD. Interleukin (IL)-1β and IL-18 levels were not significantly different. In patients with early-stage PD, NLRP3 expression was negatively correlated with disease duration, the Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part II score, and the cognitive score.</p><p><strong>Conclusion: </strong>Our findings challenge the prevailing hypothesis that NLRP3 inflammasome activation directly contributes to PD pathogenesis. Instead, the observed increase in ASC and caspase-1 expression suggests the potential involvement of alternative inflammasome pathways during disease progression.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"31-38"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Brain Stimulation for Hemiballismus: A Case Report and Review of the Literature.","authors":"Negin Eissazade, Seyedehnarges Tabatabaee, Mansour Parvaresh-Rizi, Gholamali Shahidi, Behnam Safarpour Lima, Sadra Rohani, Renato P Munhoz, Alfonso Fasano, Mohammad Rohani","doi":"10.14802/jmd.25236","DOIUrl":"10.14802/jmd.25236","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"107-110"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enriching Global Perspectives Through a Regional Lens: Recognition, Assessment, and Management of Tardive Dyskinesia in Southeast Asia.","authors":"Roongroj Bhidayasiri, Jin Kiat Ang, Kok Yoon Chee, Roger Ho, Ahmad Shahir Bin Mawardi, Adhi Wibowo Nurhidayat, Pongsatorn Paholpak, Pornjira Pariwatcharakul, Thitima Sanguanvichaikul, Eng Khean Ung, Natalia Dewi Wardani, Brian Yeo","doi":"10.14802/jmd.25146","DOIUrl":"10.14802/jmd.25146","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"11-18"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Writer's Cramp, a Task-Specific Focal Hand Dystonia, is Treatable With Dopaminergic Modulation Targeting Striatal Striosomes: A Case Report.","authors":"Nobuhiro Inoue, Satoshi Goto","doi":"10.14802/jmd.25177","DOIUrl":"10.14802/jmd.25177","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"90-93"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chorea in a Patient With GRID2-Related Disorder: Expanding the Phenotypic Spectrum Beyond Cerebellar Ataxia and Tonic Upgaze.","authors":"Gurumurthy Bharanidharan, Asish Vijayaraghavan, Syam Krishnan, Kalikavil Puthanveedu Divya, Soumya Sundaram","doi":"10.14802/jmd.25205","DOIUrl":"10.14802/jmd.25205","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"111-113"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145390518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of MAO-B and COMT Inhibitors on Sleep Disturbances in Patients With Parkinson's Disease: A Network Meta-Analysis.","authors":"Seon-Min Lee, Sung Ryul Shim, Kyum-Yil Kwon, Taeho Greg Rhee, Yu Jin Jung","doi":"10.14802/jmd.25253","DOIUrl":"10.14802/jmd.25253","url":null,"abstract":"<p><strong>Objective: </strong>Sleep disturbances are common and debilitating nonmotor symptoms (NMS) in Parkinson's disease (PD) patients and profoundly affect quality of life. Despite emerging evidence suggesting that monoamine oxidase B (MAO-B) and catechol-O-methyltransferase (COMT) inhibitors may alleviate NMS, their specific effects on sleep remain unclear. The aim of this network meta-analysis (NMA) was to compare the efficacy of these inhibitors related to sleep problems in PD patients.</p><p><strong>Methods: </strong>Following a systematic search of PubMed, Cochrane, and Embase, studies comparing MAO-B or COMT inhibitors and assessing sleep outcomes in PD patients were identified. An NMA was conducted using data from the seven studies that met our inclusion criteria. The outcomes included subjective sleep quality, daytime sleepiness, and objective polysomnography (PSG) parameters.</p><p><strong>Results: </strong>No statistically significant differences were found between the effects of the MAO-B and COMT inhibitors on improving subjective sleep quality or daytime sleepiness. However, analyses of objective PSG data revealed that, compared with rasagiline and placebo, safinamide significantly increased rapid eye movement sleep duration (mean difference, 5.70 min [95% CI, 2.26 to 9.14]) and decreased wake time after sleep onset (mean difference, -10.20 min [-19.38 to -1.02]).</p><p><strong>Conclusion: </strong>These findings suggest that safinamide may offer additional value for managing sleep disruptions beyond its known motor benefits in patients with PD. Given the limited number and small scale of available trials, the overall evidence should be interpreted cautiously. Nonetheless, this analysis highlights the need for future high-quality trials focused on sleep outcomes to guide the personalized use of MAO-B and COMT inhibitors for sleep disturbances in PD patients.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"67-75"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12885646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}