Journal of Investigative Dermatology最新文献_第2页

Clinical Snippets 临床片段

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-08-22 DOI: 10.1016/j.jid.2025.06.1290

引用次数: 0

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-08-22 DOI: 10.1016/S0022-202X(25)02302-4

引用次数: 0

Embryonic Avian Skin Explant Cultures: A Versatile Model for Investigating Tissue Patterning Mechanisms 胚胎禽皮肤外植体培养：研究组织模式机制的通用模型。

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-08-22 DOI: 10.1016/j.jid.2025.07.013

Zhou Yu , Cheng Ming Chuong

{"title":"Embryonic Avian Skin Explant Cultures: A Versatile Model for Investigating Tissue Patterning Mechanisms","authors":"Zhou Yu , Cheng Ming Chuong","doi":"10.1016/j.jid.2025.07.013","DOIUrl":"10.1016/j.jid.2025.07.013","url":null,"abstract":"<div><div>Avian skin explant cultures provide a powerful platform for studying the fundamental principles of tissue patterning during embryonic development. This ex vivo system retains the native properties of developing skin while enabling precise manipulation and live imaging to probe how biochemical and biophysical cues guide pattern formation across space and time. In this review, we highlight 3 major forms of embryonic explant culture and discuss how each has contributed to our understanding of morphogenetic processes such as feather bud initiation, spacing, orientation, elongation, and invagination during follicle formation. First, skin explant culture enables direct visualization of feather bud or scale formation and facilitate functional analysis through global or localized molecular treatments. Second, epithelial–mesenchymal recombination dissects tissue interactions by recombining epidermis and mesenchyme, revealing how inductive mesenchymal signals and epidermal competency define skin appendage identity and orientation. It can be further explored through heterotopic or heterochronic recombination. Third, skin reconstitution resets developmental programs by combining dissociated mesenchymal cells with intact epithelium, allowing the study of self-organization and the underlying rules governing periodic pattern initiation. Collectively, avian skin explant cultures serve as a versatile and accessible platform for uncovering how molecular, mechanical, and bioelectrical cues integrate to orchestrate complex tissue patterning.</div></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 10","pages":"Pages 2398-2409"},"PeriodicalIF":5.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Through the Microscope Lens: Investigating the Mechanisms of Desmosome Disruption in Pemphigus 通过显微镜观察天疱疮中桥粒断裂的机制。

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-08-12 DOI: 10.1016/j.jid.2025.05.031

Coryn L. Hoffman , Yoshitaka Shibata , Navaneetha Krishnan Bharathan , Matthew F. Helm , Sara N. Stahley , Andrew P. Kowalczyk

{"title":"Through the Microscope Lens: Investigating the Mechanisms of Desmosome Disruption in Pemphigus","authors":"Coryn L. Hoffman , Yoshitaka Shibata , Navaneetha Krishnan Bharathan , Matthew F. Helm , Sara N. Stahley , Andrew P. Kowalczyk","doi":"10.1016/j.jid.2025.05.031","DOIUrl":"10.1016/j.jid.2025.05.031","url":null,"abstract":"<div><div>Desmosomes are adhesive cell–cell junctions that are necessary for resisting mechanical stress and maintaining the integrity of the epidermis and other epithelial tissues. Pemphigus vulgaris (PV) is an autoimmune bullous disease caused by autoantibodies against desmosomal cadherins known as desmogleins. PV autoantibodies cause the loss of cell–cell adhesion and subsequent blistering of the skin and oral mucosa through a variety of mechanisms, including steric hindrance of desmoglein adhesive interactions, destabilization of desmosome assembly and disassembly dynamics, and dysregulated cell signaling. We focus this review on emerging literature and highlight microscopy techniques that have been used to study the structural changes that occur during desmosome disassembly in PV. Furthermore, we discuss recent findings demonstrating that the desmosome forms a complex with the endoplasmic reticulum and highlight the potential role of this multiorganelle complex in mediating desmosome disassembly and signaling in response to cell adhesion stress.</div></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 11","pages":"Pages 2676-2687"},"PeriodicalIF":5.7,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Privacy in Imaging for Dermatology Research 皮肤病学研究成像中的隐私。

