Journal of Infection and Chemotherapy最新文献

{"title":"The effect of pharmacist-led antimicrobial stewardship on antimicrobial use in an intensive care unit: a single-center, retrospective, observational study","authors":"Yoshihiro Nishita ,&nbsp;Natsuko Ishida ,&nbsp;Masatoshi Taga ,&nbsp;Ryoji Takata ,&nbsp;Yoshitsugu Iinuma ,&nbsp;Togen Masauji ,&nbsp;Junko Ishizaki","doi":"10.1016/j.jiac.2025.102898","DOIUrl":"10.1016/j.jiac.2025.102898","url":null,"abstract":"<div><h3>Purpose</h3><div>We investigated the long-term impact of an antimicrobial stewardship program (ASP) led by a dedicated intensive care unit (ICU) pharmacist belonging to an antimicrobial stewardship team (AST) on trends in antimicrobial use and patient outcomes.</div></div><div><h3>Methods</h3><div>This was a single-center, retrospective study of patients admitted in an open ICU. Days of therapy (DOT) and number of patients receiving antimicrobial drug (NAD) of carbapenems, anti-pseudomonal β-lactams and non-anti-pseudomonal β-lactams, and all-cause mortality at 28 days were compared between the pre-ASP period (April 2012 to March 2016) and post-ASP period (April 2016 to March 2024). We divided patients into the sepsis, non-sepsis, and non-infection groups and compared outcomes. De-escalation rates and number of days until de-escalation of carbapenems and anti-pseudomonal β-lactams were investigated in sepsis and non-sepsis cases.</div></div><div><h3>Results</h3><div>DOT decreased significantly for carbapenems, anti-pseudomonal and non-anti-pseudomonal β-lactams post-ASP. In sepsis cases, the number of days until de-escalation of carbapenems and anti-pseudomonal β-lactams significantly decreased post-ASP; the ICU pharmacist intervened in all cases for sepsis and non-sepsis post-ASP. DOT of carbapenems and anti-pseudomonal β-lactams decreased significantly in non-sepsis and non-infection cases post-ASP. NAD significantly decreased in patients treated with carbapenems, anti-pseudomonal β-lactams and non-anti-pseudomonal β-lactams post-ASP. In non-infection cases, NAD significantly decreased in patients treated with carbapenems, anti-pseudomonal β-lactams post-ASP. No significant difference occurred in all-cause mortality rate between groups.</div></div><div><h3>Conclusion</h3><div>ASP led by a pharmacist belonging to an AST in the open ICU contributed to long-term appropriate antimicrobial use of carbapenems and anti-pseudomonal β-lactams, and DOT for non-pseudomonal β-lactams.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102898"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145786750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition in nontuberculous mycobacterial pulmonary disease: A narrative review","authors":"Makoto Hayashi ,&nbsp;Takuya Yokoe ,&nbsp;Satoshi Matsukura","doi":"10.1016/j.jiac.2025.102886","DOIUrl":"10.1016/j.jiac.2025.102886","url":null,"abstract":"<div><div>The clinical outcomes of nontuberculous mycobacterial pulmonary disease (NTM-PD) are largely influenced by nutritional status. However, specific nutritional intervention strategies for NTM-PD have not been established, making management challenging. This narrative review summarizes the immunopathology associated with mycobacterial infection and the effects of malnutrition on immune responses. It further examines the clinical impact of malnutrition and the nutritional characteristics of patients with NTM-PD, highlighting the significance of nutritional intervention. Additionally, we review the current knowledge on nutritional therapy for NTM-PD, drawing insights from approaches used in related conditions. Although nutritional support may improve patient outcomes and is clearly needed, evidence regarding its effectiveness remains limited. Consequently, incorporating nutritional assessment and individualized intervention into comprehensive care currently represents the best clinical practice.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102886"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-biomarker integration in predicting bedaquiline treatment response among diabetic MDR-TB patients","authors":"Liqing Zhu ,&nbsp;Mengmeng Li ,&nbsp;Zhongjian Wang","doi":"10.1016/j.jiac.2025.102878","DOIUrl":"10.1016/j.jiac.2025.102878","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus significantly complicates multidrug-resistant tuberculosis (MDR-TB) treatment outcomes. This study investigated the predictive value of integrating bedaquiline pharmacokinetics, inflammatory markers, and glycemic parameters for treatment response in diabetic MDR-TB patients.