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IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-06-20 DOI: 10.1016/j.jid.2025.04.012
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引用次数: 0
Clinical Snippets 临床片段
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-06-20 DOI: 10.1016/j.jid.2025.04.018
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引用次数: 0
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IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-06-20 DOI: 10.1016/S0022-202X(25)00519-6
{"title":"Subscription Information","authors":"","doi":"10.1016/S0022-202X(25)00519-6","DOIUrl":"10.1016/S0022-202X(25)00519-6","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 7","pages":"Page A2"},"PeriodicalIF":5.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming Clinical Trials in Skin Cancer Research: Exploring the Potential of Flexible and Innovative Designs 转变皮肤癌研究的临床试验：探索灵活和创新设计的潜力
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-06-20 DOI: 10.1016/j.jid.2025.03.032
Rainer Puhr , Elizabeth G. Ryan , Dominique-Laurent Couturier , Alexander C.J. van Akkooi , Ines Pires da Silva , Stephane Heritier , Serigne N. Lo
{"title":"Transforming Clinical Trials in Skin Cancer Research: Exploring the Potential of Flexible and Innovative Designs","authors":"Rainer Puhr ,&nbsp;Elizabeth G. Ryan ,&nbsp;Dominique-Laurent Couturier ,&nbsp;Alexander C.J. van Akkooi ,&nbsp;Ines Pires da Silva ,&nbsp;Stephane Heritier ,&nbsp;Serigne N. Lo","doi":"10.1016/j.jid.2025.03.032","DOIUrl":"10.1016/j.jid.2025.03.032","url":null,"abstract":"<div><div>Over the past 2 decades, innovations in trial design have significantly advanced the field of clinical research. Methodological developments, such as adaptive designs, basket trials, umbrella trials, and platform trials, along with technological advancements such as virtual studies have proven effective in tackling complex research questions and managing resource constraints. These approaches enable prospectively planned modifications to trial designs and facilitate addressing multiple research questions within a single infrastructure, with technological advancements such as virtual studies enhancing accessibility, efficiency, and patient engagement. These designs can also integrate biomarker information or risk-prediction scores to enhance the efficacy of future clinical trials, through a better selection of patients. Despite the appealing flexibility of these new approaches, their adoption varies across different therapeutic domains. We explored the translation and relevance of these innovative approaches in skin cancer research with a focus on melanoma. An overview of existing melanoma clinical trials that incorporate innovative features as well as other potential studies currently under consideration are discussed. This paper highlights the potential of innovative approaches to optimize melanoma trials under the constraints of limited patient and financial resources. The presented ideas can easily be extended to other nonmelanoma skin cancer trials.</div></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 7","pages":"Pages 1569-1579"},"PeriodicalIF":5.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-05-21 DOI: 10.1016/S0022-202X(25)00442-7
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引用次数: 0
Editors’ Picks Editors ' Picks
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-05-21 DOI: 10.1016/j.jid.2025.03.023
{"title":"Editors’ Picks","authors":"","doi":"10.1016/j.jid.2025.03.023","DOIUrl":"10.1016/j.jid.2025.03.023","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 6","pages":"Page 1244"},"PeriodicalIF":5.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction notice to “Localization of the TIG3 Transglutaminase Interaction Domain and Demonstration that the Amino-Terminal Region Is Required for TIG3 Function as a Keratinocyte Differentiation Regulator” [Journal of Investigative Dermatology, Volume 128, March 2008, Pages 517-529] 对“TIG3转谷氨酰胺酶相互作用域的定位和证明氨基末端区域是TIG3作为角质细胞分化调节剂功能所必需的”的撤回通知[Journal of Investigative Dermatology， 128卷，2008年3月，517-529页]
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-05-21 DOI: 10.1016/j.jid.2025.03.008
Ralph Jans , Michael T. Sturniolo , Richard L. Eckert
{"title":"Retraction notice to “Localization of the TIG3 Transglutaminase Interaction Domain and Demonstration that the Amino-Terminal Region Is Required for TIG3 Function as a Keratinocyte Differentiation Regulator” [Journal of Investigative Dermatology, Volume 128, March 2008, Pages 517-529]","authors":"Ralph Jans ,&nbsp;Michael T. Sturniolo ,&nbsp;Richard L. Eckert","doi":"10.1016/j.jid.2025.03.008","DOIUrl":"10.1016/j.jid.2025.03.008","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 6","pages":"Page 1541"},"PeriodicalIF":5.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Snippets 临床片段
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-05-21 DOI: 10.1016/j.jid.2025.03.022
{"title":"Clinical Snippets","authors":"","doi":"10.1016/j.jid.2025.03.022","DOIUrl":"10.1016/j.jid.2025.03.022","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 6","pages":"Page 1243"},"PeriodicalIF":5.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Call to Action: Adopting the New Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines 行动呼吁：采用动物和人类临床前研究新伤口报告（WRAHPS）指南。
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-04-22 DOI: 10.1016/j.jid.2025.02.152
Lisa J. Gould , Marjana Tomic-Canic
{"title":"A Call to Action: Adopting the New Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines","authors":"Lisa J. Gould ,&nbsp;Marjana Tomic-Canic","doi":"10.1016/j.jid.2025.02.152","DOIUrl":"10.1016/j.jid.2025.02.152","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 7","pages":"Pages 1566-1568"},"PeriodicalIF":5.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Unseen: Exploring Cellular Dynamics in Nonlesional Vitiligo Skin 揭开看不见的面纱：探索非病变白癜风皮肤的细胞动力学。
IF 5.7 2区 医学
Journal of Investigative Dermatology Pub Date : 2025-04-22 DOI: 10.1016/j.jid.2025.01.033
Ribal Merhi , Katia Boniface , Julien Seneschal
{"title":"Unveiling the Unseen: Exploring Cellular Dynamics in Nonlesional Vitiligo Skin","authors":"Ribal Merhi ,&nbsp;Katia Boniface ,&nbsp;Julien Seneschal","doi":"10.1016/j.jid.2025.01.033","DOIUrl":"10.1016/j.jid.2025.01.033","url":null,"abstract":"<div><div>Vitiligo is a multifactorial disease involving genetic predispositions, intrinsic melanocyte abnormalities, and deregulated immune response. Recent studies show nonlesional skin involvement. Nonlesional melanocytes display mitochondrial dysfunction and increased oxidative stress affecting their adhesion and function and contribute to immune activation. Keratinocytes and fibroblasts display structural and functional abnormalities impairing melanocyte support and differentiation. They also contribute to the altered immune response by secreting proinflammatory chemokines. Despite immune cell infiltration, nonlesional skin remains clinically unaffected, suggesting that regulatory mechanisms maintain immune activation at a subclinical level. This review provides an overview of the cellular alterations in vitiligo nonlesional skin.</div></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 7","pages":"Pages 1604-1611"},"PeriodicalIF":5.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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