Journal of Investigative Dermatology最新文献

筛选
英文 中文
Nucleic Acid Therapy for the Skin. 皮肤核酸疗法。
IF 6.5 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-09-13 DOI: 10.1016/j.jid.2024.07.029
Andreas C Chai,Daniel J Siegwart,Richard C Wang
{"title":"Nucleic Acid Therapy for the Skin.","authors":"Andreas C Chai,Daniel J Siegwart,Richard C Wang","doi":"10.1016/j.jid.2024.07.029","DOIUrl":"https://doi.org/10.1016/j.jid.2024.07.029","url":null,"abstract":"Advances in sequencing technologies have facilitated the identification of the genes and mechanisms for many inherited skin diseases. Although targeted nucleic acid therapeutics for diseases in other organs have begun to be deployed in patients, the goal of precise therapeutics for skin diseases has not yet been realized. First, we review the current and emerging nucleic acid-based gene-editing and delivery modalities. Next, current and emerging viral and nanoparticle vehicles for the delivery of gene therapies are reviewed. Finally, specific skin diseases that could benefit optimally from nucleic acid therapies are highlighted. By adopting the latest technologies and addressing specific barriers related to skin biology, nucleic acid therapeutics have the potential to revolutionize treatments for patients with skin disease.","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"115 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connexin Hemichannel Inhibition and Human Genodermatoses. 附件半通道抑制与人类遗传性皮肤病
IF 6.5 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-09-11 DOI: 10.1016/j.jid.2024.08.003
Fabio Mammano,Amy S Paller,Thomas W White
{"title":"Connexin Hemichannel Inhibition and Human Genodermatoses.","authors":"Fabio Mammano,Amy S Paller,Thomas W White","doi":"10.1016/j.jid.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.jid.2024.08.003","url":null,"abstract":"Pathogenic variants in genes encoding connexins that cause skin diseases, such as keratitis-ichthyosis-deafness (KID) syndrome and hidrotic ectodermal dysplasia (HED) or Clouston syndrome, display increased hemichannel activity. Mechanistic insights derived from biophysical studies of the variant connexins support the hypothesis that inhibition of the acquired hemichannel activity could alleviate epidermal pathology. Use of pharmacological blockers and engineered mAbs in mouse models of HED and KID confirm that hemichannel inhibition is a promising target for new therapeutic approaches to KID and HED. Insights from this work could apply to other connexin-based genetic skin diseases in which hemichannel activity is elevated.","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"7 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of adipocyte-derived fatty-acid-binding protein 4 reduces adipocyte inflammation, improves angiogenesis, and facilitates wound healing in metabolic dysfunctions. 抑制脂肪细胞衍生的脂肪酸结合蛋白4可减少脂肪细胞炎症,改善血管生成,并促进代谢功能障碍患者的伤口愈合。
IF 6.5 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-09-09 DOI: 10.1016/j.jid.2024.08.017
Yen-Wen Wu,Jaw-Wen Chen,Hao-Yuan Tsai,Jih-Hsin Huang,Chia-Chi Chang,Ting-Ting Chang
{"title":"Inhibition of adipocyte-derived fatty-acid-binding protein 4 reduces adipocyte inflammation, improves angiogenesis, and facilitates wound healing in metabolic dysfunctions.","authors":"Yen-Wen Wu,Jaw-Wen Chen,Hao-Yuan Tsai,Jih-Hsin Huang,Chia-Chi Chang,Ting-Ting Chang","doi":"10.1016/j.jid.2024.08.017","DOIUrl":"https://doi.org/10.1016/j.jid.2024.08.017","url":null,"abstract":"Dermal white adipose tissue may participate in the wound healing process. Obesity-mediated chronic low-grade inflammation impairs wound healing by suppressing vascularity. Given that fatty-acid-binding protein (FABP) 4 is upregulated in the skin tissue of obese animals, this study aimed to investigate the effects of FABP4 inhibition on wound healing in high-fat-diet (HFD)-induced metabolic dysfunction mice in vivo. The interaction between adipocyte-derived FABP4 and vascular endothelial cell function was also investigated. In HFD-induced metabolic dysfunction mice, FABP4 