The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering最新文献

{"title":"Microfluidic platforms for size-based cell sorting","authors":"S. Karunanidhi, Michael W. Lum, Shravya R. Nagurla, W. Tang","doi":"10.1109/NANOMED.2013.6766310","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766310","url":null,"abstract":"We report on the design, fabrication, and test results of a set of microfluidic devices with channels designed to promote fluidic hydrodynamic forces to sort and separate cells based on cell sizes. A set of 14 devices were made from polydimethylsiloxane (PDMS) molded from photolithographically patterned SU-8. The spiral fluidic channels with specific numbers of turns, widths, and outer diameters were designed with branches at strategic locations along the length to divert separated particles into collection chambers. A mixture of polystyrene particles of two different diameters (7 and 20 μm) was used as the test solution to determine the sorting efficiencies. Theoretical analyses of the designed performance were based on previously published equations and were found to be within practical agreement. The optimized performance was consistently close to 90% capture and isolation efficiencies from a mixture of up to 1:100,000 of 20-μm-to-7-μm particles at a flow rate of 4.0 mL·min-1.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130597629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical study on drug delivery vehicle motion characteristics in tumor-defective blood vessels using arbitrary Lagrangian-Eulerian Algorithm","authors":"Yu-Chung Liao, R. Chein","doi":"10.1109/NANOMED.2013.6766324","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766324","url":null,"abstract":"This study presented numerical study on the motion of drug delivery vehicle (DDV) in blood vessel based the enhanced permeability and retention (EPR) effect due to the tumor-defective blood vessel. Instead of traditional particle tracing, the arbitrary Lagrangian-Eulerian Algorithm (ALE) was employed in this study to account for the force coupling between the moving DDV and blood flow. The ALE and Navier-Stokes modules facilitated by COMSOL software were employed to carry out the numerical simulations. The computational domain was treated as two-dimensional containing three trans-cellular holes caused by the tumor tissue growth. Motions of both spherical and rod-like DDV were considered in this study. The DDV was considered to enter the tumor tissues when it traveled through the defective opening gaps. The simulated results indicated that the initial locations and size played importation roles on governing the motion of DDV. The DDV had greater chance to travel through the opening gaps when its initial location was close to the vessel wall and its diameter ranged between 20 and 100 nm. The numerical simulations also demonstrated that there was significant difference on the DDV trajectories between ALE and particle tracing computations. The motion characteristics of the rod-like DDV was similar to that of its spherical counterpart except the inclusion of rotational motion. The rod-like DDV had less chance of entering the tumor tissue as compared with the spherical DDV because of its rotational motion.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134469141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IG-001—A non-biologic micellar paclitaxel formulation for the treatment of metastatic Breast cancer","authors":"K. Motamed, L. Hwang, C. Hsiao, Chulho Park, V. Trieu","doi":"10.1109/NANOMED.2013.6766323","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766323","url":null,"abstract":"We have recently shown that the dissolution profile of IG-001 is very similar to that of nabpaclitaxel/Abraxane®. Once injected into the circulation, both formulations quickly dissolve into paclitaxel complexed with endogenous circulating albumin, suggesting that both formulations deliver paclitaxel to the targeted tissue via albuminmediated transport. Herein, we provide a summary report of our clinical studies in Metastatic Breast Cancer (MBC) that includes two Phase 2 studies, interim results for a Phase 3, as well as a Phase 4 post-marketing surveillance (PMS) study.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132711266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LCP MEMS implantable pressure sensor for Intracranial Pressure measurement","authors":"Preedipat Sattayasoonthorn, J. Suthakorn, Sorayouth Chamnanvej, J. Miao, A. Kottapalli","doi":"10.1109/NANOMED.2013.6766317","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766317","url":null,"abstract":"Numerous devices for the measurement of Intracranial Pressure (ICP) have been proposed; these include both wired and wireless systems, each of which having their own shortcomings. In this work, the following requirements for minimally invasive measurement of ICP are considered: low infection, biocompatibility, small size, accuracy and ease of use. With these requirements in mind, we propose an implantable ICP sensor based on Microelectromechanical Systems (MEMS). Liquid Crystal Polymer (LCP) is chosen as the biocompatible and flexible structure. This paper describes the significant characteristics of LCP that make it well suited for biomedical applications, and comparisons are made to other polymers in terms of biocompatibility and certification. The proposed LCP pressure sensor has been successfully fabricated, with a membrane area of 2mm × 2mm × 50μm.