The Internet Journal of Dermatology最新文献_第6页

Case of Panniculitis like T-cell Lymphoma 膜炎样t细胞淋巴瘤1例

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/230c

F. Foss

{"title":"Case of Panniculitis like T-cell Lymphoma","authors":"F. Foss","doi":"10.5580/230c","DOIUrl":"https://doi.org/10.5580/230c","url":null,"abstract":"Published widely as an author or co-author of more than 100 studies, Dr. Foss serves on the editorial board for the journal Clinical Lymphoma, and is a reviewer for the New England Journal of Medicine, Journal of Clinical Oncology, Blood, Journal of American Academy of Dermatology and Cancer. Dr. Foss has been a member of numerous professional societies, including the American Medical Association, the American College of Physicians, the American Society of Clinical Oncology, and the American Association for Cancer Research. Dr. Foss received her bachelor’s degree from Dartmouth University and her medical degree from the University of Massachusetts Medical School. She completed her internship and residency at Brigham and Women’s Hospital in Boston, Massachusetts. INITIAL PRESENTATION A 39 year old man presented with the sudden onset of a 10 centimeter mass in the left thigh which was slightly tender to palpation. He was initially treated with a course of oral antibiotics without improvement. As the original mass began to slowly regress over the next several months, the patient noted the appearance of several additional subcutaneous nodules in the bilateral lower extremities. The nodules persisted and slowly enlarged in size. He was otherwise healthy with no weight loss, fevers, chills, or other symptoms, and he continued to work full time. STAGING WORK-UP – CONSIDERATIONS FOR THE DERM/ONC FROM THE REFERRING PHYSICIAN Although he presented to his primary care physician for evaluation, he was referred to the CTCL clinic at Yale for further evaluation and staging by a multi-disciplinary team. His past medical history was significant for a 10 year history of idiopathic thrombocytopenia and mild splenomegaly felt to be a complication of previous mononucleosis. HISTOLOGY Excisional biopsy of one of these nodules revealed an atypical lymphoid infiltrate with a panniculitic distribution that focally extended into the deep dermis. The infiltrate was composed of variably-sized lymphocytes ranging from small to large that also show significant cytological atypia (Figure 1). Case of Panniculitis like T-cell Lymphoma","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"154 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132293707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dilated pore of Winer, Dr. Louis H. Winer and wine glass Winer, Louis H. Winer博士和酒杯的扩张孔

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/15a9

D. Sarma

引用次数: 0

Early mycosis fungoides: Management of stage IB with phototherapy 早期蕈样真菌病:IB期光疗治疗

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/33c

J. Zic

{"title":"Early mycosis fungoides: Management of stage IB with phototherapy","authors":"J. Zic","doi":"10.5580/33c","DOIUrl":"https://doi.org/10.5580/33c","url":null,"abstract":"John Alan Zic, MD, earned his medical degree Tennessee. He then completed an internship in internal medicine at the Hospital and a residency in dermatology (serving as chief resident) at the University of Illinois at Chicago Hospital. Dr. Zic currently is Associate Professor of Medicine in the Division of Dermatology of Vanderbilt University’s School of Medicine and the Associate Dean of Admissions for the medical school. In 1996 he established the multidisciplinary Vanderbilt University Cutaneous Lymphoma Clinic. Dr. Zic has served as principal investigator in numerous studies on cutaneous lymphoma. He serves on the international editorial board of the American Journal of Drugs in Dermatology while also serving as a reviewer for numerous journals. His primary research interests focus on variables predicting response and survival of patients with cutaneous lymphomas. He is a member of several professional organizations, including the American Academy of Dermatology, the International Society for Cutaneous Lymphoma, the United States Consortium for Cutaneous lymphoma, the Society for Investigative Dermatology, and the Tennessee Dermatology Society. While at Vanderbilt University, Dr Zic has earned a Master Clinical Teacher appointment, a CANDLE Award for medical student mentoring/teaching, a Grant Liddle Award for research mentoring of young physicians and in 2007 he was elected a Founding Member of the Vanderbilt University School of Medicine Academy of Excellence in Teaching.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116182963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of postage stamp skin grafting in the treatment of non healing leg ulcers 邮票皮移植治疗小腿溃疡不愈合的疗效评价

