Journal of Movement Disorders最新文献

{"title":"Efficacy of Levodopa/Benserazide Dispersible Tablets on \"Delayed ON \" to the First Morning Dose in Patients With Parkinson's Disease With Motor Fluctuations: A Multicenter, Randomized, Open-Label, Crossover Trial.","authors":"Hee Jin Chang, Jongkyu Park, Sohee Oh, Chaewon Shin, Ji Won Kim, Jin Whan Cho, Jee-Young Lee","doi":"10.14802/jmd.25031","DOIUrl":"10.14802/jmd.25031","url":null,"abstract":"<p><strong>Objective: </strong>Delayed ON is a condition in which Parkinson's disease (PD) patients do not experience the effect of levodopa in time after taking the dosage. The ability of various oral levodopa regimens to overcome this problem has been poorly investigated. To evaluate the efficacy of levodopa/benserazide dispersible tablets in PD patients with delayed ON to the first morning dose.</p><p><strong>Methods: </strong>This multicenter, randomized, crossover trial involved 40 eligible PD patients with delayed ON. The participants were randomized to receive either levodopa/benserazide 100 mg dispersible or regular tablets for 4 weeks, followed by a one-week wash-out interval and an alternate drug for another 4 weeks. Participants took the investigational drug with the first morning dose of their antiparkinsonian medications. Other medications were not changed during the trial. The primary outcome was changes in time-to-ON after the first-morning dose recorded in a special diary before and after each therapy. We also evaluated changes in parkinsonism, motor fluctuations, and dyskinesia using the Unified PD Rating Scale and the Unified Dyskinesia Rating Scale. Finally, we investigated whether efficacy was affected by Helicobacter pylori status via baseline serum samples from every participant.</p><p><strong>Results: </strong>Nine patients dropped out during the trial. The time-to-ON was significantly reduced by the dispersible tablet compared with the regular tablet (-34.72 vs. -23.81 minutes, p=0.014). There were no significant changes in parkinsonian severity or dyskinesia with either drug. The dispersible formulation was beneficial for both Helicobacter pylori-positive and -negative groups.</p><p><strong>Conclusion: </strong>Levodopa/benserazide dispersible formulations can improve time-to-ON without exacerbating dyskinesia in PD patients suffering from delayed ON.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"244-252"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine Transporter Deficiency Syndrome: A Rare Case of Infantile-Onset Dystonia-Parkinsonism.","authors":"Bhavani Madduluri, Divyateja Garapati, Sireesha Yareeda","doi":"10.14802/jmd.25057","DOIUrl":"10.14802/jmd.25057","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"280-282"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Uncommon Cause of Progressive Rest, Postural and Kinetic Tremor With Ataxia in a Middle-Aged Man: A Rare Case of Klinefelter's Syndrome.","authors":"Malghalara Naeem, Shakya Bhattacharjee","doi":"10.14802/jmd.25081","DOIUrl":"10.14802/jmd.25081","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"283-284"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Burden of Rheumatic Chorea in the Modern Era: A Case Series From a Tertiary Health Care Center in South India.","authors":"Madathum Kuzhiyil Farsana, Vikram V Holla, Nitish Kamble, Rohan R Mahale, Faheem Arshad, Pramod Kumar Pal, Ravi Yadav","doi":"10.14802/jmd.25018","DOIUrl":"10.14802/jmd.25018","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"277-279"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Multimodal Functional Imaging: An Essential Tool for Visualizing Pathologic Progression in Parkinson's Disease.","authors":"Antonio Martín-Bastida, María Cruz Rodríguez-Oroz","doi":"10.14802/jmd.24257","DOIUrl":"10.14802/jmd.24257","url":null,"abstract":"<p><p>Research on the pathophysiology of Parkinson's disease (PD) has traditionally been performed with functional magnetic resonance imaging (fMRI); however, only a few studies have been conducted in longitudinal cohorts. In the present literature review, we aim to summarize the most recent progress in functional fMRI studies in prospective cohorts and, more specifically, in combination with other biomarkers to track the disease progression of PD. This review focuses on the potential application of multimodal longitudinal functional approaches based on the current evidence for the purpose of understanding disease progression and monitoring future therapeutic interventions.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":"197-207"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic variability in ATP13A2 mutations-First Report of SPG78 from India.","authors":"Lakshmi Priya L, Asish Vijayaraghavan, Syam Krishnan","doi":"10.14802/jmd.25100","DOIUrl":"https://doi.org/10.14802/jmd.25100","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability in Pull Test Performance Within a Tertiary Movement Disorders Center.","authors":"Carla Silva-Batista, Lee Neilson, Hanna Whang, Jacqueline Ellison, Delaram Safarpour, Lauren Talman, Fay B Horak, John Nutt, Marian L Dale","doi":"10.14802/jmd.25140","DOIUrl":"10.14802/jmd.25140","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of handedness and extrainstrumental burdens on the course of musicians' dystonia.","authors":"J Doll-Lee, E Passarotto, Altenmüller E, Lee A","doi":"10.14802/jmd.25064","DOIUrl":"https://doi.org/10.14802/jmd.25064","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the impact of extrainstrumental workload on musician's hand dystonia (MD) and its relation to playing ability by testing two hypotheses: 1) the dominant hand is more severely affected at dystonia-onset; 2) improvement during treatment depends on whether the dominant or non-dominant hand is affected.</p><p><strong>Methods: </strong>151 patients with dominant-hand MD and 92 with non-dominant hand MD were assessed regarding their playing ability at dystonia-onset (T0) and after treatment (T1).</p><p><strong>Results: </strong>There was no significant difference in playing-ability at onset between groups. Significant improvement and a greater change in playing-ability was observed in the dominant-hand group. We found no difference in the proportional frequency of right-handed and left-handed individuals in the group of patients affected on the right or left side respectively.</p><p><strong>Conclusion: </strong>These findings suggest that handedness does not influence MD localization, but the prognosis is more favorable for those with dominant hand dystonia, potentially due to metaplasticity effects.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-Guided Focused Ultrasound (MRgFUS) in Parkinson's Disease and Essential Tremor: Incisionless but Invasive! - A Narrative Review.","authors":"Vinod Metta, Hani T S Benamer, Dr Georgios Kapsas, Rukmini Mridula, Rajesh Alugolu, Hasna Hussain, Afsal Nalarakettil, Sampath Kumar N S, Mohamed Elmahdy, Rupam Borgohain, K Ray Chaudhuri","doi":"10.14802/jmd.25042","DOIUrl":"https://doi.org/10.14802/jmd.25042","url":null,"abstract":"<p><p>Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging and promising technology for treating movement disorders, such as essential tremor and tremor-dominant Parkinson's disease. It utilises advanced ultrasound transducer emitters to condense sound waves at a precisely defined point able to target various brain areas, such as the pallidothalamic tract, thalamus, and pallidum that ameliorates some of the symptoms of Parkinson's disease and other movement disorders like dystonic and action induced tremors. we review the current status of preclinical and clinical trials clinical use, treatment outcomes and indications of Magnetic resonance-guided focused ultrasound (MRgFUS).</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical imaging findings in corticobasal syndrome: a case report.","authors":"Hyunji Kim, Seo Young Kang, Ji Young Yun, Jee Hyang Jeong","doi":"10.14802/jmd.25034","DOIUrl":"https://doi.org/10.14802/jmd.25034","url":null,"abstract":"","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}