{"title":"TRIAL MASTER，控制临床药物试验的专家系统","authors":"W. Dassen, A. Gorgels, R. Mulleneers, H. Wellens","doi":"10.1109/CIC.1989.130566","DOIUrl":null,"url":null,"abstract":"An expert system has been designed to facilitate the proper application of inclusion and exclusion criteria for clinical drug trials. For six trials, these criteria were represented in rules and stored in knowledge bases. In three cases, a separate knowledge base was added, containing knowledge on ECG (electrocardiographic) criteria. For a series of 100 patients, the cardiologist and the expert system disagreed with regard to three patients. In 24 cases the patient was classified for at least one trial; 73 patients did not meet the requirements for inclusion in any trial. As an example, the evaluation of a patient with unstable angina is presented.<<ETX>>","PeriodicalId":161494,"journal":{"name":"[1989] Proceedings. Computers in Cardiology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1989-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TRIAL MASTER, an expert system to control clinical drug trials\",\"authors\":\"W. Dassen, A. Gorgels, R. Mulleneers, H. Wellens\",\"doi\":\"10.1109/CIC.1989.130566\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"An expert system has been designed to facilitate the proper application of inclusion and exclusion criteria for clinical drug trials. For six trials, these criteria were represented in rules and stored in knowledge bases. In three cases, a separate knowledge base was added, containing knowledge on ECG (electrocardiographic) criteria. For a series of 100 patients, the cardiologist and the expert system disagreed with regard to three patients. In 24 cases the patient was classified for at least one trial; 73 patients did not meet the requirements for inclusion in any trial. As an example, the evaluation of a patient with unstable angina is presented.<<ETX>>\",\"PeriodicalId\":161494,\"journal\":{\"name\":\"[1989] Proceedings. Computers in Cardiology\",\"volume\":\"10 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1989-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"[1989] Proceedings. Computers in Cardiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/CIC.1989.130566\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"[1989] Proceedings. Computers in Cardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/CIC.1989.130566","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
TRIAL MASTER, an expert system to control clinical drug trials
An expert system has been designed to facilitate the proper application of inclusion and exclusion criteria for clinical drug trials. For six trials, these criteria were represented in rules and stored in knowledge bases. In three cases, a separate knowledge base was added, containing knowledge on ECG (electrocardiographic) criteria. For a series of 100 patients, the cardiologist and the expert system disagreed with regard to three patients. In 24 cases the patient was classified for at least one trial; 73 patients did not meet the requirements for inclusion in any trial. As an example, the evaluation of a patient with unstable angina is presented.<>
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