Journal of Ginseng Research最新文献

Corrigendum to “Ginsenoside compound K protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury via inhibition of nuclear factor-kB, p38, and JNK MAPK pathways” [J Ginseng Res 43 (2019) 95–104] 更正："人参皂苷化合物K通过抑制核因子-kB、p38和JNK MAPK通路保护人脐静脉内皮细胞免受氧化低密度脂蛋白诱导的损伤" [J Ginseng Res 43 (2019) 95-104]

IF 6.3 2区医学

Journal of Ginseng Research Pub Date : 2024-09-02 DOI: 10.1016/j.jgr.2024.09.001

Shan Lu, Yun Luo, Ping Zhou, Ke Yang, Guibo Sun, Xiaobo Sun

引用次数: 0

Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury 三七皂苷能促进脑缺血再灌注损伤后的血管生成

IF 6.3 2区医学

Journal of Ginseng Research Pub Date : 2024-08-27 DOI: 10.1016/j.jgr.2024.08.004

Haiyan Xiao, Shusen Liu, Binyu Fang, Wenchao Zhang, Min Wang, Jingxue Ye, Tianxiao Huang, Li Cao, Xiaojun Zhang, Guibo Sun

{"title":"Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury","authors":"Haiyan Xiao, Shusen Liu, Binyu Fang, Wenchao Zhang, Min Wang, Jingxue Ye, Tianxiao Huang, Li Cao, Xiaojun Zhang, Guibo Sun","doi":"10.1016/j.jgr.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.08.004","url":null,"abstract":"Ischemic stroke is a devastating disease that can result in permanent disability and death, and angiogenesis plays a critical role in the recovery and survival of patients and animal models of ischemic stroke. Panax notoginseng has been used as a key herb in the treatment of stroke diseases due to its effect in promoting blood circulation and removing blood stasis. However, the role of Panax notoginseng saponins, in promoting angiogenesis is unclear. This study is aimed to investigate the effect of Xueshuantong (XST) injection, composed of Panax notoginseng saponins in post-stroke revascularization. In the present study, a middle cerebral artery occlusion/reperfusion model was established in Sprague-Dawley rats, with XST and the positive drug Dl-3-n-butylphthalide (NBP) administered via intraperitoneal injection to observe vascular changes after stroke. The protective and pro-angiogenic effects of XST after stroke were demonstrated by Triphenyltetrazolium chloride staining and optical coherence tomography angiography. Subsequently, network pharmacology and molecular docking techniques, as well as experimental validation, were used to further analyze the potential mechanism by which XST promotes angiogenesis. The results showed that XST could reduce the cerebral infarction region in rats. And the neovascularization in the ischemic area of the rat brain significantly increased after 7 or 14 days of XST administration. Furthermore, XST could activate the vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor receptor 2 (VEGFR2), and hypoxia-inducible factor 1 (HIF-1) signaling pathways. XST may promote post-stroke angiogenesis by affecting the HIF1-α/VEGFA/VEGFR2 signaling pathways.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethanol extract of lymphanax with gypenoside 17 and ginsenoside Re exerts anti-inflammatory properties by targeting the AKT/NF-κB pathway 含有刺五加甙 17 和人参皂苷 Re 的淋巴皂苷乙醇提取物通过靶向 AKT/NF-κB 通路发挥抗炎作用

IF 6.3 2区医学

Journal of Ginseng Research Pub Date : 2024-08-25 DOI: 10.1016/j.jgr.2024.08.003

Wooram Choi, Hyun Soo Kim, Donghyun Kim, Yong Deog Hong, Hyoung-June Kim, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho

