Journal of Medicinal and Chemical Sciences最新文献_第9页

Novel unsymmetric diimines: Synthesis and biological evaluation against pathogenic microorganisms 新型不对称二亚胺:合成及对病原微生物的生物学评价

Journal of Medicinal and Chemical Sciences Pub Date : 2020-03-03 DOI: 10.26655/jmchemsci.2020.3.3

D. Nartop, H. Öğütcü

引用次数: 1

Evaluation of Halocnemum strobilaceum and Hammada scoparia plants performance for contaminated soil phytoremediation 石首草和藤甲植物修复污染土壤的效果评价

Journal of Medicinal and Chemical Sciences Pub Date : 2019-07-01 DOI: 10.26655/JMCHEMSCI.2019.8.1

Fardous Bobtana, Fakhri A. Elabbar, N. Bader

引用次数: 6

Design, Synthesis, and Testing of Antiprotozoal Activity of Primin and Analogues Primin和类似物的设计、合成和抗原虫活性测试

Journal of Medicinal and Chemical Sciences Pub Date : 2019-07-01 DOI: 10.26655/JMCHEMSCI.2019.8.3

H. Nasiri, B. Ceylan, Katharina F. Hohmann, M. Kaiser, H. Schwalbe

引用次数: 0

Synthesis of Medicinally Relevant Phenyl Sulphonylamino Alkanamides and N-aryl P-toluenesulphonamides 药用苯基磺酰氨基烷酰胺和n -芳基对甲苯磺酰胺的合成

Journal of Medicinal and Chemical Sciences Pub Date : 2019-07-01 DOI: 10.26655/JMCHEMSCI.2019.8.5

Attah S. Izuchi, Efeturi A. Onoabedje, O. Ekoh, S. Okafor, U. Okoro

{"title":"Synthesis of Medicinally Relevant Phenyl Sulphonylamino Alkanamides and N-aryl P-toluenesulphonamides","authors":"Attah S. Izuchi, Efeturi A. Onoabedje, O. Ekoh, S. Okafor, U. Okoro","doi":"10.26655/JMCHEMSCI.2019.8.5","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.8.5","url":null,"abstract":"Synthesis of new medicinally important phenylsulphonyl aminoalkanamides and N-aryl p-toluene sulphonamides is reported. The reaction between benzenesulphonylchloride 7 with valine gave 3-methyl-2-[phenylsulphonyl)amino]butanoic acid 9 which is converted into 2-[acetyl (phenylsulphonyl) amino]-3-methyl butanoic acid 10 by reaction with acetic anhydride in acetic acid. The reaction of the later with SOCl2 and subsequently with NH3 afforded 2-[N-acetyl (phenylsulphonyl) amino]-3-methyl butanamide intermediate 11. The palladium catalysed reaction of the intermediate with readily available aryl chlorides and bromides afforded a variety of phenyl sulphonylaminoalkanamides 13a-c. In another synthesis, p-toluenesulphonylchloride (14) reacted with aqueous ammonia to give 4-methyl benzenesulphonamide 15 which is converted into N-(4-hydroxylphenyl)-4-methylbenzene sulphonamide 17a, N-(4-formyl phenyl)-4-methyl benzene sulphonamide 17b, N-(4-aminophenyl)-4-methyl benzenesulphonamide 17c, 4-methyl-N-(2-methylphenyl) benzene sulphonamide 17d, N-(4-Methoxyphenyl)-4-methyl benzenesulphonamide 17e in good yields, by reaction with 4-chlorophenol, 4-bromobenzaldehyde , 4-bromoaniline, 2-chlorotoluene and 1-bromo-2-methoxybenzene, respectively. Structures of the synthesized compounds were confirmed by spectroscopic and elemental analytical data","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72842825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Temperature of Water Used For Reconstitution On Stability Of Antibiotic Dry Suspension 水的温度对抗菌素干混悬液稳定性的影响

Journal of Medicinal and Chemical Sciences Pub Date : 2019-07-01 DOI: 10.26655/JMCHEMSCI.2019.8.8

