Journal of Lipid Research最新文献_第3页

Long-term Omega-3 Polyunsaturated Fatty Acid Supplementation Improves Meningeal Lymphatic Function During Brain Aging in Mice. 长期补充Omega-3多不饱和脂肪酸可改善小鼠脑衰老过程中的脑膜淋巴功能。

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-09 DOI: 10.1016/j.jlr.2025.100895

Zhoujing Liu, Jiamin Peng, Xuemin Wang, Fei Yin, Fengjuan Su, Zhong Pei, Hongfu Wu, Chuanming Luo

{"title":"Long-term Omega-3 Polyunsaturated Fatty Acid Supplementation Improves Meningeal Lymphatic Function During Brain Aging in Mice.","authors":"Zhoujing Liu, Jiamin Peng, Xuemin Wang, Fei Yin, Fengjuan Su, Zhong Pei, Hongfu Wu, Chuanming Luo","doi":"10.1016/j.jlr.2025.100895","DOIUrl":"https://doi.org/10.1016/j.jlr.2025.100895","url":null,"abstract":"Emerging evidence implicates that meningeal lymphatic dysfunction may contribute to the pathogenesis of brain age-related diseases, suggesting its potential as a therapeutic target for brain aging. This study investigated whether long-term Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) supplementation could delay brain aging through meningeal lymphatic modulation. We randomly assigned C57BL/6J mice into control, low-dose, and high-dose Omega-3 PUFAs groups, and administered dietary supplementation for 12 months until reaching 24 months of age. We then assessed the anti-aging effects on brain function and further examined meningeal lymphatic performance in clearance capacity and immune regulation. Our findings demonstrate that long-term Omega-3 PUFAs supplementation increases docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) levels in the brain, reduces age-related neuronal loss, and improves motor and cognitive behaviors in aged mice. Additionally, it reduces accumulation of toxic proteins (phosphorylated tau and amyloid-β) and metabolites (NADPH, succinyl-CoA, and cAMP) in the brain and decreases immune cell infiltration (CD68+ microglia and CD3+ T cells) in the central nervous system of aged mice. Furthermore, we demonstrate that these protective effects may be mediated through preservation of the meningeal lymphatic system during aging. In conclusion, this study elucidates a novel understanding of the anti-brain-aging mechanisms of Omega-3 PUFAs.","PeriodicalId":16209,"journal":{"name":"Journal of Lipid Research","volume":" ","pages":"100895"},"PeriodicalIF":4.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart DHA turnover is faster in female compared to male ALA- and EPA-fed mice. 与雄性ALA和epa喂养的小鼠相比，雌性小鼠的心脏DHA更新速度更快。

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-08 DOI: 10.1016/j.jlr.2025.100897

Ruxandra D Rotarescu, Mahima Mathur, Miranda R Green, G Harvey Anderson, Adam H Metherel

{"title":"Heart DHA turnover is faster in female compared to male ALA- and EPA-fed mice.","authors":"Ruxandra D Rotarescu, Mahima Mathur, Miranda R Green, G Harvey Anderson, Adam H Metherel","doi":"10.1016/j.jlr.2025.100897","DOIUrl":"10.1016/j.jlr.2025.100897","url":null,"abstract":"Young females have higher circulating docosahexaenoic acid (DHA) levels than males, though the metabolic basis remains incompletely understood. Building on previous findings that demonstrate higher hepatic synthesis of the DHA precursor, docosapentaenoic acid (DPAn-3), in males, this study extends the investigation to n-3 PUFA turnover in extrahepatic tissues of male and female C57BL/6N mice using compound-specific isotope analysis (CSIA). Animals were fed a 12-week diet enriched in either α-linolenic acid (ALA), eicosapentaenoic acid (EPA), or DHA, starting with a 4-week phase containing low carbon-13 (δ13C)-n-3 PUFA, followed by an 8-week phase with high δ13C-n-3 PUFA (n = 4 per diet, time point, sex). Heart, perirenal adipose tissue (PRAT), brain, and red blood cells (RBCs) were collected at baseline and at seven time points (1-56 days) post-diet switch, with δ13C-n-3 PUFA values modeled by one-phase exponential decay. Compared to males, females exhibited slower turnover of ALA (48%-61% slower) and DPAn-3 (26%-73% slower) from dietary ALA or EPA in the heart, PRAT, and RBCs, resulting from longer half-lives and/or lower DPAn-3 concentrations. Conversely, females showed 26%-28% faster heart DHA turnover from dietary ALA or EPA, despite similar half-lives between sexes. Notably, sex-specific differences in DHA turnover were present only in the heart, whereas DPAn-3 turnover varied across multiple tissues, suggesting a heart-specific mechanism that enhances DHA metabolism in females under low DHA intake. Further research is needed to investigate the physiological significance of these metabolic differences and their potential health implications.","PeriodicalId":16209,"journal":{"name":"Journal of Lipid Research","volume":" ","pages":"100897"},"PeriodicalIF":4.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclopropane xenolipids resemble monounsaturated fatty acids and modulate peroxisome proliferator-activated receptors. 环丙烷xenolids类似于单不饱和脂肪酸和调节过氧化物酶体增殖激活受体。

