Int. J. Comput. Model. Algorithms Medicine最新文献

Subspace Clustering of DNA Microarray Data: Theory, Evaluation, and Applications DNA微阵列数据的子空间聚类:理论、评价和应用

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2014-07-01 DOI: 10.4018/IJCMAM.2014070101

A. Tchagang, Fazel Famili, Youlian Pan

引用次数: 2

Decision Support for Mental Health: Towards the Information-based Psychiatry 心理健康决策支持:迈向信息精神病学

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2014-07-01 DOI: 10.4018/IJCMAM.2014070102

J. Kalina, J. Zvárová

引用次数: 2

Development of Stress Management System for Prevention of a Mental Disease using Smart Finger Plethysmogram Measurement 利用智能手指体积图测量预防精神疾病的压力管理系统的开发

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2014-07-01 DOI: 10.4018/IJCMAM.2014070103

Hidehiko Hayashi, Akinori Minazuki

引用次数: 0

A Technique to Exploit Free-Form Notes to Predict Customer Churn 一种利用自由形式笔记来预测客户流失的技术

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2014-03-01 DOI: 10.4018/ijcmam.2014010101

Gregory W. Ramsey, S. Bapna

引用次数: 5

The Value of Quantitative EEG Measures in the Early Diagnosis of Alzheimer's Disease 脑电图定量测量在阿尔茨海默病早期诊断中的价值

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2012-10-01 DOI: 10.4018/ijcmam.2012100101

Hideaki Tanaka

{"title":"The Value of Quantitative EEG Measures in the Early Diagnosis of Alzheimer's Disease","authors":"Hideaki Tanaka","doi":"10.4018/ijcmam.2012100101","DOIUrl":"https://doi.org/10.4018/ijcmam.2012100101","url":null,"abstract":"There is growing interest in the discovery of clinically useful, robust biomarkers for Alzheimer’s disease (AD) and pre-AD; the ability to accurately diagnose AD or to predict conversion from a preclinical state to AD would aid in both prevention and early intervention. This study aimed to evaluate the usefulness of a statistical assessment of cortical activity using electroencephalograms (EEGs) with normative data and the ability of such an assessment to contribute to the diagnosis of AD. 15 patients with AD and 8 patients with mild cognitive impairment (MCI) were studied. Eyes-closed resting EEGs were digitally recorded at 200 Hz from 20 electrodes placed according to the international 10/20 system on the scalp, and 20 artifact-free EEG epochs lasting 2.56 ms were selected. Each EEG epoch was down-sampled to 100 Hz and matched to the normal data sets. The selected EEGs from each subject were analyzed by standardized Low Resolution Electromagnetic Tomography (sLORETA) and statistically compared with the age-matched normal data sets at all frequencies. This procedure resulted in cortical z values for each EEG frequency with 0.39 Hz frequency resolution for each subject. Some of the AD and MCI patients presented a peak of negative z value around 20 Hz, revealing hypoactivity of the parahippocampal gyrus and the insula in the sLORETA cortical image. In addition, severe cases of AD showed decreased parietal activation. These results were in agreement with evidence from statistical neuroimaging using MRI/SPECT. Submission of normal EEG data sets to sLORETA might be useful for the detection of diagnostic and predictive markers of AD and MCI in individual patients. The Value of Quantitative EEG Measures in the Early Diagnosis of Alzheimer’s Disease","PeriodicalId":162417,"journal":{"name":"Int. J. Comput. Model. Algorithms Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121790028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Visual Gnosis and Face Perception 视觉诊断和面部感知

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2012-10-01 DOI: 10.4018/ijcmam.2012100102

S. Tobimatsu

{"title":"Visual Gnosis and Face Perception","authors":"S. Tobimatsu","doi":"10.4018/ijcmam.2012100102","DOIUrl":"https://doi.org/10.4018/ijcmam.2012100102","url":null,"abstract":"There are two major parallel pathways in humans: the parvocellular (P) and magnocellular (M) pathways. The former has excellent spatial resolution with color selectivity, while the latter shows excellent temporal resolution with high contrast sensitivity. Visual stimuli should be tailored to answer specific clinical and/or research questions. This chapter examines the neural mechanisms of face perception using event-related potentials (ERPs). Face stimuli of different spatial frequencies were used to investigate how low-spatial-frequency (LSF) and high-spatial-frequency (HSF) components of the face contribute to the identification and recognition of the face and facial expressions. The P100 component in the occipital area (Oz), the N170 in the posterior temporal region (T5/T6) and late components peaking at 270-390 ms (T5/T6) were analyzed. LSF enhanced P100, while N170 was augmented by HSF irrespective of facial expressions. This suggested that LSF is important for global processing of facial expressions, whereas HSF handles featural processing. There were significant amplitude differences between positive and negative LSF facial expressions in the early time windows of 270-310 ms. Subsequently, the amplitudes among negative HSF facial expressions differed significantly in the later time windows of 330–390 ms. Discrimination between positive and negative facial expressions precedes discrimination among different negative expressions in a sequential manner based on parallel visual channels. Interestingly, patients with schizophrenia showed decreased spatial frequency sensitivities for face processing. Taken together, the spatially filtered face images are useful for exploring face perception and recognition.","PeriodicalId":162417,"journal":{"name":"Int. J. Comput. Model. Algorithms Medicine","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131030045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A New Mechanical Algorithm for Calculating the Amplitude Equation of the Reaction-Diffusion Systems 计算反应扩散系统振幅方程的一种新的力学算法

