Journal of Investigative Dermatology最新文献

{"title":"Use of core outcome sets in clinical trials research: Updates to the JID guide for authors registering and reporting clinical trials","authors":"Joel M. Gelfand","doi":"10.1016/j.jid.2026.07.001","DOIUrl":"10.1016/j.jid.2026.07.001","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page 2641"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced antitumor immunity","authors":"Klara Klein,&nbsp;Litty Johnson,&nbsp;Ramona Rîca,&nbsp;Mirza Sarcevic,&nbsp;Gabriele Carta,&nbsp;Saskia Seiser,&nbsp;Adelheid Elbe-Bürger,&nbsp;Freyja Langer,&nbsp;Nowras Rahhal,&nbsp;Christoph Rademacher,&nbsp;Robert Wawrzinek,&nbsp;Federica Quattrone,&nbsp;Florian Sparber","doi":"10.1016/j.jid.2026.03.026","DOIUrl":"10.1016/j.jid.2026.03.026","url":null,"abstract":"<div><div>Despite the success of mRNA therapeutics, challenges remain in optimizing immune responses and minimizing side effects. Cell-specific antigen delivery may help reduce required doses and improve vaccine efficacy. In this study, we report on a targeted delivery system for mRNA to a specific subset of skin-resident antigen-presenting cells: Langerhans cells. By functionalizing lipid nanoparticles with a langerin-specific glycomimetic ligand, we achieve selective mRNA delivery to both murine and human primary Langerhans cells with minimal off-target uptake, at the same time resulting in significantly increased mRNA translation. This targeted mRNA delivery not only enhances antigen presentation and T-cell responses but also enables dose-sparing and superior antitumor immunity compared with conventional immunization in a B16-OVA tumor model. Importantly, our platform’s high compatibility with various lipid nanoparticle formulations offers a flexible and precise tool for skin-directed mRNA delivery.</div></div><div>Despite the success of mRNA therapeutics, challenges remain in optimizing immune responses and minimizing side effects. Cell-specific antigen delivery may help reduce required doses and improve vaccine efficacy. In this study, we report on a targeted delivery system for mRNA to a specific subset of skin-resident antigen-presenting cells: Langerhans cells. By functionalizing lipid nanoparticles with a langerin-specific glycomimetic ligand, we achieve selective mRNA delivery to both murine and human primary Langerhans cells with minimal off-target uptake, at the same time resulting in significantly increased mRNA translation. This targeted mRNA delivery not only enhances antigen presentation and T-cell responses but also enables dose-sparing and superior antitumor immunity compared with conventional immunization in a B16-OVA tumor model. Importantly, our platform’s high compatibility with various lipid nanoparticle formulations offers a flexible and precise tool for skin-directed mRNA delivery.</div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Pages 2793-2801.e6"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative circadian transcriptome analysis reveals dampened and phase-advanced rhythms in sun-exposed human skin","authors":"Michael M. Saint-Antoine,&nbsp;Zeyad El-Houni,&nbsp;Victoria L. Newton,&nbsp;Eleanor J. Bradley,&nbsp;Shruthi Ramesh,&nbsp;Hamish J.A. Hunter,&nbsp;Mike Bell,&nbsp;Alexander Eckersley,&nbsp;Michael J. Sherratt,&nbsp;Ron C. Anafi,&nbsp;Qing-Jun Meng","doi":"10.1016/j.jid.2026.03.038","DOIUrl":"10.1016/j.jid.2026.03.038","url":null,"abstract":"<div><div>Daily molecular rhythms modulate skin physiology. However, the effects of chronic sun exposure on these rhythms remain unstudied. This study aimed to identify and compare rhythmic genes and pathways in photoprotected and chronically photoexposed human skin in vivo. Skin biopsies were taken from photoprotected (upper buttock) and photoexposed (dorsal forearm) skin of 20 subjects at noon, 6 PM, midnight, and 6 AM across a 24-hour cycle, and gene expression was quantified using RNA sequencing. Cosinor analysis identified cycling genes along with their amplitudes and peak expression phases. We found that fewer genes met the criteria for cycling in photoexposed skin than in photoprotected skin, and transcripts that cycled in both sites had lower amplitudes and advanced peak times in photoexposed skin than in photoprotected skin. We identified 480 genes with significantly different rhythmic properties between the skin sites. Genes involved in DNA repair, MYC targets, E2F, and G2M checkpoint pathways were enriched among those that showed higher amplitude oscillations in photoprotected skin. Genes involved in epithelial-mesenchymal transition and apical junction pathways showed higher amplitude oscillations in photoexposed skin. These results suggest that chronic UV exposure may disrupt and/or reprogram circadian output rhythms to further alter skin physiology.