Journal of Investigative Medicine最新文献_第2页

EXPRESS: Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus. 胰岛素分离联合地特胰岛素和二甲双胍对新诊断2型糖尿病患者胰岛功能的影响。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-02 DOI: 10.1177/10815589251335049

Hui Wang, Shang Li, Tianqi Zhao, Xixi Pan, Liangxue Wang

{"title":"EXPRESS: Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus.","authors":"Hui Wang, Shang Li, Tianqi Zhao, Xixi Pan, Liangxue Wang","doi":"10.1177/10815589251335049","DOIUrl":"https://doi.org/10.1177/10815589251335049","url":null,"abstract":"This trial evaluated the effects of insulin aspart (IAsp) combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus (T2DM).Newly diagnosed T2DM patients (n = 96) were randomly divided into the control group and study group, 48 cases in each group, and treated with insulin detemir + metformin or insulin detemir + metformin + IAsp, respectively. Clinical effect was assessed, and blood glucose, body mass index (BMI), fasting insulin (FINS), insulin dosage, and blood glucose standard time were recorded. The insulin resistance index (homeostasis model assessment of insulin resistance) and insulin function index (homeostasis model assessment-β) were calculated. Adverse reactions were recorded, and quality of life and sleep quality were assessed.The total effective rate of the study group was 95.83%, which was higher than that of the control group 79.17%. The study group had lower blood glucose, BMI, and FINS, less insulin dosage, and shorter blood glucose standard time. Moreover, the study group had lower insulin resistance index and higher insulin function index, as well as better quality of life and sleep quality. The incidence of adverse reactions exhibited no difference between the two groups.Insulin detemir + metformin + IAsp is effective in the treatment of T2DM, which can effectively improve insulin function and blood glucose index, reduce BMI and insulin dosage without increasing adverse reactions, and improve quality of life and sleep quality.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251335049"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sectional analysis of disability education in American Medical Schools. 美国医学院残疾教育的横断面分析。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-02 DOI: 10.1177/10815589251334961

Lauren Garrison, Tanner Mooney, Kendall Lucara, Sebastien Fuchs, Johannie M Spaan, Belinda McCully

{"title":"Cross-sectional analysis of disability education in American Medical Schools.","authors":"Lauren Garrison, Tanner Mooney, Kendall Lucara, Sebastien Fuchs, Johannie M Spaan, Belinda McCully","doi":"10.1177/10815589251334961","DOIUrl":"10.1177/10815589251334961","url":null,"abstract":"Greater than 25% of the American population has a disability. The demand for disability-informed physicians underscores the need to better prepare physicians to care for patients with disabilities. This study presents findings from three Qualtrics survey studies that investigated (1) medical students' exposure to patients with disabilities while on clinical rotations at Western University of Health Sciences, (2) students' perceived preparedness to care for patients with disabilities nationwide, and (3) the effectiveness of Special Olympics online modules to teach students about caring for patients with disabilities. Descriptive analysis from these studies together indicated that medical students did not feel prepared to care for patients with disabilities. To remedy this, Special Olympics online modules for healthcare professionals were found to effectively enhance student physician training. These findings highlight a critical need for improved medical training to prepare the next generation of physicians to care for patients with disabilities, while outlining a possible educational tool that could be incorporated into medical school curriculum.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251334961"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Talin-1 and Pentraxin-3 levels as biomarkers for vulnerable plaques in STEMI: Correlation with SYNTAX and Gensini scores. EXPRESS：血清Talin-1和pentaxin -3水平作为STEMI易损斑块的生物标志物：与句法和Gensini评分相关。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-02 DOI: 10.1177/10815589251333444