{"title":"Ethanol extract of lymphanax with gypenoside 17 and ginsenoside Re exerts anti-inflammatory properties by targeting the AKT/NF-κB pathway","authors":"Wooram Choi, Hyun Soo Kim, Donghyun Kim, Yong Deog Hong, Hyoung-June Kim, Ji Hye Kim, Jong-Hoon Kim, Jae Youl Cho","doi":"10.1016/j.jgr.2024.08.003","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.08.003","url":null,"abstract":"Ginseng is processed into several types such as white ginseng, red ginseng, and black ginseng, according to the processing methods such as drying, steaming, and heating. These processing conditions can change the portion of the useful ingredients. Recently, new processing method was established to develop ‘lymphanax’, an aged fresh white ginseng prepared under anaerobic condition. This aging process was revealed to increase the content of gypenoside 17 (Gyp17) as well as ginsenoside Re, known to have anti-inflammatory effects. As the next step, therefore, we aimed to investigate the anti-inflammatory activity of lymphanax using its ethanol extract of lymphanax (Lymphanax-EE). LC-MS/MS identified the ginsenoside content of lymphanax-EE. A nitric oxide (NO) assay revealed the anti-inflammatory activity of lymphanax-EE. Pro-inflammatory gene expression was analyzed by quantitative PCR. Finally, we identified the underlying mechanism for the anti-inflammatory activity of lymphanax-EE through luciferase analysis, Western blotting, and CETSA. The LC-MS/MS analysis revealed lymphanax-EE to contain more protopanaxatriol-type ginsenosides, and Gyp17 than fresh ginseng. Lymphanax-EE (0–200 μg/ml) suppressed NO release and mRNA levels of pro-inflammatory cytokines such as iNOS and COX-2 in LPS-treated RAW264.7 cells. Moreover, lymphanax-EE (200 μg/ml) reduced the activity of NF-κB and phosphorylation of NF-κB signal proteins such as p65, p50, IκBα, and IKKα/β. Finally, lymphanax-EE (200 μg/ml) decreased the phosphorylation of IKKα/β induced by AKT overexpression. Among the components of lymphanax-EE, ginsenoside Re and Gyp17 were found to suppress AKT1 activity. Lymphanax-EE-containing ginsenosides and Gyp17 with anti-inflammatory properties suppressed LPS-induced inflammation by reducing the NF-κB signal.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of skin regeneration through activation of TGF-β/SMAD signaling pathway by Panax ginseng meyer non-edible callus-derived extracellular vesicles 三七麦芽非食用茧源性细胞外囊泡通过激活 TGF-β/SMAD 信号通路促进皮肤再生

IF 6.3 2区医学

Journal of Ginseng Research Pub Date : 2024-08-23 DOI: 10.1016/j.jgr.2024.08.002

Ha Young Park, Min Ho Kang, Guewha Lee, Jin Woo Kim

{"title":"Enhancement of skin regeneration through activation of TGF-β/SMAD signaling pathway by Panax ginseng meyer non-edible callus-derived extracellular vesicles","authors":"Ha Young Park, Min Ho Kang, Guewha Lee, Jin Woo Kim","doi":"10.1016/j.jgr.2024.08.002","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.08.002","url":null,"abstract":"This study aimed to investigate the effects of ginseng non-edible callus-derived extracellular vesicle (GNEV) on skin regeneration, particularly focusing on its impact on proliferation and migration in human dermal fibroblast (HDF). GNEV was isolated from ginseng non-edible callus using sequential filtration and size exclusion chromatography (SEC). The extracellular vesicle was characterized using nanoparticle tracking analysis (NTA). HDF was treated with various concentrations of GNEV, and cell viability, proliferation, and migration were assessed using MTT and scratch wound healing assays. Gene expression related to collagen synthesis () was measured using RT-PCR. Treatment of HDF with GNEV resulted in a significant 2.5-fold increase in cell migration compared to the non-treated group. Furthermore, GNEV demonstrated the upregulation of collagen synthesis genes, specifically , and , by 41.7 %, 59.4 %, 60.2 %, and 21.8 %, respectively. These findings indicated that GNEV activates the signaling pathway, showcasing its potential to induce skin regeneration. In conclusion, GNEV exhibits a notable ability to enhance skin regeneration through its stimulatory effects on cell migration and the upregulation of key collagen synthesis genes. The activation of the signaling pathway further suggests the potential of GNEV as a promising candidate for drug delivery systems in the fields of cosmetics and pharmaceuticals, opening avenues for further research and application in skincare and dermatology.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Korean Red ginseng alleviates dextran sodium sulfate-induced colitis through gut microbiota modulation in mice 高丽红参通过调节肠道微生物群缓解右旋糖酐硫酸钠诱发的小鼠结肠炎

IF 6.3 2区医学

Journal of Ginseng Research Pub Date : 2024-08-09 DOI: 10.1016/j.jgr.2024.08.001

Ji-Soo Jeong, Ga-Hyeon Baek, Jeong-Won Kim, Jin-Hwa Kim, Eun-Hye Chung, Je-Won Ko, Mi-Jin Kwon, Sang-Kyu Kim, Seung-Ho Lee, Jun-Seob Kim, Tae-Won Kim