inhibition increased angiogenesis and facilitated wound healing with reduced wound inflammation. FABP4 inhibition not only attenuated systemic inflammation, decreased body weight, and reduced insulin resistance, but also improved the sizes of adipocytes and hypoxic conditions in dermal white adipose tissue. The in vitro hypoxia was used to induce adipocyte inflammation, and the supernatants from hypoxia-stimulated adipocytes impaired the function and angiogenetic capability of human dermal microvascular endothelial cells. Both of them were improved by FABP4 inhibition. Altogether, FABP4 inhibition reduced systemic and adipocyte inflammation, improved vascular endothelial cell function, and facilitated wound healing in metabolic dysfunctions. Given the complex involvement of wound healing, future studies may be required to validate FABP4 as a potential therapeutic target for wound repair in metabolic dysfunctions.","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"260-261 1","pages":""},"PeriodicalIF":6.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reassessing Long-Term Cryopreservation Strategies for Improved Quality, Safety, and Clinical Use of Allogeneic Dermal Progenitor Cells 重新评估长期冷冻保存策略,以提高异体真皮祖细胞的质量、安全性和临床应用。
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-08-31 DOI: 10.1016/j.jid.2024.06.1285
Marjorie Flahaut , Alexis Laurent , Carla V. Fuenteslópez , Zhanfeng Cui , Hua Ye , Corinne Scaletta , Nathalie Hirt-Burri , Lee Ann Applegate , Viorica Patrulea
{"title":"Reassessing Long-Term Cryopreservation Strategies for Improved Quality, Safety, and Clinical Use of Allogeneic Dermal Progenitor Cells","authors":"Marjorie Flahaut ,&nbsp;Alexis Laurent ,&nbsp;Carla V. Fuenteslópez ,&nbsp;Zhanfeng Cui ,&nbsp;Hua Ye ,&nbsp;Corinne Scaletta ,&nbsp;Nathalie Hirt-Burri ,&nbsp;Lee Ann Applegate ,&nbsp;Viorica Patrulea","doi":"10.1016/j.jid.2024.06.1285","DOIUrl":"10.1016/j.jid.2024.06.1285","url":null,"abstract":"<div><p>In regenerative medicine, ongoing advancements in cell culture techniques, including isolation, expansion, banking, and transport, are crucial for clinical success. Cryopreservation ensures off-the-freezer availability of living cells, enabling long-term storage and transport. Customizing cryopreservation techniques and cryoprotective agents (CPAs) for specific cell types is crucial for cell source quality, sustainability, safety, and therapeutic intervention efficiency. As regenerative medicine progresses, it becomes imperative that the scientific community and industry provide a comprehensive, cell-specific landscape of available and effective cryopreservation techniques, preventing trial-and-error approaches and unlocking the full potential of cell-based therapies. Open-sharing data could lead to safer, more efficient cell therapies and treatments. Two decades of dermal progenitor cell use for burn wound treatment and Good Manufacturing Practice–compliant technology transfers have highlighted the need for further cryopreservation optimization in manufacturing workflows. In this paper, we present experimental data assessing 5 different cryopreservation formulae for long-term storage of clinical-grade FE002 primary progenitor fibroblasts, emphasizing the crucial difference between DMSO-based and DMSO-free CPAs. Our findings suggest that CryoOx, a DMSO-free CPA, is a promising alternative yielding cell viability similar to that of established commercial CPAs. This research highlights the importance of secure, robust, and efficient cryopreservation techniques in cell banking for maximizing quality, ensuring patient safety, and advancing regenerative medicine.</p></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 10","pages":"Pages 2125-2135"},"PeriodicalIF":5.7,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0022202X24018980/pdfft?md5=767719649077973ef2a295101353718d&pid=1-s2.0-S0022202X24018980-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hungry Side of Skin 皮肤饥饿的一面
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-08-30 DOI: 10.1016/j.jid.2024.04.030