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/ae

M. Sk, A. Kaur, Princejit Singh Sargodhia, M. Kaur

引用次数: 0

Hepatitis C Virus serology in patients with lichen planus 扁平苔藓患者的丙型肝炎病毒血清学研究

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/189f

C. Udayashankar, A. Nath, M. D'souza

引用次数: 8

Role of Eosinophil Cationic Protein in Asthma and Confounding Factors. 嗜酸性阳离子蛋白在哮喘中的作用及其混杂因素。

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/e4c

A. M. A. Samarai, Amina Hamed Ahmad Al Obaidi, Jasim Mohamad Al Janabi, Abdul Kareem Yahya Al Samarai

{"title":"Role of Eosinophil Cationic Protein in Asthma and Confounding Factors.","authors":"A. M. A. Samarai, Amina Hamed Ahmad Al Obaidi, Jasim Mohamad Al Janabi, Abdul Kareem Yahya Al Samarai","doi":"10.5580/e4c","DOIUrl":"https://doi.org/10.5580/e4c","url":null,"abstract":"Background: It has been found that activated eosinophils play an important role in the pathogenesis of bronchial asthma.Objective: To clarify the validity of serum Eosinophil Cationic Protein (ECP) as parameter in assessment of asthma since it reflects the pulmonary inflammation in bronchial asthma. Patients and Methods: Serum ECP was determined in 139 asthmatic patients by using enzyme linked immunosorbent assay and compared to control .Results: Serum ECP was very highly significant higher (P<0.00001) in asthmatic patients than in control. There was no overlap between the lower asthmatic limit and higher limit of the control group. In addition, the ECP variation between asthmatic and control was correlated to variations in FEV1 percent predicted (P<0.0001) between both groups. There was an association between serum ECP levels and asthma severity and pattern. A cut – off of 20 μg/l for serum ECP was with sensitivity of 89% and specificity of 88% in detection asthma cases. The area under curve was found to be 0.805, meaning that determination of serum ECP was with a predictive value in detection of asthmatic cases.Conclusion: Serum ECP level may help in discrimination between asthmatic and non asthmatic individuals, also between symptomatic and asymptomatic asthmatic individuals. The residence does not influence serum ECP in our asthmatic patients.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120900657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Clinical profile and management pattern of melasma patients in Western Nepal: A Hospital Based Study 尼泊尔西部黄褐斑患者的临床概况和管理模式:一项基于医院的研究

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/d91

B. Dwari, Subish Palaian, A. Poudel, S. Prabhu

{"title":"Clinical profile and management pattern of melasma patients in Western Nepal: A Hospital Based Study","authors":"B. Dwari, Subish Palaian, A. Poudel, S. Prabhu","doi":"10.5580/d91","DOIUrl":"https://doi.org/10.5580/d91","url":null,"abstract":"Introduction: Melasma is an acquired hypermelanosis of sun-exposed areas. Melasma is much more common in women than in men. Women are affected in 90% of cases. The patient usually presents with tan to brown patches. Multiple factors have been postulated to involve in the etiology and pathogenesis of melasma including pregnancy, oral contraceptives, genetics, sun exposure, cosmetics and race. Objectives: The objectives of the present studies are to study the demographic details of the melasma patients visiting the Manipal Teaching Hospital (MTH), to study the drugs used in management of melasma and to estimate the treatment cost to the patients. Materials and methods: We went through the records of the patient at MTH and found out the number of patients suffering from melasma and other related data from 25th November 2005 to 30th November 2007. The data obtained were analyzed as per the study objectives. Results: Altogether 107 patient files were included in the study. There were 75 (70.09%) females and 32 (29.90%) males (the total is 107). More than 50% of the patients were above the age 20 years. Most common site of occurrence of pigmentation was forehead accounting for 56.45% (n= 70) of the total case followed by cheeks 12.09% (n=15). Altogether 290 drugs were used in the patients with a Mean  SD of 2.71  0.89 drugs per patient. The Mean  SD cost of medications was NRs 458  251.36. Conclusion: The present study analyzed the clinical profile and treatment pattern of the melasma patients visiting MTH. Majority of the patients were of child bearing age. Sun screens were the most commonly employed medications followed by antioxidants 20 (6.89%) and antibiotics 18 (6.2%).","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122995008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Bexarotene in Tumor stage Mycosis Fungoides 贝沙罗汀在肿瘤期蕈样真菌病中的作用

