Journal of Investigative Medicine最新文献_第3页

Research on iron regulatory erythroid factors in children with β-thalassemia. EXPRESS: β-地中海贫血儿童铁调控红系因子的研究。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-18 DOI: 10.1177/10815589251331618

Yaxuan Cao, Ken Huang, Jianming Luo

{"title":"Research on iron regulatory erythroid factors in children with β-thalassemia.","authors":"Yaxuan Cao, Ken Huang, Jianming Luo","doi":"10.1177/10815589251331618","DOIUrl":"10.1177/10815589251331618","url":null,"abstract":"To investigate the differences in relative mRNA expression levels of the novel iron regulatory erythroid factors FAM210B, CCDC115, HO-1, PCBP1, PCBP2, NCOA4, and Nrf2 in children with β-thalassemia major (β-TM) before and after transfusion therapy. A total of 98 children with transfusion-dependent β-thalassemia were recruited from the First Affiliated Hospital of Guangxi Medical University between October 2022 and May 2023. The children were classified based on their hemoglobin (Hb) levels: 57 cases with Hb ≤ 90 g/L and 41 cases with Hb > 90 g/L. Real-time fluorescence quantitative PCR was employed to assess the relative mRNA expression between the groups. The mRNA expression levels of FAM210B, HO-1, and NCOA4 were significantly higher in the Hb ≤ 90 g/L group compared to the Hb > 90 g/L group (p < 0.05). Moreover, higher relative expression levels of FAM210B and NCOA4 correlated with an increased likelihood of requiring blood transfusions in β-TM children. The differences in the remaining factors did not reach statistical significance. FAM210B and NCOA4 may serve as indicators of erythropoiesis and the degree of anemia in children with β-TM. Further research is warranted to explore their potential as therapeutic targets for β-thalassemia and other erythropoietic disorders.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"409-417"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing different viral strains in identifying risk factors for the development of venous thromboembolism in hospitalized COVID-19 patients. EXPRESS：比较不同病毒株对COVID-19住院患者静脉血栓栓塞发生危险因素的影响。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-02-20 DOI: 10.1177/10815589251320042

Harsimran Panesar, Ruchi Raval, Amber W Chan, Jana Tancredi, Gregory Simonian, David J O'Connor

{"title":"Comparing different viral strains in identifying risk factors for the development of venous thromboembolism in hospitalized COVID-19 patients.","authors":"Harsimran Panesar, Ruchi Raval, Amber W Chan, Jana Tancredi, Gregory Simonian, David J O'Connor","doi":"10.1177/10815589251320042","DOIUrl":"10.1177/10815589251320042","url":null,"abstract":"Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been nearly seven million deaths associated with COVID-19 and over thirteen billion total vaccine doses administered worldwide. This study aimed to evaluate the patient demographics and laboratory values that might help predict individuals at risk of having a deep vein thrombosis (DVT) formation while hospitalized with COVID-19. Focusing on the four major strains alongside the associated vaccination availability periods in the United States to devise risk stratification and management algorithms. This retrospective cohort study analyzed 4429 COVID-19-positive patients admitted to a single, tertiary care institution from March 2020 to February 2024 who underwent venous duplex ultrasound due to clinical suspicion. It was found that active chemotherapy treatment, higher weight (77.0 vs 84.0 kg), and longer LOS to first duplex (5 vs 10 days) were independent predictors of mortality. In addition, men, older age (68 vs 70 years old), medical history of DVTs, and longer LOS to first duplex (5 vs 8 days) were prognostic for DVT formation. More importantly, the prevalence of DVT was not statistically different between each COVID-19 wave, despite diminished mortality and morbidity over time. This study also demonstrated many non-predictive variables including COVID-19 as the principal diagnosis, BMI, smoking status, history of atrial fibrillation, stroke, CAD, vaccination status, and traditional laboratory values. Helping establish a critical foundation to analyze trends of anticoagulant and systemic corticosteroid use in this COVID-19 patient population.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"418-426"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applicant essays and recommendation letters in residency selection:How generative artificial intelligence is changing them. EXPRESS：住院医师选择中的申请人论文和推荐信：生成式人工智能如何改变它们。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-18 DOI: 10.1177/10815589251331614

Shigeki Matsubara

引用次数: 0

Peripheral ICOS+CD4 T cell frequency: An indicator for short-term progression in resectable advanced gastric cancer following platinum-based chemotherapy. 快讯外周 ICOS+CD4 T 细胞频率：铂类化疗后可切除晚期胃癌短期进展的指标。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-02 DOI: 10.1177/10815589251327133