Ebtihal Almadani Alforjany, Ruwida Kamour

{"title":"Effect of Temperature of Water Used For Reconstitution On Stability Of Antibiotic Dry Suspension","authors":"Ebtihal Almadani Alforjany, Ruwida Kamour","doi":"10.26655/JMCHEMSCI.2019.8.8","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.8.8","url":null,"abstract":"This study is carried out to test the stability of antibiotic dry suspensions reconstituted with various water temperatures. The testing included physical, microbial and chemical changes of samples reconstituted with water at 40, 60, 70 and 80ᵒC. These changes were compared to control samples prepared with water at temperature 25ᵒC. HPLC method was followed qualitatively to identify antibiotic active constituent in addition to quantitative analysis to evaluate antibiotic contents compared to control samples. The changes were assessed within one hour after reconstitution and after four days of reconstitution. Physical tests showed changes of amoxicillinclavulenic acid suspension’s colour prepared at 80ᵒC. Sedimentation ratio, sedimentation rate and sedimentation volume decreased as temperature increased were these parameters were tested only for amoxicillin suspension. Upon centrifugation there was a decrease in sediment volume accompanied with an increase in supernatant volume resulting in changes in sediment/supernatant ratio. Microbial study showed a marked decrease in antimicrobial activity for both amoxicillin and amoxicillin/clavulenic acid suspensions. HPLC results showed a decrease in amoxicillin and clavulanate in samples prepared with heated water compared to those prepared with cooled water at 25ᵒC.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74756701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A Review on Classes, Extraction, Purification and Pharmaceutical Importance of Plants Alkaloid 植物生物碱的分类、提取纯化及药用价值综述

Journal of Medicinal and Chemical Sciences Pub Date : 2019-07-01 DOI: 10.26655/JMCHEMSCI.2019.8.2

H. Louis, Hamzart Adejoke, O. Amusan

{"title":"A Review on Classes, Extraction, Purification and Pharmaceutical Importance of Plants Alkaloid","authors":"H. Louis, Hamzart Adejoke, O. Amusan","doi":"10.26655/JMCHEMSCI.2019.8.2","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.8.2","url":null,"abstract":"The importance of natural products in the pharmaceutical industry cannot be abated because it plays a vital role in the prevention and treatments of diseases such as cancer, malaria, pile etc. These natural products e.g. alkaloid, flavonoid, phenol, saponin, and tannin are bioactive compounds in a plant which are essential in plant metabolic activities. All of these including alkaloids has been tested for their huge medicinal properties hence, serves as an alternative medicine. Although, through the modern-day technologies, these bioactive compounds are separated from the plants and synthesized into capsules and tablets for easy administration, usage, and storage. The manner of poisoning with plants can be due to unintentional ingestion, affordability, and availability, excess ingestion, improper methods of extraction and purification of plant materials. In some cases, the resultant effect(s) of these poisoning may cause serious illness, injury or even death. Thus, this review gives an overview of the pharmacological importance of named alkaloids, toxicology and methods of extraction and purification of alkaloids in the plant. Furthermore, this review will provide information to researchers to further investigate the medicinal potentials of these alkaloids, help in the development of new drugs for the treatment of various diseases, creates awareness on the side-effects of excess or abuse of medicinal plants and finally encourages rational use of natural resources for sustainability.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"174 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86904755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

A new flavonoid glycoside from Trichilia emetica 一种新的吐毛毛菌类黄酮苷

Journal of Medicinal and Chemical Sciences Pub Date : 2019-07-01 DOI: 10.26655/JMCHEMSCI.2019.8.4

A. Usman, V. Thoss, M. Nur-E-Alam

引用次数: 3

Ultrasound-assisted synthesis of auxiliary pyrazoline integrated thiazole, thiazolone derivative and their biological evaluation 超声辅助合成辅助吡唑啉整合噻唑、噻唑酮衍生物及其生物学评价

Journal of Medicinal and Chemical Sciences Pub Date : 2019-05-01 DOI: 10.26655/JMCHEMSCI.2019.4.6

