Journal of integrative neuroscience最新文献

{"title":"Feasibility of Simultaneous Anodal Transcranial Direct Current Stimulation During Gait Training in Chronic Stroke Patients: A Randomized Double-Blind Pilot Clinical Trial.","authors":"Hyeong-Min Kim, Ji-Min Na, Hyun-Seok Jo, Ki-Hong Kim, Min-Keun Song, Hyeng-Kyu Park, In-Sung Choi, Jungwon Yoon, Jae-Young Han","doi":"10.31083/j.jin2308154","DOIUrl":"https://doi.org/10.31083/j.jin2308154","url":null,"abstract":"<p><strong>Background: </strong>Transcranial direct current stimulation (tDCS) is a therapeutic tool for improving post-stroke gait disturbances, with ongoing research focusing on specific protocols for its application. We evaluated the feasibility of a rehabilitation protocol that combines tDCS with conventional gait training.</p><p><strong>Methods: </strong>This was a randomized, double-blind, single-center pilot clinical trial. Patients with unilateral hemiplegia due to ischemic stroke were randomly assigned to either the tDCS with gait training group or the sham stimulation group. The anodal tDCS electrode was placed on the tibialis anterior area of the precentral gyrus while gait training proceeded. Interventions were administered 3 times weekly for 4 weeks. Outcome assessments, using the 10-meter walk test, Timed Up and Go test, Berg Balance Scale, Functional Ambulatory Scale, Modified Barthel Index, and European Quality of Life 5 Dimensions 3 Level Version, were conducted before and after the intervention and again at the 8-week mark following its completion. Repeated-measures analysis of variance (ANOVA) was used for comparisons between and within groups.</p><p><strong>Results: </strong>Twenty-six patients were assessed for eligibility, and 20 were enrolled and randomized. No significant differences were observed between the tDCS with gait training group and the sham stimulation group in gait speed after the intervention. However, the tDCS with gait training group showed significant improvement in balance performance in both within-group and between-group comparisons. In the subgroup analysis of patients with elicited motor-evoked potentials, comfortable pace gait speed improved in the tDCS with gait training group. No serious adverse events occurred throughout the study.</p><p><strong>Conclusions: </strong>Simultaneous anodal tDCS during gait training is a feasible rehabilitation protocol for chronic stroke patients with gait disturbances.</p><p><strong>Clinical trial registration: </strong>URL: https://cris.nih.go.kr; Registration number: KCT0007601; Date of registration: 11 July 2022.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"154"},"PeriodicalIF":2.5,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Optimal Neuroplasticity: Neuromodulation for Enhanced Human Well-Being.","authors":"Yoshihiro Noda","doi":"10.31083/j.jin2308155","DOIUrl":"https://doi.org/10.31083/j.jin2308155","url":null,"abstract":"","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"155"},"PeriodicalIF":2.5,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG-Based Feature Classification Combining 3D-Convolutional Neural Networks with Generative Adversarial Networks for Motor Imagery.","authors":"Chengcheng Fan, Banghua Yang, Xiaoou Li, Shouwei Gao, Peng Zan","doi":"10.31083/j.jin2308153","DOIUrl":"https://doi.org/10.31083/j.jin2308153","url":null,"abstract":"<p><strong>Background: </strong>The adoption of convolutional neural networks (CNNs) for decoding electroencephalogram (EEG)-based motor imagery (MI) in brain-computer interfaces has significantly increased recently. The effective extraction of motor imagery features is vital due to the variability among individuals and temporal states.</p><p><strong>Methods: </strong>This study introduces a novel network architecture, 3D-convolutional neural network-generative adversarial network (3D-CNN-GAN), for decoding both within-session and cross-session motor imagery. Initially, EEG signals were extracted over various time intervals using a sliding window technique, capturing temporal, frequency, and phase features to construct a temporal-frequency-phase feature (TFPF) three-dimensional feature map. Generative adversarial networks (GANs) were then employed to synthesize artificial data, which, when combined with the original datasets, expanded the data capacity and enhanced functional connectivity. Moreover, GANs proved capable of learning and amplifying the brain connectivity patterns present in the existing data, generating more distinctive brain network features. A compact, two-layer 3D-CNN model was subsequently developed to efficiently decode these TFPF features.</p><p><strong>Results: </strong>Taking into account session and individual differences in EEG data, tests were conducted on both the public GigaDB dataset and the SHU laboratory dataset. On the GigaDB dataset, our 3D-CNN and 3D-CNN-GAN models achieved two-class within-session motor imagery accuracies of 76.49% and 77.03%, respectively, demonstrating the algorithm's effectiveness and the improvement provided by data augmentation. Furthermore, on the SHU dataset, the 3D-CNN and 3D-CNN-GAN models yielded two-class within-session motor imagery accuracies of 67.64% and 71.63%, and cross-session motor imagery accuracies of 58.06% and 63.04%, respectively.