Journal of Medicinal and Chemical Sciences最新文献

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Medical Evaluation of Test Results Related to Covid 19 in Iranian Hospitals Using QUADAS-2 to Evaluate the Quality of Studies and Meta-Analysis Using Stata / MP v.16 Software 使用QUADAS-2评估研究质量和使用Stata / MP v.16进行荟萃分析对伊朗医院Covid - 19相关检测结果的医学评价软件
Journal of Medicinal and Chemical Sciences Pub Date : 2022-03-01 DOI: 10.26655/jmchemsci.2022.2.10
H. Danesh, S. R. Ghasabeh, R. Rounasi, E. Zarepur, A. Abdolrazaghnejad
{"title":"Medical Evaluation of Test Results Related to Covid 19 in Iranian Hospitals Using QUADAS-2 to Evaluate the Quality of Studies and Meta-Analysis Using Stata / MP v.16 Software","authors":"H. Danesh, S. R. Ghasabeh, R. Rounasi, E. Zarepur, A. Abdolrazaghnejad","doi":"10.26655/jmchemsci.2022.2.10","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.10","url":null,"abstract":"The aim of current study was to evaluate the outcome of some laboratory tests and accuracy of diagnostic tests for patients with COVID-19. The QUADAS-2 tool was utilized to quality assessment of diagnostic accuracy studies. For data extraction, two reviewers blind and independently extracted data from and full text of studies that included. 95% confidence interval for effect size with fixed effect model and Inver-variance method were calculated. Meta-analysis was performed using Stata/MP v.16 software. 469 studies were reviewed, of which the full text of 52 studies was reviewed and finally twenty-two studies were selected for meta-analysis. Mean differences of Alanine transaminase was 3.40 U/L (MD, 95% CI -2.45, 9.25), correlation between Alanine transaminase and severe COVID-19 was not significantly. Stool, feces, rectal swabs 25% (ES, 95% CI 0.32, 0.82), Urine 1% (ES, 95% CI 0.05, 0.58), overall sensitivity of PCR for detection of COVID-19 was 44% (ES, 95% CI 0.19, 0.68), less sensitive observerd when PCR detection of COVID-19. Evidence revealed that at the time of admission of patients with COVID-19, a specific laboratory model can be used to perform relevant tests and make decisions about patients. PCR using sputum samples was highly sensitive for detecting COVID-19 and after that computed tomography of the chest was identified with high sensitivity. © 2022 by SPC (Sami Publishing Company).","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90368315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Internal Dynamics of Self –Medication (SM) 自我用药的内在动力学(SM)
Journal of Medicinal and Chemical Sciences Pub Date : 2022-03-01 DOI: 10.26655/jmchemsci.2022.3.5
D. Singh, B. Patnaik, I. Satpathy
{"title":"Internal Dynamics of Self –Medication (SM)","authors":"D. Singh, B. Patnaik, I. Satpathy","doi":"10.26655/jmchemsci.2022.3.5","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.3.5","url":null,"abstract":"Recently, especially during Covid-19, there has been an increasing trend of Self-Medication (SM) in rural and semi urban areas of India. There are various contributing factors for these practices. It is defined as the use of medicine by patients on his own initiative or on the advice of pharmacists, previous prescription, and suggestion of family members of friends instead of consulting qualified doctors. The medicines which are available with pharmacists without prescription or over the counter (OTC) are known to be part of self-medication. A medicine that requires doctors’ recommendation is known as prescribed product (Rx products).The present work discusses the positive sides at individual level and community level and at the same time possible risks involved at community level and individual level. It was found that even though there were various risks involved due to self-medication, people in rural and semi-urban areas also find some positive side of the same. Most importantly they believe that it reduces the cost of travelling, and cost of consultation with doctor. Sometimes due to past experience of the same sort of diseases or symptoms, people opt for self-medication practices. The study concludes that Potential benefits at individual levels were self – reliance for preventing minor disease and saving of time & energy. Similarly the same for the community level were extending the health care services to the needy people in rural and remote areas and saving scare medical resources for minor treatments /diseases. Potential risk at individual levels Failure to report or recognize the adverse drug reactions. Failure to seek appropriate medical assistance immediately and from the community point of view wasteful public expenditure and will lead to family disturbance due to death of member of family. © 2022 by SPC (Sami Publishing Company)","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84743363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Medical Investigation of the Use of Telenursing in Covid 19 Pandemic: A Mini-Review Study Covid - 19大流行期间远程护理使用的医学调查:一项小型回顾性研究
