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Does Omeprazole, the Proton-Pump Inhibitor, Affects the Structure of the Kidney of Male Albino Rats? Histological and Laboratory Study. 质子泵抑制剂奥美拉唑是否影响雄性白化大鼠肾脏结构?组织学和实验室研究。
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_11_21
Heba M Hussein, Nagwa El-Nefiawy, Haidy F Abdel Hamid, Marwa A Moneim
{"title":"Does Omeprazole, the Proton-Pump Inhibitor, Affects the Structure of the Kidney of Male Albino Rats? Histological and Laboratory Study.","authors":"Heba M Hussein,&nbsp;Nagwa El-Nefiawy,&nbsp;Haidy F Abdel Hamid,&nbsp;Marwa A Moneim","doi":"10.4103/jmau.jmau_11_21","DOIUrl":"https://doi.org/10.4103/jmau.jmau_11_21","url":null,"abstract":"<p><strong>Introduction: </strong>This study was done to assess the injurious effects of omeprazole by an <i>in vivo</i> experimental study on rat kidneys.</p><p><strong>Materials and methods: </strong>Forty-two adult male albino rats were divided into four groups: Control group (I) in which rats were not administrated any treatment. In Groups IIa, IIb, and IIc rats received daily oral omeprazole in dose of 0.75 mg per kg for 2, 4, and 6 weeks, respectively. At the end of the experiment, blood samples were collected for serum creatinine and blood urea nitrogen measurement. Then, animals were sacrificed, and kidney specimens were processed for paraffin blocks, sectioned and stained with H and E, Mallory trichrome and Periodic acid-Schiff, then examined by the light microscope. Stained sections and image analysis were used to count vacuolated cells, pyknotic nuclei, tubular casts, and area percent of collagen fiber deposition, and then, data were subjected to the statistical analysis.</p><p><strong>Results: </strong>Examination of omeprazole-treated groups showed injury of renal corpuscles, renal tubules, and vascular congestion with inflammatory cell infiltrate in renal interstitium. Thickening of basement membrane with deposition of collagen fibers was also detected. Statistically significant increase in the number of vacuolated cells, pyknotic nuclei, hyaline casts, and area percentage of collagen fiber deposition as compared with the control group was noticed, with deterioration of renal function tests.</p><p><strong>Conclusion: </strong>It was concluded that the long-term use of omeprazole resulted in structural damage of rat renal tissue associated with deterioration of renal function in a time-dependent manner.</p>","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"11 1","pages":"23-33"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/5e/JMAU-11-23.PMC10153739.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9470948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel ultrastructural morphological characterization of platelet-rich fibrin among diabetics 糖尿病患者富血小板纤维蛋白的一种新的超微结构形态学特征
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_103_22
Vinaya Rudresh, Suchetha Aghanashini, S. Srirangarajan, P. Srikumar, Ravi J Rao, B. Upasana
{"title":"A novel ultrastructural morphological characterization of platelet-rich fibrin among diabetics","authors":"Vinaya Rudresh, Suchetha Aghanashini, S. Srirangarajan, P. Srikumar, Ravi J Rao, B. Upasana","doi":"10.4103/jmau.jmau_103_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_103_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70799449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloperoxidase as a biomarker for aggressive periodontitis 髓过氧化物酶作为侵袭性牙周炎的生物标志物
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_107_22
T. Pereira, G. Salunkhe, A. Anjali, Sheetal S Choudhari, Rishikesh Mehta, Apeksha Jain
{"title":"Myeloperoxidase as a biomarker for aggressive periodontitis","authors":"T. Pereira, G. Salunkhe, A. Anjali, Sheetal S Choudhari, Rishikesh Mehta, Apeksha Jain","doi":"10.4103/jmau.jmau_107_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_107_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70799646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathological role of progesterone hormone in IDH-mutant astrocytoma 黄体酮在idh突变型星形细胞瘤中的临床病理作用
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_115_22
Eman Ahmed Abd Elmaogod, Dina A. Khairy, A. Mahmoud