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of 186 patients with MDR-TB and diabetes mellitus receiving bedaquiline-containing regimens from January 2019 to December 2023. Bedaquiline trough concentrations, inflammatory markers (CRP, IL-6, TNF-α), and glycemic indices (HbA1c, fasting glucose) were measured at baseline and during follow-up. The primary outcome was sputum culture conversion or clinical improvement at 6 months. Multivariate logistic regression identified predictors of treatment response, and a predictive model was developed using 70 % training and 30 % validation cohorts.</div></div><div><h3>Results</h3><div>Overall treatment response rate was 72.0 %. Responders demonstrated significantly higher bedaquiline trough concentrations and better glycemic control. The integrated predictive model incorporating bedaquiline concentration, baseline CRP, HbA1c, and HbA1c change achieved superior discrimination compared to individual biomarkers. Subgroup analysis revealed a critical interaction between glycemic control and drug exposure, with poor glycemic control patients showing 0 % response in the lowest bedaquiline quartile but 100 % response in higher quartiles.</div></div><div><h3>Conclusions</h3><div>Multi-biomarker integration effectively predicts bedaquiline treatment response in diabetic MDR-TB patients. The synergistic relationship between adequate drug exposure and glycemic control underscores the necessity for integrated therapeutic drug monitoring and diabetes management strategies in this high-risk population.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102878"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145634431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coverage and determinants of maternal RSV vaccination in Japan: A nationwide survey","authors":"Yusuke Okubo ,&nbsp;Risa Honjo ,&nbsp;Shinya Tsuzuki","doi":"10.1016/j.jiac.2025.102892","DOIUrl":"10.1016/j.jiac.2025.102892","url":null,"abstract":"<div><h3>Background</h3><div>Respiratory syncytial virus (RSV) is a major cause of pediatric lower respiratory tract infections worldwide, leading to substantial morbidity, hospitalizations, and healthcare costs. Maternal RSV vaccination has recently been introduced in several countries, yet in Japan its uptake remains unclear, particularly given the high out-of-pocket costs and potential socioeconomic disparities.</div></div><div><h3>Methods</h3><div>We conducted a nationwide survey of women who had given birth between July 2024 and August 2025. The questionnaire assessed maternal RSV vaccination status, its affordability, and related attitudes including the 5C model for vaccine hesitancy together with demographic characteristics. Vaccination coverage was estimated, and factors associated with uptake were analyzed using multivariable modified Poisson regression.</div></div><div><h3>Results</h3><div>Among 1279 respondents, 11.6 % had received maternal RSV vaccination. Coverage showed a clear income gradient within education strata. Uptake was lower in areas outside Kanto and among multiparous participants, and higher among those with infertility treatment, and vaccination with influenza or diphtheria-pertussis-tetanus during pregnancy. In 5C domains, confidence and collective responsibility aligned with higher uptake, whereas calculation aligned with lower uptake. Among vaccinated people, 87.2 % rated the cost as expensive. Among unvaccinated people, leading barriers were lack of awareness of benefit (28.9 %) and the vaccine itself (27.3 %); 77.5 % would accept vaccination only if no out-of-pocket payment were required.</div></div><div><h3>Conclusions</h3><div>Maternal RSV vaccination coverage in Japan was low and showed socioeconomic and regional disparities in uptake; limited awareness and high out-of-pocket payment were major barriers. Reducing out-of-pocket payments and standardizing provider recommendations could raise coverage and mitigate inequities.