Journal of Medicinal and Chemical Sciences Pub Date : 2022-03-01 DOI: 10.26655/jmchemsci.2022.2.3
H. Danesh, M. Nazari, A. Ismaili, F. Nomiri, V. Barari
{"title":"Medical Investigation of the Use of Telenursing in Covid 19 Pandemic: A Mini-Review Study","authors":"H. Danesh, M. Nazari, A. Ismaili, F. Nomiri, V. Barari","doi":"10.26655/jmchemsci.2022.2.3","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.3","url":null,"abstract":"Tele-nursing is an evolving subject and with the advent of new technologies, the scope of nurses' practice is expanding. As a systmetic review, in this study after reading the summary and full text of the articles related to the research topic, we extracted the required data, including author name, year, place, type of study, sampling method, data collection instruments and results. Finally, the data obtained from the articles was categorized and finally reported in the full text of a review article. The steps performed were designing the research question, searching and extracting research-related studies, selecting related studies, tabulating and summarizing the data, and reporting the results. The tele-nursing is a medical method to provide high quality nursing care in the field of COVID-19. Distance education by nurses is essential to promote the mental health of families and children in the field of Covid 19. Tele-nursing is a solution to meet the challenges of efficient and quality health services. © 2022 by SPC (Sami Publishing Company).","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75668579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Coverage Analysis of Complete Basic Immunization (CBI) in Pekalongan District during COVID-19 Pandemic Period with Rapid Card Check Survey in Pandemic Era 基于大流行时代快速卡检调查的新冠肺炎大流行期间北卡隆岸地区完全基本免疫接种覆盖率分析
Journal of Medicinal and Chemical Sciences Pub Date : 2022-03-01 DOI: 10.26655/jmchemsci.2022.3.7
S. Jati, A. Sriatmi, M. Martini, F. Agushybana
{"title":"Coverage Analysis of Complete Basic Immunization (CBI) in Pekalongan District during COVID-19 Pandemic Period with Rapid Card Check Survey in Pandemic Era","authors":"S. Jati, A. Sriatmi, M. Martini, F. Agushybana","doi":"10.26655/jmchemsci.2022.3.7","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.3.7","url":null,"abstract":"The goal of the immunization program is to provide protection from diseases that can be prevented by immunization (PD3I), such as tuberculosis, diphtheria, tetanus, polio, hepatitis B, and measles. Therefore, optimizing the immunization coverage is very important. The coverage of complete basic immunization in Pekalongan District decreased to 88.4% in 2017, while 7 cases of measles were still found. Further, the coverage of immunization has been a challenge in the COVID-19 pandemic situation. The objective of this study was to analyze the complete basic immunization coverage in Pekalongan Regency using Rapid Card Check. This study used an analytic observational design with quantitative and qualitative approaches. Quantitative analysis was performed using chi-square analysis, while in-depth interviews carried out a qualitative analysis to explore further the reasons for not having immunization. The number of samples was 535 toddlers aged 10-26 months. The sample was selected based on random sampling techniques, and data were collected using Rapid Card Check instrument. The coverage of immunization was 71.6%, and only 2.1% did the immunization correctly. Based on the type of antigen, the highest immunization coverage was HB0 = 88.4%, and the lowest was measles = 74.4%. The highest immunization accuracy was the type of antigen HB0 = 85.4%, and the lowest one was Polio4 = 12.0%. The coverage of complete basic immunization in Pekalongan District is still below the national target (95%) in the Covid-19 pandemic era. Therefore, intensive efforts should be made to increase the coverage in the current ear © 2022 by SPC (Sami Publishing Company)","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90830566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of Delivery and Course of Postpartum Period in Women with Uterine Fibroids during Premature Birth 早产子宫肌瘤患者的分娩特点及产后病程
