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Morphological and functional changes in mouse splenic lymphocytes following in vivo and in vitro exposure to chlorphentermine. 体内和体外暴露于氯芬特后小鼠脾淋巴细胞形态和功能的变化。
Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026508
L. Sauers, D. Wierda, E. Walker, M. Reasor
{"title":"Morphological and functional changes in mouse splenic lymphocytes following in vivo and in vitro exposure to chlorphentermine.","authors":"L. Sauers, D. Wierda, E. Walker, M. Reasor","doi":"10.3109/08923978609026508","DOIUrl":"https://doi.org/10.3109/08923978609026508","url":null,"abstract":"With repeated administration to animals, the cationic, amphiphilic drug, chlorphentermine (CP), has been shown by others to induce a phospholipidosis in lymphocytes. In the present study mouse splenic lymphocytes, exposed to CP, either in vivo or in vitro, developed morphological changes consistant with the induction of phospholipidosis. In addition, CP induced functional changes in lymphocytes. Mice, treated with CP in vivo, demonstrated a significantly depressed ability to generate a delayed hypersensitivity response or to produce antibody-secreting cells against de novo antigens. Mouse splenic lymphocytes, exposed to 10(-7) M CP for 3 days in vitro, demonstrated a significantly depressed blastogenic response to the mitogens phytohemagglutinin, concanavalin A and lipopolysaccharide. CP inhibited an event that occurred early during lymphocyte activation, but was subsequent to mitogen/receptor coupling. In addition, CP significantly depressed the increased uptake of choline that occurs in lymphocytes following cellular activation. Since the presence of phospholipidosis is indicative of an impairment in phospholipid metabolism, these results taken together provide evidence for a relationship between this phenomenon and altered immune function.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"24 1","pages":"611-31"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85869430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Humoral and cellular immunologic aspects of adjuvant and collagen arthritis in rats. 大鼠佐剂和胶原关节炎的体液和细胞免疫方面。
Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026494
Niver Panosinn, Susan Heyner, R. Capetola, Raymond F. Orzechowski
{"title":"Humoral and cellular immunologic aspects of adjuvant and collagen arthritis in rats.","authors":"Niver Panosinn, Susan Heyner, R. Capetola, Raymond F. Orzechowski","doi":"10.3109/08923978609026494","DOIUrl":"https://doi.org/10.3109/08923978609026494","url":null,"abstract":"Systemic and local immunological responses of rats sensitized with either M. butyricum or native type II collagen have been evaluated. In rats exhibiting adjuvant-induced arthritis no antibodies to collagen could be detected. In animals exhibiting collagen-induced arthritis, high antibody titers developed by day 14, and could be correlated with the severity of the arthritis. Delayed type hypersensitivity (DTH) responses were measured by a 5-iodo-2'-deoxyuridine 125-I (125-IUdR) uptake assay. Arthritic scores in rats immunized with collagen were not accompanied by a positive DTH response, whereas adjuvant arthritic rats showed a positive response. T-lymphocyte cellular responses in both adjuvant- and collagen-induced arthritic rats were measured. In neither syndrome were major alterations observed in T-lymphocyte subpopulations. These results provide evidence that adjuvant-induced arthritis and type II collagen-induced arthritis are distinct entities, and that they may be discriminated by the nature of the humoral response.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"18 1","pages":"347-70"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83462830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Adherent spleen cell production of E series prostaglandins in rats bearing variants of the R3327 Dunning prostatic adenocarcinoma: effect of cyclophosphamide. 携带R3327邓宁前列腺癌变异体的大鼠脾细胞产生E系列前列腺素:环磷酰胺的影响。
Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609028613
M Rubenstein, M W Shaw, A Dubin, P D Guinan
