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Probing cancer cell responses via using physically-modified chitosan nanosponges 利用物理修饰的壳聚糖纳米海绵探测癌细胞反应
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766322
Chung-Yao Yang, H. Shuai, K. Kao, Chun-Yen Sung, Chao-Min Cheng, J. Yeh
{"title":"Probing cancer cell responses via using physically-modified chitosan nanosponges","authors":"Chung-Yao Yang, H. Shuai, K. Kao, Chun-Yen Sung, Chao-Min Cheng, J. Yeh","doi":"10.1109/NANOMED.2013.6766322","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766322","url":null,"abstract":"This paper describes the development of physically-modified chitosan nanosponges to probe cellular behaviors and molecular-level structural responses of MDA-MB-231 cells (human breast cancer cells) adhered onto these modified nanosponges. After 4 and 12 hours culture, MDA-MB-231 cells were investigated to decipher the cellular responses on these chitosan nanosponges through using scanning electron microscopy and fluorescence microscopy. We found that MDA-MB-231 cells exhibited distinct structurally based responses attributable to chitosan nanosponges that we demonstrate as possibly applicable, for drug screening applications. In addition, we developed a chitosan-based micropatterning procedure that allowed us to re-arrange mammalian cells (i.e., HeLa cells in this study, for cancer drug screening) at the desired locations (with a single-cell array format). We believe that this study would provide further understanding of naturally derived biomaterials and facilitate the development of new biomedical devices with unique cell-material interface properties and characteristics, such as in-vitro cell culture and diagnostic platforms.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114683684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of temperature and humidity exposure on reliability of silicon nanowires 温度和湿度暴露对硅纳米线可靠性的影响
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766326
U. Wejinya, N. Willems, Zhuxin Dong
{"title":"The effects of temperature and humidity exposure on reliability of silicon nanowires","authors":"U. Wejinya, N. Willems, Zhuxin Dong","doi":"10.1109/NANOMED.2013.6766326","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766326","url":null,"abstract":"Material reliability is among the crucial factors that impact material performances before device applications. In order to predict material reliability, accelerated aging study-a study to predict material shelf life when subjected to temperature and humidity, was performed on silicon nanowires. We investigated the effects of process conditions on the diameter and the quality of SiNWs using Atomic Force Microscopy followed by statistical analysis. The experimental results revealed diameter of SiNWs has a linear relationship with changing temperature and humidity. These results are of significant importance and will be a critical design consideration for the use of SiNWs in biomedical implants.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122227976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated micropipette aspiration of cell using resistance-based voltage feedback control 使用基于电阻的电压反馈控制的自动微移液管吸进细胞
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766330
Hongkui Dong, Wenxue Wang, Zhibo Wang, Lei Zhou, Lianqing Liu
{"title":"Automated micropipette aspiration of cell using resistance-based voltage feedback control","authors":"Hongkui Dong, Wenxue Wang, Zhibo Wang, Lei Zhou, Lianqing Liu","doi":"10.1109/NANOMED.2013.6766330","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766330","url":null,"abstract":"This paper presents an automation operation system for the single cell aspiration and placement with high throughput. In the system, a glass capillary micropipette is utilized to move above the microwell substrate which contains living cells, select and aspire individual cells of interest, transfer and release them to target locations. With the microwell biochip coordinate system, the micropipette can be positioned precisely and moves automatically to target microwell with path planning and control. With the visual feedback, living cells of interest are selected and then the micropipette is moved to approach to the cells for aspiration. The cell-resistance based voltage feedback is established for cell aspiration and placement control. The goal of this work is to realize the automated and efficient operation of the cells in the microwell array including aspiration, transfer and placement.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133207752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A simple and quick fabrication method of microfluidic cell sorter using Dielectrophoresis 一种简单、快速的介质电泳制备微流控细胞分选器的方法
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766311
Yibei Zhao, J. Yeow, L. Zheng
