Journal of Lipids最新文献

{"title":"Distribution of Lipids and Prevalence of Dyslipidemia among Indian Expatriates in Qatar.","authors":"R Nirwan,&nbsp;D Singh","doi":"10.1155/2021/8866784","DOIUrl":"https://doi.org/10.1155/2021/8866784","url":null,"abstract":"<p><strong>Background: </strong>Dyslipidemia is a significant risk factor for cardiovascular diseases (CVD). If detected and managed in the early stages of life, can reduce morbidity and mortality associated with CVD in a vulnerable population. Out of the 94 expatriate nationalities in Qatar, Indians constitute the most prominent single nationality, accounting for 21.8% of the total population (2,773,885 in 2019). This study aims to determine the status of the lipid profile among Indians in Qatar. <i>Study Design</i>. We conducted an observational retrospective study on lipid profile test data of Indian expatriates visiting a private healthcare facility in Qatar from Oct 17 to Oct 2018 to evaluate the gender and age-specific distribution of lipids and the prevalence of dyslipidemia.</p><p><strong>Results: </strong>Among the total 4483 Indian expatriates (3891 men and 592 women), the mean (SD) mg/dL levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) were higher in men TC 196.9 (40.6), TG 168.9 (114.6), and LDL-C 122.9 (37.2) mg/dL compared to women TC 185 (38.1), TG 117.7 (78.2), and LDL-C 114.1 (31.1) mg/dL, <i>p</i> value < 0.0001. Utilizing predefined National Cholesterol Education Program-Adult Treatment Panel III (NCEP ATP III) limits to categorize dyslipidemias; the greater prevalence of elevated TC, TG, and LDL-C was noted in men 44.7%, 45.8%, and 40.9% than women 31.6%, 22%, and 28.7%, respectively. However, women had higher levels of mean high-density lipoprotein cholesterol (HDL-C) as 47.1 (9.8) mg/dL vs. 40.6 (8.3) mg/dL in men, <i>p</i> value < 0.05, the prevalence of dyslipidemia, low HDL-C was also more 65.7% vs. 48.9% in women than men. With age, men showed a declining trend while women showed a rising trend for mean lipid levels as well as for the prevalence of dyslipidemia, high TC, TG, and LDL-C (<i>p</i> value < 0.0001). The mean HDL-C cholesterol increased, and the prevalence of dyslipidemia, low HDL-C decreased with age in both the genders.</p><p><strong>Conclusion: </strong>Our results demonstrate the higher mean lipid levels and prevalence of atherogenic dyslipidemia among Indian expatriate men than women counterparts at the younger age group. The screening programs and awareness campaigns must be initiated to prevent the early onset of dyslipidemia induced atherosclerosis leading to CVD. Future controlled studies are needed to estimate the prevalence of dyslipidemias among Indian migrants in Qatar.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2021 ","pages":"8866784"},"PeriodicalIF":5.3,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7960024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25501176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyslipidemia and Associated Risk Factors in the Elderly Population in Asmara, Eritrea: Results from a Community-Based Cross-Sectional Study","authors":"Oliver Okoth Achila, Mathewos Araya, Arsiema Brhane Berhe, Niat Habteab Haile, Luwam Kahsai Tsige, Bethelihem Yemane Shifare, Tesfalem Abel Bitew, Israel Eyob Berhe, S. Mengistu, E. Yohaness","doi":"10.1155/2021/6155304","DOIUrl":"https://doi.org/10.1155/2021/6155304","url":null,"abstract":"Background The ultimate goal of the study was to approximate the burden and patterns of dyslipidemia in a subset of the elderly population (≥60–85 years) living in Asmara, Eritrea, and to identify modifiable risk drivers. Methods A total of 319 (145 (45.5%) male vs. 174 (54.5%) female, mean age ± SD (68.06 ± 6.16 years), participants from randomly selected estates within Asmara were enrolled. Demographic and medical information was collected using a standardized questionnaire. Anthropometric, lipid panel, fasting plasma glucose (FPG), and blood pressure (BP) measurements were subsequently taken. Results The prevalence of dyslipidemia was 70.5%. The proportions of dyslipidemias were (in order of decreasing frequency) high TC (51.2%), LDL-C (43.7%), low HDL-C (28.2%), and TG (27.6%). The average (±SD) concentrations in mg/dL of TC, LDL-C, non-HDL-C, TG, HDL-C, TC/HDL-C, and TG/HDL-C were 202.2 ± 40.63, 125.95 ± 33.16, 151.72 ± 37.19, 129 ± 57.16, 50.48 ± 10.91, 4.11 ± 0.91, and 2.72 ± 1.49, respectively. Furthermore, 17.5%, 21.6%, 11.0%, and 5.0% had abnormalities in 1, 2, 3, and 4 lipid disorders with the copresence of TC+LDL-C abnormalities dominating. Regarding National Cholesterol Education Program Third Adult Treatment Panel risk strata, 18.5%, 14.5%, 28.2%, and 12.9% were in high or very high-risk categories for TC, LDL-C, TG, and