Journal of Medical Virology最新文献

{"title":"Trend Analysis of HPV Prevalence in Weifang City Using a Bayesian Structural Time Series Model: A Longitudinal Study From 2012 to 2023","authors":"Haoran Yang,&nbsp;Jian Xu,&nbsp;Hongwei Wang,&nbsp;Hong Kou,&nbsp;Xiao Yang,&nbsp;Jing Li","doi":"10.1002/jmv.70624","DOIUrl":"10.1002/jmv.70624","url":null,"abstract":"<div>\u0000 \u0000 <p>The infection with human papillomavirus (HPV), particularly the persistent infection with high-risk HPV, is closely associated with the development of cervical cancer. A total of 81,397 specimens of cervical epithelium were collected in Weifang City from 2012 to 2023. The participants were divided into five age groups and tested for 23 HPV subtypes (13 high-risk and 10 low-risk subtypes) using a commercial kit. The overall infection rate of HPV was 23.78%, with the infection rate of high-risk HPV being 18.36%. The top five most prevalent subtypes were HPV16, 52, 58, 51, and 68. The infection rate of low-risk HPV was 5.42%, with the most common subtypes being HPV53, 81, and 66. Among different age groups, people aged 18–24 years and those aged ≥ 55 years exhibited higher infection rates, which were 33.55% and 26.29%, respectively. The predominant type of infection was single infection, followed by double infection. Joinpoint regression analysis revealed that the infection rates of HPV and HR-HPV exhibited a downward trend over time (<i>p</i> &lt; 0.05), with a significant turning point identified. Bayesian structural time series model (BSTS model) suggests that human papillomavirus vaccination may have prevented 1,705 cases of infection between 2018 and 2023, equating to a 14.5% reduction in infection rates. This study reveals the characteristics of the age distribution of HPV infection rates and genotypic infections in the region, suggests that HPV vaccination may influence the trend of HPV infection, and provides an epidemiological basis for disease prevention in the region.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New-Onset Major Depressive Disorder, Schizophrenia and Bipolar Disorder in People With Human Papillomavirus Diagnosis: A Population-Based Cohort Study","authors":"Hui-Chin Chang,&nbsp;Yen-Ju Chu,&nbsp;Chia-Chi Chang,&nbsp;Wei-Ting Hsu,&nbsp;Tsung-Hsuan Hung,&nbsp;Yu-Jung Su,&nbsp;Shiu-Jau Chen,&nbsp;Shuo-Yan Gau","doi":"10.1002/jmv.70618","DOIUrl":"10.1002/jmv.70618","url":null,"abstract":"<div>\u0000 \u0000 <p>Human papillomavirus (HPV), a common DNA virus known for its physical health implications, may also play a role in psychiatric conditions, though this link is not well understood. We conducted a retrospective cohort study using the TriNetX research network to examine the relationship between HPV and three major psychiatric disorders: major depressive disorder (MDD), schizphrenia and bipolar disorder (BD). Adults (≥ 18 years) diagnosed with HPV were 1:1 propensity score–matched to individuals without HPV based on demographics, comorbidities, and socioeconomic factors. Using ICD-10-CM codes, we identified new diagnoses of MDD and BD. Cox proportional hazard models estimated hazard ratios (HRs) with 95% confidence intervals (CIs), and Kaplan–Meier analyses assessed cumulative incidence. Sensitivity analyses confirmed the robustness of our findings. We found that HPV diagnosis was significantly associated with increased risks of MDD (HR: 1.28; 95% CI: 1.25–1.31) and BD (HR: 1.31; 95% CI: 1.26–1.37), whereas the association with schizophrenia was not significant (HR: 1.07; 95% CI: 0.97–1.18). These associations were stronger among females, younger adults, and individuals with sleep disorders. Our results suggest that HPV diagnosis is associated with increased psychiatric vulnerability. Further studies are warranted to validate these findings in different populations and clarify underlying mechanisms.