Journal of Evidence‐Based Medicine最新文献

{"title":"Expert Consensus on Perioperative Physician–Pharmacist Airway Co-Management","authors":"Dongmei Meng,&nbsp;Yuan Qiu,&nbsp;Shiyue Li,&nbsp;Jun Liu,&nbsp;Lunxu Liu,&nbsp;Qiang Pu,&nbsp;Zhen You,&nbsp;Lan Lan,&nbsp;Dehui Chen,&nbsp;Guoying Wang,&nbsp;Ping Wang,&nbsp;Xiaowen Zhang,&nbsp;Hui Xie,&nbsp;Yuwen He,&nbsp;Suzhen He,&nbsp;Zhihua Zheng,&nbsp;Li Wei,&nbsp;Jun Zhao,&nbsp;Jianguo Zhu,&nbsp;Hui Tian,&nbsp;Anchang Liu,&nbsp;Chuangqi Chen,&nbsp;Kejing Tang,&nbsp;Gening Jiang,&nbsp;Yuping Li,&nbsp;Gang Jin,&nbsp;Zheng Jiao,&nbsp;Jian Hu,&nbsp;Sheng Yan,&nbsp;Haibin Dai,&nbsp;Qiang Zhang,&nbsp;Yong Cui,&nbsp;Xingang Li,&nbsp;Zhigang Zhao,&nbsp;Daqiang Sun,&nbsp;Libing Ma,&nbsp;Yingtong Zeng,&nbsp;Dan Guo,&nbsp;Lei Zhang,&nbsp;Li Wei,&nbsp;Jianxing He","doi":"10.1111/jebm.70008","DOIUrl":"https://doi.org/10.1111/jebm.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Airway management during the perioperative period is a vital component of perioperative care. However, there is a lack of consensus on the selection of medications, timing of administration, and the management of airway complications. This consensus aimed to promote a more rational and standardized application of airway management medications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Clinical medical and pharmaceutical experts were invited to participate in this study using the modified Delphi method. Participants completed two rounds of online surveys, with the second round based on the responses from the first round.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants (<i>n</i> = 42) reached a consensus on 11 clinical issues and formed 11 recommendations for clinical practice, each with a consensus degree of more than 80%. The recommendations covered aspects of preoperative, intraoperative, and postoperative risk factors evaluation, along with crucial points of medication monitoring in preventing and treating perioperative pulmonary complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The modified Delphi method resulted in consensus recommendations for the perioperative physician–pharmacist airway co-management. We hope this consensus will prevent pulmonary complications and improve patient outcomes through collaborative discussions between physicians and pharmacists.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Icebergs in Evidence-Based Medicine","authors":"José Nunes de Alencar","doi":"10.1111/jebm.70028","DOIUrl":"https://doi.org/10.1111/jebm.70028","url":null,"abstract":"","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesizing Public Health Preparedness Mechanisms for High-Impact Infectious Disease Threats: A Jurisdictional Scan","authors":"KM Saif-Ur-Rahman,&nbsp;Nikita N. Burke,&nbsp;Lena Murphy,&nbsp;Randal Parlour,&nbsp;Máirín Boland,&nbsp;Petek Eylul Taneri,&nbsp;Bearach Reynolds,&nbsp;Mary Horgan,&nbsp;John N. Lavis,&nbsp;Declan Devane","doi":"10.1111/jebm.70019","DOIUrl":"https://doi.org/10.1111/jebm.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>High-impact infectious diseases pose major global health challenges, underscoring the urgent need for robust public health preparedness. Despite efforts to improve global health security, recent pandemics have revealed significant weaknesses in health systems’ preparedness and response capabilities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We reviewed and synthesized key strategies and lessons from existing public health preparedness plans for high-impact infectious diseases. This included examining national and global plans, focusing on strategic approaches, evidence integration, and real-world implementation lessons. A narrative synthesis, based on the Public Health Emergency Preparedness (PHEP) model, identified effective practices and areas needing improvement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We screened 1987 documents, selecting 38 for detailed analysis. Findings highlighted strategies for long-term health emergency preparedness, workforce development, enhancing global health frameworks, and investing in infrastructure. Challenges included maintaining laboratory detection, managing sentinel surveillance, and logistical issues. Effective approaches emphasized early threat detection, rapid response, healthcare capacity, medical supply management, and strategic communication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Effective public health preparedness for high-impact infectious diseases requires a coordinated approach, including early threat detection, rapid response, robust healthcare systems, and strategic communication. Past outbreaks show the need for continuous investment, evidence-based policies, and adaptable health systems. Future research should assess ongoing preparedness efforts and implementation challenges.