{"title":"Clinicopathological role of progesterone hormone in IDH-mutant astrocytoma","authors":"Eman Ahmed Abd Elmaogod, Dina A. Khairy, A. Mahmoud","doi":"10.4103/jmau.jmau_115_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_115_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70800144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpha thalassemia/intellectual disability syndrome X-linked expression varies significantly between androgen receptor-positive and androgen receptor-negative prostatic adenocarcinoma: Relation to epidermal growth factor receptor expression and clinicopathological factors α地中海贫血/智力残疾综合征x连锁表达在雄激素受体阳性和雄激素受体阴性的前列腺癌中有显著差异:与表皮生长因子受体表达和临床病理因素的关系
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_119_22
Marwa Abd El-Azeem, D. Radi
{"title":"Alpha thalassemia/intellectual disability syndrome X-linked expression varies significantly between androgen receptor-positive and androgen receptor-negative prostatic adenocarcinoma: Relation to epidermal growth factor receptor expression and clinicopathological factors","authors":"Marwa Abd El-Azeem, D. Radi","doi":"10.4103/jmau.jmau_119_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_119_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70800209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autofluorescence in flow cytometry: A diagnostic conundrum secondary to drugs 流式细胞术中的自体荧光:继药物之后的诊断难题
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_117_22
M. Kotru, Shilpi More, Malvika Shastri, Monica Gupta
{"title":"Autofluorescence in flow cytometry: A diagnostic conundrum secondary to drugs","authors":"M. Kotru, Shilpi More, Malvika Shastri, Monica Gupta","doi":"10.4103/jmau.jmau_117_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_117_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70800283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The possible ameliorative effect of naringenin versus flaxseed oil on renal lead toxicity in male albino Rats: A histological and immunohistochemical study 柚皮素与亚麻籽油对雄性白化大鼠肾铅毒性的可能改善作用:组织学和免疫组织化学研究
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_61_23
DoaaRamadan Sadek, RaniaHamdy Elsyade
{"title":"The possible ameliorative effect of naringenin versus flaxseed oil on renal lead toxicity in male albino Rats: A histological and immunohistochemical study","authors":"DoaaRamadan Sadek, RaniaHamdy Elsyade","doi":"10.4103/jmau.jmau_61_23","DOIUrl":"https://doi.org/10.4103/jmau.jmau_61_23","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70800967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipoma of the fallopian tube with sebaceous metaplasia of the uterine cervix – Incidental or Pathological – Documentation of a rare case report 输卵管脂肪瘤伴子宫颈皮脂腺化生-偶发或病理性-罕见病例报告
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_10_23
Ayeesha Thajudeen, A. Kannan, Vijayashree Raghavan, M. Mahadaven
{"title":"Lipoma of the fallopian tube with sebaceous metaplasia of the uterine cervix – Incidental or Pathological – Documentation of a rare case report","authors":"Ayeesha Thajudeen, A. Kannan, Vijayashree Raghavan, M. Mahadaven","doi":"10.4103/jmau.jmau_10_23","DOIUrl":"https://doi.org/10.4103/jmau.jmau_10_23","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70799774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental teratoma: A case report of an unusual entity 胎盘畸胎瘤:罕见畸胎瘤1例报告
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_116_22
P. Diwaker, Malvika Shastri, D. Bansal, P. Gogoi
{"title":"Placental teratoma: A case report of an unusual entity","authors":"P. Diwaker, Malvika Shastri, D. Bansal, P. Gogoi","doi":"10.4103/jmau.jmau_116_22","DOIUrl":"https://doi.org/10.4103/jmau.jmau_116_22","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70800274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy and perception of an origami-based paper microscope when compared to the conventional light microscope in oral cytology 与传统光学显微镜相比，折纸显微镜在口腔细胞学中的准确性和感知
Journal of Microscopy and Ultrastructure Pub Date : 2023-01-01 DOI: 10.4103/jmau.jmau_37_23
H. Prasad, ME. Adhi Sivasankari, K. Srichinthu, Perumal Prema, M. Rajmohan, Sivanandhan Shanmuganathan
{"title":"Accuracy and perception of an origami-based paper microscope when compared to the conventional light microscope in oral cytology","authors":"H. Prasad, ME. Adhi Sivasankari, K. Srichinthu, Perumal Prema, M. Rajmohan, Sivanandhan Shanmuganathan","doi":"10.4103/jmau.jmau_37_23","DOIUrl":"https://doi.org/10.4103/jmau.jmau_37_23","url":null,"abstract":"","PeriodicalId":16340,"journal":{"name":"Journal of Microscopy and Ultrastructure","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70801159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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