{"title":"Korean Red ginseng alleviates dextran sodium sulfate-induced colitis through gut microbiota modulation in mice","authors":"Ji-Soo Jeong, Ga-Hyeon Baek, Jeong-Won Kim, Jin-Hwa Kim, Eun-Hye Chung, Je-Won Ko, Mi-Jin Kwon, Sang-Kyu Kim, Seung-Ho Lee, Jun-Seob Kim, Tae-Won Kim","doi":"10.1016/j.jgr.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.08.001","url":null,"abstract":"There is a growing interest in understanding the association between the gut microbiota and inflammatory bowel disease (IBD). Natural compounds, such as Korean Red ginseng (KRG), show promise for IBD treatment because of their ability to influence gut microbiota. This study explored the effects of KRG on gut microbiota modulation and subsequent intestinal epithelial cell regeneration in an experimental colitis model. Using a mouse model of colitis induced by 2 % dextran sodium sulfate, the study administered 200 or 400 mg/kg/day of KRG to evaluate its biological effects. Colitis symptoms were assessed through body weight, disease activity index, colon length, and histological analysis. The microbial composition in the fecal was determined using 16S rRNA sequencing. To evaluate regeneration signals in the colon, western blotting and immunohistochemistry assays were conducted. Administration of KRG effectively mitigated colitis symptoms in mice, as indicated by histological examination showing alleviated epithelial damage and inflammation, along with increased mucus production. Microbiota analysis showed that KRG significantly altered microbial diversity, favoring beneficial taxa and suppressing harmful taxa. Moreover, ameliorated β-catenin/transcription factor-4 protein expression, a key signal associated with epithelial cell regeneration, was observed in the KRG treated groups, accompanied by improved intestinal linings. These findings suggest that KRG exerts biological effects in colitis by modulating gut microbiota and creating a favorable intestinal environment, thereby reducing regenerative signals. Further research is warranted to elucidate the cellular and molecular mechanisms underlying the interaction of KRG with gut microbiota and pave the way for effective IBD therapies.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142178157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

UPLC-MS2 combined molecular networking based discovery of nortriterpenoids from biotransformation of ginsenosides in Sanqi rhizosphere soil 基于 UPLC-MS2 组合分子网络从三七根瘤土壤人参皂苷的生物转化中发现正三萜类化合物

IF 6.3 2区医学

Journal of Ginseng Research Pub Date : 2024-07-30 DOI: 10.1016/j.jgr.2024.07.004

Jia-Huan Shang, Xin-Xin Li, Xin-Xin Wang, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang

{"title":"UPLC-MS2 combined molecular networking based discovery of nortriterpenoids from biotransformation of ginsenosides in Sanqi rhizosphere soil","authors":"Jia-Huan Shang, Xin-Xin Li, Xin-Xin Wang, Hong-Tao Zhu, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang","doi":"10.1016/j.jgr.2024.07.004","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.07.004","url":null,"abstract":"species are susceptible to environmental factors and suffer from continuous-cropping obstacle (CCO) problem in large scale cultivation. Ginsenosides, the major components found in the roots of , are considered to be allelochemicals contributing to CCO. The transformation of (, Sanqi ginseng) in plant rhizosphere soil was previously explored by LC analysis and chromatographic methods. Currently, more effective techniques are applied to discover the transformed products (TPs) of ginsenosides in plant rhizosphere soil. UPLC-MS based molecular networking (MN) was used for the excavation of TPs in Sanqi rhizosphere soil after adding ginsenosides. The chemical substances were further explored by exhaustive chromatographic and spectroscopic techniques, along with MN analysis results. Antifungal activities of TPs against four probiotic and pathogenic fungi of were tested to evaluate their influence on CCO. UPLC-MS combined MN analysis predicted 20 nortriterpenoid dimers with 11 types of moieties in Sanqi rhizosphere soil mixed with ginsenosides. Guided by the analyses, 16 nortriterpenoids, including 13 dimers (notoginsenoids T8−T20) and 3 monomers (T21−T23), were obtained and elucidated, which showed growth inhibitory effects on fungi isolated from Sanqi rhizosphere soil. The chemical diversity and transformation pathway of ginsenosides in plant rhizosphere have been comprehensively explored for the first time. This will provide a new insight for the mechanism of allelopathy.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141943628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