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential Association of Infectious Mononucleosis With Diffuse Large B-Cell Lymphoma: A Mendelian Randomization and miRNA Profiling Approach","authors":"Weimin Huang,&nbsp;Jing Ai,&nbsp;Lanlan Jia,&nbsp;Jinying Gan,&nbsp;Junteng Chen,&nbsp;Manwen Tian,&nbsp;Lingzhen Chen,&nbsp;Yongmin Zhang","doi":"10.1002/jmv.70621","DOIUrl":"10.1002/jmv.70621","url":null,"abstract":"<div>\u0000 \u0000 <p>Diffuse large B-cell lymphoma (DLBCL) is clinically heterogeneous malignancy with complex etiological factors. The role of Epstein-Barr virus (EBV) infection, particularly infectious mononucleosis (IM), in DLBCL development remains controversial. This study aims to elucidate the potential mechanisms underlying the inverse association between IM and DLBCL by investigating the causal relationship between EBV and DLBCL using Mendelian randomization (MR) and comprehensive miRNA profiling. We employed a two-sample MR approach to assess the causal effect of EBV infection on DLBCL risk, using genetic variants associated with IM and DLBCL from genome-wide association studies (GWAS). miRNA profiling was performed on bulk RNA sequencing data from IM and DLBCL samples. Differential expression analysis, functional enrichment, and protein-protein interaction (PPI) network analysis were conducted to identify key regulatory pathways and potential therapeutic targets. MR analysis demonstrated a potential inverse association between IM and DLBCL, with an odds ratio (OR) of 0.796 (95%CI: 0.635–0.999, <i>p</i>-value = 0.049). Differential miRNA expression analysis identified significant dysregulation in 146 miRNAs in IM and 328 miRNAs in DLBCL, with nine shared miRNAs suggesting overlapping regulatory pathways. Functional enrichment highlighted critical pathways such as autophagy and apoptotic signaling. The prognostic model successfully stratified patients into high- and low-risk groups, significantly correlating with survival outcomes. Drug sensitivity analysis indicated increased responsiveness to targeted therapies in high-risk patients. These findings suggest biological mechanisms that may underlie the observed inverse association between IM and DLBCL and provide candidate miRNAs for prognostic evaluation. Further validation in larger, multi-ethnic cohorts with molecular subtyping is needed.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Guillain–Barré Syndrome Complicated by Refractory Cytomegalovirus Disease","authors":"Hengyu Zhao,&nbsp;赵恒宇,&nbsp;Wenshan Zhong,&nbsp;钟文珊,&nbsp;Lulin Wang,&nbsp;王璐琳,&nbsp;Qiaoyan Lian,&nbsp;练巧燕,&nbsp;Jie Zhang,&nbsp;张婕,&nbsp;Chunrong Ju,&nbsp;巨春蓉","doi":"10.1002/jmv.70619","DOIUrl":"10.1002/jmv.70619","url":null,"abstract":"","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Effectiveness of Metformin in Preventing Herpes Zoster Among Japanese Patients With Type 2 Diabetes: A Target Trial Emulation”","authors":"","doi":"10.1002/jmv.70622","DOIUrl":"10.1002/jmv.70622","url":null,"abstract":"<p>S. Hiroki, T. Fukasawa, K. Yokogawa, and K. Kawakami, “Effectiveness of Metformin in Preventing Herpes Zoster Among Japanese Patients With Type 2 Diabetes: A Target Trial Emulation,” <i>Journal of Medical Virology</i> 97 (2025): 1-10, https://doi.org/10.1002/jmv.70606.