Journal of immunopharmacology最新文献_第10页

Investigations on the age-dependence of T-lymphocyte subpopulations and lymphocyte reactivity. t淋巴细胞亚群和淋巴细胞反应性的年龄依赖性研究。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409028609

J J Reiter, G Ehrlich, U Bicker

引用次数: 2

Effects of oral aspirin and oxaprozin on the development of lupus-like disease in MRL/1 mice. 口服阿司匹林和奥沙普嗪对MRL/1小鼠狼疮样疾病发展的影响

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409026459

R P Carlson, S C Gilman, T G Hodge, L O'Neill-Davis, E M Blazek, A J Lewis

引用次数: 5

Effects of cytochalasins on lymphocytes: some distinctive features of cytochalasin-E. 细胞松弛素对淋巴细胞的作用:细胞松弛素e的一些特征。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409019460

B K Mookerjee, C Y Jung

{"title":"Effects of cytochalasins on lymphocytes: some distinctive features of cytochalasin-E.","authors":"B K Mookerjee, C Y Jung","doi":"10.3109/08923978409019460","DOIUrl":"https://doi.org/10.3109/08923978409019460","url":null,"abstract":"Cytochalasin-E (CE) has specific properties that distinguishes it from other cytochalasin congeners. We have taken advantage of these in investigating the mechanisms operative in the effects of cytochalasins on lymphocyte proliferative responses to phytomitogens. Like the other cytochalasins, CE inhibits these responses only when present during the early phases of exposure of lymphocytes to mitogens, but not when added later on. The effects of CE are irreversible since prior incubation of lymphocyte in CE renders them incapable of response. Unlike the effects of cytochalasin A, the only other irreversibly active congener, lymphocytes preincubated in CE completely recover the ability to respond if they are cultured in cytochalasin-free medium for 48 hours. Unlike cytochalasins A and B, cytochalasin-E does not inhibit glucose transport into lymphocytes and all. We have shown that human lymphocytes bind cytochalasins at 3 distinct classes of sites named L, M, and H (J. Biol. Chem. 256:1290-1300, 1981). CE binds irreversibly to the L and H-sites on the short to medium term but does not bind to the glucose displaceable M-site at all. CE may have potential usefulness as affinity label towards isolation of specific binding sites since the chemical structure offers feasible approaches towards isotopic labelling.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"6 3","pages":"185-203"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978409019460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17548568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Lymphocyte subpopulations in gastric disease; effect of histamine and cimetidine on immunoregulatory T cell subsets. 胃病的淋巴细胞亚群;组胺和西咪替丁对免疫调节性T细胞亚群的影响。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409019459

M Raptopoulou-Gigi, P Boura, N Valcanos, G Goulis

引用次数: 8

Effect of tricyclic antidepressant drugs on lymphocyte membrane structure. 三环类抗抑郁药物对淋巴细胞膜结构的影响。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409026463

K L Audus, M A Gordon

引用次数: 15

Humoral and cellular immunologic responses in collagen-induced arthritis in rats: their correlation with severity of arthritis. 大鼠胶原诱导关节炎的体液和细胞免疫反应:它们与关节炎严重程度的相关性。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409028610

R P Carlson, E M Blazek, L J Datko, A J Lewis

引用次数: 9

Regulation of the human polymorphonuclear leukocyte inflammatory response by inhibitors of arachidonic acid metabolism. 花生四烯酸代谢抑制剂对人多形核白细胞炎症反应的调节。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409028602

D E Yocum, S Hempel, W W Busse

{"title":"Regulation of the human polymorphonuclear leukocyte inflammatory response by inhibitors of arachidonic acid metabolism.","authors":"D E Yocum, S Hempel, W W Busse","doi":"10.3109/08923978409028602","DOIUrl":"https://doi.org/10.3109/08923978409028602","url":null,"abstract":"Perturbation of the neutrophil membrane by opsonized zymosan particles activates the cell's \"respiratory burst.\" Associated with this activation process is the generation of highly reactive oxygen products, including superoxide, and the release of lysosomal enzymes. Membrane activation also stimulates arachidonic acid metabolism and the generation of a wide variety of products through both the lipoxygenase and cyclooxygenase pathways. In isolated human neutrophils, we have evaluated the effects inhibitors of cyclooxygenase and lipoxygenase upon opsonized zymosan stimulated chemiluminescence, superoxide generation, oxygen consumption, and beta-glucuronidase release. Nordihydroguaiaretic acid (NDGA), an inhibitor of the lipoxygenase enzyme, suppressed chemiluminescence, superoxide generation, oxygen consumption, and beta-glucuronidase release. Both indomethacin, a cyclooxygenase inhibitor, and 5,8,11,14 - eicosatetraynoic acid (ETYA) an inhibitor of both cyclooxygenase and lipoxygenase, inhibited all tested neutrophil functions. However, when compared to NDGA, indomethacin and ETYA were considerably less potent. Our observations suggest that the lipooxygenase derived metabolites play a predominant regulatory role in these neutrophil inflammatory functions.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"6 4","pages":"237-55"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978409028602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17166068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Manganese chloride enhances murine cell-mediated cytotoxicity: effects on natural killer cells. 氯化锰增强小鼠细胞介导的细胞毒性:对自然杀伤细胞的影响。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409026455