{"title":"Adherent spleen cell production of E series prostaglandins in rats bearing variants of the R3327 Dunning prostatic adenocarcinoma: effect of cyclophosphamide.","authors":"M Rubenstein,&nbsp;M W Shaw,&nbsp;A Dubin,&nbsp;P D Guinan","doi":"10.3109/08923978609028613","DOIUrl":"https://doi.org/10.3109/08923978609028613","url":null,"abstract":"<p><p>Prostaglandins of the E series (PGE) have been implicated in many facets of immunoregulation, as well as having a possible role in metastatic dissemination. Variant sublines of the Dunning R3327 rat prostatic adenocarcinoma, differing in growth rate, hormonal responsiveness and in propensity for metastasis, were carried in Fisher X Copenhagen F1 animals. Adherent spleen cells were assayed in vitro for their ability to convert arachidonic acid to prostaglandins of the E series. These glass adherent cells presumably include the monocytic and T cell populations which have been implicated as being immunoregulatory. The results indicated that those spleen cells obtained from animals carrying the metastatic R3327-MAT-LyLu subline tumor converted more arachidonic acid to PGE's than cells derived from animals bearing non-metastatic sublines. Cyclophosphamide therapy did not alter such conversion. Multiple regulatory mechanisms for prostaglandin metabolism are suggested.</p>","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 2","pages":"145-63"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609028613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14220071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Interleukin 1 and 2 production in homosexual men: a controlled trial of therafectin (SM-1213), a possible immunomodulator. 男同性恋者白细胞介素1和2的产生:治疗素(SM-1213)的对照试验，一种可能的免疫调节剂
Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609031082
J M Goldsmith, J Huprikar, S J Wu, J P Phair
{"title":"Interleukin 1 and 2 production in homosexual men: a controlled trial of therafectin (SM-1213), a possible immunomodulator.","authors":"J M Goldsmith,&nbsp;J Huprikar,&nbsp;S J Wu,&nbsp;J P Phair","doi":"10.3109/08923978609031082","DOIUrl":"https://doi.org/10.3109/08923978609031082","url":null,"abstract":"<p><p>Patients with the acquired immunodeficiency syndrome (AIDS) are susceptible to a variety of opportunistic pathogens which require intact cellular immunity for control and eradication. We evaluated interleukin 1 and 2 production in 12 homosexual men without AIDS but with evidence of altered cell-mediated immunity and serologic evidence of infection with human T-cell lymphotrophic virus type III (HTLV-III), the etiologic agent of AIDS and found production of both factors diminished compared to heterosexual controls. Therafectin (SM-1213) is a new agent which selectively activates macrophages and stimulated interleukin 1 production in vitro. Therafectin was administered to these same 12 patients in a double-blind, placebo controlled trial. We failed to find any significant changes in their immunologic status including interleukin 1 or 2 production.</p>","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609031082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14076732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Antitumor activity of optical isomers of cyclophosphamide, ifosfamide and trofosfamide as compared to clinically used racemates. 环磷酰胺、异环磷酰胺和对磷酰胺光学异构体与临床外消旋体的抗肿瘤活性比较。
Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026500
H Kuśnierczyk, C Radzikowski, M Paprocka, W Budzyński, J Rak, R Kinas, K Misiura, W Stec
{"title":"Antitumor activity of optical isomers of cyclophosphamide, ifosfamide and trofosfamide as compared to clinically used racemates.","authors":"H Kuśnierczyk,&nbsp;C Radzikowski,&nbsp;M Paprocka,&nbsp;W Budzyński,&nbsp;J Rak,&nbsp;R Kinas,&nbsp;K Misiura,&nbsp;W Stec","doi":"10.3109/08923978609026500","DOIUrl":"https://doi.org/10.3109/08923978609026500","url":null,"abstract":"<p><p>The relationship between enantiomeric homogeneity of three oxazaphosphorine drugs: cyclophosphamide, ifosfamide and trofosfamide and their antitumor activity was evaluated by standard screening tests against four in vivo transplantable tumor models: L 1210 and P 388 lymphoid leukemias, Lewis lung carcinoma and 16/C line of mouse mammary adenocarcinoma. It was shown that the stereodifferentiation of anti-tumor effect of enantiomers was not outstanding although quite consistently in favour of levorotatory forms. The only exception was seen for cyclophosphamide enantiomers tested against leukemias where R/+/form was more effective than S/-/or racemate.</p>","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 4","pages":"455-80"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609026500","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14923702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Hemopoietic effects of intravenous soluble glucan administration. 静脉注射可溶性葡聚糖的造血作用。