Yu Zhang, Xiaodi Zhao, Zhiling Ma, Peng Wang, Sen Zhang, Jiaxin Li

{"title":"Peripheral ICOS+CD4 T cell frequency: An indicator for short-term progression in resectable advanced gastric cancer following platinum-based chemotherapy.","authors":"Yu Zhang, Xiaodi Zhao, Zhiling Ma, Peng Wang, Sen Zhang, Jiaxin Li","doi":"10.1177/10815589251327133","DOIUrl":"10.1177/10815589251327133","url":null,"abstract":"Peripheral frequency of inducible T cell co-stimulator (ICOS) + CD4 T cells is associated with early response to immunotherapy and prognosis in gastric cancer (GC); however, limited studies have clarified its association with chemotherapy response. This was a prospective, pilot study. A total of 120 participants with newly diagnosed GC were recruited; 50 advanced GC patients (T3-4N1-3M0-1) underwent curative surgery followed by platinum-based chemotherapy, and their prognosis and survival were assessed. The frequency of ICOS + CD4 T cells in the peripheral blood of each patient was examined using flow cytometry. The frequency of ICOS+CD4 T cells in stage III GC patients was significantly higher than that of stages I and II combined (p = 0.0204) and stage IV GC patients (p = 0.0117). In xenograft GC animals, a positive correlation was noted between the peripheral frequency of ICOS + CD4 and the tumor volume in mice (p = 0.0496). Co-culture experiments showed that the presence of GC cells increased the ratio of ICOS + CD4 T cells derived from peripheral blood in a dose-dependent manner. The initial peripheral frequency of ICOS + CD4 T cells in the GC progression-group was significantly lower than that in the stable-group after 3 months of platinum-based chemotherapy (p = 0.0318). High frequency of peripheral ICOS + CD4 was significantly positively correlated with peripheral IFN-γ concentration in tumor-bearing mice. The frequency of ICOS + CD4 serves as an index reflecting the tumor burden of GC. It effectively predicts the short-term progression risk for resectable advanced GC under platinum-based chemotherapy, primarily because it can reflect the basal immune status of the body.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"384-400"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of beta-blocker therapy in methamphetamine users with cardiovascular conditions. EXPRESS: β受体阻滞剂治疗甲基苯丙胺使用者心血管疾病的结果

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-04 DOI: 10.1177/10815589251327524

Anna Bjarvin, Sydney Cross, Stone Holtzman, Judy Kim, Janpreet Bhandohal, Baldeep Mann, Aslan GhandForoush, Fowrooz Joolhar

{"title":"Outcomes of beta-blocker therapy in methamphetamine users with cardiovascular conditions.","authors":"Anna Bjarvin, Sydney Cross, Stone Holtzman, Judy Kim, Janpreet Bhandohal, Baldeep Mann, Aslan GhandForoush, Fowrooz Joolhar","doi":"10.1177/10815589251327524","DOIUrl":"10.1177/10815589251327524","url":null,"abstract":"Methamphetamine use is associated with a range of cardiovascular conditions, including hypertension and heart failure. Beta-blocker use is commonly avoided when treating patients intoxicated with methamphetamines due to a fear of inducing unopposed alpha stimulation and worsening hypertension. We performed a retrospective review of medical records in a county hospital in California with a high prevalence of methamphetamine users. We included adults who tested positive for methamphetamines on urine toxicology, subjects who received beta-blockers within 48 h of their arrival were assigned to the case group, and those who received a non-beta-blocker antihypertensive or no antihypertensive were assigned to the control group. We compared the length of stay (LOS), readmission rate within 30 days, and systolic blood pressure (SBP) and diastolic blood pressure (DBP) between the groups at admission and 24 h. There was no significant difference between LOS and 30-day readmission rates between subjects who received beta-blockers and subjects who did not. Subjects who received carvedilol were compared to subjects in the control group who received another antihypertensive. SBP was significantly higher in the carvedilol group at admission, but there was no significant difference between groups after 24 h, and there was no significant difference in LOS. Treatment with beta-blockers in the case group did not increase LOS or readmission rates compared to the control group, and treatment with carvedilol effectively reduced SBP in patients with hypertension and methamphetamine-induced cardiomyopathy. Our results indicate that beta-blockers, particularly carvedilol, are an effective treatment modality in methamphetamine users.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"376-383"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Translational science and related disciplines". “转化科学及相关学科”的勘误表。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-04-16 DOI: 10.1177/10815589251335165