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-05 DOI: 10.1016/j.jlr.2025.100896

Jean Debédat, Lorena Pastor, Trina A Knotts, Jordan G Pitman, Kristine Griffett, Sean H Adams

{"title":"Cyclopropane xenolipids resemble monounsaturated fatty acids and modulate peroxisome proliferator-activated receptors.","authors":"Jean Debédat, Lorena Pastor, Trina A Knotts, Jordan G Pitman, Kristine Griffett, Sean H Adams","doi":"10.1016/j.jlr.2025.100896","DOIUrl":"https://doi.org/10.1016/j.jlr.2025.100896","url":null,"abstract":"Cyclopropane fatty acids (CpFAs) are members of the mammalian lipidome, originating from the diet and gut microbial metabolism. Despite being fully saturated, conformational modeling of CpFAs from C12 to C24 in length revealed that they are bent lipids sharing structural similarities with monounsaturated fatty acids (MUFAs). We therefore hypothesized that CpFAs might share some bioactivities with MUFAs. We modeled and docked a total of 429 known and theoretical CpFAs, MUFAs and saturated lipids into peroxisome proliferator activated receptor (PPAR) α, δ, and γ nuclear receptor structures. CpFAs showed unique spatial binding patterns, especially with PPARδ. In vitro, several CpFAs bound PPARα and δ with potencies comparable to dietary MUFAs, while in 3T3-L1 preadipocytes they upregulated the PPARδ/γ target gene Angptl4, indicating downstream functional engagement. These findings suggest that CpFAs share some structural and functional aspects with MUFAs, and represent an underrecognized class of metabolically relevant food- and gut-derived lipids.","PeriodicalId":16209,"journal":{"name":"Journal of Lipid Research","volume":" ","pages":"100896"},"PeriodicalIF":4.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue. 内皮细胞SR-B1对于产热是不可缺少的，但促进棕色脂肪组织选择性摄取胆固醇。

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-03 DOI: 10.1016/j.jlr.2025.100894

Kimberley M Hurkmans, Markus Heine, Franz Rinninger, Michelle Y Jaeckstein, Chieko Mineo, Philip W Shaul, Joerg Heeren