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102892"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplacental transfer of antibodies against pertussis and respiratory syncytial virus and follow-up after birth","authors":"Yukako Kosaka ,&nbsp;Takashi Ito ,&nbsp;Kyoko Hattori ,&nbsp;Ayumi Saito ,&nbsp;Yusuke Okuda ,&nbsp;Daigo Ochiai ,&nbsp;Kenji Ishikura ,&nbsp;Kazuhiko Katayama ,&nbsp;Tetsuo Nakayama","doi":"10.1016/j.jiac.2025.102877","DOIUrl":"10.1016/j.jiac.2025.102877","url":null,"abstract":"<div><h3>Objectives</h3><div>Maternal immunization is recommended through transplacental antibody transfer to protect newborn babies against respiratory syncytial virus (RSV) and pertussis. The objective of the study is to realize the current situation of maternal transfer of antibodies against RSV and pertussis before introduction of RSV maternal vaccine.</div></div><div><h3>Methods</h3><div>Maternal serum samples were taken from 421 pregnant women before delivery, and 366 paired umbilical cord blood samples were obtained. Pertussis toxin (PT) antibodies and neutralizing test (NT) antibodies against RSV were examined. Follow-up serum samples were obtained from 22 infants at 2 and 6 months, and one and 1.5 years after birth.</div></div><div><h3>Results</h3><div>RSV NT antibody was positive in all maternal sera and showed higher levels in umbilical cord blood, with a 1.31-fold increase. It decreased to 1/3 levels at 2 months and 1/8–9 levels at 6 months after birth in comparison with umbilical blood. Three subjects were considered RSV infection between 2 and 6 months after birth. The positive rate of PT antibody was approximately 30 % in pregnant women with extremely low levels, which decreased to undetectable at 2 months, increased at 6 months with routine immunization, decreased at one year, and increased at 1.5 years with a booster dose of pertussis-containing vaccine.</div></div><div><h3>Conclusion</h3><div>The transplacental transfer ratio was 1.31 for both RSV and pertussis antibodies. Transferred RSV NT decreased to 1/3 levels at 2 months and 1/8–9 levels at 6 months. PT antibody levels were undetectable until 2 months. The data suggests the critical role of maternal immunization.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102877"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145587606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between blood posaconazole concentration and serum potassium levels","authors":"Yuichi Shibata ,&nbsp;Nobuhiro Asai ,&nbsp;Mao Hagihara ,&nbsp;Hiroshige Mikamo","doi":"10.1016/j.jiac.2025.102868","DOIUrl":"10.1016/j.jiac.2025.102868","url":null,"abstract":"<div><h3>Background</h3><div>Some studies have suggested a correlation between posaconazole (PSCZ) concentration and efficacy in preventing fungal infections; the international guidelines recommend therapeutic drug monitoring. However, few studies have investigated the association between PSCZ concentration and its representative adverse effect of hypokalemia. This study aimed to measure serum PSCZ concentrations and investigate the relationship between this parameter and hypokalemia.</div></div><div><h3>Methods</h3><div>This study was conducted at Aichi Medical University Hospital. All patients in the hematology department who orally received PSCZ were included, wherein their trough serum concentrations (Cmins) of PSCZ were measured using high-performance liquid chromatography. Serum potassium levels were monitored for 60 days following PSCZ initiation. Hypokalemia was defined as serum potassium levels of &lt;3.0 mEq/L and ≥10.0 % decreases from baseline following PSCZ administration.</div></div><div><h3>Results</h3><div>A total of 24 patients were included. The incidence of hypokalemia was 41.7 %. The median PSCZ concentrations were comparable between patients who developed hypokalemia and those who did not (2.5 μg/mL vs 2.4 μg/mL, <em>p</em> = 0.98). In both groups, approximately 80 % of the patients (80.0 % vs. 78.6 %, <em>p</em> = 0.98) showed PSCZ concentrations below 4.0 μg/mL. No significant correlations were found between PSCZ Cmin and the rate of serum potassium level reduction (γ = −0.21, <em>p</em> = 0.32) or minimum potassium level (γ = −0.03, <em>p</em> = 0.88).</div></div><div><h3>Conclusions</h3><div>PSCZ might cause hypokalemia regardless of Cmin; clinicians in hematology should remain vigilant.