Journal of Marmara University Institute of Health Sciences最新文献

{"title":"The involvement of Akt and GSK-3: Two pathways, two pathology","authors":"C. Şahin, G. Unal, F. Aricioglu","doi":"10.5455/MUSBED.20140321043920","DOIUrl":"https://doi.org/10.5455/MUSBED.20140321043920","url":null,"abstract":"","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"102 1","pages":"51-57"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83418711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Cytotoxic and Genotoxic Potential of Cinnamomum Cassia Bark Water Extract","authors":"Sumru Sozer Karadagli, B. Agrap, Ferzan Lermioglu Erciyas","doi":"10.5455/MUSBED.20140115040354","DOIUrl":"https://doi.org/10.5455/MUSBED.20140115040354","url":null,"abstract":"Amac: Son zamanlarda, tarcin ile ilgili calismalar zengin polifenol icerigine bagli antioksidan aktivitesi uzerinde yogunlasmistir. Polifenollerin ayni zamanda pro-oksidan olarak hareket ettikleri ve DNA’da oksidatif zincir kiriklarina neden olduklari bildirilmistir. Bu calismada Cinnamomum cassia su ekstresinin insan periferal kan lenfositlerindeki sitotoksik ve genotoksik potansiyelini arastirdik. Yontemler: Cinnamomum cassia su ekstresi, toz haline getirilmis tarcin kabugunun ultra saf suda 72 saat maserasyonu ile hazirlandi. Ekstrenin lenfositlerdeki sitotoksik etkisi WST-1 yontemi ile arastirildi. Ekstrenin DNA’da hasar olusturucu potansiyelini degerlendirmek icin alkali Komet yontemi uygulandi. DNA hasari kuyruk DNA yuzdesi ve kuyruk momenti seklinde ifade edildi. Bulgular: Lenfositlerin canliligi ekstre ile 24 saat muamele sonrasi konsantrasyona bagimli olarak azaldi. Ekstre ≥400 μg/ml konsantrasyonlarda negatif kontrole gore anlamli duzeyde DNA hasarina neden oldu. Sonuc: Calisma sonuclarimiz Cinnamomum cassia kabugu su ekstresinin in vitro olarak sitotoksik ve genotoksik etki potansiyelini gostermektedir. Ekstrenin ozellikle yuksek dozlarda ya da uzun sureli kullaniminda guvenliligi acisindan bu bulgu onemli gorunmektedir ve bu nedenle in vivo calismalarla aydinlatilmalidir. Anahtar sozcukler: Cinnamomum cassia, alkali Komet yontemi, sitotoksisite, pro-oksidan aktivite ABS TRACT Investigation of cytotoxic and genotoxic potential of cinnamomum cassia bark water extract","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"38 3","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91423478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the integrated approach to prognosis for schizophrenic patient who has been served in the community mental health center","authors":"M. Delice, S. Akgül, M. Yıldız","doi":"10.5455/musbed.20140527033751","DOIUrl":"https://doi.org/10.5455/musbed.20140527033751","url":null,"abstract":"","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"32 1","pages":"122-125"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72660267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Klotho gene, aging and DNA methylation","authors":"E. Çağlayan, K. Turan","doi":"10.5455/musbed.20140826121007","DOIUrl":"https://doi.org/10.5455/musbed.20140826121007","url":null,"abstract":"","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"200 1","pages":"182-192"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75514775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signal transduction of zymosan and spleen tyrosine kinase","authors":"Demet Unsal, Meryem Temiz, B. Tunctan, S. Firat","doi":"10.5455/musbed.20140627013019","DOIUrl":"https://doi.org/10.5455/musbed.20140627013019","url":null,"abstract":"","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"196 1","pages":"148-157"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73617884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Evaluation of Some Tetrazole Derivatives as Cholinesterase Inhibitors","authors":"U. Mohsen, L. Yurttaş, A. Özdemir, G. Turan-Zitouni, Z. Kaplancıklı","doi":"10.5455/MUSBED.20140207083648","DOIUrl":"https://doi.org/10.5455/MUSBED.20140207083648","url":null,"abstract":"Amac: Bu calismada, ondort farkli 2-[(1-metil-1H-tetrazol-5-il) tiyo]-1-(substitue fenil) etanon (1–14) turevinin sentezleri ve antikolinesteraz aktivitelerinin arastirilmasi amaclandi. Yontem: 1-(Substitue fenil)-2-[(1-metil-1H-tetrazol-5-il) tiyo] etanon (1–14) turevi bilesikler, 1-metil-1H-tetrazol-5-tiyol ile bazi fenacil bromur turevlerinin reaksiyonuyla sentezlenmistir. Bilesiklerin kimyasal yapilari, IR, 1H-NMR, 13C-NMR ve FAB+-MS spektral verileri ve elementel analiz verileri ile aydinlatilmistir. Tum turevlerin asetilkolinesteraz enzimini (AChE) inhibisyon yetenekleri modifiye Ellman spektrofotometrik metodu kullanilarak degerlendirilmistir. Bulgular: Bilesik 2 ve 3 AChE uzerinde %29.56 ve %24.38 inhibisyon oranlari ile en aktif bilesikler olarak bulunmustur. Sonuc: Bilesiklerden fenil artigi uzerinde 3-konumunda elektron verici metil ve kloro substituentleri icerenler en yuksek antikolinesteraz aktivite gostermislerdir. Anahtar sozcukler: Tetrazol, kolinesteraz inhibitorleri ABS TRACT Biological evaluation of some tetrazole derivatives as cholinesterase inhibitors","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"42 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89072981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of tissue factor activities and sialic acid levels in D-galactose induced aging model","authors":"Nsal Stundag, Ş. Oktay, E. Emekli-Alturfan, A. Alturfan, K. Yanar, M. Mengi, Tamer Cebe, M. Toprak, S. Aydin, U. Çakatay","doi":"10.5455/MUSBED.20140103081933","DOIUrl":"https://doi.org/10.5455/MUSBED.20140103081933","url":null,"abstract":"","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"43 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80077020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of