Journal of Medicinal and Chemical Sciences Pub Date : 2022-01-01 DOI: 10.26655/jmchemsci.2022.1.4
Ivleva Natalya Aleksandrovna, Tyurina Natalya Aleksandrovna, Kidyaeva Irina Aleksandrovna, Suvanov Bakhtiyar Sabitkhanovich, Volgin Yaroslav Yurievich
{"title":"Features of Delivery and Course of Postpartum Period in Women with Uterine Fibroids during Premature Birth","authors":"Ivleva Natalya Aleksandrovna, Tyurina Natalya Aleksandrovna, Kidyaeva Irina Aleksandrovna, Suvanov Bakhtiyar Sabitkhanovich, Volgin Yaroslav Yurievich","doi":"10.26655/jmchemsci.2022.1.4","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.1.4","url":null,"abstract":"Women's most typical complaints in the early postpartum period are pain and exhaustion. Pain can make it difficult for a mother to care for herself and her child. Untreated pain is linked to an increased risk of opiate usage, postpartum depression, and the development of chronic pain. Postpartum pain management includes both nonpharmacologic and pharmacologic therapy. This study focused on the features of the course of labour and the postpartum period in women with uterine fibroids in preterm labour. A retrospective analysis of 50 birth histories of women with uterine fibroids who delivered prematurely was carried out. During gestation, most pregnant women have a threat of spontaneous abortion and premature birth. In childbirth, most pregnant women experienced complications such as weakness of labour, cervical dystocia, fetal hypoxia, which often led to the need for an emergency caesarean surgery. More than half of pregnant women with uterine fibroids in the successive and early postpartum period experience bleeding due to uterine hypotension. The combination of uterine fibroids with preterm labour is a particular problem, as it often leads to complications in childbirth and the early postpartum period. This group of patients requires careful pre-gravid preparation, as well as special attention of the antenatal clinic doctor with personalized gynecological and obstetric tactics.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89442737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepato-Renal Dysfunctions Induced by Gold Nanoparticles and Preservative Efficacy of Black Seed Oil 金纳米颗粒致肝肾功能障碍及黑籽油的防腐作用
Journal of Medicinal and Chemical Sciences Pub Date : 2022-01-01 DOI: 10.26655/jmchemsci.2022.1.15
O. A. Ghareeb
{"title":"Hepato-Renal Dysfunctions Induced by Gold Nanoparticles and Preservative Efficacy of Black Seed Oil","authors":"O. A. Ghareeb","doi":"10.26655/jmchemsci.2022.1.15","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.1.15","url":null,"abstract":"Gold nanoparticles (GNPs) represent the most important applications of nanotechnology in fields of medicine. The study aimed at clarifying their toxic effect, especially upon biochemical parameters related to liver and kidney functions of lab animals. Twenty-four healthy rats were distributed on 4 groups, each containing 6 rats. Control group included rats without any treatment, while GNPs group of mice were under intoxication with gold nanoparticles at a dosage of 50 μl/day for 7 days. As for the GNPs + BS group, intoxicated rats with GNPs were given oil of black seed at a dosage of 10 ml / kg. Finally, BS group included rats were under treatment of 1 ml/ kg of black seed oil. Serum levels of hepato-renal parameters including alanine amino transferase, aspartate amino transferase, alkaline phosphatase, blood urea, creatinine, and uric acid, were measured to detect impaired liver and kidneys functions. Rats treated with GNPs indicated a substantial (P < 0.05) increase in all these biomarkers levels contrasted to the group of control. Then, co-administration of black seed oil together with GNPs had a significant effect on reducing hepatorenal functions disorders. Thus, from these results, it can be concluded that the black seed oil has shown a defensive effect against the disturbances caused by GNPs in the liver and kidney functions of rats.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83260043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of Drug Therapy in Non-Communicable Diseases; a Review Study 非传染性疾病药物治疗评价;回顾研究