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jebm.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Most Recent Research Advancements of AI in the Area of Evidence-Based Science: Analyses Based on the Global Evidence Summit 2024","authors":"Jie Zhang,&nbsp;Xufei Luo,&nbsp;Meihua Wu,&nbsp;Zijing Wang,&nbsp;Luyuan Sun,&nbsp;Shiyue Zhou,&nbsp;Qianling Shi,&nbsp;Yaolong Chen,&nbsp;the ADVANCED Working Group","doi":"10.1111/jebm.70027","DOIUrl":"https://doi.org/10.1111/jebm.70027","url":null,"abstract":"","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Manual to Machine: Revolutionizing Day Surgery Guideline and Consensus Quality Assessment With Large Language Models","authors":"Xingyu Wan,&nbsp;Ruiyan Wang,&nbsp;Junxian Zhao,&nbsp;Tianhu Liang,&nbsp;Bingyi Wang,&nbsp;Jie Zhang,&nbsp;Yujia Liu,&nbsp;Yan Ma,&nbsp;Yaolong Chen,&nbsp;Xinghua Lv","doi":"10.1111/jebm.70017","DOIUrl":"https://doi.org/10.1111/jebm.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the methodological and reporting quality of clinical practice guidelines/expert consensus for ambulatory surgery centers published since 2000, combining manual assessment with large language model (LLM) analysis, while exploring LLMs' feasibility in quality evaluation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We systematically searched Chinese/English databases and guideline repositories. Two researchers independently screened literature and extracted data. Quality assessments were conducted using AGREE II and RIGHT tools through both manual evaluation and GPT-4o modeling.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>54 eligible documents were included. AGREE II domains showed mean compliance: Scope and purpose 25.00%, Stakeholder involvement 20.16%, Rigor of development 17.28%, Clarity of presentation 41.56%, Applicability 18.06%, Editorial independence 26.39%. RIGHT items averaged: Basic information 44.44%, Background 36.11%, Evidence 14.07%, Recommendations 34.66%, Review and quality assurance 3.70%, Funding and declaration and management of interests 24.54%, Other information 27.16%. LLMs'-evaluated documents demonstrated significantly higher scores than manual assessments in both tools. Subgroup analyses revealed superior quality in documents with evidence retrieval, conflict disclosure, funding support, and LLM integration (<i>P</i> &lt;0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Current guidelines and consensus related to day surgery need to improve their methodological quality and quality of reporting. The study validates LLMs' supplementary value in quality assessment while emphasizing the necessity of maintaining manual evaluation as the foundation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jebm.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Empowered Evidence-Based Research and Clinical Decision-Making","authors":"Xufei Luo,&nbsp;Long Ge,&nbsp;Lu Zhang,&nbsp;Yaolong Chen,&nbsp;Liang Du,&nbsp;ADVANCED working group","doi":"10.1111/jebm.70014","DOIUrl":"https://doi.org/10.1111/jebm.70014","url":null,"abstract":"","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication Management in Patients With Polypharmacy in Primary Care: A Scoping Review of Clinical Practice Guidelines","authors":"Loes Engels,&nbsp;Marjan van den Akker,&nbsp;Petra Denig,&nbsp;Henri Stoffers,&nbsp;Heike Gerger,&nbsp;Jolijn Bohnen,&nbsp;Jesse Jansen","doi":"10.1111/jebm.70015","DOIUrl":"10.1111/jebm.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Inappropriate polypharmacy increases the risk of medication-related issues. Adequate management of polypharmacy is a challenge involving different healthcare professionals, complex decision-making and ideally including patient involvement. The objective of this scoping review was to provide an overview of national recommendations for medication management of patients with polypharmacy in primary care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A scoping review of clinical practice guidelines focusing on medication management in adults with polypharmacy, applicable to primary care was performed. Databases (G-I-N, Turning Research into Practice and PubMed), network, and a global report were screened for guidelines published after 2000 in English, Dutch, German, Spanish, French, or Russian. Raw data were extracted in duplicate using an extraction framework focusing on strategies, involvement of professionals, patient involvement, and implementation. Qualitative content analysis was used. Guideline quality was assessed using AGREE-II. The study was registered with the Open Science Framework.