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-08-06 DOI: 10.1016/j.jid.2025.06.1288

Liam J. Caffery , Ryan P. Sullivan , Aideen McInerney-Leo , Craig Lawn , Roshni A. Mendis , Monika Janda , Allan C. Halpern , H. Peter Soyer

引用次数: 0

American Hair Research Society Mentorship Grant Program: Short-Term Training Opportunities with Experts 美国头发研究协会导师资助计划：短期专家培训机会。

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-08-05 DOI: 10.1016/j.jid.2025.06.1576

Christopher S. Potter , Victoria Ceh , Valerie D. Callender , Dirk Elston , Amy McMichael , Paradi Mirmirani , Curtis Thompson , Koen Van de Wetering , John P. Sundberg

引用次数: 0

Emerging Roles of Ferroptosis in Skin Pathophysiology 铁下垂在皮肤病理生理中的新作用。

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-08-05 DOI: 10.1016/j.jid.2025.06.1289

Alex S. Reznik , Kavita Vats , Kunal Singh , Alicia Mizes , Erik Jaklitsch , Hülya Bayır , Valerian E. Kagan , Yuri L. Bunimovich

{"title":"Emerging Roles of Ferroptosis in Skin Pathophysiology","authors":"Alex S. Reznik , Kavita Vats , Kunal Singh , Alicia Mizes , Erik Jaklitsch , Hülya Bayır , Valerian E. Kagan , Yuri L. Bunimovich","doi":"10.1016/j.jid.2025.06.1289","DOIUrl":"10.1016/j.jid.2025.06.1289","url":null,"abstract":"<div><div>Programmed cell death (PCD) is a hallmark of tissue homeostasis and numerous human diseases. Ferroptosis, a more recently discovered type of PCD, is uniquely dependent on enzymatically driven accumulation of specific hydroperoxy-phospholipid species and iron-dependent reduction–oxidation (redox) dysregulation. Emerging evidence suggests that ferroptosis plays a critical role in the pathogeneses of several dermatologic disorders, including infections, malignancies, and chronic inflammatory and autoimmune diseases. In this study, we review relevant regulatory mechanisms of ferroptosis, illustrate the challenges faced by the studies of ferroptosis, and highlight ferroptosis vulnerabilities in the redox balance of the skin. Furthermore, we review the link between ferroptosis and skin immunosurveillance and discuss ferroptosis functions in select skin diseases. Additional mechanistic studies that link ferroptosis to dysregulated cellular metabolism and proliferation, inflammation, and carcinogenesis will accelerate the emergence of new preventative and therapeutic strategies across a variety of dermatologic conditions.</div></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 11","pages":"Pages 2701-2718"},"PeriodicalIF":5.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering Depigmentation: Mouse Models for Vitiligo Research 解读色素沉着：白癜风研究的小鼠模型。

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-07-23 DOI: 10.1016/j.jid.2025.06.1582

Tyler J. Long , Todd F. Pearson , John E. Harris

引用次数: 0

0048 Innate cell infiltration into the skin is suppressed in dirty mice following alarming stimulation 0048脏老鼠在受到刺激后，皮肤内的先天细胞浸润受到抑制

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-07-21 DOI: 10.1016/j.jid.2025.06.049

A. Mathers , M. Story , L.K. Ferris

引用次数: 0

0011 JAK2 is a key target for itch induced by AD-associated cytokines and pruritogens in human sensory neurons 0011 JAK2是人类感觉神经元中ad相关细胞因子和瘙痒原诱导的瘙痒的关键靶点

IF 5.7 2区医学

Journal of Investigative Dermatology Pub Date : 2025-07-21 DOI: 10.1016/j.jid.2025.06.012

S. Yotsumoto , K. Yamamura , M. Sumasu , B. Wang , M. Kido-Nakahara , G. Tsuji , T. Nakahara

引用次数: 0