</p><p><strong>Conclusions: </strong>The 3D-CNN-GAN algorithm significantly enhances the generalizability of EEG-based motor imagery brain-computer interfaces (BCIs). Additionally, this research offers valuable insights into the potential applications of motor imagery BCIs.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"153"},"PeriodicalIF":2.5,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-State Brain Function Alteration in Colorectal Cancer Patients.","authors":"Yanan Xu, Zihan Ma, Jieyu Chen, Huiyan Zhang, Guo Shen, Gang Huang, Wenwen Zhang, Lianping Zhao","doi":"10.31083/j.jin2308151","DOIUrl":"https://doi.org/10.31083/j.jin2308151","url":null,"abstract":"<p><strong>Background and purpose: </strong>To investigate the abnormal pattern of altered functional activity in the brain and the neuroimaging mechanisms underlying the cognitive impairment of patients with colorectal cancer (CRC) via resting-state functional magnetic resonance imaging (rs-fMRI).</p><p><strong>Materials and methods: </strong>CRC patients (n = 56) and healthy controls (HCs) (n = 50) were studied. The participants underwent rs-fMRI scans and the Montreal Cognitive Assessment (MoCA). The amplitude of low-frequency fluctuations (ALFF), degree centrality (DC), regional homogeneity (ReHo), and MoCA scores, were calculated for participants.</p><p><strong>Results: </strong>The scores of executives, visuospatial, memory, language and attention were lower in CRC patients. ReHo and ALFF values in the left postcentral gyrus, ReHo values in the right postcentral gyrus, ALFF and DC values in the left middle occipital gyrus, ReHo and DC values in the right lingual gyrus, DC values in the right angular gyrus and precuneus, and ALFF values in the left middle temporal gyrus decreased conspicuously in the CRC patients.</p><p><strong>Conclusion: </strong>CRC patients have abnormal resting state function, mainly in the brain areas involved in cognitive function. The overlapping brain regions with abnormal functional indicators are in the middle occipital gyrus, postcentral gyrus, and lingual gyrus. This study reveals the potential biological pathways involved in brain impairment and neurocognitive decline in patients with CRC.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"151"},"PeriodicalIF":2.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of the Persyst Automated Seizure Detector in the Neonatal Population.","authors":"Eleanor Duckworth, Daniyal Motan, Kitty Howse, Stewart Boyd, Ronit Pressler, Maria Chalia","doi":"10.31083/j.jin2308150","DOIUrl":"https://doi.org/10.31083/j.jin2308150","url":null,"abstract":"<p><strong>Background: </strong>Neonatal seizures are diagnostically challenging and predominantly electrographic-only. Multichannel video continuous electroencephalography (cEEG) is the gold standard investigation, however, out-of-hours access to neurophysiology support can be limited. Automated seizure detection algorithms (SDAs) are designed to detect changes in EEG data, translated into user-friendly seizure probability trends. The aim of this study was to evaluate the diagnostic accuracy of the Persyst neonatal SDA in an intensive care setting.</p><p><strong>Methods: </strong>Single-centre retrospective service evaluation study in neonates undergoing cEEG during intensive care admission to Great Ormond Street Hospital (GOSH) between May 2019 and December 2022. Neonates with <44 weeks corrected gestational age, who had a cEEG recording duration >60 minutes, whilst inpatient in intensive care, were included in the study. One-hour cEEG clips were created for all cases (seizures detected) and controls (seizure-free) and analysed by the Persyst neonatal SDA. Expert neurophysiology reports of the cEEG recordings were used as the gold standard for diagnostic comparison. A receiver operating characteristic (ROC) curve was created using the highest seizure probability in each recording. Optimal seizure probability thresholds for sensitivity and specificity were identified.</p><p><strong>Results: </strong>Eligibility screening produced 49 cases, and 49 seizure-free controls. Seizure prevalence within those patients eligible for the study, was approximately 19% with 35% mortality. The most common case seizure aetiology was hypoxic ischaemic injury (35%) followed by inborn errors of metabolism (18%). The ROC area under the curve was 0.94 with optimal probability thresholds 0.4 and 0.6. Applying a threshold of 0.6, produced 80% sensitivity and 98% specificity.