</p><p>In the originally published version of this article, the title was incorrectly printed as:</p><p>“Effectiveness of Metformin in Preventing Herpes Zoster Japanese Patients With Type 2 Diabetes: A Target Trial Emulation”</p><p>The omission of the word “Among” occurred during the publisher's production process. The authors' original manuscript contained the correct title and it should read as follows:</p><p>“Effectiveness of Metformin in Preventing Herpes Zoster <b>Among</b> Japanese Patients With Type 2 Diabetes: A Target Trial Emulation.”</p><p>We apologize for this error.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70622","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemagglutinin of Emerging Low Pathogenic Avian Influenza Viruses Underpins High Pathogenicity to Mammals","authors":"Xiaoyi Gao,&nbsp;Jinze Dong,&nbsp;Linlin Wang,&nbsp;Chuankuo Zhao,&nbsp;Xinsen Li,&nbsp;Shujun Zhang,&nbsp;Yudong Li,&nbsp;Yong Zhou,&nbsp;Wenjing Peng,&nbsp;Yanxin Hu,&nbsp;Qi Tong,&nbsp;Litao Liu,&nbsp;Honglei Sun,&nbsp;Yipeng Sun,&nbsp;Jinhua Liu,&nbsp;Zhimin Jiang,&nbsp;Juan Pu","doi":"10.1002/jmv.70615","DOIUrl":"https://doi.org/10.1002/jmv.70615","url":null,"abstract":"<div>\u0000 \u0000 <p>The pathogenicity of emerging early zoonotic avian H7N9 and H3N8 low-pathogenic avian influenza viruses (LPAIVs) in humans is significantly enhanced compared to that of their internal gene providers, H9N2 avian influenza viruses (AIVs), suggesting a pivotal role for surface HA or NA. Here, we generated several reassortant AIVs that combined HA, NA, or HA + NA from emerging zoonotic H7N9 or H3N8 LPAIV with internal H9N2 AIV genes and investigated the impact of HA and NA on the replication and pathogenicity of reassortants in human cells and mice. The crucial affected phase was determined by analyzing the receptor binding, viral adsorption, HA cleavage efficiency, viral endocytosis, and budding. We found that mice infected with the virus containing the early zoonotic H7N9 LPAIV HA, but not NA, exhibited high mortality, weight loss, severe lung damage, and increased viral load in the lungs. We found that HA substitution enhanced viral replication in human A549 cells and displayed dual sialic acid receptor binding ability. This substitution also facilitated viral attachment to mammalian cells and promoted endocytosis by enhancing HA0 cleavage efficiency; however budding was not affected. Additionally, HA from emerging zoonotic H3N8 LPAIVs elevate the pathogenicity of reassortants in mice. Together, our study revealed that HA of emerging zoonotic LPAIVs contributes to high pathogenicity in mammals by augmenting viral entry and causing lung injury, thereby highlighting HA with double receptor binding properties and HA cleavage efficiency as new markers for risk assessment of emerging zoonotic AIVs in the future.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EBV Infection Alters NK Cell Phenotype Distinctly From hCMV","authors":"Maria O. Ustiuzhanina,&nbsp;Julia D. Vavilova,&nbsp;Maria A. Salnikova,&nbsp;Aglaya A. Chertkova,&nbsp;Nadezhda A. Alekseeva,&nbsp;Anna A. Boyko,&nbsp;Anastasia I. Palamarchuk,&nbsp;Maria A. Streltsova,&nbsp;Dmitriy M. Chudakov,&nbsp;Elena I. Kovalenko","doi":"10.1002/jmv.70620","DOIUrl":"https://doi.org/10.1002/jmv.70620","url":null,"abstract":"<div>\u0000 \u0000 <p>Natural killer (NK) cells are vital in the antiviral response regulated by inhibitory and activating receptors, including NKG2 and KIR families, which bind HLA-I. While the adaptive features of NK cells in response to human cytomegalovirus (hCMV) have been well described, their behavior during Epstein-Barr virus (EBV) infection and the influence of KIR-HLA combinations in healthy carriers of these viruses remains unclear. We performed high-resolution HLA genotyping, phenotypic profiling of NK cell