棕榈油煎街果对瑞士白化小鼠肝脏和肾脏生物标志物的影响。

IF 5.9 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Lipids Pub Date : 2020-12-04 eCollection Date: 2020-01-01 DOI:10.1155/2020/8819749
Hailemariam Amsalu, Tesaka Wondimnew, Tigist Mateos, Minale Fekadie, Gesese Bogale
{"title":"棕榈油煎街果对瑞士白化小鼠肝脏和肾脏生物标志物的影响。","authors":"Hailemariam Amsalu,&nbsp;Tesaka Wondimnew,&nbsp;Tigist Mateos,&nbsp;Minale Fekadie,&nbsp;Gesese Bogale","doi":"10.1155/2020/8819749","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Foods fried with oils at streets contain many harmful substances for health. Locally fried foods are consumed commonly in our society, yet their health effect is not studied.</p><p><strong>Objective: </strong>To assess the effect of palm oil-fried street kokor on liver and kidney biomarkers of Swiss Albino mice.</p><p><strong>Methods: </strong>Thirty-two male and female Swiss Albino mice with the age of 10-12 weeks old were divided randomly into four groups of eight members with equal male and female subgroups. The control group (group I) received only a standard pellet, and the experimental groups (group II, group III, and group IV) received 10%, 20%, and 30% kokor of their daily food consumption, respectively. At the end of the 6<sup>th</sup> week, they were sacrificed by thoracoabdominal incision after anesthetizing by diethyl ether. Blood was taken from each mouse by cardiac puncture and analyzed for liver and kidney function tests.</p><p><strong>Result: </strong>The serum levels of liver damage biomarkers (alanine transaminase (ALT) and aspartate transaminase (AST)) and kidney damage biomarkers (urea and creatinine) of experimental groups were increased significantly relative to the control groups (<i>P</i> < 0.05). Level of biochemical profiles increased as the dose of kokor increased.</p><p><strong>Conclusions: </strong>Palm oil-fried street kokor damaged the liver and kidney of the mice, and the damage was exacerbated as the dose of kokor increased.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2020 ","pages":"8819749"},"PeriodicalIF":5.9000,"publicationDate":"2020-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8819749","citationCount":"7","resultStr":"{\"title\":\"The Effect of Palm Oil-Fried Street Kokor on Liver and Kidney Biomarkers of Swiss Albino Mice.\",\"authors\":\"Hailemariam Amsalu,&nbsp;Tesaka Wondimnew,&nbsp;Tigist Mateos,&nbsp;Minale Fekadie,&nbsp;Gesese Bogale\",\"doi\":\"10.1155/2020/8819749\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Foods fried with oils at streets contain many harmful substances for health. Locally fried foods are consumed commonly in our society, yet their health effect is not studied.</p><p><strong>Objective: </strong>To assess the effect of palm oil-fried street kokor on liver and kidney biomarkers of Swiss Albino mice.</p><p><strong>Methods: </strong>Thirty-two male and female Swiss Albino mice with the age of 10-12 weeks old were divided randomly into four groups of eight members with equal male and female subgroups. The control group (group I) received only a standard pellet, and the experimental groups (group II, group III, and group IV) received 10%, 20%, and 30% kokor of their daily food consumption, respectively. At the end of the 6<sup>th</sup> week, they were sacrificed by thoracoabdominal incision after anesthetizing by diethyl ether. Blood was taken from each mouse by cardiac puncture and analyzed for liver and kidney function tests.</p><p><strong>Result: </strong>The serum levels of liver damage biomarkers (alanine transaminase (ALT) and aspartate transaminase (AST)) and kidney damage biomarkers (urea and creatinine) of experimental groups were increased significantly relative to the control groups (<i>P</i> < 0.05). Level of biochemical profiles increased as the dose of kokor increased.</p><p><strong>Conclusions: </strong>Palm oil-fried street kokor damaged the liver and kidney of the mice, and the damage was exacerbated as the dose of kokor increased.</p>\",\"PeriodicalId\":16274,\"journal\":{\"name\":\"Journal of Lipids\",\"volume\":\"2020 \",\"pages\":\"8819749\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2020-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2020/8819749\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Lipids\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2020/8819749\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Lipids","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2020/8819749","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 7

摘要

背景:街头的油炸食品含有许多对健康有害的物质。当地的油炸食品在我们的社会中很常见,但它们对健康的影响还没有研究。目的:探讨棕榈油煎街果对瑞士白化病小鼠肝脏和肾脏生物标志物的影响。方法:将32只10 ~ 12周龄雄性、雌性瑞士白化病小鼠随机分为4组,每组8只,雌雄亚组相等。对照组(I组)只给予标准颗粒,实验组(II组、III组和IV组)分别给予每日食物摄入量的10%、20%和30%。第6周末,经乙醚麻醉后,采用胸腹切口处死。每只小鼠通过心脏穿刺取血,分析肝肾功能。结果:试验组大鼠血清肝损伤生物标志物(谷丙转氨酶(ALT)、天冬氨酸转氨酶(AST))和肾损伤生物标志物(尿素、肌酐)水平均显著高于对照组(P < 0.05)。生化谱水平随剂量的增加而增加。结论:棕榈油煎街果对小鼠肝、肾均有损伤,且随着剂量的增加损伤程度加重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Effect of Palm Oil-Fried Street Kokor on Liver and Kidney Biomarkers of Swiss Albino Mice.

The Effect of Palm Oil-Fried Street Kokor on Liver and Kidney Biomarkers of Swiss Albino Mice.

Background: Foods fried with oils at streets contain many harmful substances for health. Locally fried foods are consumed commonly in our society, yet their health effect is not studied.

Objective: To assess the effect of palm oil-fried street kokor on liver and kidney biomarkers of Swiss Albino mice.

Methods: Thirty-two male and female Swiss Albino mice with the age of 10-12 weeks old were divided randomly into four groups of eight members with equal male and female subgroups. The control group (group I) received only a standard pellet, and the experimental groups (group II, group III, and group IV) received 10%, 20%, and 30% kokor of their daily food consumption, respectively. At the end of the 6th week, they were sacrificed by thoracoabdominal incision after anesthetizing by diethyl ether. Blood was taken from each mouse by cardiac puncture and analyzed for liver and kidney function tests.

Result: The serum levels of liver damage biomarkers (alanine transaminase (ALT) and aspartate transaminase (AST)) and kidney damage biomarkers (urea and creatinine) of experimental groups were increased significantly relative to the control groups (P < 0.05). Level of biochemical profiles increased as the dose of kokor increased.

Conclusions: Palm oil-fried street kokor damaged the liver and kidney of the mice, and the damage was exacerbated as the dose of kokor increased.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Lipids
Journal of Lipids BIOCHEMISTRY & MOLECULAR BIOLOGY-
自引率
0.00%
发文量
7
审稿时长
12 weeks
期刊介绍: Journal of Lipids is a peer-reviewed, Open Access journal that publishes original research articles and review articles related to all aspects of lipids, including their biochemistry, synthesis, function in health and disease, and nutrition. As an interdisciplinary journal, Journal of Lipids aims to provide a forum for scientists, physicians, nutritionists, and other relevant health professionals.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信