Journal of Medicinal and Chemical Sciences最新文献

{"title":"Inhibition of Garlic Ethanol Extracts (Allium Sativum L.) as a Solvent in Alginate Impression Materials in the Growth of Candida Albicans","authors":"Dendy Murdiyanto, Aryani Faizah, Mandira Dhaksi Mustikaningrum","doi":"10.26655/jmchemsci.2022.2.1","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.2.1","url":null,"abstract":"Alginate is an impression material currently used in dentistry because it has numerous advantages. However, alginate will come into direct contact with blood, saliva, and plaque in its use. Hence, it has the potential to contain pathogenic micro-organisms. One of the micro-organisms that can be pathogenic is Candida Albicans. It can infect the oral cavity and cause candidiasis. Therefore, it is necessary to inhibit Candida Albicans’ growth in the form of a natural ingredient from garlic (Allium sativum L.). Garlic (Allium sativum L.) has benefits as an antifungal since it has an active ingredient, namely allicin. The objective is examining the effect of garlic (Allium sativum L.) ethanol extract as a solvent in alginate impression materials on the growth inhibition of Candida Albicans. The research method was disc diffusion with alginate manipulation using a solvent in distilled water and with ethanol extract of garlic concentrations of 10%, 20%, 40%, and 80%. After that, the clear zone around the disc was measured with a caliper. One-way ANOVA test results indicated that the value was p=0.000 (p<0.05). It means that there were significant differences in the entire treatment group. The results of the Post Hoc LSD test showed that there were significant differences among the sample groups. Therefore, the ethanol extract of garlic (Allium sativum L.) as a solvent in the alginate impression material has an effect on the growth inhibition of Candida Albicans (in vitro).","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89153203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classical Approaches and Their Creative Advances in the Synthesis of Coumarins: A Brief Review","authors":"Yasser Fakri Mustafa","doi":"10.26655/jmchemsci.2021.6.10","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.10","url":null,"abstract":"Coumarin chemical nucleus is a gift awarded from nature to humanity. The multifarious derivatives and the broad range of their bio-medicinal potentials are the basis for this description. In the last several decades, though numerous coumarin-based products have been primarily separated from their biological origins, the laboratory synthesis of the coumarins is developing. Various synthetic trails namely Knoevenagel, Claisen, Perkin, Pechmann, Wittig, and Reformatsky have been reported. Several advanced innovations have been created to maximize yield, minimize overall reaction time, avoid side products, and make synthetic reactions environmentally friendly. These include the employment of ultrasonic, microwave, and solvent-free conditions. This brief review focuses on the classic methods for synthesizing coumarins, and the advantages derived from the use of creative catalytic tools.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77376021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhabdomyolysis in Severe Covid19: A Mini Review Study","authors":"Mozhgan Taebi, Arefeh Tajik, Amirhossein Zarepur, E. Zarepur, Raheleh Tavakolimoghadam, H. Danesh","doi":"10.26655/jmchemsci.2022.1.10","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.1.10","url":null,"abstract":"Introduction: Rhabdomyolysis can be a symptom of COVID-19, with very few cases described so far. AKI and renal failure following rhabdomyolysis are a potentially dangerous complication. Diagnosis of rhabdomyolysis in COVID-19 is difficult due to overlap. \u0000Materials and Method: The present study was a PICO review that examined rhabdomyolysis in COVID-19. The documents browsed by Google Scholar, Sid and Mag Iran databases were analyzed using the keywords rhabdomyolysis, creatine kinase, COVID-19, acute renal failure. \u0000Results:  Rhabdomyolysis following COVID-19 and SARS-CoV-2 reports of viral contamination of striated muscle may result in muscle destruction. Rhabdomyolysis in COVID-19 is a late complication. Evaluation of CK and myoglobin levels is important for the diagnosis of rhabdomyolysis in COVID19 patients. The mechanism of rhabdomyolysis in COVID-19 is unknown and various mechanisms are used. \u0000Conclusion: Rhabdomyolysis may cause acute kidney damage (AKI). Prompt diagnosis is a prerequisite for successful treatment and prevention of complications.