HDL-C, respectively. The high burden of dyslipidemia coexisted with an equally high burden of abdominal obesity (43.1%), FPG ≥ 100 mg/dL (16%), hypertension (28.5%), and physical inactivity. Overall, dyslipidemia was associated with sex (females: aOR = 2.6, 95%CI = 1.1–6.1, p = 0.017) and daily physical activity—higher in individuals undertaking physical activity for <1 hour (aOR = 2.6, 95%CI = 1.1–6.1, p = 0.029), 1-2 hours (aOR = 3.2, 95%CI = 1.24–8.5, p = 0.016), and 2-3 hours (aOR = 2.0, 95%CI = 0.7–5.8, p = 0.192) (Ref: >3 hours). Additional associations included increasing FPG (aOR = 1.02, 95%CI = 1.0–1.04, p = 0.039), and BMI (aOR = 1.19, 95%CI = 1.09–1.3, p < 0.001). These factors, along with waist circumference (WC), consumption of traditional foods, systolic BP, and diastolic BP, were, with some variations, associated with disparate dyslipidemias. Conclusions The burden of dyslipidemia in the elderly population in Asmara is high. Modifiable risk drivers included FPG, WC, physical inactivity, and low consumption of traditional food. Overall, efforts directed at scaling up early recognition and treatment, including optimal pharmacological and nonpharmacological therapy, at all levels of care, should be instituted.","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"12 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90224783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Novelty of Icosapent Ethyl in the Management of Hypertriglyceridemia and Alleviating Cardiovascular Risk.","authors":"Muhammad Shoaib Khan, Muhammad Ishaq, Muhammad Talha Ayub, Ateeq U Rehman, John J Hayes, Mohammad Mortada, Robert W W Biederman","doi":"10.1155/2021/6696915","DOIUrl":"10.1155/2021/6696915","url":null,"abstract":"<p><p>Hypertriglyceridemia is believed to be independently associated with an elevated risk of cardiovascular disease (CVD) events. Lifestyle changes and dietary modifications are recommended for individuals with high serum triglyceride (TG) levels (150-499 mg/dl), and pharmacological therapy in addition to lifestyle modification is recommended when serum TG levels ≥ 500 mg/dl. A residual cardiovascular risk remains even in statin appropriate treated patients with CVD risk factors, and in this patient population, hypertriglyceridemia poses an independent and increased risk of ischemic events. In December 2019, the US FDA approved icosapent ethyl (IPE) as an adjunct to a maximally tolerated statin to reduce the risk of CVD events in adults with serum triglycerides > 150 mg/dl and have either established cardiovascular disease or diabetes and two or more additional CVD risk factors. Since IPE significantly decreases total ischemic events in the aforementioned patient population, it would be intriguing to know whether IPE alone added an advantage to lifestyle modification in the low-risk population, who has serum triglyceride between 150 mg/dl and 499 mg/dl.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2021 ","pages":"6696915"},"PeriodicalIF":5.9,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38869661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Fatty Acid Profiles of Stipe and Blade from the Norwegian Brown Macroalgae Laminaria Hyperborea with Special Reference to Acyl Glycerides, Polar Lipids, and Free Fatty Acids\".","authors":"Lena Foseid,&nbsp;Hanne Devle,&nbsp;Yngve Stenstrøm,&nbsp;Carl Fredrik Naess-Andresen,&nbsp;Dag Ekeberg","doi":"10.1155/2021/1207139","DOIUrl":"https://doi.org/10.1155/2021/1207139","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2017/1029702.].</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2021 ","pages":"1207139"},"PeriodicalIF":5.3,"publicationDate":"2021-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38878660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Protective Effects of Simvastatin, a Lipid Lowering Agent, Against Oxidative Damage in Experimental Diabetic Rats\".","authors":"Ahmed M Mohamadin,&nbsp;Ahmed A Elberry,&nbsp;Hala S Abdel Gawad,&nbsp;Gehan M Morsy,&nbsp;Fahad A Al-Abbasi","doi":"10.1155/2020/4536827","DOIUrl":"https://doi.org/10.1155/2020/4536827","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/2011/167958.].