Journal of Investigative Dermatology最新文献

{"title":"Cutaneous B-Cell lymphoma incidence trends in the United States: A surveillance, epidemiology, and end results analysis of 10,975 cases","authors":"Joshua A. Kent, Yoni Sacknovitz, Samuel A. Fisch, Sarah A. Erem, Barbara Pro, Seda S. Tolu, Alejandro Gru, Alfred I. Neugut, Larisa J. Geskin","doi":"10.1016/j.jid.2026.04.017","DOIUrl":"10.1016/j.jid.2026.04.017","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Pages 2907-2910"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A guide for studying spatiotemporal variability in murine hair cycle and hair growth wave patterns in vivo","authors":"Jung Min Park,&nbsp;Soung-Hoon Lee,&nbsp;Areum Cho,&nbsp;Nanda Maya Mali,&nbsp;Ralf Paus,&nbsp;Raul Ramos,&nbsp;Maksim V. Plikus,&nbsp;Ji Won Oh","doi":"10.1016/j.jid.2026.03.046","DOIUrl":"10.1016/j.jid.2026.03.046","url":null,"abstract":"<div><div>The cyclic remodeling of hair follicles in mice has long served as an informative model for studying coordinated tissue transformation in an epithelial–mesenchymal miniorgan. Yet, previous comprehensive studies of the murine hair cycle have been limited in both the timescale and the anatomical regions evaluated. We have developed a methodology to assess the growth pattern dynamics of cycling hair follicle populations using a highly resolved whole-mount approach. This approach has uncovered previously unrecognized yet biologically essential insights into the natural variability of hair cycle patterns between anatomical skin domains and individual animals as well as across sex and age groups, informing future murine dermatological research. We revealed that hair cycle dynamics are more variable between individual mice than was previously appreciated, becoming more complex in late hair cycles. Moreover, prominent spatiotemporal variability exists not only in telogen but also in anagen duration, reflected in significant hair fiber length differences between anatomical body regions and time points. Our skin-wide hair cycle analysis offers a practical guide for future dermatological studies aimed at determining subtle yet significant hair growth phenotypes, evaluating skin regeneration mechanisms, and uncovering hair growth-inducing or suppressing candidate drugs and genetic mutations in mouse models.</div></div><div>The cyclic remodeling of hair follicles in mice has long served as an informative model for studying coordinated tissue transformation in an epithelial–mesenchymal miniorgan. Yet, previous comprehensive studies of the murine hair cycle have been limited in both the timescale and the anatomical regions evaluated. We have developed a methodology to assess the growth pattern dynamics of cycling hair follicle populations using a highly resolved whole-mount approach. This approach has uncovered previously unrecognized yet biologically essential insights into the natural variability of hair cycle patterns between anatomical skin domains and individual animals as well as across sex and age groups, informing future murine dermatological research. We revealed that hair cycle dynamics are more variable between individual mice than was previously appreciated, becoming more complex in late hair cycles. Moreover, prominent spatiotemporal variability exists not only in telogen but also in anagen duration, reflected in significant hair fiber length differences between anatomical body regions and time points. Our skin-wide hair cycle analysis offers a practical guide for future dermatological studies aimed at determining subtle yet significant hair growth phenotypes, evaluating skin regeneration mechanisms, and uncovering hair growth-inducing or suppressing candidate drugs and genetic mutations in mouse models.</div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Pages 2779-2792.e4"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148007691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"049 Efficacy and Safety of Dupilumab Combined with Compound Fuling Decoction in the Treatment of Moderate-to-Severe Atopic Dermatitis","authors":"Yun Wang","doi":"10.1016/j.jid.2026.09.074","DOIUrl":"10.1016/j.jid.2026.09.074","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S270"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"051 Sensory neuron-derived Neuromedin B drives pruritus and type 2 skin inflammation in Atopic Dermatitis","authors":"Haiyu Wen,&nbsp;Jiangwei Cheng,&nbsp;Jianjun Qiao,&nbsp;Xinghua Gao","doi":"10.1016/j.jid.2026.09.076","DOIUrl":"10.1016/j.jid.2026.09.076","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S270"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"066 Mechanical scratching synergizes with IL-4/IL-13 signaling to promote atopic dermatitis progression via the Integrinβ6/p-FAK/YAP axis","authors":"Hu Jiahui,&nbsp;Geng Songmei","doi":"10.1016/j.jid.2026.09.091","DOIUrl":"10.1016/j.jid.2026.09.091","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S273"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"072 Ellagic Acid, a Dietary Polyphenol, Alleviates Atopic Dermatitis-Like Lesions: Links to Gut Microbiota Remodeling and Keratinocyte Inflammation","authors":"Xue Song","doi":"10.1016/j.jid.2026.09.097","DOIUrl":"10.1016/j.jid.2026.09.097","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S274"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"097 Trends and disparities in the burden of atopic dermatitis among children and adolescents in G20 members, 1990–2023: a GBD 2023 analysis with exploratory Mendelian randomization","authors":"Deyao Kong","doi":"10.1016/j.jid.2026.09.122","DOIUrl":"10.1016/j.jid.2026.09.122","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S278"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"044 Dual-Model AI–Based Quantitative Grading of Pautrier Microabscesses and Clinicopathologic–Topological Correlates in Mycosis Fungoides","authors":"Huanyu Wu,&nbsp;Ruiqun Qi,&nbsp;Hongduo Chen","doi":"10.1016/j.jid.2026.09.069","DOIUrl":"10.1016/j.jid.2026.09.069","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S269"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"045 Artificial Intelligence Integrates Multi-omics to Screen Molecular Subtypes and Prognostic Markers of Systemic Lupus Erythematosus","authors":"Kaili Chen,&nbsp;Hui Chen,&nbsp;Haijing Wu,&nbsp;Qianjin Lu","doi":"10.1016/j.jid.2026.09.070","DOIUrl":"10.1016/j.jid.2026.09.070","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S269"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"003 Salicylic acid alleviates rosacea-like inflammation by downregulating histone H4K16 lactylation and P2RX7-NLRP3 pathway","authors":"Yan Wu,&nbsp;Jingyu Wang,&nbsp;Yan Sun,&nbsp;Ruiqun Qi","doi":"10.1016/j.jid.2026.09.028","DOIUrl":"10.1016/j.jid.2026.09.028","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S262"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}