R J Smialowicz, R R Rogers, M M Riddle, R W Luebke, D G Rowe, R J Garner

{"title":"Manganese chloride enhances murine cell-mediated cytotoxicity: effects on natural killer cells.","authors":"R J Smialowicz, R R Rogers, M M Riddle, R W Luebke, D G Rowe, R J Garner","doi":"10.3109/08923978409026455","DOIUrl":"https://doi.org/10.3109/08923978409026455","url":null,"abstract":"Natural killer (NK) cell activity of mice given a single injection of manganese chloride (MnCl2) was significantly enhanced as measured in a 4-hr in vitro 51Cr release assay. Enhanced activity persisted for several days after injection. This cytotoxic activity was associated with nonadherent spleen cells and was completely eliminated by injecting MnCl2-treated mice with anti-asialo GM1 serum. Manganese-enhanced natural cytotoxicity was observed in several mouse strains with differing NK cell reactivity (CBA/J, C57BL/6, A/J, C3H/HeJ, and C57BL/6 beige mice) and with several tumor target cells with differing sensitivity to NK cytolysis (YAC-1, RBL-5, EL-4, and P815). The growth of B16-F10 melanoma lung tumors was inhibited in mice injected with MnCl2 one day before tumor challenge. Manganese chloride enhancement of NK cell activity appeared to be mediated by interferon (IFN). Low levels of IFN were detected in the serum of mice as early as 4 hr after MnCl2 injection. Rabbit anti-mouse IFN alpha, beta but not anti-mouse IFN gamma completely eliminated the MnCl2-enhanced NK cell activity in the spleens of mice. The observed enhancement of NK cell activity by MnCl2 is similar to that reported for more complex molecules that act by inducing IFN production.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"6 1-2","pages":"1-23"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978409026455","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17270495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Effects of dextran sulphate (DXS) on lymphocyte localization in complement-deficient mice: evidence that the fifth component of complement is not implicated in the DXS activity. 葡聚糖硫酸盐(DXS)对补体缺陷小鼠淋巴细胞定位的影响:补体第五组分与DXS活性无关的证据。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409026462

A Bellavia, P Di Fiore, G C Romano, A Salerno

引用次数: 1

Reevaluation of the effect of levamisole in chronic brucellosis: in vitro and in vivo effect on monocyte phagocytosis. 左旋咪唑治疗慢性布鲁氏菌病效果的再评价:体内外对单核细胞吞噬的影响。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409019456

P Boura, M Raptopoulou-Gigi, E Acriviadis, G Goulis

{"title":"Reevaluation of the effect of levamisole in chronic brucellosis: in vitro and in vivo effect on monocyte phagocytosis.","authors":"P Boura, M Raptopoulou-Gigi, E Acriviadis, G Goulis","doi":"10.3109/08923978409019456","DOIUrl":"https://doi.org/10.3109/08923978409019456","url":null,"abstract":"The in vitro effect of levamisole on peripheral blood monocyte (P.B.M.) phagocytosis was studied in 32 patients with chronic brucellosis and 20 normal subjects. It was shown that levamisole enhances P.B.M. phagocytic capacity, not reaching however normal levels. A subgroup of 11 patients were treated with levamisole for 6 months and the drug effect on cellular and humoral immunity and monocyte phagocytosis was also studied. By the end of the 6 month treatment-study period, the following results were obtained: 1. six patients were symptom free while five had significantly improved. 2. T lymphocyte number and monocyte phagocytosis reached normal values. 3. Significant specific cellular immunity against both brucella antigens was noted. 4. B. lymphocytes showed no significant changes. 5. Antiglobulin titers varied. These findings suggest that the good therapeutical effect of levamisole in patients with chronic brucellosis could probably be a attributed to the enhancement of both T-cell function and monocyte phagocytosis.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"6 3","pages":"135-46"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978409019456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17394368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9