</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2020 ","pages":"4536827"},"PeriodicalIF":5.3,"publicationDate":"2020-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38794615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical Properties, Fatty Acid Composition, and the Effect of Heating on the Reduction of Cyclopropenoid Fatty Acids on Baobab (<i>Adansonia digitata</i> L.) Crude Seed Oil.","authors":"Upendo L Msalilwa,&nbsp;Edna E Makule,&nbsp;Linus K Munishi,&nbsp;Patrick A Ndakidemi","doi":"10.1155/2020/6691298","DOIUrl":"https://doi.org/10.1155/2020/6691298","url":null,"abstract":"<p><p>The baobab seed oil has been consumed by humans due to its medicinal and nutrient values for many years. However, the consumption of baobab seed oil has been perceived by different communities as a health risk caused by cyclopropenoid fatty acids (CPFAs), which are carcinogenic ingredients present in the oil. This study investigated the physicochemical properties and fatty acid profile of baobab crude seed oil collected from semiarid areas in Tanzania and determined the effects of heating on the reduction of CPFAs. The baobab seed crude oil was extracted by Soxhlet using n-hexane, and the fatty acid composition of the baobab seed crude oil was determined by gas-liquid chromatography (GLC). Since CPFAs are resistant to lower temperatures, the effect of heating on the CPFA content of baobab crude seed oil was studied at 150°C, 200°C, and 250°C. The <i>A. digitata</i> crude seed oil was found to contain mainly twelve essential fatty acids and two different CPFAs. The most abundant fatty acids were palmitic acid, oleic acid, and linoleic acid in all the baobab population hotspots occurring in Tanzania. There was no significant difference in most physicochemical properties and fatty acid composition across the different semiarid areas in Tanzania. The major breakdown of CPFAs occurs at 200°C, and that would be the optimal temperature recommended for the refining process of the baobab crude oil. The study recommended refining of the baobab oil at higher temperatures ranging from 200 - 250°C as the best way of reducing CPFAs.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2020 ","pages":"6691298"},"PeriodicalIF":5.3,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6691298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38878659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Palm Oil-Fried Street Kokor on Liver and Kidney Biomarkers of Swiss Albino Mice.","authors":"Hailemariam Amsalu,&nbsp;Tesaka Wondimnew,&nbsp;Tigist Mateos,&nbsp;Minale Fekadie,&nbsp;Gesese Bogale","doi":"10.1155/2020/8819749","DOIUrl":"https://doi.org/10.1155/2020/8819749","url":null,"abstract":"<p><strong>Background: </strong>Foods fried with oils at streets contain many harmful substances for health. Locally fried foods are consumed commonly in our society, yet their health effect is not studied.</p><p><strong>Objective: </strong>To assess the effect of palm oil-fried street kokor on liver and kidney biomarkers of Swiss Albino mice.</p><p><strong>Methods: </strong>Thirty-two male and female Swiss Albino mice with the age of 10-12 weeks old were divided randomly into four groups of eight members with equal male and female subgroups. The control group (group I) received only a standard pellet, and the experimental groups (group II, group III, and group IV) received 10%, 20%, and 30% kokor of their daily food consumption, respectively. At the end of the 6^th week, they were sacrificed by thoracoabdominal incision after anesthetizing by diethyl ether. Blood was taken from each mouse by cardiac puncture and analyzed for liver and kidney function tests.</p><p><strong>Result: </strong>The serum levels of liver damage biomarkers (alanine transaminase (ALT) and aspartate transaminase (AST)) and kidney damage biomarkers (urea and creatinine) of experimental groups were increased significantly relative to the control groups (<i>P</i> < 0.05). Level of biochemical profiles increased as the dose of kokor increased.</p><p><strong>Conclusions: </strong>Palm oil-fried street kokor damaged the liver and kidney of the mice, and the damage was exacerbated as the dose of kokor increased.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2020 ","pages":"8819749"},"PeriodicalIF":5.3,"publicationDate":"2020-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8819749","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38854579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Physicochemical and Functional Properties of Coconut Oil by Incorporating Bioactive Compounds in Selected Spices.","authors":"Dilini N Perera, Geeth G Hewavitharana, S B Navaratne","doi":"10.1155/2020/8853940","DOIUrl":"10.1155/2020/8853940","url":null,"abstract":"<p><p>Lipid oxidation has been identified as a major deterioration process of vegetable oils, which leads to the production of primary and secondary oxidative compounds that are harmful to human health. Oleoresins of ginger, garlic, nutmeg, pepper, cloves, and cinnamon were extracted and incorporated into coconut oil, and change occurrence on physicochemical properties, thermal stability, shelf life, and antioxidant activity was monitored against the same properties of pure coconut oil. Lipid oxidation was assessed in terms of the free fatty acid level and peroxide value. For the comparison purpose, another oil sample was