</div></div><div>Daily molecular rhythms modulate skin physiology. However, the effects of chronic sun exposure on these rhythms remain unstudied. This study aimed to identify and compare rhythmic genes and pathways in photoprotected and chronically photoexposed human skin in vivo. Skin biopsies were taken from photoprotected (upper buttock) and photoexposed (dorsal forearm) skin of 20 subjects at noon, 6 PM, midnight, and 6 AM across a 24-hour cycle, and gene expression was quantified using RNA sequencing. Cosinor analysis identified cycling genes along with their amplitudes and peak expression phases. We found that fewer genes met the criteria for cycling in photoexposed skin than in photoprotected skin, and transcripts that cycled in both sites had lower amplitudes and advanced peak times in photoexposed skin than in photoprotected skin. We identified 480 genes with significantly different rhythmic properties between the skin sites. Genes involved in DNA repair, MYC targets, E2F, and G2M checkpoint pathways were enriched among those that showed higher amplitude oscillations in photoprotected skin. Genes involved in epithelial-mesenchymal transition and apical junction pathways showed higher amplitude oscillations in photoexposed skin. These results suggest that chronic UV exposure may disrupt and/or reprogram circadian output rhythms to further alter skin physiology.</div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Pages 2850-2862.e2"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages and limitations of in vitro models for atopic dermatitis: A consensus expert opinion","authors":"Rens H.W. Peters,&nbsp;Jos P.H. Smits,&nbsp;Ellen H. van den Bogaard,&nbsp;Evelyn Kelemen,&nbsp;Inge Kortekaas Krohn,&nbsp;Shauni De Vriese,&nbsp;Danuta Gutowska-Owsiak,&nbsp;Lisa M. Sevilla,&nbsp;Paloma Pérez,&nbsp;Dijana Furundžić,&nbsp;Sarah Hedtrich,&nbsp;Anna Zalewska-Janowska,&nbsp;Michel Simon,&nbsp;Sandrine Dubrac","doi":"10.1016/j.jid.2026.04.032","DOIUrl":"10.1016/j.jid.2026.04.032","url":null,"abstract":"<div><div>Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by an aberrant T helper 2 immune response and impaired epidermal barrier function, regardless of phenotypes and endotypes. Historically, AD has been extensively studied in mouse models, which have intrinsic limitations, notably in the translatability of results to patients. Moreover, ethical concerns have driven the field toward the development of organotypic AD skin models. The recent steep increase in their use warrants an expert opinion on the advantages and limitations of such models and opportunities for their improvement, which are presented in this paper.</div></div><div>Atopic dermatitis (AD) is a common chronic inflammatory skin disease characterized by an aberrant T helper 2 immune response and impaired epidermal barrier function, regardless of phenotypes and endotypes. Historically, AD has been extensively studied in mouse models, which have intrinsic limitations, notably in the translatability of results to patients. Moreover, ethical concerns have driven the field toward the development of organotypic AD skin models. The recent steep increase in their use warrants an expert opinion on the advantages and limitations of such models and opportunities for their improvement, which are presented in this paper.