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight guidelines originating from eight countries were included. The most common recommended strategy was a medication review conducted by a general practitioner and/or a community pharmacist. Tasks and target population differed per guideline. Most guidelines recommended involving the patient in the process, mostly to elicit the patient's experiences and treatment goals. Few guidelines included advice on the implementation of recommendations. Three out of eight guidelines were of good quality (AGREE-II score &gt;70% in 5/6 domains).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Most guidelines recommended a medication review, with patient involvement, as a strategy for medication management in polypharmacy in primary care. Guidance on task division and implementation of guidelines in practice was less clear. This review illustrates room for guideline improvements.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Risk Factors and Development of a Prediction Model for Intraoperative Cerebrospinal Fluid Leakage During Transsphenoidal Pituitary Adenoma Surgery","authors":"Jie Wang,&nbsp;Zhuoyuan Li,&nbsp;Yunfeng Wang,&nbsp;Zheng Peng,&nbsp;Xiaojian Li,&nbsp;Chunlei Chen,&nbsp;Huiying Yan,&nbsp;Wei Jin,&nbsp;Fang Wang,&nbsp;Lu Chen,&nbsp;Chunhua Hang,&nbsp;Wei Li","doi":"10.1111/jebm.70013","DOIUrl":"https://doi.org/10.1111/jebm.70013","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Cerebrospinal fluid (CSF) leakage may occur during transsphenoidal resection of pituitary adenomas, with implications for patient prognosis. However, although the risk factors for intraoperative CSF leakage have been widely studied and continuously explored, there are still some unknown factors that play a role.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective study was conducted by collecting clinical data from 281 patients who underwent transsphenoidal resection of pituitary adenoma at Nanjing Drum Tower Hospital between October 2020 and October 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed CSF leakage occurred in 60 (21.4%) patients. In the univariate analysis, we found that tumor anteroposterior diameter (<i>p</i> = 0.024), hepatic insufficiency (<i>p</i> = 0.004), tough tumor texture (<i>p</i> &lt; 0.001), and surgical protocol as complete removal (<i>p</i> = 0.01) significantly predicted the occurrence of CSF leakage. In the univariate analysis, we found that anteroposterior diameter was associated with the occurrence of intraoperative CSF leakage compared with another diameter (<i>p</i> = 0.04), indicating that the probability of CSF leakage significantly increased at the anteroposterior diameter of pituitary adenoma ≥2 cm. We included anteroposterior tumor diameter, hepatic insufficiency, complete removal, and tumor tough texture together in a multifactorial logistic regression analysis and produced a nomogram graph based on the results. In the multifactorial logistic regression analysis, the anteroposterior tumor diameter, tumor tough texture, hepatic insufficiency, and the surgical option of complete removal predicted intraoperative CSF leakage with an AUC of 0.804.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This provides a reference for assessing the risk of CSF leakage in patients before and early in the surgical procedure and may have clinical implications for better patient treatments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statistical Analysis of a Large-Scale Mental Health Survey Among Adolescents in Zigong, a Less-Developed City in China","authors":"Tao Zhou,&nbsp;Qiangjian Zhang,&nbsp;Na Zhao,&nbsp;Wei Xie,&nbsp;Hao Wang","doi":"10.1111/jebm.70010","DOIUrl":"https://doi.org/10.1111/jebm.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate and report the psychosocial health status from a survey of adolescent populations in Zigong City, Sichuan Province, China, and analyze the overall condition of adolescent mental health in economically less-developed prefecture-level urban areas of China.