Journal of immunopharmacology最新文献_第9页

The immunomodulatory effect of yeast glucan on delayed hypersensitivity. 酵母葡聚糖对迟发性超敏反应的免疫调节作用。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409028606

H A Pérez, J Bolívar, G San Blas

引用次数: 5

Complement and its fractions (C3-C4) pattern in subjects with neoplasia. 肿瘤患者的补体及其组分(C3-C4)模式。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409019457

A Mangano, L Messina, S Birgillito, F Stivala, A Bernardini

引用次数: 11

Effects of pyrethroids on lymphocyte membrane lipid packing order. 拟除虫菊酯对淋巴细胞膜脂质排列顺序的影响。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409028611

K J Stelzer, M A Gordon

{"title":"Effects of pyrethroids on lymphocyte membrane lipid packing order.","authors":"K J Stelzer, M A Gordon","doi":"10.3109/08923978409028611","DOIUrl":"https://doi.org/10.3109/08923978409028611","url":null,"abstract":"The effects of pyrethroids on the membrane lipid packing order of murine splenic lymphocytes have been investigated by utilizing the fluorescent probe 1,6-diphenyl-1,3,5-hexatriene. Fluorescence anisotropy and lifetime measurements indicated alterations in the environment of the probe at pyrethroid concentrations near 1 microM. Decreased packing order of membrane lipids was detected for permethrin and cypermethrin by decreased anisotropy values. Permethrin and cypermethrin decreased fluorescence lifetime over a concentration range similar to that causing anisotropy changes. Anisotropy was predominantly increased in the presence of fluvalinate and fenpropathrin, indicating pronounced quenching of fluorescence by these compounds. However, the anisotropy changes in response to fluvalinate and fenpropathrin occurred at concentrations which were similar to effective concentrations of permethrin and cypermethrin. Compared to the other pyrethroids tested, allethrin required approximately 10 fold higher concentrations to alter anisotropy and lifetime values. Effects of pyrethroids on the phase transition of dipalmitoyl phosphatidylcholine liposomes were also studied to give further insight into the membrane interactions of these compounds. Results from the liposomal system indicate that the effects of pyrethroids on membrane order which were observed in the lymphocyte may be generalizable to other cell types.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"6 4","pages":"389-410"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978409028611","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17582342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Enhancement of the immune response to sheep erythrocytes in mice by phosphodiesterase-inhibiting dipyridamole derivatives. 抑制磷酸二酯酶的双嘧达莫衍生物增强小鼠对绵羊红细胞的免疫反应。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409026457

R Lichtner, N Wedderburn

引用次数: 4

The effect of the non-steroidal anti-inflammatory drug Etodolac on macrophage migration in vitro and in vivo. 非甾体抗炎药依托度酸对体内外巨噬细胞迁移的影响。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409019461

F Gervais, R R Martel, E Skamene

引用次数: 10

Circulating T-cell subpopulations in lithium-associated granulocytosis. 锂相关粒细胞缺乏症的循环t细胞亚群。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409019462