</p><p><strong>Conclusions: </strong>The Persyst neonatal SDA demonstrates high diagnostic accuracy in identifying neonatal seizures; comparable to the accuracy of the standard Persyst SDA in adult populations, other neonatal SDAs, and amplitude integrated EEG (aEEG). Overdiagnosis of seizures is a risk, particularly from cEEG recording artefact. To fully examine its clinical utility, further investigation of the Persyst neonatal SDA's accuracy is required, as well as confirming the optimal seizure probability thresholds in a larger patient cohort.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"150"},"PeriodicalIF":2.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives.","authors":"Wael Mohamed, Mohamed Abdelhalim Eltantawi, Vidhu Agarwal, Sara Bandres-Ciga, Mary B Makarious, Yasser Mecheri, Yared Zenebe Zewde, Walaa A Kamel, Bashayer Al-Mubarak, Karem H Alzoubi, Najib Kissani, Badrah S Alghamdi, Samia Ben Sassi","doi":"10.31083/j.jin2308152","DOIUrl":"https://doi.org/10.31083/j.jin2308152","url":null,"abstract":"<p><p>Over 80% of genetic studies in the Parkinson's disease (PD) field have been conducted on individuals of European descent. There is a social and scientific imperative to understand the genetic basis of PD across global populations for therapeutic development and deployment. PD etiology is impacted by genetic and environmental factors that are variable by ancestry and region, emphasising the need for worldwide programs to gather large numbers of patients to identify novel candidate genes and risk loci involved in disease. Only a handful of documented genetic assessments have investigated families with PD in AfrAbia, which comprises the member nations of the Arab League and the African Union, with very limited cohort and case-control studies reported. This review article summarises prior research on PD genetics in AfrAbia, highlighting gaps and challenges. We discuss the etiological risk spectrum in the context of historical interactions, highlighting allele frequencies, penetrance, and the clinical manifestations of known genetic variants in the AfrAbian PD patient community.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"152"},"PeriodicalIF":2.5,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Effective Connectivity of the Pain Matrix in Herpes Zoster and Postherpetic Neuralgia Patients: Granger Causality Analysis of Resting-State fMRI.","authors":"Huiting Lv, Lili Gu, Jiaxin Xiong, Zihan Li, Yangyang Xie, Wanqing Zou, Hongmei Kuang, Shunda Hong, Jian Jiang","doi":"10.31083/j.jin2308147","DOIUrl":"https://doi.org/10.31083/j.jin2308147","url":null,"abstract":"<p><strong>Background: </strong>Shingles can cause long-term pain and negative emotions, along with changes in brain function. In this study, Granger Causality Analysis (GCA) was used to compare herpes zoster (HZ) and postherpetic neuralgia (PHN) differences in effective connections within the \"pain matrix\" between patients and healthy controls to further understand patterns of interaction between brain regions and explore the relationship between changes in effective connections and clinical features.</p><p><strong>Methods: </strong>Resting-state functional magnetic resonance imaging (fMRI) scans were performed on 55 HZ; 55 PHN; and 50 age-, sex- matched healthy controls (HCs). The brain regions associated with the pain matrix are used as the seeds of effective connectivity. GCA was used to analyze effective connections in brain regions that differed significantly between groups. Then the correlation between GCA values and clinical indicators was studied.</p><p><strong>Results: </strong>Compared with HC, GCA values between the thalamus and the amygdala, between the thalamus and the precentral gyrus, from the thalamus to the postcentral gyrus, and from the parahippocampal gyrus to the amygdala, anterior cingulate gyrus were significantly reduced in HZ patients. Compared with HC, GCA values between the insular and the postcentral gyrus, from the insular to the inferior parietal lobe, and from the postcentral gyrus to the amygdala were significantly reduced in PHN patients. Compared with HZ, GCA values between the inferior parietal lobe and the parahippocampal gyrus, between the inferior parietal lobe and the anterior cingulate gyrus, and from the anterior cingulate gyrus to the amygdala were significantly increased in PHN patients. The visual analogue scale (VAS) score of PHN patients was positively correlated with the GCA value from the central posterior lobe to the insula.</p><p><strong>Conclusions: </strong>PHN and HZ patients showed a broad reduction in effective connections, mainly reflected in abnormal pain pathway regulation, pain perception, negative emotion and memory production, providing new perspectives to understand the neuroimaging mechanisms of shingles.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"147"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of EEG Response to Unpleasant, Pleasant, and Neutral Tactile Stimuli.","authors":"Galina Portnova, Larisa Mayorova","doi":"10.31083/j.jin2308148","DOIUrl":"https://doi.org/10.31083/j.jin2308148","url":null,"abstract":"<p><strong>Background: </strong>The study of tactile perception during a childhood is extremely important for understanding the social and communicative aspects of the child's development. Tactile perception of stimuli with different valence can have different normative stages of development.