Journal of Medicinal and Chemical Sciences Pub Date : 2021-11-16 DOI: 10.26655/jmchemsci.2022.2.8
Hamid Mirjalili, Hadis Amani, Afsaneh Ismaili, Maryam Milani Fard, A. Abdolrazaghnejad
{"title":"Evaluation of Drug Therapy in Non-Communicable Diseases; a Review Study","authors":"Hamid Mirjalili, Hadis Amani, Afsaneh Ismaili, Maryam Milani Fard, A. Abdolrazaghnejad","doi":"10.26655/jmchemsci.2022.2.8","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.8","url":null,"abstract":"This study is a conceptual review. Various protocols have been proposed for non-communicable diseases worldwide. The importance of this large group of diseases has prompted the World Health Organization (WHO) to plan effectively to set targets to reduce mortality from these diseases by one-third by 2030 in the Sustainable Development Plan. In asthma, corticosteroids are still recognized as the most potent anti-asthma drugs, and there is still no drug with the same effect, and biological agents (drugs such as amalizumab) significantly improve the management of severe asthma. Regarding diabetes, the recommendations of the WHO were reviewed, and the first recommendation is that if metformin, which is recommended as the first oral antidiabetic drug in all guidelines, cannot control hyperglycemia, sulfonylurea should be prescribed to patients with type 2 diabetes. Non-communicable diseases in Iran cause 45% of the disease burden in men and 33% of the disease burden in women, of the total causes of the disease burden in both sexes (6-10). Obesity and overweight, arterial hypertension, inadequate physical activity and addiction are 86% of the risk factors for diseases and 11% of all diseases. These risk factors have caused 6.1 million years of adapted life expectancy in Iran.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85217833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
A Review of Antibiotic Consumptions at Moewardi Municipality Hospital Dental Ward Surakarta, Indonesia Using Algorithm Gyssens 使用Gyssens算法对印尼苏拉塔市Moewardi市医院牙科病房抗生素使用情况进行回顾
Journal of Medicinal and Chemical Sciences Pub Date : 2021-11-13 DOI: 10.26655/jmchemsci.2022.2.6
Morita Sari, Syifa Shafira
{"title":"A Review of Antibiotic Consumptions at Moewardi Municipality Hospital Dental Ward Surakarta, Indonesia Using Algorithm Gyssens","authors":"Morita Sari, Syifa Shafira","doi":"10.26655/jmchemsci.2022.2.6","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.6","url":null,"abstract":"Antibiotics are chemicals that kill or stop the growth of microscopic organisms or microbes, such as bacteria, fungi, or protozoa. Therefore, antibiotics can be used to treat diseases caused by germs in the body. The objective of the research was to know the description and pattern of antibiotic prescription at Dr. Moewardi Municipality Hospital Dental Ward, Surakarta. This study was based on the observational description with a cross-sectional study design. The samples taken for observation were 321 patients with medical records from September-December 2018. We applied secondary retrospective data and Defined Daily Doses (DDD)/Anatomical Therapeutic Chemical (ATC) from World Health Organization (WHO) Constanta. The data was then rated for its accuracy by tracing using Algorithm Gyssens. The results showed 71.96% of the patients received treatment and drug prescriptions, of which 36.45% were antibiotics. Amoxicillin was the most widely used antibiotic, followed by Clindamycin and Cefixime. The DDD/ATC ratio was 1.639982. The results from observation and identification with Gyssens category revealed that the categories 0, IIA, IIIB, IIIA, IVB, and V accounted for 75.35%, 2.82%, 8.45%, 7.75%, 4.93%, and 0.7%, respectively, of the consumed antibiotics. Accordingly, there is a rational prescription at Dr. Moewardi Municipality Hospital Dental Ward, Surakarta, but it still needs improvement.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86050620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparing the Sedative Effect of Oral Midazolam versus Oral Ketamine on Children Aged 1-7 Years in Need of Radiologic Procedures 口服咪达唑仑与口服氯胺酮对1-7岁需要放射治疗的儿童镇静效果的比较