subsets, and serological testing for hCMV and EBV-specific IgG in 85 healthy adult donors. hCMV-seropositive individuals exhibited significant expansions of NKG2C⁺ and HLA-DR⁺ NK cell subsets, with the proportion of NKG2C⁺ cells strongly correlating with hCMV-IgG titers. In contrast, EBV infection was associated with increased frequencies of terminally differentiated CD56^dim, NKG2A^–, CD57+ NK cells and elevated expression of inhibitory KIRs, but not NKG2C or HLA-DR. EBV-IgG titers correlated with CD57 and KIR2DS4 levels. Among KIR2DS4-expressing donors, carriage of at least one HLA-C2 allele was associated with elevated EBV-IgGs. The precise analysis of KIR2DL2/DL3, KIR2DS4, and KIR2DL1 revealed dependencies on EBV-IgG titers, with no associations with hCMV. These findings highlight the differential impacts of hCMV and EBV on NK cells and underscore the relevance of HLA-KIR landscapes in shaping antiviral immunity.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EBV Infection Alters NK Cell Phenotype Distinctly From hCMV","authors":"Maria O. Ustiuzhanina,&nbsp;Julia D. Vavilova,&nbsp;Maria A. Salnikova,&nbsp;Aglaya A. Chertkova,&nbsp;Nadezhda A. Alekseeva,&nbsp;Anna A. Boyko,&nbsp;Anastasia I. Palamarchuk,&nbsp;Maria A. Streltsova,&nbsp;Dmitriy M. Chudakov,&nbsp;Elena I. Kovalenko","doi":"10.1002/jmv.70620","DOIUrl":"https://doi.org/10.1002/jmv.70620","url":null,"abstract":"<div>\u0000 \u0000 <p>Natural killer (NK) cells are vital in the antiviral response regulated by inhibitory and activating receptors, including NKG2 and KIR families, which bind HLA-I. While the adaptive features of NK cells in response to human cytomegalovirus (hCMV) have been well described, their behavior during Epstein-Barr virus (EBV) infection and the influence of KIR-HLA combinations in healthy carriers of these viruses remains unclear. We performed high-resolution HLA genotyping, phenotypic profiling of NK cell subsets, and serological testing for hCMV and EBV-specific IgG in 85 healthy adult donors. hCMV-seropositive individuals exhibited significant expansions of NKG2C⁺ and HLA-DR⁺ NK cell subsets, with the proportion of NKG2C⁺ cells strongly correlating with hCMV-IgG titers. In contrast, EBV infection was associated with increased frequencies of terminally differentiated CD56^dim, NKG2A^–, CD57+ NK cells and elevated expression of inhibitory KIRs, but not NKG2C or HLA-DR. EBV-IgG titers correlated with CD57 and KIR2DS4 levels. Among KIR2DS4-expressing donors, carriage of at least one HLA-C2 allele was associated with elevated EBV-IgGs. The precise analysis of KIR2DL2/DL3, KIR2DS4, and KIR2DL1 revealed dependencies on EBV-IgG titers, with no associations with hCMV. These findings highlight the differential impacts of hCMV and EBV on NK cells and underscore the relevance of HLA-KIR landscapes in shaping antiviral immunity.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Specific Sexually Transmitted Pathogens on Cervix: A Prospective Study Based on Cervical Cancer Screening Cohort","authors":"Simiao Chen,&nbsp;Tingyuan Li,&nbsp;Yakun Wang,&nbsp;Yu Dai,&nbsp;Qinjing Pan,&nbsp;Zhihui Zhang,&nbsp;Xun Zhang,&nbsp;Qiong Liao,&nbsp;Shijun Jia,&nbsp;Dongsheng Wang,&nbsp;Lingling Zhu,&nbsp;Xingsheng Cai,&nbsp;Chunlin Wang,&nbsp;Lingmei Yan,&nbsp;Xiaoyan Le,&nbsp;Hua Yang,&nbsp;Youlin Qiao,&nbsp;Jennifer S. Smith,&nbsp;Yuqian Zhao,&nbsp;Lan Zhu,&nbsp;Wen Chen","doi":"10.1002/jmv.70616","DOIUrl":"https://doi.org/10.1002/jmv.70616","url":null,"abstract":"<div>\u0000 \u0000 <p>Previous studies showed the association between sexually transmitted infections (STIs) and cervical lesions remains ambiguous. This study was