{"title":"TRIAL MASTER, an expert system to control clinical drug trials","authors":"W. Dassen, A. Gorgels, R. Mulleneers, H. Wellens","doi":"10.1109/CIC.1989.130566","DOIUrl":"https://doi.org/10.1109/CIC.1989.130566","url":null,"abstract":"An expert system has been designed to facilitate the proper application of inclusion and exclusion criteria for clinical drug trials. For six trials, these criteria were represented in rules and stored in knowledge bases. In three cases, a separate knowledge base was added, containing knowledge on ECG (electrocardiographic) criteria. For a series of 100 patients, the cardiologist and the expert system disagreed with regard to three patients. In 24 cases the patient was classified for at least one trial; 73 patients did not meet the requirements for inclusion in any trial. As an example, the evaluation of a patient with unstable angina is presented.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122918641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An intelligent information system for interpreting ECG tracings used in a CCU nurse training program","authors":"F. Wiener, I. Bergman, H. Hammerman","doi":"10.1109/CIC.1989.130549","DOIUrl":"https://doi.org/10.1109/CIC.1989.130549","url":null,"abstract":"The expert/information system shell SMR (simulation of medical reasoning) was used to record ECG (electrocardiographic) morphology and interval data and to provide diagnostic interpretations and advice for therapy. The knowledge base contains decision rules relating the ECG data to 65 supraventricular arrhythmias. A treatment protocol is given for each disorder. An SMR decision rule is an inference statement and Boolean combination of criteria statements, all in natural language. Reasoning chains are formed with previous inferences used as criteria in subsequent rules. Mutually exclusive criteria referring to a numerical measurement or a qualitative fact are defined as criteria groups. Criteria statements and group names are organized into data screens for recording data. The nurse reads 25 ECGs and enters the findings into the system. The SMR report lists the data, the ECG diagnosis, and the suggested therapy. If the SMR conclusions differ from the trainee's, the SMR explanation facility is used to find the reasons for the discrepancy. The case record is updated and rerun until agreement is reached.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123734008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A novel limit alarmer for reliable intensive care monitoring","authors":"A. Makivirta, A. Kari, E. Koski, T. Sukuvaara","doi":"10.1109/CIC.1989.130530","DOIUrl":"https://doi.org/10.1109/CIC.1989.130530","url":null,"abstract":"A median filter is combined with narrow adjustable monitoring limits and wide physiologically determined alarm limits. This ensures both quick alarming in the case of a catastrophic failure and reliable therapy monitoring with alarms. Results of the clinical assessment of this dual-limit alarmer are provided. Results of the clinical evaluation indicate a significant reduction in the frequency of false alarm (63% per patient hour).<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"246 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122930792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Casaleggio, M. Morando, S. Pestelli, S. Ridella
{"title":"Study of the correlation dimension of ECG signals based on MIT-BIH Arrhythmia Data Base ECGs","authors":"A. Casaleggio, M. Morando, S. Pestelli, S. Ridella","doi":"10.1109/CIC.1989.130578","DOIUrl":"https://doi.org/10.1109/CIC.1989.130578","url":null,"abstract":"The correlation dimensions of random noise and electrocardiograms of both normal and sick subjects have been analyzed and compared. The noisy signal has been obtained by using the random function of a DEC VAX computer; ECG data have been obtained from the MIT-BIH Arrhythmia Data Base. It was expected that a lower dimensionality of the ECG signal would be obtained with respect to the noisy one. This hypothesis has been confirmed by the analysis. An attempt was made to evaluate differences in the dimensionality of sick and normal subjects. The complexity and time-consuming aspects of the computations made it possible to examine only four patients. Up to now, there has not been enough evidence of significant differences between sick and normal subjects, and thus it is necessary to increase the number of analyzed cases. In order to obtain a good saturation of the correlation dimension, the embedding space has been spanned from 2 to 50.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126140669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Van de Bruaene, P. Van Nechel, M. Alexandersson, L. Jordaens
{"title":"A database for management of AICD-patients","authors":"F. Van de Bruaene, P. Van Nechel, M. Alexandersson, L. Jordaens","doi":"10.1109/CIC.1989.130594","DOIUrl":"https://doi.org/10.1109/CIC.1989.130594","url":null,"abstract":"A user-friendly pacemaker management system (PatientLog), implemented on an IBM personal computer (AT), was adapted to facilitate the control of AICD (automatic implantable cardioverter defibrillator) patients. Most parameters used for pacemakers are suitable for AICDs, while some new fields have been defined within the available frame of the database to cope with the specific technical information of AICDs. Patient cards, intervention cards, and follow-up cards are used in a way similar to that for pacemaker systems. Ten patients are now being followed with a total of 16 devices and more than 250 follow-ups. The graphical facilities of the system are very attractive and enhance correct decision-making during follow-up.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127524776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Kornreich, T. Montague, P. Smets, P. Rautaharju, M. Kavadias