{"title":"A simple and quick fabrication method of microfluidic cell sorter using Dielectrophoresis","authors":"Yibei Zhao, J. Yeow, L. Zheng","doi":"10.1109/NANOMED.2013.6766311","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766311","url":null,"abstract":"We present a simple, fast and cheap fabrication method of a microfluidic device by combining many easy techniques, such as laser ablating microchannels on polyimide, creating chip by sandwiching geometry customized channel in between Indium Tin Oxide (ITO) coated glass that is served as electrodes. This chip is used in the phenomenon of Dielectrophoresis for cell sorting. In the fabrication methodology, two layers of polyimide sheets with different channel shapes are stacked in between two pieces ITO coated glass. Inlet and outlet holes are drilled through the glass and connected to the tubes with cubic prefabricated polydimethylsiloxane (PDMS) punctured by needles. The performance of the chip is demonstrated by simulating the particle movement under the influence of negative DEP (n-DEP). The results indicate that this device can be used to sort particles responding to n-DEP effects.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"307 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116593113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A hybrid approach for vessel enhancement and fast level set segmenatation based 3d blood vessel extraction using MR brain image 基于磁共振脑图像血管增强和快速水平集分割的三维血管提取混合方法
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766319
Syed Ali Hassan, Jungwon Yoon
{"title":"A hybrid approach for vessel enhancement and fast level set segmenatation based 3d blood vessel extraction using MR brain image","authors":"Syed Ali Hassan, Jungwon Yoon","doi":"10.1109/NANOMED.2013.6766319","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766319","url":null,"abstract":"In this research we present a robust prototyping method for segmentation of brain MR images to extract the 3d evolution model of the blood vessel present in the complex regions under the surface. We proposed a hybrid technology based on two levels, the smoothing and segmentation process for extraction of blood vessels. For this approach we compared robust automated algorithms for filtering the MR images. Furthermore, in second stage fast level set segmentation process was implemented to complete the extraction of blood vessels process with in a magnetic resonance (MR) image. Vessel extraction process was implemented in a virtual environment and used to convert complex vascular geometry of the selected MR region into a replica with large anatomical coverage and high spatial resolution. Experiments were conducted to evaluate the performance of the VED filters enhancing vessels in brain region and further used with fast level set segmentation to extract the vessel models.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123733836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The study on the effect of load mass on the movement of the cross-scale stage based on the stick-slip driving 基于粘滑驱动的跨尺度平台载荷质量对其运动影响的研究
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766321
Bowen Zhong, Zhenhua Wang, Ziqi Jin, F. Gao, Lining Sun
{"title":"The study on the effect of load mass on the movement of the cross-scale stage based on the stick-slip driving","authors":"Bowen Zhong, Zhenhua Wang, Ziqi Jin, F. Gao, Lining Sun","doi":"10.1109/NANOMED.2013.6766321","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766321","url":null,"abstract":"In this paper, the relationship of the movement of stick-slip driving and the load mass was studied. Firstly, the research status and the principle of stick-slip driving was introduced. Secondly, the dynamic model of stick-slip driving was built. By using dynamic models, the relationship curve of the every step displacement and the load mass was received through the simulation in Matlab software. Furthermore, in corroboration of the dynamic model, the prototype was designed and the experiment system was built. From the testing of stick-slip prototype, the step displacement in every load mass was tested 10 times and the relationship curve of the average every step displacement and load mass was obtained. The simulation results are validated by the testing results and the method of increasing the load mass to adjust the stick-slip driving step displacement and velocity were proved. In the future, the relationship of the movement speed and the driving frequency should be researched for improving the movement performance of the stick-slip driving.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128624028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic cell sorter for photodynamic urine diagnosis 用于光动力尿液诊断的微流控细胞分选器
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766309
D. Takagi, Y. Hirai, T. Tsuchiya, O. Tabata, S. Anai, Y. Chihara, K. Fujimoto, Y. Hirao