引用次数: 0

EXPRESS: Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus. 胰岛素分离联合地特胰岛素和二甲双胍对新诊断2型糖尿病患者胰岛功能的影响。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-02 DOI: 10.1177/10815589251335049

Hui Wang, Shang Li, Tianqi Zhao, Xixi Pan, Liangxue Wang

{"title":"EXPRESS: Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus.","authors":"Hui Wang, Shang Li, Tianqi Zhao, Xixi Pan, Liangxue Wang","doi":"10.1177/10815589251335049","DOIUrl":"https://doi.org/10.1177/10815589251335049","url":null,"abstract":"This trial evaluated the effects of insulin aspart (IAsp) combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus (T2DM).Newly diagnosed T2DM patients (n = 96) were randomly divided into the control group and study group, 48 cases in each group, and treated with insulin detemir + metformin or insulin detemir + metformin + IAsp, respectively. Clinical effect was assessed, and blood glucose, body mass index (BMI), fasting insulin (FINS), insulin dosage, and blood glucose standard time were recorded. The insulin resistance index (homeostasis model assessment of insulin resistance) and insulin function index (homeostasis model assessment-β) were calculated. Adverse reactions were recorded, and quality of life and sleep quality were assessed.The total effective rate of the study group was 95.83%, which was higher than that of the control group 79.17%. The study group had lower blood glucose, BMI, and FINS, less insulin dosage, and shorter blood glucose standard time. Moreover, the study group had lower insulin resistance index and higher insulin function index, as well as better quality of life and sleep quality. The incidence of adverse reactions exhibited no difference between the two groups.Insulin detemir + metformin + IAsp is effective in the treatment of T2DM, which can effectively improve insulin function and blood glucose index, reduce BMI and insulin dosage without increasing adverse reactions, and improve quality of life and sleep quality.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251335049"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization and perception of generative artificial intelligence by medical students in residency applications. EXPRESS：医学生在住院医师申请中对生成式人工智能的使用和感知。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-24 DOI: 10.1177/10815589251322102

Blake Smith, Tanya Ramadoss, Vanessa D'Amario, Mohammadali M Shoja, Vijay Rajput, Jorge Cervantes

{"title":"Utilization and perception of generative artificial intelligence by medical students in residency applications.","authors":"Blake Smith, Tanya Ramadoss, Vanessa D'Amario, Mohammadali M Shoja, Vijay Rajput, Jorge Cervantes","doi":"10.1177/10815589251322102","DOIUrl":"10.1177/10815589251322102","url":null,"abstract":"After completing medical school in the United States, most students apply to residency programs to progress in their training. The residency application process contains numerous writing sections, including the personal statement, curriculum vitae, and \"impactful experiences\" section. This study's purpose is to investigate the perception of third and fourth-year medical students on generative artificial intelligence (GenAI) and its influence on the residency application process. We developed a 13-question survey using the REDCap application to explore participants' educational background, year in school, preferred medical specialty, and perception of current or potential use of GenAI within residency applications. More than half of the responders have already used or plan to use GenAI for assistance in developing their personal statements for their applications. A considerable percentage (43.3%) will use GenAI to edit/modify a draft of the personal statement. More than half of survey participants believe that in the future, GenAI may alter the significance program directors place on letters of recommendation (LORs) in their selection criteria for deciding who to interview and select. Our survey results indicate that a number of students are either using or are receptive to the idea of using GenAI to draft or refine certain components of their residency application, such as the personal statement and impactful experiences section. As the application of GenAI expands, in-person interactions in the evaluation of candidates may become increasingly critical, and although personal statements and LORs are currently significant components of the residency application, their future roles remain a question.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"338-344"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the risk of heart failure increased in patients with inflammatory bowel disease? A meta-analysis. EXPRESS：炎症性肠病患者心力衰竭的风险增加了吗？一个荟萃分析。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-22 DOI: 10.1177/10815589251324837

Aman Goyal, Muhammad Daoud Tariq, Sonia Hurjkaliani, Adeena Maryyum, Kamya Thakkar, Tanya Thakur, Dushyant Singh Dahiya

引用次数: 0

Faculty should be cautiously optimistic about the role of generative AI in medical education. EXPRESS：教师应该对生成式人工智能在医学教育中的作用持谨慎乐观的态度。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1177/10815589251327523

Hongnan Ye

引用次数: 0