{"title":"Endothelial SR-B1 is dispensable for thermogenesis but promotes selective cholesterol uptake in brown adipose tissue.","authors":"Kimberley M Hurkmans, Markus Heine, Franz Rinninger, Michelle Y Jaeckstein, Chieko Mineo, Philip W Shaul, Joerg Heeren","doi":"10.1016/j.jlr.2025.100894","DOIUrl":"10.1016/j.jlr.2025.100894","url":null,"abstract":"In an interplay with parenchymal cells of metabolically active organs, such as heart and adipose tissues, vascular endothelial cells are important for the regulation of nutrient uptake and organ-specific energy metabolism. Based on high expression of the scavenger receptor class B type I (SR-B1) in capillary endothelial cells of white adipose tissue and brown adipose tissue (BAT), we proposed a functional role for this receptor in lipid handling and adaptive thermogenesis. To address this hypothesis, we generated mice with an endothelial-specific KO of SR-B1 and performed metabolic turnover and indirect calorimetry studies in response to environmental cues, such as cold exposure and high-fat diet feeding. Compared with control littermates, endothelial-specific SR-B1 KO mice had substantially lower SR-B1 mRNA and protein levels in heart, skeletal muscle, BAT, and white adipose tissue but not in liver, indicating that SR-B1 is primarily expressed by endothelial cells in peripheral organs. We did not detect major differences in gene expression of thermogenic and lipid-handling genes, energy expenditure assessed by indirect calorimetry, or clearance of metabolic tracers for glucose and triglycerides between endothelial SR-B1 KO mice and controls under basal conditions, thermogenic activation, or high-fat diet feeding. However, consistent with the importance of SR-B1 expression by hepatocytes for HDL metabolism, mice lacking endothelial SR-B1 had lower selective cholesterol uptake in the heart and BAT compared with control littermates. We conclude that endothelial SR-B1 is not essential for adaptive thermogenesis and handling of triglyceride-rich lipoproteins, but it is involved in regulating cholesterol homeostasis in the heart and BAT.","PeriodicalId":16209,"journal":{"name":"Journal of Lipid Research","volume":" ","pages":"100894"},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LDL transcytosis passes through the trans-Golgi network and requires Rab10. LDL胞吞作用通过反式高尔基体网络，需要Rab10。

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-02 DOI: 10.1016/j.jlr.2025.100893

Tse Wing Winnie Ho, Changsen Wang, Warren L Lee

{"title":"LDL transcytosis passes through the trans-Golgi network and requires Rab10.","authors":"Tse Wing Winnie Ho, Changsen Wang, Warren L Lee","doi":"10.1016/j.jlr.2025.100893","DOIUrl":"10.1016/j.jlr.2025.100893","url":null,"abstract":"Atherosclerosis begins with the subendothelial retention of LDLs from the circulation. While LDL transcytosis across the endothelium is mediated by scavenger receptor class B type I and activin-like kinase receptor 1 and is usually independent of LDL receptor, the intracellular mechanisms and route of LDL transcytosis remain unclear. Using total internal reflection fluorescence microscopy in LDL receptor-depleted human coronary artery endothelial cells, we found that LDL transcytosis can proceed both directly and indirectly from an intracellular compartment. During LDL transcytosis, LDL was observed to colocalize with the Golgi apparatus over time, specifically with the trans-Golgi network marker TGN46. Systematic examination of endothelial Rab proteins known to regulate Golgi traffic identified Rabs 6a and 10 to be required for LDL transcytosis. Depletion of Rab10 or Rab6a significantly inhibited LDL transcytosis but had no effect on albumin transcytosis. Expression and localization of scavenger receptor class B type I and activin-like kinase receptor 1 were also unimpaired. Conversely, overexpression of Rab10 increased LDL transcytosis. Finally, depletion of Rab10 increased colocalization of LDL with the trans-Golgi network and led to expansion of the Golgi, indicative of impaired exocytosis from the Golgi. However, colocalization of Rab10 with LDL did not increase over time, and Rab10 did not accumulate at the base of the cell, suggesting its role is specifically related to LDL exit from the Golgi rather than direct transport. In summary, during LDL transcytosis, internalized LDL is transported to the Golgi, which serves as a reservoir of LDL that can undergo exocytosis. Our results identify specific Rab proteins as critical regulators of this process.","PeriodicalId":16209,"journal":{"name":"Journal of Lipid Research","volume":" ","pages":"100893"},"PeriodicalIF":4.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: The one-key-to-two-doors role of lipidomics: plasma lipidome, cardiovascular risk and statin usage [Journal of Lipid Research 66/5 (2025) 100802]. 脂质组学的一键到两门作用：血浆脂质组学、心血管风险和他汀类药物的使用[Journal of脂质研究66/5(2025)100802]。

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-01 Epub Date: 2025-08-25 DOI: 10.1016/j.jlr.2025.100869

Anatol Kontush

引用次数: 0

Characterization of a PNLIP variant identified in Amish pediatric patients with congenital pancreatic lipase deficiency. 先天性胰脂肪酶缺乏症患儿PNLIP变异的特征

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-01 Epub Date: 2025-08-19 DOI: 10.1016/j.jlr.2025.100878