levels of cortizol, anxiety and depression in patients with oral lichen planus (OLP)","authors":"F. Pekiner, M. O. Borahan, Semih Özbayrak","doi":"10.5455/musbed.20140208013705","DOIUrl":"https://doi.org/10.5455/musbed.20140208013705","url":null,"abstract":"","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"21 1","pages":"24-28"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78770801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report and Update of Giant Cell Fibroma","authors":"M. Madi, S. Shetty, S. Babu, S. Achalli","doi":"10.5455/MUSBED.20140121101731","DOIUrl":"https://doi.org/10.5455/MUSBED.20140121101731","url":null,"abstract":"ABSTRACT A case report and update of giant cell fibroma The giant cell fibroma is a fibrous tumour with a distinctive clinicopathologic features which sets it apart from a conventional fibroma. It represents approximately 2% to 5% of all oral fibrous proliferations submitted for biopsy and is found predominantly in Caucasians and rarely in other races. Most often giant cell fibroma is mistaken for papilloma because of its papillary surface or fibroma because of its fibrous or elastic nature. Here, we report a case of giant cell fibroma, in the region of the incisive papilla, in a 30-year old autistic female. Key words: Giant cell fibroma, fibroma, histopathology, giant cells MUSBED 2014;4(1):58-62 Olgu Sunumu / Case Report INTRODUCTION The giant cell fibroma (GCF) is an interesting non-neoplastic lesion of the oral mucosa. It was first described by Weathers and Callihan in 1974. It was named for its characteristically large, stellate-shaped, mononuclear and multinucleated giant cells. Weathers and Callihan reviewed more than 2000 specimens at Emory University of which 108 specimens met the criteria for reclassification of GCF (1). Before Weathers’ and Callihans’ distinction of GCF, Eversole and Rovin compared and contrasted 279 fibrous hyperplastic gingival lesions, which falls into four categories: pyogenic granuloma, peripheral gingival fibroma, peripheral giant cell granuloma, and peripheral ossifying fibroma. Each has its own diagnostic histopathologic characteristics but exhibit overlap of clinical presentation (2,3). After distinguishing GCF among fibrous hyperplasias, Weathers and Campbell further elucidated the structure of the lesion when they studied them under light microscopy. They concluded again that dominant cells in the GCF were indeed unique, and that GCF merited its own classification (4,5). Giant cell fibroma is a fibrous oral benign asymptomatic pedunculated or sessile nodule less than 1 cm in size, more commonly seen in the mandibular gingiva and the lesion may persist for several years (6,7). The giant cell fibroma is a localized reactive proliferation of fibrous tissue, much like the irritation fibroma. It usually remains small and may have a broad base or be on a thick stalk. It is painless and often has lobules or nodules on its surface. The most characteristic histological feature is the presence of large spindle-shaped and stellate-shaped mononuclear cells and multinucleated cells (4). Very few case reports are seen regarding this tumour and controversy regarding the origin of this lesion continues (8). Here, we report a case of a 30-year old female who had","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"12 1","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89494999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eğri kök kanallarında şekillendirme sırasında oluşan streslerin sonlu elemanlar yöntemi ile değerlendirilmesi","authors":"Dilek Türkaydın, M. Günday, B. Ekici","doi":"10.5455/MUSBED.20130124112218","DOIUrl":"https://doi.org/10.5455/MUSBED.20130124112218","url":null,"abstract":"Objective:  The aim of this study is to determine stress evaluation of root canal wall during shaping curved canals with ProTaper and HeroShaper systems by using three-dimensional finite element universal.  Methods:  The geometries of the ProTaper Universal and HeroShaper Ni-Ti rotary systems’ selected files were created using three-dimensional finite element modelsThe three-dimensional FEA model within a curved canal was established by integrating a simulated canal and natural tooth. A micro-focus CT scanner was used to scan the models. After integration and modification a final three-dimensional model with a smooth surface and mostly centered canal was established. The stresses on the instrument during simulated shaping of a root canal were analyzed numerically by using a three-dimensional finite element package, LS-DYNA, taking into account the nonlinear mechanical behavior of the nickel-titanium material. Stress distribution in the instruments and the canal walls was recorded during simulated shaping.  Results:  With ProTaper file system, stress concentrations were determined towards the outer aspect of the curvature in the apical portion of the canal but in HeroShaper system stress was more concentrated in the middle portion of the canal and were less than ProTaper model.  Conclusion:  HeroShaper files cut more efficiently and generated less stress on the canal walls than ProTaper files because of their possitive rake angle. It was observed that there was stress concentration towards the outer aspect of the curvature in the apical portion of the canal with the ProTaper file system. This shows us that these files are more feasible for apical transportation. Key words:  Curved canals, HeroShaper, ProTaper, finite element analysis, stress","PeriodicalId":16169,"journal":{"name":"Journal of Marmara University Institute of Health Sciences","volume":"138 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77462774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}