</p><p><strong>Methods: </strong>In the present study, we examined changes in linear and nonlinear electroencephalogram (EEG) parameters during the presentation of pleasant (C-tactile optimal stroking), unpleasant (ice stroking), and neutral tactile stimuli in three groups of healthy volunteers: preschoolers 4 and 5 years, school-age children from 8 to 10 years, and adults from 20 to 40 years.</p><p><strong>Results: </strong>According to our findings, child maturation plays a significant role in the perception of pleasant and neutral tactile stimuli. Patterns of EEG dynamics related to tactile perception showed greater similarity between adult volunteers and school-aged children than preschoolers.</p><p><strong>Conclusions: </strong>Non-linear EEG parameters such as fractal dimension (FD), envelope mean frequency (EMF), and power spectral density (PSD) dynamics of the theta-rhythm were particularly sensitive to developmental changes in tactile perception. Hjorth complexity and peak alpha frequency (PAF) scores may serve as indicators of mature perception of С-tactile (CT)-stimuli.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"148"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxic Signal Transduction and Compensatory Mechanisms in the Neurovascular Unit.","authors":"Xinxin Ma, Zhihao Zou, Qinghai Shi","doi":"10.31083/j.jin2308149","DOIUrl":"https://doi.org/10.31083/j.jin2308149","url":null,"abstract":"<p><p>Hypoxic hypoxia arises from an inadequate oxygen supply to the blood, resulting in reduced arterial oxygen partial pressure and a consequent decline in oxygen diffusion into tissue cells for utilization. This condition is characterized by diminished oxygen content in the blood, while the supply of other nutrients within the blood remains normal. The brain is particularly sensitive to oxygen deficiency, with varying degrees of hypoxic hypoxia resulting in different levels of neural functional disorder. Since the brain has a specific threshold range for the perception of hypoxic hypoxia, mild hypoxic hypoxia can trigger compensatory protective responses in the brain without affecting neural function. These hypoxic compensatory responses enable the maintenance of an adequate oxygen supply and energy substrates for neurons, thereby ensuring normal physiological functions. To further understand the hypoxic compensatory mechanisms of the central nervous system (CNS), this article explores the structural features of the brain's neurovascular unit model, hypoxic signal transduction, and compensatory mechanisms.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"149"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycine Receptor Beta Subunit (GlyR-β) Promotes Potential Angiogenesis and Neurological Regeneration during Early-Stage Recovery after Cerebral Ischemia Stroke/Reperfusion in Mice.","authors":"Yuan Xu, Yushi Yang, Jie Yang, Junshuan Cui, Jian Yan, Jiannan Jiang, Zhangwei Yan, Hua Yang","doi":"10.31083/j.jin2308145","DOIUrl":"https://doi.org/10.31083/j.jin2308145","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke is mainly caused by cerebral artery thrombosis. This study investigated the role of glycine receptor beta subunit (GlyR-β) in the recovery from cerebral ischemia stroke/reperfusion.</p><p><strong>Methods: </strong>The oxygen glucose deprivation and recovery (OGD/R) bEnd3 cell model and the middle cerebral artery occlusion/reperfusion (MCAO/R) mouse model were used in this study.</p><p><strong>Results: </strong>Expression of both the <i>GlyR-β</i> gene and vascular endothelial growth factor (<i>Vegf</i>), cell proliferation, and tube formation ability was decreased in bEnd3 cells after OGD/R, and was reversed by overexpression of GlyR-β. Neurological function, asindicated by Zea Longa scores, area of cerebral ischemia, and pathological changes were increased in mice after MCAO/R, and were ameliorated by overexpression of the glycine receptor beta (<i>Glrb</i>) gene at 24 h and 7 d after MCAO/R. Expression of GlyR-β and Gap-43 was decreased, and the expression of CD34, Vegf, and Bdnf, and cell growth as determined by a bromodeoxyuridine (BrdU) assay, increased in the affected brain tissue of MCAO/R mice in a time-dependent manner. GlyR-β overexpression resulted in enhanced expression of CD34, Vegf, Growth association protein 43 (Gap-43), and brain-derived neurotrophic factor (Bdnf) and cell growth in affected brain tissue of MCAO/R mice in a time-dependent manner.</p><p><strong>Conclusions: </strong>GlyR-β promoted potential angiogenesis and neurological regeneration in affected brain tissue, thus promoting recovery from cerebral ischemia stroke/reperfusion.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 8","pages":"145"},"PeriodicalIF":2.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}