A D Crockard, Z R Desai, K T Ennis

{"title":"Circulating T-cell subpopulations in lithium-associated granulocytosis.","authors":"A D Crockard, Z R Desai, K T Ennis","doi":"10.3109/08923978409019462","DOIUrl":"https://doi.org/10.3109/08923978409019462","url":null,"abstract":"Granulocytosis is a common feature in patients undergoing lithium therapy. With increasing evidence that T lymphocytes play a role in the control of granulopoiesis, we have investigated the effect of lithium administration on circulating levels of T helper and T suppressor cells, as identified by monoclonal antibodies, to determine whether lithium-induced granulocytosis is mediated through changes in peripheral blood T cell subsets. Lithium carbonate was administered to 10 subjects over a 2 week period. Differential leucocyte counts and T, B, T helper and T suppressor lymphocyte enumerations were performed prior to administration of lithium (Day 1) and on 2 occasions (Day 7 and 14) during ingestion of the drug. Ten healthy control subjects were similarly investigated. Small, but significant elevation (p less than 0.05) in neutrophil counts at 7 and 14 days were observed in subjects taking lithium, serum lithium levels at these times were 0.56 +/- 0.27 and 0.68 +/- 0.17 mmol/l, respectively; lymphocyte and monocyte levels were unaffected. The percentages and absolute numbers of circulating T, B, T helper and T suppressor lymphocytes were not significantly altered (p greater than 0.05) during lithium administration and did not differ significantly (p greater than 0.05) from those recorded for the control group. We were thus unable to demonstrate that short-term lithium administration induced changes in the circulating levels of T helper (OKT4+) or T suppressor (OKT8+) cells.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"6 3","pages":"215-26"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978409019462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17300450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Relationship of arachidonic acid metabolism to indomethacin-sensitive immunoregulatory function and lymphocyte PGE sensitivity in peripheral blood mononuclear cells of disseminated solid tumor cancer patients. 播散性实体瘤癌患者外周血单核细胞花生四烯酸代谢与消炎痛敏感免疫调节功能及淋巴细胞PGE敏感性的关系

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409019463

D P Braum, J E Harris, M Rubenstein

{"title":"Relationship of arachidonic acid metabolism to indomethacin-sensitive immunoregulatory function and lymphocyte PGE sensitivity in peripheral blood mononuclear cells of disseminated solid tumor cancer patients.","authors":"D P Braum, J E Harris, M Rubenstein","doi":"10.3109/08923978409019463","DOIUrl":"https://doi.org/10.3109/08923978409019463","url":null,"abstract":"The relationship between the conversion of arachidonic acid (AA) to E series prostaglandins (PGE), indomethacin-sensitive immunoregulation and lymphocyte PGE sensitivity was investigated in the peripheral blood mononuclear cells (PBMC) of normal subjects and disseminated solid tumor patients. Production of PGE was assessed by thin layer chromatography of ether-extracted glass adherent cells following a 24-hour pulse with 3H-AA. Immunoregulatory cell function was assessed in PHA-stimulated PBMC cultured in the presence of the prostaglandin synthetase inhibitor, indomethacin. Lymphocyte PGE sensitivity was assessed in PHA stimulated glass nonadherent cells cultured in the presence of 10(-8) M PGE. The cells from cancer patients demonstrated greater AA conversion to PGE and greater indomethacin sensitive immunoregulatory cell function than the cells of normal subjects. However, lymphocyte PGE sensitivity was comparable for both groups. When levels of arachidonic acid conversion to PGE were correlated to levels of indomethacin-sensitive immunoregulatory cell function by linear regression analysis, a significant correlation was found. These data suggest that the increased indomethacin-sensitive immunoregulatory cell function seen in PBMC from cancer patients can be directly correlated with increased production of E series prostaglandins by cancer patient peripheral blood monocytes.","PeriodicalId":16049,"journal":{"name":"Journal of immunopharmacology","volume":"6 3","pages":"227-36"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08923978409019463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17494971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Comparative investigations of various immunoregulatory substances in the delayed type hypersensitivity test of the mouse. 小鼠延迟型超敏反应试验中各种免疫调节物质的比较研究。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409026458

U Bicker, K D Friedberg, B Isert, K Mengel

引用次数: 11

Influence of lead acetate on hypersensitivity. Experimental study. 醋酸铅对过敏反应的影响。实验研究。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409026461

A Laschi-Loquerie, J Descotes, P Tachon, J C Evreux

引用次数: 15

The effects of the antirheumatic agents N-(2-carboxyphenyl)-4-chloroanthranilic acid disodium (CCA) and D-penicillamine on the NK and ADCC activities and interferon production of lymphocytes. 抗风湿药N-(2-羧基苯基)-4-氯氨基苯酸二钠(CCA)和d -青霉胺对淋巴细胞NK和ADCC活性及干扰素产生的影响。

Journal of immunopharmacology Pub Date : 1984-01-01 DOI: 10.3109/08923978409019458

M Ohara, S Igarashi, C Kobashi, M Nanamiya, H Yoshida, R Kasukawa

引用次数: 1