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A survey on the mental health status of 95,455 adolescents in Zigong was conducted using eight scales: the Strengths and Difficulties Questionnaire for Students, the Pre-psychosis Questionnaire, the Patient Health Questionnaire, the Generalized Anxiety Disorder Scale, the Children's Revised Impact of Event Scale, the Pittsburgh Sleep Quality Index, the Internet Gaming Disorder Scale Short Form, and the Warwick-Edinburgh Mental Well-Being Scale. The survey assessed mental health across eight dimensions: emotional and behavioral problems, prodromal psychosis risk, depression, anxiety, stress reactions, sleep quality, internet addiction, and positive mental health. The statistical significance of the results was validated using the Kruskal–Wallis test, Mann–Whitney <i>U</i> test, and Chi-square test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 76.14% of adolescents in Zigong exhibited normal psychosocial health status, indicating no immediate cause for concern. Approximately 5.58% of students were identified as being in a state of extremely high-risk psychosocial alertness, necessitating prompt intervention measures. Among all educational stages, middle-school students displayed the most severe psychosocial health issues, with approximately 8.39% classified as being in an extremely high-risk psychosocial alertness state. Furthermore, female adolescents exhibited more pronounced mental health issues compared with their male counterparts.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prominence of psychological issues among Chinese adolescents in less-developed cities underscores the urgent need for normalized and systematic intervention measures. Particular attention should be directed toward implementing targeted interventions for middle-school students and female students to address their psychosocial well-being.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment for Depression Among Adults: An Evidence and Gap Map of Systematic Reviews","authors":"Liping Guo,&nbsp;Junjie Ren,&nbsp;Zhipeng Wei,&nbsp;Xinyu Huang,&nbsp;Nina Dela Cruz,&nbsp;Leonor Rodriguez Estrada,&nbsp;Zhichun Zhang,&nbsp;Howard White,&nbsp;Kehu Yang","doi":"10.1111/jebm.70011","DOIUrl":"https://doi.org/10.1111/jebm.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify and map systematic reviews on the effectiveness of treatment for depressive disorders among adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrieved systematic reviews and meta-analyses of randomized controlled trials involving adults with depressive symptoms from twelve English and four Chinese databases (June 21, 2022). Using an interactive map, we visualized the effectiveness of evidence on depression based on an intervention-outcome framework. The interventions included psychotherapy, pharmacotherapy, complementary and alternative treatments, and others. The outcomes included the remission of depressive symptoms, symptoms of depressive disorder, life and social skills, and adverse events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 994 systematic reviews and meta-analyses, including 32 that were review protocols, highlighting the distribution of psychotherapy, pharmacotherapy, and complementary and alternative treatments. However, the evidence and gap map (EGM) revealed significant gaps in evidence for specific interventions, populations, outcomes, and regions. While psychotherapy, pharmacotherapy, and complementary and alternative treatments dominate the landscape, the review highlighted a lack of research on interventions for specific types of depression, such as depression in people with bipolar disorder and treatment-resistant depression. It was a similar situation for underserved populations, including young and middle-aged adults, males, sexual minority individuals, and people with disabilities. The map also suggested the need for more research on the potential risks and side effects associated with both pharmacological and nonpharmacological treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The contribution of this EGM was to present the available evidence on psychotherapy, pharmacotherapy, and complementary and alternative treatments for depression in adults, making available an evidence base that could inform future policy decisions and practice. It also identified evidence gaps in interventions, outcomes, population, regions, and evidence confidence. The need for further research on tailored treatments for specific populations was highlighted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16090,"journal":{"name":"Journal of Evidence‐Based Medicine","volume":"18 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}