Journal of Investigative Medicine最新文献

EXPRESS: Spexin as a Potential Biomarker for Autoimmune Inflammation in Graves' Disease.

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-04 DOI: 10.1177/10815589251335050

Betul Cigdem Yortanli, Ummugulsum Can, Mehmet Yortanlı, Korhan Kollu, Selma Ozlem Celikdelen, Gulsum Tugce Catak, Oguzhan Aksu, Muhammet Kızılarslanoglu

{"title":"EXPRESS: Spexin as a Potential Biomarker for Autoimmune Inflammation in Graves' Disease.","authors":"Betul Cigdem Yortanli, Ummugulsum Can, Mehmet Yortanlı, Korhan Kollu, Selma Ozlem Celikdelen, Gulsum Tugce Catak, Oguzhan Aksu, Muhammet Kızılarslanoglu","doi":"10.1177/10815589251335050","DOIUrl":"https://doi.org/10.1177/10815589251335050","url":null,"abstract":"Graves' disease (GD) is an autoimmune thyroid disorder characterized by excessive thyroid hormone production driven by thyroid-stimulating hormone receptor antibodies (TRAb). This study aimed to investigate the relationship between serum spexin (SPX) levels, TRAb levels, thyroid ultrasound findings, and metabolic parameters in GD patients, while evaluating SPX as a potential biomarker for autoimmune inflammation. A prospective, single-center study included 45 GD patients and 45 healthy controls. Serum TSH, fT3, fT4, anti-thyroglobulin, anti-thyroid peroxidase, TRAb, and SPX levels were measured. Thyroid ultrasonography classified patients into mild, moderate, and high heterogeneity groups. SPX levels were significantly higher in GD patients compared to controls (p < .001) and showed a strong positive correlation with TRAb levels (r = .579, p < .001) and thyroid heterogeneity (p < .001). Newly diagnosed patients (<6 months) exhibited the highest SPX levels, which decreased with prolonged disease duration. Receiver Operating Characteristic (ROC) analysis identified a cutoff value of 105 pg/mL for SPX, yielding 60% sensitivity and 91.1% specificity (AUC: 0.765, p < .001). SPX levels were also inversely correlated with disease duration and positively associated with inflammatory markers, suggesting its utility in monitoring disease activity and progression. These findings highlight SPX as a novel biomarker for assessing disease severity and autoimmune inflammation in GD. Incorporating SPX measurements into clinical practice may aid in early diagnosis, disease stratification, and therapeutic monitoring, ultimately improving personalized care for GD patients.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251335050"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESS: Pediatric AML Prognostication with an m6A-Focused Lasso Model.

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-04 DOI: 10.1177/10815589251334964

Jing Zhang, Taoli Suo, Yanli Cheng, Hongyu Shi, Haiyan Lu

{"title":"EXPRESS: Pediatric AML Prognostication with an m6A-Focused Lasso Model.","authors":"Jing Zhang, Taoli Suo, Yanli Cheng, Hongyu Shi, Haiyan Lu","doi":"10.1177/10815589251334964","DOIUrl":"https://doi.org/10.1177/10815589251334964","url":null,"abstract":"Acute myeloid leukemia (AML) presents varying prognoses in pediatric and adult patients, with dysregulated m6A-related genes playing a pivotal role in its pathogenesis. Through an analysis of single-cell RNA sequencing data from the Gene Expression Omnibus, we uncovered distinct patterns of m6A gene expression specific to pediatric AML cases. Additionally, we devised a Lasso risk regression model to evaluate prognosis within different AML subsets, showcasing the clinical utility of m6A-related genes in predicting AML outcomes. Our study underscores the unique and significant m6A gene expression profiles observed in pediatric AML, emphasizing their potential relevance in prognostic assessment. The demonstrated effectiveness of the Lasso risk regression model further underscores the importance of m6A-related genes as valuable predictors of AML outcomes. These findings not only unveil novel insights into the prognostic implications of m6A-related genes in pediatric AML but also advocate for their application as prognostic markers to enhance personalized treatment strategies in both pediatric and adult AML populations.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251334964"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESS: Cross sectional analysis of disability education in American medical schools.

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-02 DOI: 10.1177/10815589251334961

Lauren Garrison, Tanner Mooney, Kendall Lucara, Sebastien Fuchs, Johannie Spaan, Belinda McCully

引用次数: 0

EXPRESS: Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus.

