Journal of immunopharmacology最新文献_第5页

Immune function in adult C57BL/6J mice following exposure to urethan pre- or postnatally. 成年C57BL/6J小鼠在出生前后暴露于脲聚糖后的免疫功能。

Journal of immunopharmacology Pub Date : 1986-01-01

R W Luebke, M M Riddle, R R Rogers, D G Rowe, R J Garner, R J Smialowicz

{"title":"Immune function in adult C57BL/6J mice following exposure to urethan pre- or postnatally.","authors":"R W Luebke, M M Riddle, R R Rogers, D G Rowe, R J Garner, R J Smialowicz","doi":"","DOIUrl":"","url":null,"abstract":"Administration of urethan (URE or ethyl carbamate) to mice results in the development of a variety of tumors, and, in certain strains of mice, marked suppression of the immune response. Perinatal exposure of mice to URE has been found to result in increased tumor induction compared to exposure of adult animals. In the present study, the effects of perinatal exposure to URE on the development of immunocompetence was investigated. Pregnant mice were injected with total doses of either 0.5 or 1.0 mg URE/g of body weight over days 7-16 of gestation or pups of nontreated dams were administered a total dose of 2.0 mg URE/g of body weight over postpartum days 5-14. Postnatal exposure to URE suppressed NK (natural killer) cell activity but left intact other measured parameters of the host defense system. Prenatal exposure, on the other hand, resulted in elevated leukocyte counts and a trend toward increased spleen and thymus size in offspring of treated mothers. Humoral immune function, as measured by the IgM response to sheep erythrocytes, was suppressed in pups from dams injected with a total of 1.0 mg/g URE. These results indicate that marked differences in immunopharmacologic effects may be observed if chemical exposure occurs at different times during the ontogeny of the immune system.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 2","pages":"243-57"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14841813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppression of spontaneous insulin-dependent diabetes in BB rats by administration of ciamexone. ciamexone对BB大鼠自发性胰岛素依赖性糖尿病的抑制作用。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609026496

U Kiesel, K Maruta, U Treichel, U Bicker, H Kolb

{"title":"Suppression of spontaneous insulin-dependent diabetes in BB rats by administration of ciamexone.","authors":"U Kiesel, K Maruta, U Treichel, U Bicker, H Kolb","doi":"10.3109/08923978609026496","DOIUrl":"https://doi.org/10.3109/08923978609026496","url":null,"abstract":"BB rats spontaneously develop an insulin dependent diabetes which resembles in many features human type I diabetes. We have tested the effect of the immunomodulatory drug Ciamexone, a 2-cyan-aziridine-derivative, on the development of diabetes in BB rats. Ciamexone was given once daily during 6 days per week beginning with the age of 42 or 50 days up to 120 days. For comparison cyclosporin A (10 mg/kg) was applied following the same protocol. At 1 mg/kg ciamexone administration led to complete prevention of diabetes in females but was not beneficial in males. At 10 mg/kg the drug caused significant suppression of diabetes development in males but more pronounced in females. Both, a reduction of the incidence of diabetes and a delay in the onset of hyperglycaemia was observed only in females. After administration of cyclosporin A none of the animals developed diabetes. Ciamexone treatment did not affect granulocyte and lymphocyte counts and subsets in the peripheral blood except for a tendency to suppress eosinophilia. The growth of animals was not retarded. It is concluded that ciamexone seems to influence the autoimmune state of the BB rat resulting in partial suppression of the disease.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"8 3","pages":"393-406"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978609026496","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14878340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Immune function in adult C57BL/6J mice following exposure to urethan pre- or postnatally. 成年C57BL/6J小鼠在出生前后暴露于脲聚糖后的免疫功能。

Journal of immunopharmacology Pub Date : 1986-01-01 DOI: 10.3109/08923978609028617

R. Luebke, M. Riddle, R. Rogers, D. G. Rowe, R. Garner, R. Smialowicz

{"title":"Immune function in adult C57BL/6J mice following exposure to urethan pre- or postnatally.","authors":"R. Luebke, M. Riddle, R. Rogers, D. G. Rowe, R. Garner, R. Smialowicz","doi":"10.3109/08923978609028617","DOIUrl":"https://doi.org/10.3109/08923978609028617","url":null,"abstract":"Administration of urethan (URE or ethyl carbamate) to mice results in the development of a variety of tumors, and, in certain strains of mice, marked suppression of the immune response. Perinatal exposure of mice to URE has been found to result in increased tumor induction compared to exposure of adult animals. In the present study, the effects of perinatal exposure to URE on the development of immunocompetence was investigated. Pregnant mice were injected with total doses of either 0.5 or 1.0 mg URE/g of body weight over days 7-16 of gestation or pups of nontreated dams were administered a total dose of 2.0 mg URE/g of body weight over postpartum days 5-14. Postnatal exposure to URE suppressed NK (natural killer) cell activity but left intact other measured parameters of the host defense system. Prenatal exposure, on the other hand, resulted in elevated leukocyte counts and a trend toward increased spleen and thymus size in offspring of treated mothers. Humoral immune function, as measured by the IgM response to sheep erythrocytes, was suppressed in pups from dams injected with a total of 1.0 mg/g URE. These results indicate that marked differences in immunopharmacologic effects may be observed if chemical exposure occurs at different times during the ontogeny of the immune system.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"38 2 1","pages":"243-57"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74590981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Immunosuppressive agents and plasmapheresis in immunological disorders. 免疫紊乱中的免疫抑制剂和血浆置换。

Journal of immunopharmacology Pub Date : 1985-01-01 DOI: 10.3109/08923978509026465