Grace E Curry, Nicole L Bertsch, Tran Quach, Rhonda Anderson, Neel Matiwala, Karlla W Brigatti, Steven J Wilhelm, Katie B Williams, Mark E Lowe, Zineb Ammous, Xunjun K Xiao

{"title":"Characterization of a PNLIP variant identified in Amish pediatric patients with congenital pancreatic lipase deficiency.","authors":"Grace E Curry, Nicole L Bertsch, Tran Quach, Rhonda Anderson, Neel Matiwala, Karlla W Brigatti, Steven J Wilhelm, Katie B Williams, Mark E Lowe, Zineb Ammous, Xunjun K Xiao","doi":"10.1016/j.jlr.2025.100878","DOIUrl":"10.1016/j.jlr.2025.100878","url":null,"abstract":"Congenital pancreatic lipase deficiency (CPLD, OMIM #614338) is a rare exocrine pancreatic disorder presenting in late infancy with steatorrhea, fat-soluble vitamin deficiency, and low pancreatic lipase activity. Variants of the pancreatic triglyceride lipase (PNLIP) gene have been linked to CPLD. Six children from four Amish families exhibited CPLD symptoms, and two had decreased fecal elastase levels when tested. A novel homozygous PNLIP variant, c.869G>A (p.S290N), was identified in these children. This study aimed to characterize the PNLIP variant to understand its mechanism underlying CPLD. The variant impact was first evaluated using computational modeling. Functional analyses included activity assays, cellular PNLIP partition assessments, and endoplasmic reticulum (ER) stress evaluation in transfected cells. Computational modeling showed that p.Ser290 is highly conserved across species and the variant causes steric hindrance, resulting in protein misfolding. Functional assays revealed that the PNLIP variant had a complete loss of activity compared to the wild type (WT), with defects in catalytic function and secretion. Immunoblotting showed reduced PNLIP variant in the medium and increased accumulation in the detergent-insoluble fraction, consistent with protein misfolding. Variant-expressing cells had elevated levels of BiP, an ER stress marker, and increased Xbp1 mRNA splicing, suggesting an elevated ER stress and unfolded protein response (UPR). In conclusion, the PNLIP p.S290N variant causes CPLD through a loss-of-function mechanism, characterized by loss of enzymatic activity and defective secretion due to protein misfolding. Further studies are needed to determine whether the misfolding variant protein induces proteotoxicity, potentially increasing the risk of pancreatic injury, including chronic pancreatitis.","PeriodicalId":16209,"journal":{"name":"Journal of Lipid Research","volume":" ","pages":"100878"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid-lowering drug targets influence inflammatory bowel disease through gut microbiota and inflammatory cytokines. 降脂药物靶点通过肠道微生物群和炎症细胞因子影响炎症性肠病。

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-01 DOI: 10.1016/j.jlr.2025.100871

Xin Huang, Qihang Li, Ping Guo, Weiming Gong, Ying Wang, Zhongshang Yuan

{"title":"Lipid-lowering drug targets influence inflammatory bowel disease through gut microbiota and inflammatory cytokines.","authors":"Xin Huang, Qihang Li, Ping Guo, Weiming Gong, Ying Wang, Zhongshang Yuan","doi":"10.1016/j.jlr.2025.100871","DOIUrl":"10.1016/j.jlr.2025.100871","url":null,"abstract":"Patients with dyslipidemia are at higher risk for inflammatory bowel disease (IBD), yet the impact of lipid-lowering medications on IBD remains unclear. This study investigates the causal relationship between lipid-lowering drug target and IBD, with a focus on the roles of gut microbiota and inflammatory cytokines. Genetic variants associated with lipid-lowering drug targets were extracted from the Global Lipids Genetics Consortium, whereas summary statistics for IBD, Crohn's disease (CD), and ulcerative colitis were sourced from the International Inflammatory Bowel Disease Genetics Consortium. Drug-target Mendelian randomization analysis revealed that inhibiting angiopoietin-like protein 3 increased the risk of IBD and CD, whereas inhibition of apolipoprotein C-III (APOC3) heightened the risk of CD. Conversely, enhancement of LPL and LDL receptor reduced the risk of IBD and CD. Mediation analysis demonstrated that gut microbiota and inflammatory cytokines partially mediated these effects, with specific pathways such as Lachnospiraceae FCS020 (17.26%) for APOC3 and Clostridium sensu stricto 1 (20.12%) for LPL accounting for significant portions of the effects. These findings suggest that lipid-lowering drugs targeting angiopoietin-like protein 3 and APOC3 may increase the risk of IBD, whereas those targeting LPL and LDL receptor may reduce the risk. The results highlight potential for repurposing lipid-lowering drugs for IBD prevention and warrant future clinical trials to explore these targets further.","PeriodicalId":16209,"journal":{"name":"Journal of Lipid Research","volume":" ","pages":"100871"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DHA and EPA exacerbate hypoxia-induced ferroptosis in gastric and small intestinal mucosa by disrupting the balance between SLC7A11 upregulation and PUFA-PL accumulation. DHA和EPA通过破坏SLC7A11上调与PUFA-PL积累之间的平衡，加剧了缺氧诱导的胃和小肠粘膜铁下垂。