{"title":"Microfluidic cell sorter for photodynamic urine diagnosis","authors":"D. Takagi, Y. Hirai, T. Tsuchiya, O. Tabata, S. Anai, Y. Chihara, K. Fujimoto, Y. Hirao","doi":"10.1109/NANOMED.2013.6766309","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766309","url":null,"abstract":"We report a new microfluidic cell sorting system for early diagnosis of genitourinary cancer based on photodynamic analysis of urine. In the developed system, genitourinary cancer cells are detected using 5-aminolevulinic acid (5-ALA)-induced fluorescence and then sorted for gene alteration analysis. The unique characteristic of this cell sorter is that the microchannel's microstructure is fabricated using one-step UV photolithography, to create a disposable, low-cost device that has low autofluorescence. In this paper, we examine the performance of the microfluidic cell sorting system for diagnosing genitourinary cancer, and evaluate the accuracy of cancer cell separation when using the 5-ALA treatment, and also when using fluorescent beads.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116594337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Combined experimental and numerical simulation study of PDMS pneumatic micropumps PDMS气动微泵实验与数值模拟相结合的研究
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766328
Ping Yao, Shuangxi Xie, Zhu Liu, Z. Dong, Lianqing Liu, Wenxue Wang, S. Tung
{"title":"Combined experimental and numerical simulation study of PDMS pneumatic micropumps","authors":"Ping Yao, Shuangxi Xie, Zhu Liu, Z. Dong, Lianqing Liu, Wenxue Wang, S. Tung","doi":"10.1109/NANOMED.2013.6766328","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766328","url":null,"abstract":"This paper presents a combined experimental and numerical simulation study of polydimethylsiloxane (PDMS) pneumatic micropumps. The micropumps consist of three pneumatic PDMS membranes, one pump chamber, and two check valves. In particular, two flow stoppers in fluidic channel corresponding to the check valves can avoid back flow, and increase the flow rate. The flow rates of the micropumps have been tested under operational parameters including varied applied pneumatic pressures and pumping frequencies. A maximal flow rate of 449 μL/min is achieved at the driving frequency of 25 Hz and applied pressure of 15 psi. The numerical simulation using COMSOL software verified that the experimental results have a consistent trend for flow rate variation with respect to frequency and the peak flow rate at an optimal frequency.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129914986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Nanotube devices for digital profiling of cancer biomarkers and circulating tumor cells 用于癌症生物标志物和循环肿瘤细胞数字分析的纳米管装置
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766325
Farhad Khosravi, Ben King, B. Panchapakesan, Sesh Rai, G. Kloecker, E. Wickstrom
{"title":"Nanotube devices for digital profiling of cancer biomarkers and circulating tumor cells","authors":"Farhad Khosravi, Ben King, B. Panchapakesan, Sesh Rai, G. Kloecker, E. Wickstrom","doi":"10.1109/NANOMED.2013.6766325","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766325","url":null,"abstract":"We present our results on development of handheld point of care nanotube devices for digital profiling of cancer biomarkers and circulating tumor cells. A scalable nano-manufacturing technique was utilized to develop devices out of transparent thin films of nanotubes. Generation 1 wafers yielded 60 devices per wafer. Generation 2 wafers yielded 240 devices per wafer. Using PASE functionalization of nanotube device arrays, we investigated the detection of cancer biomarkers such as molecular EpCAM and EpCAM in cancer cells. Results suggest detection of 1 ng/ml of EpCAM using nanotube FET devices. Simple and reliable detection of specific versus non-specific interactions of EpCAM in CTCs with 95% confidence intervals were obtained. These devices have high potential as handheld systems for cancer biomarker testing and CTCs in clinic.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114692695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Test of A CNT gyroscope based on field emission 基于场发射的碳纳米管陀螺仪测试
The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering Pub Date : 2013-11-01 DOI: 10.1109/NANOMED.2013.6766316
Zhan Yang, M. Nakajima, Yajing Shen, Pengbo Wang, Changhai Ru, Yahua Zhang, Lining Sun, T. Fukuda
{"title":"Test of A CNT gyroscope based on field emission","authors":"Zhan Yang, M. Nakajima, Yajing Shen, Pengbo Wang, Changhai Ru, Yahua Zhang, Lining Sun, T. Fukuda","doi":"10.1109/NANOMED.2013.6766316","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766316","url":null,"abstract":"A gyroscope based on Coriolis effect and fabricated by Carbon Nanotube (CNT) was presented. The gyroscope was designed A CNT is vibration at x direction, when there a rotation around z direction, acceleration happens to the y direction. The natural frequency of MWCNT is depending on the inner diameter, outer diameter and length. The CNT was driven by the electrostatic force to its nature frequency. A CNT with a length of 1 μm was used for emitter and an anode with a bias angle is etched by Focused Ion Beam (FIB) which is set to the opposite to the CNT. An electrode is set near the CNT tip, which is employed to pulling the CNT for mechanical resonances by an AC voltage. The CNT with a resonate frequency of 1 MHz and mechanical quality factor Q of ~400 was tested at rotation speed of 20 rad.s.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134601971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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