G C Tsokos, J E Balow

引用次数: 9

The effect of TP-5 and its analogs on skin grafts in mice. TP-5及其类似物对小鼠皮肤移植的影响。

Journal of immunopharmacology Pub Date : 1985-01-01

B Szende, L Kisfaludy, K Lapis, L Dénes, L Szporny, O Nyéke, I Schön, G Hajós, J Ember, M Constantin

引用次数: 0

Multivariate analysis of the factors associated with the yield and purity of human monocyte isolation by countercurrent centrifugal elutriation (CCE). 逆流离心洗脱(CCE)分离人单核细胞产量和纯度相关因素的多因素分析。

Journal of immunopharmacology Pub Date : 1985-01-01 DOI: 10.3109/08923978509026472

P J Miller, J Beman, T Delawter, H C Stevenson

{"title":"Multivariate analysis of the factors associated with the yield and purity of human monocyte isolation by countercurrent centrifugal elutriation (CCE).","authors":"P J Miller, J Beman, T Delawter, H C Stevenson","doi":"10.3109/08923978509026472","DOIUrl":"https://doi.org/10.3109/08923978509026472","url":null,"abstract":"Substantial variability in the purity and yield of human monocytes following countercurrent centrifugal elutriation (CCE) has been reported for some time; the factors influencing this variability have not been rigorously studied in the past. Utilizing 50 normal donors, we examined several dozen preprocedural variables possibly influencing 174 separate CCE experiments, and we determined the impact of these variables on the yield and purity of monocytes obtained following cytapheresis and CCE. Donor age was not correlated with CCE monocyte yield or purity; male gender correlated with higher monocyte purity following CCE purification. The major correlates of the yield and purity of monocytes obtained by CCE were the numbers and concentration of monocytes found in the leukocyte population entered into the elutriator apparatus. Fifty-eight percent of all donors gave a very consistent yield of monocytes by CCE, with a standard error from the mean of less than 15% over the 3 years of this study. All donors consistently gave fractions with a high percentage of monocytes, with the standard error of the mean CCE monocyte purity being less than 5% over the duration of the study. Thus, while the purity of monocytes collected by CCE is highly reproducible, the yield of monocytes by this procedure is somewhat less so. These monocyte purification endpoints are affected by a number of preprocedural variables centering mainly around the percentage, concentration, and total numbers of monocytes in the cytapheresis cell population.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"7 1","pages":"99-123"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978509026472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15122243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In vitro stimulation of macrophages by quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine]. quadrol [N,N,N'，N'-四(2-羟丙基)乙二胺]对巨噬细胞的体外刺激。

Journal of immunopharmacology Pub Date : 1985-01-01 DOI: 10.3109/08923978509026478

M V Bhide, S Patel, E C Rowland, D J Smith

引用次数: 5

Enhancement of human allogeneic cytotoxic responses by interferons. 干扰素增强人同种异体细胞毒性反应。

Journal of immunopharmacology Pub Date : 1985-01-01 DOI: 10.3109/08923978509026484

G Inghirami, J Y Djeu, J E Balow, G C Tsokos

引用次数: 3

Immunomodulatory activity of Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid). wy - 18251(3-(对氯苯基)噻唑[3,2-a]苯并咪唑-2-乙酸)的免疫调节活性。

Journal of immunopharmacology Pub Date : 1985-01-01 DOI: 10.3109/08923978509026471

S C Gilman, R P Carlson, A J Lewis

{"title":"Immunomodulatory activity of Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid).","authors":"S C Gilman, R P Carlson, A J Lewis","doi":"10.3109/08923978509026471","DOIUrl":"https://doi.org/10.3109/08923978509026471","url":null,"abstract":"The in vitro and in vivo effects of the experimental immunomodulatory agent Wy-18,251 (3-(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid) were studied in comparison with levamisole and indomethacin. Levamisole (4 mg/kg, i.v.) but not Wy-18,251 (less than or equal to 10 mg/kg, i.v.) enhanced carbon clearance rates in vivo in mice. Both Wy-18,251 and levamisole (100 mg/kg, p.o.) significantly suppressed the symptoms of experimental allergic encephalomyelitis (EAE) in rats injected with spinal cord emulsion, but neither were as effective as tilorone in this model. Wy-18,251 and levamisole (1-100 mg/kg, p.o.) suppressed the in vivo generation of plaque-forming cells (PFC) in mice immunized with sheep red blood cells while indomethacin (9 mg/kg, p.o.) enhanced PFC formation. All 3 agents (10(-5) - 10(-6) M) enhanced the in vitro ovalbumin (OA)-specific and Con A- or PHA-induced proliferative response and Con A-stimulated interleukin 2 (IL-2) synthesis of rat spleen cells. Furthermore, in vivo treatment of rats with 1-10 mg/kg (p.o.) of Wy-18,251 and levamisole but not indomethacin increased the subsequent in vitro mitogen or antigen (OA) responsiveness of spleen cells. None of the drugs (10(-5) - 10(-7) M) influenced the natural killer cell (NK) activity of rat spleen cells when incorporated directly into the 51Cr release NK assay.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"7 1","pages":"79-98"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978509026471","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14990106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Effects of Wy-18,251 (3-p-chlorophenyl)thiazolo[3,2-a]benzimidazole- 2-acetic acid), levamisole and indomethacin on the generation of murine T suppressor cells in vitro. y- 18251(3-对氯苯基)噻唑[3,2-a]苯并咪唑- 2-乙酸)、左旋咪唑和吲哚美辛对体外小鼠T抑制细胞生成的影响。

Journal of immunopharmacology Pub Date : 1985-01-01 DOI: 10.3109/08923978509026489

C M Rogers, T J Rogers, S C Gilman

引用次数: 9