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124611537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiments of carbon nanocomposite implants for patient specific ENT care","authors":"M. Chua, C. Chui, Chin-Boon Chng, D. Lau","doi":"10.1109/NANOMED.2013.6766318","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766318","url":null,"abstract":"We have developed the first patient specific carbon nanotube composite artificial tracheal implant tested on a porcine model in vivo. The experimental subject has survived with the implant with no apparent problems. Carbon nanocomposite material and the patient specific approach have also been used to develop a voice prosthesis device, as well as new microclips for wound closure. This paper presents our experimental investigation with the carbon nanocomposite materials for constructing patient specific ENT implants.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132080603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated micro-chip for cell array positioning, in-situ impedance measurement and electroperation","authors":"Xiaoliang Guo, Rong Zhu","doi":"10.1109/NANOMED.2013.6766327","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766327","url":null,"abstract":"This paper reports a biocompatible microchip integrating function of dielectrophoresis (DEP)-based cell array positioning with in-situ real-time impedance measurement and electroporation (EP) of living cells. The DEP-based cell manipulation [1], impedance measurement [2], and cell electroporation [3] are commonly-used label-free techniques for studying of living cells, but they are generally applied separately and rare to be integrated in one chip due to complex structure and crosstalk among them. In this paper we present a novel microchip, in which the cells are manipulated and trapped onto the electrode array (4×8). The impedance spectroscopy of individual cell trapped on electrode array can be measured in situ and the trapped cells can be also electroporated with a high transfection rate (about 90%).","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130297322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous topography imaging and molecular recognition with low crosstalk and high sensitivity","authors":"Haitao Yang, Guangyong Li","doi":"10.1109/NANOMED.2013.6766329","DOIUrl":"https://doi.org/10.1109/NANOMED.2013.6766329","url":null,"abstract":"Atomic force microscope has been used to recognize biomolecules through a functionalize tip. In order to achieve simultaneous topography imaging and molecular recognition, existing method such as PicoTREC (commercialized by Agilent Inc.) extracts the topography image from the lower amplitude of the cantilever oscillation while extracts recognition image from the upper amplitude of the cantilever oscillation. To avoid crosstalk between topography and recognition images, PicoTREC requires using cantilever with small quality factor (Q≈1). Such low Q, however, results in low force sensitivity, thus a large tip-sample interaction force during imaging, which is destructive to the soft biological samples. In this paper, we propose an innovative method for simultaneous topography imaging and molecular recognition using cantilever with high Q but with minimized crosstalk. For cantilever with large quality factor (Q>10) in liquid, the upper part and lower part of the cantilever's oscillation becomes symmetric. The topography information that exists in the lower amplitude of the deflection signal also exists in the upper amplitude. Because of the symmetry of the deflection signal, the topography information in the upper amplitude can be cancelled by the lower amplitude. However, the control system will conversely respond to the decrease of the amplitude caused by the molecule binding. So taking use of the lower amplitude, the topography crosstalk in the upper amplitude can be cancelled and the molecule recognition information can be kept. So using this method, high-Q cantilever can be used for simultaneous topography and molecular recognition without crosstalk. The high-Q cantilever will result in high-force sensitivity that will be less destructive to the soft biological samples. This technique will make the simultaneous topography imaging and molecular recognition possible on soft biological sample surfaces, such as the cell membrane. In this paper, the simulation is utilized to demonstrate the principle of our proposed method, and then initial experiments are also performed to validate our method.","PeriodicalId":163282,"journal":{"name":"The 7th IEEE International Conference on Nano/Molecular Medicine and Engineering","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127503783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}