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-01 Epub Date: 2025-08-12 DOI: 10.1016/j.jlr.2025.100876

Zhenmei Song, Xuexin Wang, Jie Zeng, Fangli Ren, Yinyin Wang, Meng Li, Qing Lin, Wenli Li, Xingchen Liao, Dezhi Wang

{"title":"DHA and EPA exacerbate hypoxia-induced ferroptosis in gastric and small intestinal mucosa by disrupting the balance between SLC7A11 upregulation and PUFA-PL accumulation.","authors":"Zhenmei Song, Xuexin Wang, Jie Zeng, Fangli Ren, Yinyin Wang, Meng Li, Qing Lin, Wenli Li, Xingchen Liao, Dezhi Wang","doi":"10.1016/j.jlr.2025.100876","DOIUrl":"10.1016/j.jlr.2025.100876","url":null,"abstract":"Hypoxia, resulting from environmental factors or diseases, can disrupt the gastrointestinal mucosal barrier. Our previous study demonstrated that hypoxia induced ferroptosis in the gastric and small intestinal mucosa by upregulating ALOX5, NOX4, and polyunsaturated fatty acid-containing phospholipids (PUFA-PLs). The impact of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on ferroptosis is currently a subject of debate. While DHA and EPA upregulate SLC7A11 expression, mitigating lipid peroxidation, they also elevate PUFA-PL levels, exacerbating it. This study investigated the effects and underlying mechanisms of DHA and EPA supplementation on gastric and small intestinal mucosal ferroptosis under normoxic and hypoxic conditions in vitro and in vivo. Under normoxia, DHA and EPA upregulated SLC7A11 expression through the cAMP/PKA/ATF3 pathway, thereby enhancing cellular resistance to lipid peroxidation associated with increased PUFA-PL levels and preventing ferroptosis. In contrast, under hypoxia, DHA and EPA exacerbated ferroptosis by further increasing PUFA-PL levels, which, in combination with hypoxia-induced ALOX5 and NOX4 expression, resulted in excessive lipid peroxidation that overwhelmed the protective mechanisms mediated by SLC7A11 upregulation. These findings indicate that DHA and EPA exacerbate hypoxia-induced ferroptosis in gastric and small intestinal mucosa. Therefore, individuals at risk of hypoxia should carefully consider the potential risks associated with DHA and EPA intake.","PeriodicalId":16209,"journal":{"name":"Journal of Lipid Research","volume":" ","pages":"100876"},"PeriodicalIF":4.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: Functional characterization of missense variants affecting the extracellular domains of ABCA1 using a fluorescence-based assay [Journal of Lipid Research 65/1 (2024) 100482]. 使用基于荧光的测定影响ABCA1细胞外结构域的错义变异的功能表征[Journal of脂质研究65/1(2024)100482]。

IF 4.1 2区医学

Journal of Lipid Research Pub Date : 2025-09-01 Epub Date: 2025-08-29 DOI: 10.1016/j.jlr.2025.100891

Marianne Teigen, Åsa Schawlann Ølnes, Katrine Bjune, Trond P Leren, Martin Prøven Bogsrud, Thea Bismo Strøm

引用次数: 0