conducted among 8371 women from a screening cohort. Seven specific sexually transmitted pathogens (STPs), including one viral [high-risk human papillomavirus (hrHPV), low-risk HPV (lrHPV)], five bacterial [Ureaplasma parvum (UP), Mycoplasma hominis (MH), Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), and Mycoplasma genitalium (MG)], and one parasitic [Trichomonas vaginalis (TV)] pathogen, were tested by Next Generation Sequencing assay using well-stored baseline samples. Odds ratios (ORs) for incident cervical lesions with different STPs were calculated by Logistic Regression analysis. Within 3-year follow-up, 133 and 72 participants were diagnosed with histopathological cervical intraepithelial neoplasia grade 1 (CIN1) and CIN2+, respectively. The adjusted ORs (aORs) of atypical squamous cells of undetermined significance or worse (ASC-US+) for women with hrHPV, lrHPV, UP, MH, TV, CT, and MG infections were 2.62 (95% CI: 2.19–3.13), 1.94 (95% CI: 1.55–2.43), 1.48 (95% CI: 1.26–1.74), 1.47 (95% CI: 1.25–1.73), 1.65 (95% CI: 1.27–2.15), 1.26 (95% CI: 0.79–2.01) and 2.33 (95% CI: 1.41–3.85), respectively. The aORs of cytological high-grade squamous intraepithelial lesions (HSIL) for women with hrHPV, TV, and MG infections were 13.01 (95% CI: 5.78–29.31), 3.48 (95% CI: 1.38–8.75), and 5.87 (95% CI: 1.58–21.77). The aORs of CIN1 for hrHPV, lrHPV, and MH were 6.88(95% CI: 4.79–9.90), 2.04(95% CI: 1.29–3.14), and 1.47(95% CI: 1.02–2.11). The aOR of CIN2+ for women with hrHPV infection was 17.56 (95% CI: 10.31–29.92), no significance was observed for CIN2+ with non-hrHPV STIs. Specific STP infections were significantly associated with subsequent cervical cytological ASC-US+ (hrHPV, lrHPV, UP, MH, TV, and MG) and HSIL (hrHPV, TV, and MG). Infection with lrHPV and MH could increase the CIN1 risk in future though no obvious CIN2+ risk elevation was observed.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Effects of Different Feeding Patterns on the Gut Virome of 6-Month-Old Infants”","authors":"","doi":"10.1002/jmv.70623","DOIUrl":"https://doi.org/10.1002/jmv.70623","url":null,"abstract":"<p>Pan, C., Xu, P., Yuan, M., Wei, S., Lu, Y., Lu, H. and Zhang, W. (2025). Effects of Different Feeding Patterns on the Gut Virome of 6-Month-Old Infants. Journal of Medical Virology, 97: e70344. https://doi.org/10.1002/jmv.70344</p><p>In the published article, on page 4, the captions for “Figure 2”, “Figure 3”, and “Figure 4” were misplaced. Specifically, the text currently labeled for one figure corresponds to another figure, failing to establish the correct correspondence between the figures and their captions. The correct correspondence should be as follows:</p><p>Figure 2. The composition of enterovirus family. (A). Heatmap representing the reads number of each viral family of individual library on log10 scale. The composition of the virus genome is represented by rectangles of different colors, and the name of the virus family is represented on the right. Sample groups and virus family types are displayed in the corresponding colors (see color legend). (B). The bar chart shows the proportion of different virus families in each individual library.</p><p>Figure 3. Comparison of virus alpha diversity (Shannon index) between groups of different feeding patterns at the (A) order and (B) family. The horizontal bars inside the box represent the median values.</p><p>Figure 4. PCoA analysis of different feeding patterns at the level of the order (A) and the family (B).</p><p>We apologize for this error.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 10","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}