Journal of immunopharmacology Pub Date : 1986-01-01
M L Patchen, T J MacVittie
{"title":"Hemopoietic effects of intravenous soluble glucan administration.","authors":"M L Patchen,&nbsp;T J MacVittie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A soluble form of the reticuloendothelial- and immune modulating agent glucan (glucan-F) has been evaluated for its effects on hemopoiesis. A single 5.0 mg intravenous injection of glucan-F into C3H/HeN mice increased peripheral white blood cellularity, bone marrow and splenic cellularity, bone marrow and splenic granulocyte-macrophage progenitor cell numbers (GM-CFC), and splenic pluripotent stem cell (CFU-s) and erythroid progenitor cell (CFU-e) numbers. Serum levels of granulocyte-macrophage colony stimulating activity (CSA) were also elevated following glucan-F administration. These hemopoietic responses correlate well with those previously shown to be induced by intravenous administration of particulate glucan (glucan-P). In contrast to glucan-P, however, intravenous glucan-F administration has been shown not to induce granuloma formation and severe hepatosplenomegaly, thus the potential clinical use of glucan-F as a hemopoietic stimulant is more likely than that of glucan-P.</p>","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 3","pages":"407-25"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14878341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effect(s) of rIL-2 modulation. I. The effects of chemotherapeutic/cytotoxic agents on human natural killer cells and lymphokine-activated killer cells. il -2调节的保护作用。1 .化疗/细胞毒性药物对人自然杀伤细胞和淋巴因子活化杀伤细胞的影响。
Journal of immunopharmacology Pub Date : 1986-01-01
E W Ades, A Hinson
{"title":"Protective effect(s) of rIL-2 modulation. I. The effects of chemotherapeutic/cytotoxic agents on human natural killer cells and lymphokine-activated killer cells.","authors":"E W Ades,&nbsp;A Hinson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study investigated whether in vitro immunotherapy with rIL-2 which augments human natural cytotoxicity and generation of lymphokine-activated killer cells diminished or inhibits the severity of therapeutically induced human in vitro NK immunosuppression. We demonstrate that rIL-2 induces a rapid and potent enhancement of cytolytic killing and that pretreatment of effector cells for one hour with rIL-2 yields effector cells which are more resistant to drug-induced immunosuppression. Additionally, we demonstrate cells pretreated for 24 hours with rIL-2 were less sensitive to drug inhibitory effects than rIL-2 non-treated or one hour pretreated effector cells. Our data suggest prophylactic treatment with IL-2 for drug induced immunosuppression is feasible.</p>","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 4","pages":"481-97"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14615783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specificity of acebutolol-induced antinuclear antibodies. 乙酰丁醇诱导的抗核抗体的特异性。
Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026509
S Querin, M N Feuillet-Fieux, L Jacob, G Niel, J F Bach
{"title":"Specificity of acebutolol-induced antinuclear antibodies.","authors":"S Querin,&nbsp;M N Feuillet-Fieux,&nbsp;L Jacob,&nbsp;G Niel,&nbsp;J F Bach","doi":"10.3109/08923978609026509","DOIUrl":"https://doi.org/10.3109/08923978609026509","url":null,"abstract":"<p><p>Treatment with the beta blocker acebutolol may trigger antinuclear antibody (ANA) production. We retrospectively studied 97 sera from 47 patients who developed ANA during acebutolol treatment. Anti-histone and anti-denatured (ss) DNA antibodies were found in 53% and 66% respectively of the sera tested. The activities of these two antibodies correlated well with the total ANA titer. Anti-native (ds) DNA were absent or present at low titer. This immunochemical pattern of acebutolol-induced ANA is similar to that reported for other drug-induced ANA. To date, the presence such isolated ANA is not known to expose patients to any particular risk other than exceptional and minor clinical manifestations of lupus which are rapidly reversible following therapy cessation.</p>","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 4","pages":"633-49"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609026509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14615785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Regulation of human cytotoxic responses by complement: C3, C3b and C3d preparations enhance human allogeneic cytotoxic responses. 补体对人细胞毒反应的调节:C3、C3b和C3d制剂增强人同种异体细胞毒反应。
Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026504
G C Tsokos, G Inghirami, J D Lambris
{"title":"Regulation of human cytotoxic responses by complement: C3, C3b and C3d preparations enhance human allogeneic cytotoxic responses.","authors":"G C Tsokos,&nbsp;G Inghirami,&nbsp;J D Lambris","doi":"10.3109/08923978609026504","DOIUrl":"https://doi.org/10.3109/08923978609026504","url":null,"abstract":"<p><p>Complement components and complement breakdown products have been found to participate in the regulation of the immune response. In the present study we investigated the effect of C3 and its fragments, C3b, C3c and C3d on human allogeneic cell mediated lympholysis (CML). C3 and C3b at a concentration of 275 M X 10(-9) and C3d at a concentration of 330 M X 10(-9) enhanced human allogeneic CML by at least two fold. In contrast C3c did not affect CML responses. Both C3b and C3d had to be present at the initiation of the cultures in order to exert their effect. Similar doses of C3b and C3d did not affect the mixed lymphocyte responses (3H-thymidine uptake) while higher doses were clearly inhibitory. None of the preparations induced proliferative or cytotoxic responses in the absence of allogeneic stimulating cells. C3b and C3d added to the mixed lymphocyte cultures caused increased production of interleukin 2. We conclude that C3b and C3d facilitate allogeneic cytotoxic responses through increased production of interleukin 2.</p>","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 4","pages":"529-41"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609026504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14083276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Morphological and functional changes in mouse splenic lymphocytes following in vivo and in vitro exposure to chlorphentermine. 体内和体外暴露于氯芬特后小鼠脾淋巴细胞形态和功能的变化。
Journal of immunopharmacology Pub Date : 1986-01-01
L J Sauers, D Wierda, E R Walker, M J Reasor
{"title":"Morphological and functional changes in mouse splenic lymphocytes following in vivo and in vitro exposure to chlorphentermine.","authors":"L J Sauers,&nbsp;D Wierda,&nbsp;E R Walker,&nbsp;M J Reasor","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With repeated administration to animals, the cationic, amphiphilic drug, chlorphentermine (CP), has been shown by others to induce a phospholipidosis in lymphocytes. In the present study mouse splenic lymphocytes, exposed to CP, either in vivo or in vitro, developed morphological changes consistant with the induction of phospholipidosis. In addition, CP induced functional changes in lymphocytes. Mice, treated with CP in vivo, demonstrated a significantly depressed ability to generate a delayed hypersensitivity response or to produce antibody-secreting cells against de novo antigens. Mouse splenic lymphocytes, exposed to 10(-7) M CP for 3 days in vitro, demonstrated a significantly depressed blastogenic response to the mitogens phytohemagglutinin, concanavalin A and lipopolysaccharide. CP inhibited an event that occurred early during lymphocyte activation, but was subsequent to mitogen/receptor coupling. In addition, CP significantly depressed the increased uptake of choline that occurs in lymphocytes following cellular activation. Since the presence of phospholipidosis is indicative of an impairment in phospholipid metabolism, these results taken together provide evidence for a relationship between this phenomenon and altered immune function.</p>","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 4","pages":"611-31"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14160303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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