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78136638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the relationship between abo blood groups and severity and mortality in patients with covid-19","authors":"A. Abdolrazaghnejad, Babak Karimi Tezerji, Aghil Miri","doi":"10.26655/jmchemsci.2021.6.15","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.15","url":null,"abstract":"The aim of this study was to investigate the relationship between ABO blood groups and the rate and severity of morbidity and mortality in patients with Covid-19 in Zahedan. The present study is a descriptive-analytical study and includes a sample of 349 patients with Covid-19 referred to hospitals in Zahedan from March 2016 to August 2017. The sampling method was census and for data collection, case studies and checklists were used. The data were analyzed by Chi-square test through SPSS software. Among the 328 patients, 132(41%) had blood type O, 92(28%) had blood type A, 80(24%) had blood group B and 24(7%) had AB blood type. There was no significant relationship between blood groups and age (P <0.150). Patients in the age group of 30-60 years with 208 (63.4%) had the highest number, of whom 78 (23.8%) had blood type O. There was a significant relationship between blood groups and gender (P = 0.001), so male patients with 178 (54.3%) were more, of whom 72 (22%) had blood type O. There was no significant relationship between blood groups and place of hospitalization (P <0.121);however, inpatient department patients with 150 (45.7%) had the highest number, of whom 62 (41.3%) had blood type O. There was no significant relationship between blood groups and severity of covid-19 (P <0.121);however, patients with moderate severity had the highest number with 150 (45.7%) patients, of whom 62 (41.3%) had blood type O. © 2021 Journal of Medicinal and Chemical Sciences. All rights reserved.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83758753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Applying Structured Teaching Programme on Knowledge and Attitude Regarding Umbilical Cord Blood Collection and Its Barriers among Maternity Nurses","authors":"H. Mohammed, R. S. A. Elhady, Hemmat Mostafa Hassan, Rehab Soliman Abd El Aliem","doi":"10.26655/jmchemsci.2022.1.11","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.1.11","url":null,"abstract":"Umbilical cord blood collection increases the life expectancy of end-stage or chronically ill patients. The knowledge and attitude of health professionals are essential to the success of this attempt. This inquiry aimed to evaluate the effect of applying a structured teaching program on knowledge and attitude concerning umbilical cord blood collection and its barriers among maternity nurses. A quasi-experimental research design was used. It was carried out in Obstetrics and Gynaecological departments (antenatal, postnatal, and operating room) at Banha University Hospital. Based on a convenient sampling method, 89 maternity nurses at Banha University Hospital were chosen. To gather the data, two instruments were utilized: a) An organized interview questionnaire sheet, including two sections of socio-demographic features of maternity nurses and knowledge of maternity nurses concerning umbilical cord blood collection and its barriers; b) a modified Likert scale to assess the nurses' attitudes regarding umbilical cord blood collection and its barriers. The results showed that a minority of the nurses (11.2%) had good knowledge about umbilical cord blood collection and its barriers pre-intervention, which increased to (86.5%) post-intervention; however, only one-fifth of nurses (20.0 %) had a positive attitude of umbilical cord blood collection and its barriers pre-intervention which increased to (89.9%) post-intervention. Additionally, a highly direct correlation between total knowledge and total attitude score pre-and post-intervention was noticed. Structured teaching program regarding umbilical cord blood collection significantly improved nurses' knowledge and attitude regarding umbilical cord blood collection and its barriers. As a recommendation, appropriately designed in-service training programs concerning umbilical cord blood banking and its barriers must be founded to improve nurses' knowledge and attitude to suit newly developed concepts in care.