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-02 DOI: 10.1177/10815589251335049

Hui Wang, Shang Li, Tianqi Zhao, Xixi Pan, Liangxue Wang

{"title":"EXPRESS: Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus.","authors":"Hui Wang, Shang Li, Tianqi Zhao, Xixi Pan, Liangxue Wang","doi":"10.1177/10815589251335049","DOIUrl":"https://doi.org/10.1177/10815589251335049","url":null,"abstract":"This trial evaluated the effects of insulin aspart (IAsp) combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus (T2DM).Newly diagnosed T2DM patients (n = 96) were randomly divided into the control group and study group, 48 cases in each group, and treated with insulin detemir + metformin or insulin detemir + metformin + IAsp, respectively. Clinical effect was assessed, and blood glucose, body mass index (BMI), fasting insulin (FINS), insulin dosage, and blood glucose standard time were recorded. The insulin resistance index (homeostasis model assessment of insulin resistance) and insulin function index (homeostasis model assessment-β) were calculated. Adverse reactions were recorded, and quality of life and sleep quality were assessed.The total effective rate of the study group was 95.83%, which was higher than that of the control group 79.17%. The study group had lower blood glucose, BMI, and FINS, less insulin dosage, and shorter blood glucose standard time. Moreover, the study group had lower insulin resistance index and higher insulin function index, as well as better quality of life and sleep quality. The incidence of adverse reactions exhibited no difference between the two groups.Insulin detemir + metformin + IAsp is effective in the treatment of T2DM, which can effectively improve insulin function and blood glucose index, reduce BMI and insulin dosage without increasing adverse reactions, and improve quality of life and sleep quality.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251335049"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESS: Serum Talin-1 and Pentraxin-3 Levels as Biomarkers for Vulnerable Plaques in STEMI: Correlation with Syntax and Gensini Scores.

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-02 DOI: 10.1177/10815589251333444

Rukiye Nar, Harun Akarsu, Gokay Nar, Sara Cetin Sanlialp, Gursel Sen, Isik Tekin

{"title":"EXPRESS: Serum Talin-1 and Pentraxin-3 Levels as Biomarkers for Vulnerable Plaques in STEMI: Correlation with Syntax and Gensini Scores.","authors":"Rukiye Nar, Harun Akarsu, Gokay Nar, Sara Cetin Sanlialp, Gursel Sen, Isik Tekin","doi":"10.1177/10815589251333444","DOIUrl":"https://doi.org/10.1177/10815589251333444","url":null,"abstract":"Cardiovascular diseases, especially ischemic heart diseases, are the leading cause of death globally, highlighting the need for improved diagnostic tools for vulnerable plaques. This study aimed to evaluate the potential of soluble Talin-1 (sTalin-1) and Pentraxin-3 (PTX-3) as biomarkers in patients with ST-elevation myocardial infarction (STEMI). Conducted as a single-center observational study, it included 40 STEMI patients and 30 controls with normal coronary arteries. Serum levels of sTalin-1 and PTX-3 were measured using enzyme-linked immunosorbent assays (ELISA), and disease severity was assessed with Syntax and Gensini scores. Results showed that STEMI patients had significantly lower levels of sTalin-1 and higher levels of PTX-3 compared to controls. ROC curve analysis revealed an area under the curve (AUC) of 0.785 for sTalin-1 and 0.702 for PTX-3 in differentiating between STEMI patients and controls. While sTalin-1 demonstrated high specificity but low sensitivity, PTX-3 exhibited moderate sensitivity and specificity. Talin-1 levels negatively correlated with Syntax and Gensini scores, suggesting its role in assessing disease severity. These findings suggest that decreased serum levels of sTalin-1 and increased levels of PTX-3 in STEMI patients could serve as potential biomarkers for identifying vulnerable plaques and assessing disease severity. The study supports the potential use of sTalin-1 and PTX-3 in the diagnostic and prognostic evaluation of acute coronary syndromes.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251333444"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPRESS: Assessment of serum level of galectin-9 in systemic lupus erythematosus patients in Tanta university hospitals.