Rukiye Nar, Harun Akarsu, Gokay Nar, Sara Cetin Sanlialp, Gursel Sen, Isik Tekin

{"title":"Serum Talin-1 and Pentraxin-3 levels as biomarkers for vulnerable plaques in STEMI: Correlation with SYNTAX and Gensini scores.","authors":"Rukiye Nar, Harun Akarsu, Gokay Nar, Sara Cetin Sanlialp, Gursel Sen, Isik Tekin","doi":"10.1177/10815589251333444","DOIUrl":"10.1177/10815589251333444","url":null,"abstract":"Cardiovascular diseases, especially ischemic heart diseases, are the leading cause of death globally, highlighting the need for improved diagnostic tools for vulnerable plaques. This study aimed to evaluate the potential of soluble Talin-1 (sTalin-1) and Pentraxin-3 (PTX-3) as biomarkers in patients with ST-elevation myocardial infarction (STEMI). Conducted as a single-center observational study, it included 40 STEMI patients and 30 controls with normal coronary arteries. Serum levels of sTalin-1 and PTX-3 were measured using enzyme-linked immunosorbent assays (ELISA), and disease severity was assessed with SYNTAX and Gensini scores. Results showed that STEMI patients had significantly lower levels of sTalin-1 and higher levels of PTX-3 compared to controls. ROC curve analysis revealed an area under the curve (AUC) of 0.785 for sTalin-1 and 0.702 for PTX-3 in differentiating between STEMI patients and controls. While sTalin-1 demonstrated high specificity but low sensitivity, PTX-3 exhibited moderate sensitivity and specificity. Talin-1 levels negatively correlated with SYNTAX and Gensini scores, suggesting its role in assessing disease severity. These findings suggest that decreased serum levels of sTalin-1 and increased levels of PTX-3 in STEMI patients could serve as potential biomarkers for identifying vulnerable plaques and assessing disease severity. The study supports the potential use of sTalin-1 and PTX-3 in the diagnostic and prognostic evaluation of acute coronary syndromes.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251333444"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESS: Assessment of serum level of galectin-9 in systemic lupus erythematosus patients in Tanta university hospitals. EXPRESS：坦塔大学附属医院系统性红斑狼疮患者血清半凝集素-9水平的评估。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-02 DOI: 10.1177/10815589251333729

Aya Hamed Abdelgalil, Radwa Mahmoud Elsharaby, Salwa Elmorsy Abd ElGany, Wesam Salah Ibrahim

{"title":"EXPRESS: Assessment of serum level of galectin-9 in systemic lupus erythematosus patients in Tanta university hospitals.","authors":"Aya Hamed Abdelgalil, Radwa Mahmoud Elsharaby, Salwa Elmorsy Abd ElGany, Wesam Salah Ibrahim","doi":"10.1177/10815589251333729","DOIUrl":"https://doi.org/10.1177/10815589251333729","url":null,"abstract":"Background: galectin-9 (Gal-9) has a significant regulatory function in autoimmune disorders, including systemic lupus erythematosus (SLE). The objective of this study was to assess the blood levels of Galectin-9 in patients with SLE and investigate the correlation between the protein and disease activity.Methods: The study employed a case-control design involving 75 participants, aged between 25 and 55 years, representing both sexes, all of whom had been diagnosed with SLE and were either in a quiescent or active phase of the disease. Three equal groups of participants were created.Results: It was shown that Galectin-9 has 88% sensitivity and 80% specificity, with an area under the curve (AUC) of 0.901. With a computed positive predictive value of 81% and a negative predictive value of 87%, the total accuracy was 84%. Additionally, a strong positive connection (R=0.606) was found between anti-double strand DNA and Gal-9 levels, urea (R=0.482), creatinine (R=0.530), proteinuria (R=0.488), albumin-to-creatinine ratio (R=0.7) and SLEDAI (R=0.815) and there is negative correlation with hemoglobin (R=-0.772), white blood cells (R=-0.849), platelets (R=-0.481) and complement 3 (R=-0.578).Conclusions: Compared to healthy persons, patients with SLE had considerably higher serum concentrations of Gal-9. Patients without active illness did not have elevated levels of Gal-9; those with active SLE did. Moreover, Gal-9 showed a robust association with the activity of SLE illness, indicating a possible involvement in the onset of SLE.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251333729"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "GDF11 Level and Its Effect on Prognosis in Patients with Acute Myeloid Leukemia". “GDF11水平及其对急性髓性白血病患者预后的影响”的更正。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 DOI: 10.1177/10815589251330477

引用次数: 0

Utilization and perception of generative artificial intelligence by medical students in residency applications. EXPRESS：医学生在住院医师申请中对生成式人工智能的使用和感知。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-24 DOI: 10.1177/10815589251322102

Blake Smith, Tanya Ramadoss, Vanessa D'Amario, Mohammadali M Shoja, Vijay Rajput, Jorge Cervantes

