Journal of Investigative Medicine最新文献_第2页

Serum Talin-1 and Pentraxin-3 levels as biomarkers for vulnerable plaques in STEMI: Correlation with SYNTAX and Gensini scores. EXPRESS：血清Talin-1和pentaxin -3水平作为STEMI易损斑块的生物标志物：与句法和Gensini评分相关。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-08-01 Epub Date: 2025-04-02 DOI: 10.1177/10815589251333444

Rukiye Nar, Harun Akarsu, Gokay Nar, Sara Cetin Sanlialp, Gursel Sen, Isik Tekin

{"title":"Serum Talin-1 and Pentraxin-3 levels as biomarkers for vulnerable plaques in STEMI: Correlation with SYNTAX and Gensini scores.","authors":"Rukiye Nar, Harun Akarsu, Gokay Nar, Sara Cetin Sanlialp, Gursel Sen, Isik Tekin","doi":"10.1177/10815589251333444","DOIUrl":"10.1177/10815589251333444","url":null,"abstract":"Cardiovascular diseases, especially ischemic heart diseases, are the leading cause of death globally, highlighting the need for improved diagnostic tools for vulnerable plaques. This study aimed to evaluate the potential of soluble Talin-1 (sTalin-1) and Pentraxin-3 (PTX-3) as biomarkers in patients with ST-elevation myocardial infarction (STEMI). Conducted as a single-center observational study, it included 40 STEMI patients and 30 controls with normal coronary arteries. Serum levels of sTalin-1 and PTX-3 were measured using enzyme-linked immunosorbent assays (ELISA), and disease severity was assessed with SYNTAX and Gensini scores. Results showed that STEMI patients had significantly lower levels of sTalin-1 and higher levels of PTX-3 compared to controls. ROC curve analysis revealed an area under the curve (AUC) of 0.785 for sTalin-1 and 0.702 for PTX-3 in differentiating between STEMI patients and controls. While sTalin-1 demonstrated high specificity but low sensitivity, PTX-3 exhibited moderate sensitivity and specificity. Talin-1 levels negatively correlated with SYNTAX and Gensini scores, suggesting its role in assessing disease severity. These findings suggest that decreased serum levels of sTalin-1 and increased levels of PTX-3 in STEMI patients could serve as potential biomarkers for identifying vulnerable plaques and assessing disease severity. The study supports the potential use of sTalin-1 and PTX-3 in the diagnostic and prognostic evaluation of acute coronary syndromes.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"504-513"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenging biological samples and strategies for DNA extraction. EXPRESS：挑战生物样品和DNA提取策略。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-08-01 Epub Date: 2025-03-03 DOI: 10.1177/10815589251327503

Ajay K Rana

{"title":"Challenging biological samples and strategies for DNA extraction.","authors":"Ajay K Rana","doi":"10.1177/10815589251327503","DOIUrl":"10.1177/10815589251327503","url":null,"abstract":"Despite the significant progress of DNA profiling in forensic science, the extraction of DNA from challenging samples remains a formidable obstacle in forensic laboratories. Particularly, hard tissues (bones, teeth, hair, and nails), formalin-fixed tissues, and contaminated samples pose considerable difficulties. DNA extraction from such samples is often complicated, resulting in scanty, degraded, and contaminated DNA. Moreover, the presence of inhibitors from the surrounding environment further hinders DNA quantification and amplification, presenting additional challenges. This review article delves into the molecular basis of these challenges and examines the mechanistic principles underlying standard DNA extraction protocols. To overcome these obstacles, skilled efforts and additional pre-processing techniques are generally required before organic or silica column-based DNA extraction. Such techniques may involve scraping the waste, sample cleaning with detergents, disinfecting, demineralization of bones and teeth, long proteolytic enzyme treatment, in some cases, harsh methods like hot alkali treatment, tailored to the specific sample type. By addressing these challenges and understanding the molecular intricacies involved in DNA extraction, forensic scientists can improve the reliability and success rate of DNA analysis from difficult forensic samples. This review serves as a comprehensive resource for understanding the complexities of DNA extraction and offers potential solutions for recovering the DNA from highly challenging samples.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"443-459"},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric AML prognostication with an m6A-focused LASSO model. EXPRESS：以m6a为中心的Lasso模型预测儿童AML

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-08-01 Epub Date: 2025-04-04 DOI: 10.1177/10815589251334964

Jing Zhang, Taoli Suo, Yanli Cheng, Hongyu Shi, Haiyan Lu

引用次数: 0

Retraction: "Mir-3150B-3P Inhibits the Proliferation and Invasion of Cervical Cancer Cells by Targeting Tnfrsf11A". 撤稿：Mir-3150B-3P靶向Tnfrsf11A抑制宫颈癌细胞增殖和侵袭

IF 2 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-04-14 DOI: 10.1177/10815589251332430

引用次数: 0

Corrigendum to "GDF11 Level and Its Effect on Prognosis in Patients with Acute Myeloid Leukemia". “GDF11水平及其对急性髓性白血病患者预后的影响”的更正。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI: 10.1177/10815589251330477

引用次数: 0

Response to: Faculty should be cautiously optimistic about the role of generative AI in medical education. 对以下问题的回应：教师应该对生成式人工智能在医学教育中的作用持谨慎乐观的态度。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-28 DOI: 10.1177/10815589251333745