prepared by incorporating vitamin E too. Results revealed that both peroxide value and FFA of pure and flavored coconut oil samples after a one-week storage period were 3.989 ± 0.006 and 3.626 ± 0.002 mEq/kg and 0.646 ± 0.001 and 0.604 ± 0.002 (%), respectively. Saponification value, iodine value, smoke point, and the flashpoint of flavored oil were decreased while increasing the viscosity during storage. The highest phenolic content and DPPH free radical scavenging activity were found in flavored coconut oil. Since spices containing antioxidants, the thermal stability of flavored oil was better than that of pure coconut oil. Both oleoresins and vitamin E-incorporated samples showed the same pattern of increment of FFA and peroxide value during storage; however, those increments were slower than those of pure coconut oil.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2020 ","pages":"8853940"},"PeriodicalIF":5.3,"publicationDate":"2020-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38256300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule.","authors":"Motasim M Jawi, Jiri Frohlich, Sammy Y Chan","doi":"10.1155/2020/3491764","DOIUrl":"10.1155/2020/3491764","url":null,"abstract":"<p><p>Lipoprotein(a) [Lp(a)], aka \"Lp little a\", was discovered in the 1960s in the lab of the Norwegian physician Kåre Berg. Since then, we have greatly improved our knowledge of lipids and cardiovascular disease (CVD). Lp(a) is an enigmatic class of lipoprotein that is exclusively formed in the liver and comprises two main components, a single copy of apolipoprotein (apo) B-100 (apo-B100) tethered to a single copy of a protein denoted as apolipoprotein(a) apo(a). Plasma levels of Lp(a) increase soon after birth to a steady concentration within a few months of life. In adults, Lp(a) levels range widely from <2 to 2500 mg/L. Evidence that elevated Lp(a) levels >300 mg/L contribute to CVD is significant. The improvement of isoform-independent assays, together with the insight from epidemiologic studies, meta-analyses, genome-wide association studies, and Mendelian randomization studies, has established Lp(a) as the single most common independent genetically inherited causal risk factor for CVD. This breakthrough elevated Lp(a) from a biomarker of atherosclerotic risk to a target of therapy. With the emergence of promising second-generation antisense therapy, we hope that we can answer the question of whether Lp(a) is ready for prime-time clinic use. In this review, we present an update on the metabolism, pathophysiology, and current/future medical interventions for high levels of Lp(a).</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2020 ","pages":"3491764"},"PeriodicalIF":5.9,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37677201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Transcriptional Regulatory System of theS. cerevisiae OLE1Gene Responds to Fatty Acid Species and Intracellular Amount, and not Simply Membrane Status","authors":"M. Willey, M. Ochs, Clara Busse, V. McDonough","doi":"10.1155/2020/3903257","DOIUrl":"https://doi.org/10.1155/2020/3903257","url":null,"abstract":"We examined the effects of unsaturated fatty acid (UFA) species and their concentration on the expression ofOLE1,which encodes the stearoyl CoA desaturase, inSaccharomyces cerevisiae. We controlled the amount of UFA taken up by the cell by varying the concentration of tergitol in the medium. When cultured with 1 mM fatty acid in 0.1% tergitol, cells took up much more fatty acid than when cultured with the same concentration of fatty acid at 1% tergitol, although the amount incorporated was dependent on UFA species. For each fatty acid tested, we found that the higher uptake (0.1% tergitol condition) had a stronger impact onOLE1regulation. A principal product of the desaturase 16:1∆9, and the nonnative UFA 18:2∆9,12, most strongly repressed the reporter constructOLE1-lacZtranscription, while the other major product of the desaturase, 18:1∆9, and the nonnative UFA 17:1∆10 caused a more diminished response. Based on these results, our initial hypothesis was thatOLE1was regulated in response to membrane fluidity; however, subsequent work does not support that idea; we have found that conditions that affect membrane fluidity such as growth temperature and growth with saturated ortransfatty acid supplementation, do not regulateOLE1in the direction predicted by fluidity changes. We conclude that at least one signal that regulatesOLE1transcriptional expression is most likely based on the fatty acids themselves.","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"1 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2020-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88120348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}