{"title":"Utilization and perception of generative artificial intelligence by medical students in residency applications.","authors":"Blake Smith, Tanya Ramadoss, Vanessa D'Amario, Mohammadali M Shoja, Vijay Rajput, Jorge Cervantes","doi":"10.1177/10815589251322102","DOIUrl":"10.1177/10815589251322102","url":null,"abstract":"After completing medical school in the United States, most students apply to residency programs to progress in their training. The residency application process contains numerous writing sections, including the personal statement, curriculum vitae, and \"impactful experiences\" section. This study's purpose is to investigate the perception of third and fourth-year medical students on generative artificial intelligence (GenAI) and its influence on the residency application process. We developed a 13-question survey using the REDCap application to explore participants' educational background, year in school, preferred medical specialty, and perception of current or potential use of GenAI within residency applications. More than half of the responders have already used or plan to use GenAI for assistance in developing their personal statements for their applications. A considerable percentage (43.3%) will use GenAI to edit/modify a draft of the personal statement. More than half of survey participants believe that in the future, GenAI may alter the significance program directors place on letters of recommendation (LORs) in their selection criteria for deciding who to interview and select. Our survey results indicate that a number of students are either using or are receptive to the idea of using GenAI to draft or refine certain components of their residency application, such as the personal statement and impactful experiences section. As the application of GenAI expands, in-person interactions in the evaluation of candidates may become increasingly critical, and although personal statements and LORs are currently significant components of the residency application, their future roles remain a question.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"338-344"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the risk of heart failure increased in patients with inflammatory bowel disease? A meta-analysis. EXPRESS：炎症性肠病患者心力衰竭的风险增加了吗？一个荟萃分析。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-22 DOI: 10.1177/10815589251324837

Aman Goyal, Muhammad Daoud Tariq, Sonia Hurjkaliani, Adeena Maryyum, Kamya Thakkar, Tanya Thakur, Dushyant Singh Dahiya

引用次数: 0

Faculty should be cautiously optimistic about the role of generative AI in medical education. EXPRESS：教师应该对生成式人工智能在医学教育中的作用持谨慎乐观的态度。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1177/10815589251327523

Hongnan Ye

引用次数: 0

Implementation of telepsychiatry in an urban pediatric satellite emergency department. EXPRESS：远程精神病学在城市儿童卫星急诊科（ED）的实施。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-26 DOI: 10.1177/10815589251318621

Jillian E Nickerson, Alexandra Rucker, Molly Walker, Christopher Gable, Tanika Jones, Theresa Ryan Schultz, Shireen Atabaki

{"title":"Implementation of telepsychiatry in an urban pediatric satellite emergency department.","authors":"Jillian E Nickerson, Alexandra Rucker, Molly Walker, Christopher Gable, Tanika Jones, Theresa Ryan Schultz, Shireen Atabaki","doi":"10.1177/10815589251318621","DOIUrl":"10.1177/10815589251318621","url":null,"abstract":"While pediatric mental health emergencies are increasing in frequency and severity, psychiatric resources remain concentrated in tertiary care facilities. Telepsychiatry has successfully mitigated these challenges in rural emergency departments (EDs), suggesting potential benefits for urban EDs that lack psychiatric resources. We implemented telepsychiatry in an urban ED to reduce ED length of stay and the need for transferring pediatric patients with mental and behavioral health complaints. We conducted a retrospective review of patients aged 0-17 presenting from July 1, 2018 to May 31, 2020 (PRE-intervention) and from June 1, 2020 to June 30, 2023 (POST-intervention) for psychiatric evaluation, suicidal ideation, homicidal ideation, behavioral issues, intentional ingestion, or altered mental status. Our outcomes of interest were ED length of stay, proportion transferred, and proportion with a repeat visit within 30 days for a mental health complaint. There were 199 patients; 74 PRE and 125 POST. Post-intervention, 91% (114 patients) were evaluated completely via telepsychiatry; thus only 11 (9%) required transfer. The median age was 14 years (range 8-17). The most common complaints were suicidal ideation, intentional ingestion, and behavioral problems. Seventy-four percent of patients (n = 84) evaluated by telepsychiatry were discharged from the satellite ED. The median length of stay decreased significantly from 473 min (95% CI: 431-733) to 275 min (95% CI: 316-462) after implementation. Repeat visits for mental health complaints within 30 days decreased from 23% to 10%. Implementing a telepsychiatry evaluation program in an urban pediatric satellite ED reduced transfers and decreased patient length of stay.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"345-352"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The American Federation for Medical Research maintains commitment to decades of support of vaccine and vaccination research to improve public health. 快讯：美国医学研究联合会坚持几十年来对疫苗和疫苗接种研究的支持，以改善公众健康。

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1177/10815589251327504

Zanthia Wiley, Sidharth Mahapatra, Gaurav Agarwal, Stephanie Baer, Syed Bukhari, Jorge Cervantes, Ricardo Correa, Steven Crosby, Samrat Das, Joshua De Leon, John Dickinson, Janice P Dutcher, Sebastien Fuchs, Andrea Hahn, Octavian C Ioachimescu, Sheetal Kandiah, Mimi S Kim, Anupam Kotwal, Richard McCallum, Christina A Muzny, Viranuj Sueblinvong, Jeffrey Salomon, David A Stevenson, Attaya Suvannasankha, Laneshia K Tague, Theo Trandafirescu, Peter H Wiernik

引用次数: 0