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85655968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Care Management Program Utilization among Antenatal Mothers with Pregnancy-Induced Hypertension","authors":"H. Elbana, R. S. A. Elhady, H. Mohammed","doi":"10.26655/jmchemsci.2022.1.12","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.1.12","url":null,"abstract":"Pregnancy complications contribute considerably to maternal and newborn morbidity and mortality. The present study aimed to evaluate the effect of self-care management program utilization among antenatal mothers with pregnancy-induced hypertension (PIH). The study used a quasi-experimental design. It study was carried out in the out-patient clinic in Benha university hospital, Egypt. Based on a purposive sample, 67 pregnant women diagnosed with pregnancy-induced hypertension were included. To collect the data, two instruments were used, a structured interviewing questionnaire, and self-care reported practice assessment. The analysis of data revealed that more than three quarters (80.6% of pregnant women) had incorrect knowledge about self-care of PIH and only 37.3 % of pregnant women had adequate knowledge score at pre-intervention that increased to 77.6 % in post-intervention. Additionally, a highly statistically significant difference was revealed between total self-care practices scores related to pregnancy-induced hypertension before and after intervention (p<0.001). Also, a highly statistical difference was revealed between total knowledge and practice scores of studied women at pre and post-intervention (p <0.001).  The utilization of a self-care management program highly improved pregnant participants’ knowledge and their self-care practice regarding the management of pregnancy-induced hypertension. The current study suggested that pregnant women be made more aware of pregnancy problems, including pregnancy-induced hypertension and its related impacts on mothers and fetal health, as well as a greater understanding of self-care management.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85161797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Inflammatory Biomarkers in Predicting in-Stent Restenosis","authors":"Mehran Karimzadeh Jouzdani, Maziar Karimzadeh Jouzdani, B. Mohebbi","doi":"10.26655/jmchemsci.2021.6.12","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.12","url":null,"abstract":"The present study aimed to assess the role of inflammatory markers including erythrocyte sedimentation rate (ESR), highly sensitive C-reactive protein (hs-CRP), neutrophils to lymphocytes ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in predicting ISR. This retrospective case-control study was conducted on 818 consecutive patients suffering acute coronary syndrome and underwent coronary stenting and referred to Rajaie Cardiovascular Medical and Research Center due to being suspicion to ISR. By referring to patients' clinical records as well as accessing their angiographic movie via the Cath lab computer system, patients who had ISR over a two-year period were identified from other patients who did not have re-stenosis. Overall, 19.1% were diagnosed to have ISR within a two-year following-up. However, there was no difference in NLR and PLR across the two ISR (+) and ISR (-) groups. In ISR group, the serum levels of ESR and CRP were significantly higher in smokers versus non-smokers, in diabetics versus non-diabetics, and also in those with chronic kidney disease as compared with those without kidney involvement. The levels of inflammatory indices of ESR and CRP were positively associated with the length of stent and negatively associated with the diameter of stent. Assessing the levels of ESR and CRP can successfully predict ISR in the patients initially undergoing coronary stenting. Such predicting role may be influenced by the interfering role of some cardiovascular risk factors such as smoking, diabetes mellitus, and chronic renal failure.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90800658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Inflammatory Markers between Women with Eclampsia- Preeclampsia and Normotensive Pregnant Women in Gynecology","authors":"S. Aghili, Toktam Alirezaei, Shahin Nikmanzar, S. Saleh-Gargari","doi":"10.26655/jmchemsci.2021.6.5","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.5","url":null,"abstract":"Hypertension is a medical problem during pregnancy and one of the types of hypertensions during pregnancy is eclampsia-preeclampsia. The aim of this study was to compare inflammatory markers between women with eclampsia - preeclampsia and pregnant women with normal blood pressure admitted to the gynecology ward of Shahada Tarnish and Mehrieh hospitals in 1998-99. This descriptive-analytical study was performed with a cross-sectional design. The study population consisted of all patients diagnosed with eclampsia-preeclampsia and pregnant mothers in Shohada-e-Tajrish and Mahdieh Hospitals in Tehran