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-02 DOI: 10.1177/10815589251333729

Aya Hamed Abdelgalil, Radwa Mahmoud Elsharaby, Salwa Elmorsy Abd ElGany, Wesam Salah Ibrahim

{"title":"EXPRESS: Assessment of serum level of galectin-9 in systemic lupus erythematosus patients in Tanta university hospitals.","authors":"Aya Hamed Abdelgalil, Radwa Mahmoud Elsharaby, Salwa Elmorsy Abd ElGany, Wesam Salah Ibrahim","doi":"10.1177/10815589251333729","DOIUrl":"https://doi.org/10.1177/10815589251333729","url":null,"abstract":"Background: galectin-9 (Gal-9) has a significant regulatory function in autoimmune disorders, including systemic lupus erythematosus (SLE). The objective of this study was to assess the blood levels of Galectin-9 in patients with SLE and investigate the correlation between the protein and disease activity.Methods: The study employed a case-control design involving 75 participants, aged between 25 and 55 years, representing both sexes, all of whom had been diagnosed with SLE and were either in a quiescent or active phase of the disease. Three equal groups of participants were created.Results: It was shown that Galectin-9 has 88% sensitivity and 80% specificity, with an area under the curve (AUC) of 0.901. With a computed positive predictive value of 81% and a negative predictive value of 87%, the total accuracy was 84%. Additionally, a strong positive connection (R=0.606) was found between anti-double strand DNA and Gal-9 levels, urea (R=0.482), creatinine (R=0.530), proteinuria (R=0.488), albumin-to-creatinine ratio (R=0.7) and SLEDAI (R=0.815) and there is negative correlation with hemoglobin (R=-0.772), white blood cells (R=-0.849), platelets (R=-0.481) and complement 3 (R=-0.578).Conclusions: Compared to healthy persons, patients with SLE had considerably higher serum concentrations of Gal-9. Patients without active illness did not have elevated levels of Gal-9; those with active SLE did. Moreover, Gal-9 showed a robust association with the activity of SLE illness, indicating a possible involvement in the onset of SLE.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"10815589251333729"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "GDF11 Level and Its Effect on Prognosis in Patients with Acute Myeloid Leukemia".

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 DOI: 10.1177/10815589251330477

引用次数: 0

Utilization and perception of generative artificial intelligence by medical students in residency applications.

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-24 DOI: 10.1177/10815589251322102

Blake Smith, Tanya Ramadoss, Vanessa D'Amario, Mohammadali M Shoja, Vijay Rajput, Jorge Cervantes

{"title":"Utilization and perception of generative artificial intelligence by medical students in residency applications.","authors":"Blake Smith, Tanya Ramadoss, Vanessa D'Amario, Mohammadali M Shoja, Vijay Rajput, Jorge Cervantes","doi":"10.1177/10815589251322102","DOIUrl":"10.1177/10815589251322102","url":null,"abstract":"After completing medical school in the United States, most students apply to residency programs to progress in their training. The residency application process contains numerous writing sections, including the personal statement, curriculum vitae, and \"impactful experiences\" section. This study's purpose is to investigate the perception of third and fourth-year medical students on generative artificial intelligence (GenAI) and its influence on the residency application process. We developed a 13-question survey using the REDCap application to explore participants' educational background, year in school, preferred medical specialty, and perception of current or potential use of GenAI within residency applications. More than half of the responders have already used or plan to use GenAI for assistance in developing their personal statements for their applications. A considerable percentage (43.3%) will use GenAI to edit/modify a draft of the personal statement. More than half of survey participants believe that in the future, GenAI may alter the significance program directors place on letters of recommendation (LORs) in their selection criteria for deciding who to interview and select. Our survey results indicate that a number of students are either using or are receptive to the idea of using GenAI to draft or refine certain components of their residency application, such as the personal statement and impactful experiences section. As the application of GenAI expands, in-person interactions in the evaluation of candidates may become increasingly critical, and although personal statements and LORs are currently significant components of the residency application, their future roles remain a question.","PeriodicalId":16112,"journal":{"name":"Journal of Investigative Medicine","volume":" ","pages":"338-344"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the risk of heart failure increased in patients with inflammatory bowel disease? A meta-analysis.

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-02-22 DOI: 10.1177/10815589251324837

Aman Goyal, Muhammad Daoud Tariq, Sonia Hurjkaliani, Adeena Maryyum, Kamya Thakkar, Tanya Thakur, Dushyant Singh Dahiya

引用次数: 0

Faculty should be cautiously optimistic about the role of generative AI in medical education.

IF 2.5 4区医学

Journal of Investigative Medicine Pub Date : 2025-04-01 Epub Date: 2025-03-01 DOI: 10.1177/10815589251327523

Hongnan Ye

引用次数: 0