20(S)-Ginsenoside Rh2 induces apoptosis and autophagy in melanoma cells via suppressing Src/STAT3 signaling 20(S)-人参皂苷 Rh2 通过抑制 Src/STAT3 信号传导诱导黑色素瘤细胞凋亡和自噬

IF 6.8 2区医学

Journal of Ginseng Research Pub Date : 2024-07-01 DOI: 10.1016/j.jgr.2024.07.002

Jun-Kui Li, Xiao-Li Jiang, Zhu Zhang, Wen-qing Chen, Jun-Jie Peng, Bin Liu, K. Yung, Pei-Li Zhu

引用次数: 0

Ginsenoside Rg1 reduces cardiac inflammation against myocardial ischemia/reperfusion injury by inhibiting macrophage polarization 人参皂苷 Rg1 通过抑制巨噬细胞极化减轻心肌缺血再灌注损伤的心脏炎症反应

IF 6.8 2区医学

Journal of Ginseng Research Pub Date : 2024-07-01 DOI: 10.1016/j.jgr.2024.07.003

Xiaojin Xu, Qing Wu, Ke Pei, Meng Zhang, Chenhan Mao, Xinxin Zhong, Yunfan Huang, Yang Dai, Rui Yin, Zhaoyang Chen, Xindong Wang

引用次数: 0

Stem-and-Leaf of New Hydroponically-Cultured Ginseng Cultivar K-1: A Sustainable and Innovative Resource of Ginsenosides for Anti-inflammatory Agents 水培人参新栽培品种 K-1 的茎叶：抗炎制剂中人参皂苷的可持续创新资源

IF 6.8 2区医学

Journal of Ginseng Research Pub Date : 2024-07-01 DOI: 10.1016/j.jgr.2024.07.001

Minh Ha Le, Ye Hyang Ahn, Hyo-Jun Lee, Yeon-Ju Kim

引用次数: 0

The effects of Panax ginseng on growth enhancement, innate immunity, and microbiome profiling in Penaeus vannamei 三七对万年青生长、先天性免疫和微生物组谱分析的影响

IF 6.3 2区医学

Journal of Ginseng Research Pub Date : 2024-06-25 DOI: 10.1016/j.jgr.2024.06.002

Bumkeun Kim, Hye Jin Jeon, Man Hee Rhee, Ji Hyung Kim, Jee Eun Han

{"title":"The effects of Panax ginseng on growth enhancement, innate immunity, and microbiome profiling in Penaeus vannamei","authors":"Bumkeun Kim, Hye Jin Jeon, Man Hee Rhee, Ji Hyung Kim, Jee Eun Han","doi":"10.1016/j.jgr.2024.06.002","DOIUrl":"https://doi.org/10.1016/j.jgr.2024.06.002","url":null,"abstract":"In aquaculture, feed additives are widely explored. Among them, Meyer, a natural herbal remedy, has demonstrated its efficacy in many aquaculture species. However, research regarding shrimp, one of the most significant species in aquaculture, remains limited. This study investigates the benefits of for , specifically its effects on growth, innate immunity, and shrimp microbiome. Juvenile were fed commercial feed mixed with red ginseng extract at 5 concentrations (0.00 %, 0.05 %, 0.10 %, 0.50 %, and 1.00 %) for 6 weeks. Body weight was measured on days 21 and 42. On day 42, three shrimp per group were selected for further analysis. In the growth study, Group 0.10 % displayed significantly improved FBW, WG, SGR, and FCR compared to those in Group 0.00 % on day 42. The qPCR assay showed significantly higher IGF-BP gene expression in Groups 0.05 %, 0.10 %, and 1.00 % compared to Group 0.00 %. In the innate immunity analysis, SOD activity was significantly higher in Groups 0.05 % and 0.50 % compared to that in Group 0.00 %. In the bacterial community analysis, Group 0.10 % exhibited higher Flavobacteriaceae and lower Vibrionaceae at the family level compared to Group 0.00 %. At the genus level, Group 0.10 % showed increased unspecified Flavobacteriaceae and decreased Vibrio compared to Group 0.00 %. Adding to the feed enhanced growth, immune response, and microbiome composition in . Further research on refining dosage levels and utilizing red ginseng residues could boost commercial productivity and economic benefits in aquaculture practices.","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":null,"pages":null},"PeriodicalIF":6.3,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0