Subspace Clustering of DNA Microarray Data: Theory, Evaluation, and Applications

Abstract

Identification of biological significant subspace clusters biclusters and triclusters of genes from microarray experimental data is a very daunting task that emerged, especially with the development of high throughput technologies. Several methods and applications of subspace clustering biclustering and triclustering in DNA microarray data analysis have been developed in recent years. Various computational and evaluation methods based on diverse principles were introduced to identify new similarities among genes. This review discusses and compares these methods, highlights their mathematical principles, and provides insight into the applications to solve biological problems.