Shivang Parikh , Carmit Levy
{"title":"The Hungry Side of Skin","authors":"Shivang Parikh ,&nbsp;Carmit Levy","doi":"10.1016/j.jid.2024.04.030","DOIUrl":"10.1016/j.jid.2024.04.030","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 10","pages":"Pages 2117-2119"},"PeriodicalIF":5.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Landscape within Cutaneous Lesions of Human Bullous Pemphigoid 人类大疱性类天疱疮皮肤病变中的免疫格局
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-08-22 DOI: 10.1016/j.jid.2024.04.008
Kalpani de Silva , Jun Yan
{"title":"Immune Landscape within Cutaneous Lesions of Human Bullous Pemphigoid","authors":"Kalpani de Silva ,&nbsp;Jun Yan","doi":"10.1016/j.jid.2024.04.008","DOIUrl":"10.1016/j.jid.2024.04.008","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 10","pages":"Pages 2111-2113"},"PeriodicalIF":5.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Childhood Obesity, Weight Change, and Pediatric Immune-Mediated Skin Diseases 儿童肥胖症、体重变化和小儿免疫性皮肤病。
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-08-21 DOI: 10.1016/j.jid.2024.01.037
Seong Rae Kim , Seong-Joon Koh , Hyunsun Park
{"title":"Childhood Obesity, Weight Change, and Pediatric Immune-Mediated Skin Diseases","authors":"Seong Rae Kim ,&nbsp;Seong-Joon Koh ,&nbsp;Hyunsun Park","doi":"10.1016/j.jid.2024.01.037","DOIUrl":"10.1016/j.jid.2024.01.037","url":null,"abstract":"<div><p>Whether childhood obesity or weight gain leads to the development of pediatric immune-mediated skin diseases remains unclear. We aimed to determine the associations between body mass index or body mass index changes and the development of 3 main immune-mediated skin diseases—alopecia areata, atopic dermatitis (AD), and psoriasis—by analyzing a longitudinal cohort of 2,161,900 Korean children from 2009 to 2020. The findings indicated that children who were obese had a higher risk of pediatric immune-mediated skin diseases than those with normal weight (<em>P</em> for trend &lt; .01). An increase in body mass index was associated with a higher risk of AD, whereas a decrease in body mass index was correlated with a reduced risk of AD. Children who gained weight, transitioning from normal to overweight, exhibited a higher AD risk than those who maintained a normal weight (adjusted hazard ratio = 1.15, 95% confidence interval = 1.11–1.20). However, those who shifted from being overweight to achieving a normal weight (adjusted hazard ratio = 0.87, 95% confidence interval = 0.81–0.94) had a lower AD risk than children who were overweight who maintained their weight. In summary, early childhood obesity may increase the risk of pediatric immune-mediated skin diseases. Weight gain may increase AD risk, whereas weight loss may lower the risk.</p></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 9","pages":"Pages 1975-1984.e10"},"PeriodicalIF":5.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editors’ Picks 编辑推荐
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-08-21 DOI: 10.1016/j.jid.2024.07.002
{"title":"Editors’ Picks","authors":"","doi":"10.1016/j.jid.2024.07.002","DOIUrl":"10.1016/j.jid.2024.07.002","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 9","pages":"Page 1908"},"PeriodicalIF":5.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Snippets 临床片段
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-08-21 DOI: 10.1016/j.jid.2024.07.003
{"title":"Clinical Snippets","authors":"","doi":"10.1016/j.jid.2024.07.003","DOIUrl":"10.1016/j.jid.2024.07.003","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 9","pages":"Page 1907"},"PeriodicalIF":5.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription Information 订阅信息
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2024-08-21 DOI: 10.1016/S0022-202X(24)01930-4
{"title":"Subscription Information","authors":"","doi":"10.1016/S0022-202X(24)01930-4","DOIUrl":"10.1016/S0022-202X(24)01930-4","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"144 9","pages":"Page A2"},"PeriodicalIF":5.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信