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2012-10-01 DOI: 10.4018/ijcmam.2012100103

Houye Liu, Weiming Wang

引用次数: 4

A Multiscale Computational Model of Chemotactic Axon Guidance 趋化轴突导向的多尺度计算模型

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2012-10-01 DOI: 10.4018/ijcmam.2012100105

G. Aletti, P. Causin, G. Naldi, M. Semplice

{"title":"A Multiscale Computational Model of Chemotactic Axon Guidance","authors":"G. Aletti, P. Causin, G. Naldi, M. Semplice","doi":"10.4018/ijcmam.2012100105","DOIUrl":"https://doi.org/10.4018/ijcmam.2012100105","url":null,"abstract":"In the development of the nervous system, the migration of neurons driven by chemotactic cues has been known since a long time to play a key role. In this mechanism, the axonal projections of neurons detect very small differences in extracellular ligand concentration across the tiny section of their distal part, the growth cone. The internal transduction of the signal performed by the growth cone leads to cytoskeleton rearrangement and biased cell motility. A mathematical model of neuron migration provides hints of the nature of this process, which is only partially known to biologists and is characterized by a complex coupling of microscopic and macroscopic phenomena. This chapter focuses on the tight connection between growth cone directional sensing as the result of the information collected by several transmembrane receptors, a microscopic phenomenon, and its motility, a macroscopic outcome. The biophysical hypothesis investigated is the role played by the biased re-localization of ligand-bound receptors on the membrane, actively convected by growing microtubules. The results of the numerical simulations quantify the positive feedback exerted by the receptor redistribution, assessing its importance in the neural guidance mechanism. DOI: 10.4018/978-1-60960-491-2.ch028","PeriodicalId":162417,"journal":{"name":"Int. J. Comput. Model. Algorithms Medicine","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127952791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Single Nucleotide Polymorphism and its Application in Mapping Loci Involved in Developing Human Diseases and Traits 单核苷酸多态性及其在人类疾病和性状相关位点定位中的应用

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2012-10-01 DOI: 10.4018/ijcmam.2012100106

Rui-Ru Ji

引用次数: 5

Human Oral Bioavailability Prediction of Four Kinds of Drugs 四种药物的人体口服生物利用度预测

Int. J. Comput. Model. Algorithms Medicine Pub Date : 2012-10-01 DOI: 10.4018/ijcmam.2012100104

A. Yan, Zhi Wang, Jiaxuan Li, Meng Meng

{"title":"Human Oral Bioavailability Prediction of Four Kinds of Drugs","authors":"A. Yan, Zhi Wang, Jiaxuan Li, Meng Meng","doi":"10.4018/ijcmam.2012100104","DOIUrl":"https://doi.org/10.4018/ijcmam.2012100104","url":null,"abstract":"In the development of drugs intended for oral use, good drug absorption and appropriate drug delivery are very important. Now the predictions for drug absorption and oral bioavailability follow similar approach: calculate molecular descriptors for molecules and build the prediction models. This approach works well for the prediction of compounds which cross a cell membrane from a region of high concentration to one of low concentration, but it does not work very well for the prediction of oral bioavailability, which represents the percentage of an oral dose which is able to produce a pharmacological activity. The models for bioavailability had limited predictability because there are a variety of pharmacokinetic factors influencing human oral bioavailability. Recent study has shown that good quantitative relationship could be obtained for subsets of drugs, such as those that have similar structure or the same pharmacological activity, or those that exhibit similar absorption and metabolism mechanisms. In this work, using MLR (Multiple Linear Regression) and SVM (Support Vector Machine), quantitative bioavailability prediction models were built for four kinds of drugs, which are Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Antagonists, Calcium Channel Blockers, Sodium and Potassium Channels Blockers and Quinolone Antimicrobial Agents. Explorations into subsets of compounds were performed and reliable prediction models were built for these four kinds of drugs. This work represents an exploration in predicting human oral bioavailability and could be used in other dataset of compounds with the same pharmacological activity. Human Oral Bioavailability Prediction of Four Kinds of Drugs","PeriodicalId":162417,"journal":{"name":"Int. J. Comput. Model. Algorithms Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116742134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9