Jorge L Cervantes

引用次数: 0

Metformin: Its salutary effects beyond diabetes mellitus. 表达:二甲双胍;它的有益作用超越了糖尿病。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-03 DOI: 10.1177/10815589251327511

Khalid Sawalha, Nitesh Gautam, Kalaivani Sivakumar, Hakan Paydak, Jawaher L Mehta

引用次数: 0

Predictors for significant hepatic fibrosis in chronic HBV patients in daily clinical practice: A prospective study. EXPRESS：慢性HBV患者在日常临床实践中显著肝纤维化的预测因素：一项前瞻性研究。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-19 DOI: 10.1177/10815589251331892

Fadi Abu Baker, Saif Abu Mouch, Dorin Nicola, Randa Taher Natour, Oren Shibolet

{"title":"Predictors for significant hepatic fibrosis in chronic HBV patients in daily clinical practice: A prospective study.","authors":"Fadi Abu Baker, Saif Abu Mouch, Dorin Nicola, Randa Taher Natour, Oren Shibolet","doi":"10.1177/10815589251331892","DOIUrl":"10.1177/10815589251331892","url":null,"abstract":"Accurate knowledge of fibrosis levels is essential for effective treatment decisions and prognostication in chronic hepatitis B (CHB) infection. Current guidelines recommend liver biopsy and elastography as the most reliable methods for assessing fibrosis in CHB patients. However, these methods are not widely implemented due to the limited availability, high costs, and invasiveness of liver biopsy. Thus, we aimed to identify simple clinical predictors of significant liver fibrosis in CHB patients in daily practice. We prospectively recruited CHB patients to undergo shear wave elastography (SWE), abdominal ultrasound, and blood tests. In parallel, we extracted data on patient demographics, habits, medical backgrounds, medications, and CHB status and treatment. Multivariate logistic regression analyses were used to determine predictors of significant fibrosis. Of the 173 patients included in the final analysis, 40 (23.0%) had evidence of significant fibrosis on two-dimensional SWE. Age > 50 years (odds ratio (OR): 3.53; 95% confidence interval (CI): 1.34-9.25; p = 0.001), alanine aminotransferase > 40 (OR: 8.16; 95% CI: 4.6-15.3; p = 0.001), hepatitis B virus DNA> 2000 (OR: 9.20; 95% CI: 3.4-19.0; p < 0.001), concomitant diabetes mellitus (OR: 3.58; 95% CI: 1.89-5.49; p = 0.040), moderate-to-severe steatosis on ultrasound (OR: 4.50; 95% CI: 2.35-9.95; p = 0.014), and heavy smoking were independent predictors of significant fibrosis. In conclusion, we identified clinical and laboratory variables that may effectively identify CHB patients at high risk of significant fibrosis. These can aid in resource allocation in daily practice with limited resources.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"401-408"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to: Applicant essays and recommendation letters in residency selection: How generative artificial intelligence is changing them. 回应：住院医师选择中的申请人论文和推荐信：生成人工智能如何改变它们。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-28 DOI: 10.1177/10815589251333743

Jorge L Cervantes

引用次数: 0

Cer mortality in patients with systemic lupus erythematosus. EXPRESS：系统性红斑狼疮患者的癌症死亡率。

IF 1.9 4区医学

Journal of Investigative Medicine Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI: 10.1177/10815589251327522

Jia Yi Tan, Arya Mariam Roy, Michael Guma

{"title":"Cer mortality in patients with systemic lupus erythematosus.","authors":"Jia Yi Tan, Arya Mariam Roy, Michael Guma","doi":"10.1177/10815589251327522","DOIUrl":"10.1177/10815589251327522","url":null,"abstract":"Systemic lupus erythematosus (SLE) is linked with an increased risk of cancers, particularly hematologic malignancies. Cancer mortality among patients with SLE in the United States remains unclear. Our cross-sectional study sought to measure trends in cancer mortality among patients with SLE in the last two decades. Cancer deaths among patients with SLE from 1999 to 2020 were analyzed from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER). Age-adjusted mortality rates (AAMRs) per 1,000,000 individuals were measured. We used joinpoint trend analysis to determine the average annual percent change (AAPC) in AAMR trends. From 1999 to 2020, there were 2481 cancer deaths with comorbid SLE. Overall, the AAMRs of cancer among patients with SLE increased from 0.71 in 1999 to 1.19 per 1,000,000 individuals in 2020, with the AAPC at +1.19. Women had a higher AAMR from cancer death with comorbid SLE than men (1.39 vs 0.29 per 1,000,000 individuals). The highest AAMR was observed among African Americans (1.23 per 1,000,000 individuals), followed by Hispanics (0.61 per 1,000,000 individuals), Whites (0.58 per 1,000,000 individuals), and Asians (0.36 per 1,000,000 individuals). Those who lived in the West region and the rural region had the highest AAMR, respectively (0.69 vs 0.70 per 1,000,000 individuals). The three most common causes of cancer deaths were lung cancer (28.70%), breast cancer (8.83%), and non-Hodgkin lymphoma (4.96%). Cancer mortality in SLE patients has risen, with higher rates among African Americans, highlighting the need for targeted interventions.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"427-431"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0