during 2019 to 2020. The study sample consisted of 400 patients who were selected by convenience or convenience sampling method and 200 patients with a diagnosis of eclampsia-preeclampsia were in the experimental group and 200 pregnant women were in the control group. The subjects completed pre-prepared forms for study variables, i.e. information on maternal age, maternal weight, infant weight, gestational age, neutrophil count and lymphocytes. To analyze the collected data, tests such as Pearson correlation coefficient and independent t-test were used and analyzed by SPSS software version 23. The results showed that a statistically significant difference was found between NLR and PLR MPV. Finally, the results of this study showed that platelet count; MPV, NLR, PLR were significantly different in the two groups of preeclampsia patients and pregnant women with normal blood pressure and that these indicators can be used to predict preeclampsia.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90585312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Effects of Monosodium Glutamate on Brain of Infant Albino Swiss Mice Mus Musculus","authors":"Majeda Noori Ibrahim, Evan Mohammed Mostafa, F. N. Toama","doi":"10.26655/jmchemsci.2021.6.4","DOIUrl":"https://doi.org/10.26655/jmchemsci.2021.6.4","url":null,"abstract":"Monosodium glutamate (MSG) is one of additive compounds that can easily cross the placenta and affect brain development. The current study aims to investigate the detrimental effects of monosodium glutamate (MSG) on Albino Swiss Mice Mus musculus fetal brain during pregnancy and after delivery. Forty-eight pregnant mice were divided into two groups: control group(24) received only distilled water while the second group (treated group 24 mice) received 0.2ml/daily of MSG solution from the 17th days of pregnancy until the 21st days after birth (lactation period). Infant mice were randomly selected from each group and sacrificed in 15th, 21st, 30th and 60th days after birth. Histopathological examination of brain showed significant differences between treated and control groups. Histological lesions including: megakaryocyte, necrosis, blood capillary stenosis, fraction of nerve fiber and blood capillary collapsing, eosinophil cell, medullary necrosis and necrosis, eosinophilic nerve fiber, horseshoe shape nucleus, rosette shape pattern, acidophilic cytoplasm, swelling cell, gliosis, coalesces and occluded blood vessel. In conclusion, monosodium glutamate has clear histological effects on the brain of infant mice.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74428212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical and Ethical Challenges in Caring for Covid 19 Patients","authors":"A. Abdolrazaghnejad, Asma Khoshroo, A. Massoudifar","doi":"10.26655/jmchemsci.2022.1.13","DOIUrl":"https://doi.org/10.26655/jmchemsci.2022.1.13","url":null,"abstract":"The present study was performed to determine the ethical issues of medical care in Covid 19 disease. The steps were done in such a way that one of the researchers examined the search criteria among the articles and the criteria for including and deleting articles based on their titles and abstracts. In the second stage, the titles were reviewed. Out of 5833 retrieved articles, 5421 were retained after the repetition of duplicates. 201 cases were deleted due to insufficient data reporting, and 1059 cases were deleted due to poor quality. Finally, 153 articles were eligible. Only 20 articles of the studied articles had full text and related to the field of research card. In the third stage, the articles were searched manually; all libraries of Zahedan medical universities were examined, but no new ones were added by deleting articles that did not meet the inclusion criteria; the full text of all articles that met the inclusion criteria was reviewed. Then, their results were extracted according to the investigated factors and provided to two other researchers for reviewing. The quality of the studies was assessed through the STROBE checklist (14). In this systematic review, the articles that met the inclusion criteria were studied and analyzed. Excluded from all retrieved articles were studies that had unspecified sample size and implementation, or articles whose full text was not available. Finally, 20 cases were reviewed and analyzed. To extract the data, two experienced researchers simultaneously reviewed and analyzed the articles.","PeriodicalId":16365,"journal":{"name":"Journal of Medicinal and Chemical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85798277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}