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/111f

R. Talpur, M. Duvic

{"title":"Bexarotene in Tumor stage Mycosis Fungoides","authors":"R. Talpur, M. Duvic","doi":"10.5580/111f","DOIUrl":"https://doi.org/10.5580/111f","url":null,"abstract":"Dr Rakhshandra Talpur has been a post-doctoral fellow, instructor and research scientist in the Department of Dermatology at The University of Texas, M. D. Anderson Cancer Center for the last eleven years and is a key member of our clinical research team in CTCL. She has worked on numerous clinical trials studying the immunology of T-cell mediated disorders and skin cancers, as well as clinical drug development in T-cell lymphomas, psoriasis, and various skin cancers. Madeleine Duvic, MD, is Professor of Internal Medicine and Dermatology, and Deputy Chairman of the Department of Dermatology at The University of Texas, M. D. Anderson Cancer Center in Houston, Texas. She is a founding member of the United States Cutaneous Lymphoma Consortium (USCLC), a Board member of the International Society for Cutaneous Lymphoma, and also serves as Director of The Cutaneous Lymphoma Clinic at MD Anderson Cancer Center. Dr. Duvic has also served on the Board of Directors of the American Academy of Dermatology (AAD). She is certified in Internal Medicine and Dermatology. She has been a principal and co-principal investigator on numerous clinical trials studying the immunology of T-cell mediated disorders and skin cancers, as well as clinical drug development and translational research in T-cell lymphomas, melanoma, and various skin cancers. A prolific author, she has written manuscripts, book chapters, abstracts, and over 300 peer-reviewed journal articles. She is co-author on a recent book on Retinoids and Carotenoids in Dermatology.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115587667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term safety profile of siplizumab, a humanized anti-CD2 monoclonal antibody, in subjects with chronic plaque psoriasis siplizumab是一种人源抗cd2单克隆抗体，用于慢性斑块型银屑病患者的长期安全性分析

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/1997

B. White, B. Harris

{"title":"Long-term safety profile of siplizumab, a humanized anti-CD2 monoclonal antibody, in subjects with chronic plaque psoriasis","authors":"B. White, B. Harris","doi":"10.5580/1997","DOIUrl":"https://doi.org/10.5580/1997","url":null,"abstract":"Background: Prolonged depletion of activated T cells via targeted therapy may reduce disease activity in chronic plaque psoriasis, but may potentially lead to increased risk of serious infection.Objectives: To evaluate the long-term safety profile of siplizumab, an anti-CD2 monoclonal antibody, in chronic plaque psoriasis subjects who experienced persistent siplizumabinduced lymphocyte depletion.Methods: Subjects (n=94) with absolute lymphocyte counts (ALC) >30% lower than baseline or absolute CD4 count <250 cells/μL post-siplizumab treatment were followed prospectively for up to 5.25 years from last siplizumab dose for occurrence of selected medically important events: infection, malignancy, and autoimmune diseases.Results: Five selected medical events were reported: cholecystitis, colitis, myelofibrosis, encephalitis, and bronchitis; first three met serious adverse event criteria, none were considered siplizumab-related. Repletion of ALC to normal levels occurred in 53% of subjects within 2 years after treatment cessation.Conclusion: Preselected medically important events were uncommon in subjects with siplizumab-induced lymphocyte depletion. This study was funded by MedImmune, LLC.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"248 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134333376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Epithelioid Cell Histiocytoma: a Case Report and Brief Review of the Literature, with an Emphasis on Differential Diagnosis 上皮样细胞组织细胞瘤:1例报告及文献回顾，并着重于鉴别诊断

The Internet Journal of Dermatology Pub Date : 2008-12-31 DOI: 10.5580/28b

D. Sarma, S. Repertinger

引用次数: 1