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102868"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central nervous system cryptococcosis with brain stem hemorrhage during chemotherapy for pediatric acute myeloblastic leukemia patient","authors":"Sawa Tomomatsu ,&nbsp;Kozo Nagai ,&nbsp;Kanji Tsuruta ,&nbsp;Yoshito Honma ,&nbsp;Sanae Kawakami ,&nbsp;Fumihiro Ochi ,&nbsp;Eiichi Yamamoto","doi":"10.1016/j.jiac.2025.102876","DOIUrl":"10.1016/j.jiac.2025.102876","url":null,"abstract":"<div><div>Cryptococcosis is a deep-seated fungal disease caused by the fungus Cryptococcus neoformans and is known to be a rare occurrence in cancer patients during chemotherapy. A 10-year-old girl was diagnosed with acute myeloid leukemia (AML), and intensive chemotherapy was initiated following the JPLSG-AML-20 protocol. Complete remission was achieved after the first induction therapy. She reached nadir following the third consolidation chemotherapy and suffered from high-grade fever. Subsequently, right hemiplegia and left abducens nerve palsy appeared, and MRI revealed two loci of T1 low/T2 high intensity in the brain stem area. Cerebrospinal fluid (CSF) analysis did not show any common inflammatory findings, but cryptococcus neoformans was detected by a Biofire® FilmArray® meningitis/encephalitis (ME) panel. She received a combination of liposomal amphotericin B for six weeks and 5-fluorocytosine for four weeks as induction therapy, followed by maintenance therapy with fluconazole for 12 months. During recovery from bone marrow suppression, the patient developed immune reconstitution inflammatory syndrome (IRIS) accompanied by worsening headache and vomiting, which improved with steroids. Right hemiplegia gradually improved within a month and left abducens nerve palsy resolved at 4 months after initiation of treatment. We experienced an atypical case of cryptococcal meningoencephalitis presenting with stroke-like symptoms during intensive chemotherapy. When a central nervous system (CNS) infection occurs during neutropenia, abnormalities in the CSF examination are less likely to be detected. Multiplex genetic testing of CSF may be considered a useful diagnostic adjunct in immunocompromised patients with neurologic symptoms.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102876"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145584430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumbar-peritoneal shunt-associated meningitis and peritoneal abscess due to Corynebacterium striatum: A case report and literature review","authors":"Akiho Maeda ,&nbsp;Koji Hayashi ,&nbsp;Rina Izumi ,&nbsp;Yusuke Tsujigiwa ,&nbsp;Yuka Nakaya ,&nbsp;Yoshitomo Fukuoka ,&nbsp;Kohei Ueda ,&nbsp;Norichika Hashimoto","doi":"10.1016/j.jiac.2025.102895","DOIUrl":"10.1016/j.jiac.2025.102895","url":null,"abstract":"<div><div>We describe the first case of both a peritoneal abscess and a lumbar-peritoneal (LP) shunt infection related to <em>Corynebacterium striatum</em> (<em>C. striatum</em>). An 85-year-old Japanese male with a history of diabetes, hyperlipidemia, and a pulmonary vein isolation procedure for atrial fibrillation presented with urinary incontinence, gait disturbance, and cognitive decline. He was diagnosed with normal-pressure hydrocephalus (NPH) and underwent LP shunt surgery. Postoperatively, he developed pneumonia followed by an intra-abdominal abscess and bacterial meningitis. <em>C. striatum</em> was isolated from both cerebrospinal fluid (CSF) and intraperitoneal abscess. Despite antibiotic treatment including vancomycin, he developed septic shock and ultimately resulted in his death.</div><div>The LP shunt likely facilitated the entry of <em>C. striatum</em> into the CSF, resulting in meningitis and subsequent abscess formation. Despite appropriate antibiotic treatment including vancomycin, <em>C. striatum</em> infections can be resistant and lead to severe outcomes. This case highlights a new complication associated with <em>C. striatum</em>: bacterial meningitis and intraperitoneal abscesses via an LP shunt, expanding its clinical spectrum.