</div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (358KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Pages 2673-2686"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicle-derived mir-148a-3p promotes plasmablast differentiation in bullous pemphigoid via BACH2 repression and mTOR activation","authors":"Jine Zhang,&nbsp;Jieyu Zhang,&nbsp;Shengxian Shen,&nbsp;Xia Li,&nbsp;Yaxing Bai,&nbsp;Bing Wang,&nbsp;Gang Wang,&nbsp;Hui Fang","doi":"10.1016/j.jid.2026.05.020","DOIUrl":"10.1016/j.jid.2026.05.020","url":null,"abstract":"<div><div>Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by the production of autoantibodies; however, the molecular mechanisms regulating plasma cell differentiation remain unclear. This study investigated the role of plasma-derived extracellular vesicles (EVs) and their microRNA cargo in regulating this process. EVs isolated from patients with BP and healthy controls were functionally assessed. BP-derived EVs significantly enhanced plasmablast differentiation, increased pathogenic autoantibody production, and elevated IL-6 secretion. High-throughput sequencing identified miR-148a-3p as a selectively enriched and functionally critical microRNA within BP EVs. Mechanistically, miR-148a-3p promoted plasmablast differentiation by targeting the BACH2/mTOR signaling pathway. This was validated using dual-luciferase reporter assays, western blotting, RT-qPCR, and flow cytometry. These findings reveal, to our knowledge, a previously unrecognized EV-mediated regulatory mechanism in BP pathogenesis and identify miR-148a-3p as a potential diagnostic biomarker and therapeutic target.</div></div><div>Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by the production of autoantibodies; however, the molecular mechanisms regulating plasma cell differentiation remain unclear. This study investigated the role of plasma-derived extracellular vesicles (EVs) and their microRNA cargo in regulating this process. EVs isolated from patients with BP and healthy controls were functionally assessed. BP-derived EVs significantly enhanced plasmablast differentiation, increased pathogenic autoantibody production, and elevated IL-6 secretion. High-throughput sequencing identified miR-148a-3p as a selectively enriched and functionally critical microRNA within BP EVs. Mechanistically, miR-148a-3p promoted plasmablast differentiation by targeting the BACH2/mTOR signaling pathway. This was validated using dual-luciferase reporter assays, western blotting, RT-qPCR, and flow cytometry. These findings reveal, to our knowledge, a previously unrecognized EV-mediated regulatory mechanism in BP pathogenesis and identify miR-148a-3p as a potential diagnostic biomarker and therapeutic target.</div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Pages 2736-2746.e9"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"053 Opsin 3 in keratinocytes mediates the light-induced exaggeration of atopic derma","authors":"Liya Mao","doi":"10.1016/j.jid.2026.09.078","DOIUrl":"10.1016/j.jid.2026.09.078","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S271"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"065 Mechanism of Ion Channel Protein TMEM16A Inducing Skin Inflammation in Atopic Dermatitis via NF-κB Signaling Pathway","authors":"Caixia Kou","doi":"10.1016/j.jid.2026.09.090","DOIUrl":"10.1016/j.jid.2026.09.090","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S273"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"083 Decoding the “Barrier–Microbiota–Immunity” Network Driven by High-Salt Microenvironment in Atopic Dermatitis","authors":"Xuefei Liu,&nbsp;Fengli Xiao","doi":"10.1016/j.jid.2026.09.108","DOIUrl":"10.1016/j.jid.2026.09.108","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S276"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"084 Differential CD4+ and CD8+ Cutaneous TRM Cell Responses in Murine Models of DNCB- versus MC903-Induced Atopic Dermatitis","authors":"Bo Peng,&nbsp;Fengli Xiao","doi":"10.1016/j.jid.2026.09.109","DOIUrl":"10.1016/j.jid.2026.09.109","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S276"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"081 Cold Exposure Exacerbates Atopic Dermatitis through a TRPA1 - SREBP1 - Unsaturated Fatty Acid Metabolic Reprogramming Axis","authors":"Mengyao Yi,&nbsp;Zhaowei Chu,&nbsp;Delu Che,&nbsp;Ruiqi Li,&nbsp;Yifan Xia,&nbsp;Tao Jia,&nbsp;Miao Qin,&nbsp;Xueshan Du,&nbsp;Jiahui Hu,&nbsp;Songmei Geng","doi":"10.1016/j.jid.2026.09.106","DOIUrl":"10.1016/j.jid.2026.09.106","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"146 10","pages":"Page S275"},"PeriodicalIF":7.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}