N. Manju, B. Kalluraya, Asma, S. Madankumar, B. C. Revanasiddappa, Chandra

{"title":"Ultrasound-assisted synthesis of auxiliary pyrazoline integrated thiazole, thiazolone derivative and their biological evaluation","authors":"N. Manju, B. Kalluraya, Asma, S. Madankumar, B. C. Revanasiddappa, Chandra","doi":"10.26655/JMCHEMSCI.2019.4.6","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.4.6","url":null,"abstract":"In this paper, we describe a simplecatalyst-free protocol for the synthesis of thiazole, thiazolone integrated pyrazole derivatives, under ultra-sonication technique. Thiazolone derivatives 5a, 5e, 5i, 5d, 5h, 5l were derived from [2+3] cyclocondensation reaction between carbothioamide pyrazoline (4 a-c) as S-N bi-nucleophile with DMAD/DEAD. The target molecules 5b, 5f, 5j,5c, 5g, 5k weresynthesized by reaction of (4 a-c) with substituted bromoethanone. Formation of the products was confirmed by FT-IR, 1H-NMR, 13C-NMR, LC-MS and X-ray analysis. Docking studies were carried out against the antimicrobial target (3UDI) to know interaction of the molecules (ligands) with the docked target. Among the docked compounds thiazolone derivative 5d showed the minimum binding energy of -9.08 kJ/mol with ligand efficiency of -0.23. All the synthesized compounds were examined primarily for their in-vitro antibacterial and antioxidant activity (IC50). Compound 5g (18±0.0) and 5d (19.5±0.5) showed significant bacterial inhibition against E.coli and S.aureus. Compound 5k (16.57) were showed substantial DPPH free radical inhibition activity as compared to the reference drug Ascorbic acid.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81561420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Journey Towards FeCl3 Catalysed Synthesis of Multisubstituted Pyrrole FeCl3催化合成多取代吡咯的探索

Journal of Medicinal and Chemical Sciences Pub Date : 2019-05-01 DOI: 10.26655/JMCHEMSCI.2019.4.7

R. Kaur, Kapil Kumar

引用次数: 2

ASSESMENT OF GROUNDWATER SAMPLES FROM SA'ADATU RIMI COLLEGE OF EDUCATION, KUMBOTSO, KANO 卡诺州kumbotso市sa 'adatu rimi教育学院地下水样本的评估

Journal of Medicinal and Chemical Sciences Pub Date : 2019-05-01 DOI: 10.26655/JMCHEMSCI.2019.4.5

Sadiq Abdurrahman Abubakar Shawai, Muhammad Sani Nahannu, H. Mukhtar, I. M. Isma'il

{"title":"ASSESMENT OF GROUNDWATER SAMPLES FROM SA'ADATU RIMI COLLEGE OF EDUCATION, KUMBOTSO, KANO","authors":"Sadiq Abdurrahman Abubakar Shawai, Muhammad Sani Nahannu, H. Mukhtar, I. M. Isma'il","doi":"10.26655/JMCHEMSCI.2019.4.5","DOIUrl":"https://doi.org/10.26655/JMCHEMSCI.2019.4.5","url":null,"abstract":"Human activities are a major factor determining the quality of surface and groundwater through atmospheric pollution, effluent discharges, use of agricultural chemicals, eroded soil and land use.The purpose of this research was to determine the physicochemical parameters of water samples collected from Sa’adatu Rimi College of Education, Kumbotso Kano and to compare with the standards given by World Health Organization (WHO) and Nigeria Standard for Drinking Water Quality (NSDWQ). Four samples were collected from different locations within the college premises for the analysis. The analyzed parameters are pH, temperature, Total dissolved solids, Total suspended solids, Suspended solid, Electrical conductivity, Alkalinity, Mg2+,Ca2+, ammonia, sulphate,Nitrate, Nitrite,Turbidity, Salinity, Total hardness, free carbon dioxide, Iron and Chloride. The results indicated that all the analyzed parameters are within the permissible limits recommended byWHO and NSDWQwith exception of turbidity level at A sampling station, pH concentration at B, C, and D sampling point and nitriteconcentrations at C and D sampling point. The results also showed that, the concentration of total hardness were slightly above the maximum permissible limit (MPL) recommended by NSDWQ. This paper also recommended that, the college management should provide a basis for the regular monitoring of water quality status.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77453610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0