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102895"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of invasive group B streptococcal infections in adults and older individuals in a super-aging society in Japan, 2016–2023","authors":"Hideaki Takahashi ,&nbsp;Haruko Miyazaki ,&nbsp;Yuki Watanabe ,&nbsp;Daisuke Kawahata ,&nbsp;Yutaka Nasu ,&nbsp;Misako Takata ,&nbsp;Hidemasa Nakaminami ,&nbsp;Hidehiro Watanabe ,&nbsp;Yuji Hirai ,&nbsp;Kimiko Ubukata ,&nbsp;Shigeki Nakamura","doi":"10.1016/j.jiac.2025.102897","DOIUrl":"10.1016/j.jiac.2025.102897","url":null,"abstract":"<div><h3>Background</h3><div>Group B <em>Streptococcus</em> (GBS), a commensal bacterium in the gastrointestinal tract, can cause invasive GBS (iGBS) infections, particularly in older adults with underlying comorbidities. We determined the relationship between mortality and host-related or virulence factors in older adults with iGBS infections.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 105 cases of iGBS infection treated between January 2016 and October 2023 at Tokyo Medical University Hospital and two affiliated hospitals. The association between patient outcomes and demographics, underlying diseases, clinical manifestations, medical treatment, biomarkers, antimicrobial agents used at admission, and capsular type of GBS isolates was examined.</div></div><div><h3>Results</h3><div>The median age of the patients was 78 years (interquartile range, 64–85 years), and 89.5 % had underlying comorbidities, such as diabetes, chronic kidney disease, and malignancies. Common clinical manifestations include skin and soft tissue infections, bacteremia, and urosepsis. The overall mortality rate was 11.4 %. White blood cell (WBC) counts (breakpoint,10 × 10³/μL) on admission were significantly lower in fatal cases (<em>P</em> &lt; 0.001; odds ratio, 9.6), but no significant differences were observed for other biomarkers. The Kaplan–Meier estimate of 28-day survival was associated with WBC count (<em>P</em> &lt; 0.001). The most common capsular type was Ib, followed by type V. Levofloxacin resistance was predominantly identified in type Ib. No significant association was found between capsular type and mortality rates.</div></div><div><h3>Conclusion</h3><div>Effective prevention of iGBS infections in older individuals requires large-scale surveillance, including environmental factors, and the development of comprehensive and multifaceted prevention strategies for high-risk older populations.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102897"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RSV epidemiology in Italian adults over 60: a multicenter cross-sectional study","authors":"Federica Novazzi ,&nbsp;Laura Pellegrinelli ,&nbsp;Federica A.M. Giardina ,&nbsp;Carla Acciarri ,&nbsp;Stefano Menzo ,&nbsp;Elisa Vian ,&nbsp;Valeria Biscaro ,&nbsp;Giulia Piccirilli ,&nbsp;Tiziana Lazzarotto ,&nbsp;Sara Uceda Renteria ,&nbsp;Annapaola Callegaro ,&nbsp;Guglielmo Ferrari ,&nbsp;Elisabetta Pagani ,&nbsp;Elisa Masi ,&nbsp;Cristina Galli ,&nbsp;Claudia Tiberio ,&nbsp;Martina Esposito ,&nbsp;Alessandra Pierangeli ,&nbsp;Guido Antonelli ,&nbsp;Eleonora Lalle ,&nbsp;Matteo Fracella","doi":"10.1016/j.jiac.2025.102881","DOIUrl":"10.1016/j.jiac.2025.102881","url":null,"abstract":"<div><h3>Objective</h3><div>Respiratory syncytial virus (RSV) infections have a significant impact on public health, particularly among children and the elderly. However, the burden on older adults in Italy is underestimated due to a lack of comprehensive data.</div></div><div><h3>Methods</h3><div>Data on the molecular detection of RSV in respiratory samples from laboratories across Italy, from north to south, between September 2021 and May 2023 were collected and analyzed.</div></div><div><h3>Results</h3><div>A total of 138,783 tests were provided by 13 laboratories, with an overall RSV positivity rate of 6.4 %. Among adults aged ≥60 years (35.4 % of the total), the RSV positivity rate was 3.5 %. Two epidemic waves were observed, peaking in December 2021 and January 2023, with the second wave showing a higher number of cases. RSV subtyping revealed that RSV-B was the predominant subtype in both epidemic seasons, compared to RSV-A.</div></div><div><h3>Conclusion</h3><div>Analyses of RSV circulation in older adults highlight seasonal variability and underscore the importance of testing in this population. These findings may inform surveillance, clinical management, and the development of future preventive strategies, including vaccination.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"32 1","pages":"Article 102881"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145677998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}