Journal of Medicinal and Chemical Sciences Pub Date : 2021-11-13 DOI: 10.26655/jmchemsci.2022.2.5
M. Ziaei, Mahjoubeh Keykha, F. Kazemi, A. Abdolrazaghnejad
{"title":"Comparing the Sedative Effect of Oral Midazolam versus Oral Ketamine on Children Aged 1-7 Years in Need of Radiologic Procedures","authors":"M. Ziaei, Mahjoubeh Keykha, F. Kazemi, A. Abdolrazaghnejad","doi":"10.26655/jmchemsci.2022.2.5","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.5","url":null,"abstract":"Sedation is one of the most important criteria for eliciting the cooperation of young patients. The purpose of this study was to compare the sedative effect of oral administration of ketamine and midazolam in children admitted to an emergency department in Zahedan. In this double-blind clinical trial, children were placed in grades one and two according to the ASA status classification system. Then, they were randomized into two groups of 50 individuals each. One group received 0.5mg/kg midazolam and the other received 5 mg/kg ketamine. The medication was administered orally in both groups. The scores of children’s sedation and separation from their parents were recorded, and the obtained data were analyzed in SPSS using Chi-square test and independent t-test. The mean heart rate of patients before the intervention in the two groups had a slight difference, which was not statistically significant (P = 0.159). But after the intervention, this mean was significantly different in the two groups (P = 0.018). The mean scores of sedations and separation from the parent were not significantly different at 10, 20, and 30 minutes after medication in the two groups before and after the intervention. The mean length of hospitalization after sedation in the two groups differed significantly (p = 0.007) in the ketamine group (28.62 minutes) and the midazolam group (34.04 minutes). In the ketamine group, the mean heart rate decreased less after the intervention and the length of hospital stay was shorter compared with the midazolam group. Also, the percentage of children who showed earlier onset of sedation (20 minutes after taking the drug) was higher [in the ketamine group]. Therefore, ketamine seems more desirable for treatment and radiographic procedures in the emergency department.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89934514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Coupled Plasma Filtration Adsorption as a Potential Therapy for Critically III Covid-19 Patients 耦合血浆过滤吸附作为Covid-19危重症患者的潜在治疗方法
Journal of Medicinal and Chemical Sciences Pub Date : 2021-11-13 DOI: 10.26655/jmchemsci.2022.2.7
Jonny Army, Laurencia Violetta
{"title":"Coupled Plasma Filtration Adsorption as a Potential Therapy for Critically III Covid-19 Patients","authors":"Jonny Army, Laurencia Violetta","doi":"10.26655/jmchemsci.2022.2.7","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.7","url":null,"abstract":"The Corona-19 virus disease (Covid-19) continues to cause an increasing number of deaths, mainly due to acute respiratory disorders. The high pandemic mortality and morbidity prompted clinicians to seek suitable adjunctive therapeutic methods to eliminate high cytokine levels effectively. This study aimed to review the combined plasma filtration adsorption (CPFA) technology and its potential efficacy in treating critically ill Covid-19. CPFA combines plasma separation, adsorption, and hemofiltration techniques that meet the need to remove substances such as cytokines. Findings from the report suggest an immune dysregulation known as cytokine storm syndrome plays a role in severe and critically ill Covid-19 patients. Extracorporeal blood purification targets cytokine elimination and is preferred as a bridging strategy to improve survival. Combined adsorption plasma filtration (CPFA) can remove various substances, including cytokines, without depleting physiologically essential proteins. CPFA can be considered and assessed in clinical trials to treat critically ill Covid-19 patients. Paired Plasma Filtration Adsorption (PPFA) can be viewed as a potentially effective therapy in treating Covid-19 patients in critical condition.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77870209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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