{"title":"Editor's Picks September 2025","authors":"","doi":"10.1016/j.jid.2025.06.1580","DOIUrl":"10.1016/j.jid.2025.06.1580","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 9","pages":"Page 2119"},"PeriodicalIF":5.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Facing Our FAERS: Disproportionality Analyses, Signal Detection, and Interpretation","authors":"Ravi Ramessur, Joel M. Gelfand","doi":"10.1016/j.jid.2025.06.1579","DOIUrl":"10.1016/j.jid.2025.06.1579","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 9","pages":"Pages 2115-2117"},"PeriodicalIF":5.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Embryonic Avian Skin Explant Cultures: A Versatile Model for Investigating Tissue Patterning Mechanisms","authors":"Zhou Yu , Cheng Ming Chuong","doi":"10.1016/j.jid.2025.07.013","DOIUrl":"10.1016/j.jid.2025.07.013","url":null,"abstract":"<div><div>Avian skin explant cultures provide a powerful platform for studying the fundamental principles of tissue patterning during embryonic development. This ex vivo system retains the native properties of developing skin while enabling precise manipulation and live imaging to probe how biochemical and biophysical cues guide pattern formation across space and time. In this review, we highlight 3 major forms of embryonic explant culture and discuss how each has contributed to our understanding of morphogenetic processes such as feather bud initiation, spacing, orientation, elongation, and invagination during follicle formation. First, skin explant culture enables direct visualization of feather bud or scale formation and facilitate functional analysis through global or localized molecular treatments. Second, epithelial–mesenchymal recombination dissects tissue interactions by recombining epidermis and mesenchyme, revealing how inductive mesenchymal signals and epidermal competency define skin appendage identity and orientation. It can be further explored through heterotopic or heterochronic recombination. Third, skin reconstitution resets developmental programs by combining dissociated mesenchymal cells with intact epithelium, allowing the study of self-organization and the underlying rules governing periodic pattern initiation. Collectively, avian skin explant cultures serve as a versatile and accessible platform for uncovering how molecular, mechanical, and bioelectrical cues integrate to orchestrate complex tissue patterning.</div></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 10","pages":"Pages 2398-2409"},"PeriodicalIF":5.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deciphering Depigmentation: Mouse Models for Vitiligo Research","authors":"Tyler J. Long , Todd F. Pearson , John E. Harris","doi":"10.1016/j.jid.2025.06.1582","DOIUrl":"10.1016/j.jid.2025.06.1582","url":null,"abstract":"<div><div>Vitiligo is an autoimmune skin disease characterized by melanocyte loss and skin depigmentation. Although significant advances have been made in understanding the pathogenesis of vitiligo, the development of novel treatments has depended and will likely continue to depend on preclinical animal model research. This review provides a comprehensive overview of established mouse models for vitiligo, categorizing them on the basis of their mechanisms of melanocyte loss, immune involvement, and relevance to human disease. Finally, we explore emerging areas in vitiligo research, emphasizing the need for refined models that better replicate human disease heterogeneity and therapeutic responses. By critically evaluating available mouse models, this review aims to guide researchers in selecting appropriate models to advance vitiligo research and treatment development.</div></div>","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 9","pages":"Pages 2135-2146"},"PeriodicalIF":5.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"0048 Innate cell infiltration into the skin is suppressed in dirty mice following alarming stimulation","authors":"A. Mathers , M. Story , L.K. Ferris","doi":"10.1016/j.jid.2025.06.049","DOIUrl":"10.1016/j.jid.2025.06.049","url":null,"abstract":"","PeriodicalId":16311,"journal":{"name":"Journal of Investigative Dermatology","volume":"145 8","pages":"Page S8"},"PeriodicalIF":5.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}