{"title":"Multigroup diagnostic classification using body surface potential maps","authors":"F. Kornreich, T. Montague, P. Smets, P. Rautaharju, M. Kavadias","doi":"10.1109/CIC.1989.130516","DOIUrl":"https://doi.org/10.1109/CIC.1989.130516","url":null,"abstract":"Multivariate analysis was performed on 120-lead electrocardiographic (ECG) data in order to derive diagnostic criteria for correct classification of 159 normal subjects (N), 103 patients with anterior myocardial infarction (AMI), 130 patients with inferior myocardial infarction (IMI), and 116 patients with pure left ventricular hypertrophy (LVH). The analysis used instantaneous voltage measurements obtained by sampling the time-normalized P, PR, QRS, and STT waveforms at equal intervals. The durations of these waveforms were measured prior to time normalization. Linear discriminant functions were computed for each possible bigroup comparison, and the six best discriminators of each pairwise comparison were selected for the final multigroup classification model. A total of eight features from five torso sites accounted for the correct assignment of 93% of N, 92% of AMI, 94% of IMI, and 82% of LVH. The misclassification matrix illustrated the relatively high rate of false negatives in LVH (11%). The improvement in classification over the standard 12 lead ECG was highest for LVH (11%) and lowest for N (4%); AMI and IMI rates were improved by 7% and 6%, respectively.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130675281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Kiauta, Franc Jager, Z. Bjelogrlic, Saga Sega, A. Grad
{"title":"Personal computer-based analysis of heart rate fluctuations in human subjects (ECG)","authors":"T. Kiauta, Franc Jager, Z. Bjelogrlic, Saga Sega, A. Grad","doi":"10.1109/CIC.1989.130580","DOIUrl":"https://doi.org/10.1109/CIC.1989.130580","url":null,"abstract":"A personal-computer-based system for quantitation of spontaneous and provoked heart rate fluctuations in a clinical setting is described. The system was developed for screening and subsequent follow-up of neurological patients with autonomic-nervous-system lesions. The testing battery includes the Valsalva maneuver, a deep breathing test, a sustained handgrip test, face immersion, an orthostatic test and spectral analysis of heart rate variability in the supine and standing positions. The results of these tests performed on a group of 79 healthy volunteers of both sexes, aged 21 to 60 years, demonstrate the dependence of cardiovascular reactivity on age and its independence of sex.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129620900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Algorithm for detection of ventricular fibrillation on line in a CCU","authors":"L. Patomaki, M. Jarviluoto","doi":"10.1109/CIC.1989.130529","DOIUrl":"https://doi.org/10.1109/CIC.1989.130529","url":null,"abstract":"A new simple and fast algorithm for VFIB (ventricular fibrillation) detection has been developed and tested in an AHA (American Heart Association) database. The algorithm is based on the portions of small and high derivatives in the ECG (electrocardiographic) signal. The performance is found to be adequate while showing detection for all VFIB episodes in the AHA database within 14 s, on average. All the false positives were found to be VTAC (ventricular tachycardia) episodes, which usually precede the VFIB.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126956908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Wollschlager, A. Zeiher, H. Klein, W. Kasper, S. Wollschlager, A. Geibel, H. Just
{"title":"Transesophageal echo computer tomography: a new method for dynamic 3-D imaging of the heart (echo-CT)","authors":"H. Wollschlager, A. Zeiher, H. Klein, W. Kasper, S. Wollschlager, A. Geibel, H. Just","doi":"10.1109/CIC.1989.130474","DOIUrl":"https://doi.org/10.1109/CIC.1989.130474","url":null,"abstract":"Summary form only given. A device for the acquisition of standardized parallel echocardiographic imaging planes covering the entire heart and the large vessels has been developed. It consists of a conventional transesophageal probe with an additional fully flexible distal portion, which serves as housing for a freely moving ultrasonic transducer. The transducer is pulled back from the most distal part of the tube in 0.5-mm increments, providing exact parallel and equidistant imaging planes. At each plane, one complete cardiac cycle is recorded with ECG triggering delivering images in 30-ms intervals corresponding to the echocardiographic frame rate and cover the dynamic cardiac anatomy of one heart cycle. Thereafter, a dedicated software for dynamic 3-D reconstruction allows the computation of any desired tomographic view of the beating heart and the large vessels in real time.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126970752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Haude, R. Brennecke, R. Erbel, U. Renneisen, M. Lang, H. Deutsch, J. Meyer
{"title":"Computerized estimation of quality standards for the X-ray densitometric assessment of myocardial perfusion","authors":"M. Haude, R. Brennecke, R. Erbel, U. Renneisen, M. Lang, H. Deutsch, J. Meyer","doi":"10.1109/CIC.1989.130554","DOIUrl":"https://doi.org/10.1109/CIC.1989.130554","url":null,"abstract":"The densitometric evaluation of heart-phase-gated digital subtraction coronary angiograms derives different parameters which provide information about coronary blood flow, myocardial perfusion, and coronary flow reserve: appearance time, rise time, mean ascending time, and maximum intensity. The reliability and reproducibility of these measurements and of the derived parameters were investigated. Four digital subtraction coronary angiograms were obtained in ten patients, including two baseline measurements and two measurements under hyperemia induced by papaverine ic. Different reproducibility results were found for the parameters, depending on the heart phase of the densogram (diastolic better than systolic) and the region of interest (ROI) (septal ROIs revealed better reproducibilities than apical). Results under hyperemia were improved compared to baseline. Best results were obtained for rise time and mean ascending time, while the worst result was obtained for maximum intensity. In general, the reproducibility was poor but was markedly improved when the parameters were calculated from quality checked densograms.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125653180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}