Int. J. Knowl. Discov. Bioinform.最新文献_第7页

A Novel Evolutionary Biclustering Approach using MapReduce(EBC-MR) 基于MapReduce(EBC-MR)的进化双聚类方法

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/IJKDB.2016010103

R. Rathipriya

引用次数: 5

Mapping Affymetrix Microarray Probes to the Rat Genome via a Persistent Index 通过持久索引定位Affymetrix微阵列探针到大鼠基因组

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/JKDB.2010100204

S. Fairley, J. McClure, Neil Hanlon, Robert W. Irving, M. McBride, A. Dominiczak, Ela Pustulka-Hunt

引用次数: 8

Low Dose Pioglitazone Attenuates Oxidative Damage in Early Alzheimer's Disease by Binding mitoNEET: Transcriptome-To-Reactome™ Biosimulation of Neurons 低剂量吡格列酮通过结合mitoNEET:神经元转录组-反应组™生物模拟减轻早期阿尔茨海默病的氧化损伤

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/IJKDB.2015010103

Charles D. Hammack, George Perry, R. LeBaron, G. Villareal, C. Phelix

{"title":"Low Dose Pioglitazone Attenuates Oxidative Damage in Early Alzheimer's Disease by Binding mitoNEET: Transcriptome-To-Reactome™ Biosimulation of Neurons","authors":"Charles D. Hammack, George Perry, R. LeBaron, G. Villareal, C. Phelix","doi":"10.4018/IJKDB.2015010103","DOIUrl":"https://doi.org/10.4018/IJKDB.2015010103","url":null,"abstract":"Oxidative damage OD is considered to be a central component in the progression of Alzheimer's disease AD. 8-hydroxyguanosine 8-OHG, a readily oxidized ribonucleic acid found in AD, was used as a biomarker to investigate the role of OD in the progression of the disease. A disruption in two critical Thioredoxin-Dependent Peroxiredoxin System components, peroxiredoxin-3 Prx-3 and thioredoxin Trx, may serve as a source of the increased accumulation of OD observed in AD. We demonstrate that OD, in the form of 8-OHG, was quantitatively most significant during the earliest stage of AD [F 3, 25 = 5.08, p <.01]. A drastic decline in mitochondrial protein levels of Prx-3 [F 3, 25 = 8.74, p. < 01] and Trx [F 3, 25 = 4.33, p. < 05] were also observed across the progression of the disease. We then tested the efficacy of pioglitazone, a thiazolidinedione class drug aimed to delay onset of AD by acting on mitoNEET. Our results showed a significant reduction in the oxidized variant of mitoNEET within the incipient population when a 0.8mg dose was simulated in silico p = 0.0242; a. < 05.","PeriodicalId":160270,"journal":{"name":"Int. J. Knowl. Discov. Bioinform.","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134208735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Prediction of Protein-Protein Interactions Between Human Host and Two Mycobacterial Organisms 人类宿主与两种分枝杆菌之间蛋白-蛋白相互作用的预测

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/jkdb.2010100201

O. Krishnadev, S. Bisht, N. Srinivasan

引用次数: 7

A Distributed Scalar Controller Selection Scheme for Redundant Data Elimination in Sensor Networks 传感器网络中冗余数据消除的分布式标量控制器选择方案

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/IJKDB.2017010107

S. Priyadarshini, S. Panigrahi

引用次数: 4

Characterization and Classification of Local Protein Surfaces Using Self-Organizing Map 基于自组织图谱的局部蛋白质表面表征与分类

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/jkdb.2010100203

Lee Sael, D. Kihara

引用次数: 15

A Transfer Learning Approach and Selective Integration of Multiple Types of Assays for Biological Network Inference 生物网络推理的迁移学习方法和多类型分析的选择性集成

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/jkdb.2010100205

Tsuyoshi Kato, Kinya Okada, H. Kashima, Masashi Sugiyama

引用次数: 41

Figure Based Biomedical Document Retrieval System using Structural Image Features 基于结构图特征的生物医学文献检索系统

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/jkdb.2012010103

Harikrishna G. N. Rai, K. Deepak, P. R. Krishna

{"title":"Figure Based Biomedical Document Retrieval System using Structural Image Features","authors":"Harikrishna G. N. Rai, K. Deepak, P. R. Krishna","doi":"10.4018/jkdb.2012010103","DOIUrl":"https://doi.org/10.4018/jkdb.2012010103","url":null,"abstract":"Multi-modal and Unstructured nature of documents make their retrieval from healthcare document repositories a challenging task. Text based retrieval is the conventional approach used for solving this problem. In this paper, the authors explore an alternate avenue of using embedded figures for the retrieval task. Usually, context of a document is directly reflected in the associated figures, therefore embedded text within these figures along with image features have been used for similarity based retrieval of figures. The present work demonstrates that image features describing the structural properties of figures are sufficient for the figure retrieval task. First, the authors analyze the problem of figure retrieval from biomedical literature and identify significant classes of figures. Second, they use edge information as a means to discriminate between structural properties of each figure category. Finally, the authors present a methodology using a novel feature descriptor namely Fourier Edge Orientation Autocorrelogram FEOAC to describe structural properties of figures and build an effective Biomedical document retrieval system. The experimental results demonstrate the better retrieval performance and overall improvement of FEOAC for figure retrieval task, especially when most of the edge information is retained. Apart from invariance to scale, rotation and non-uniform illumination, the proposed feature descriptor is shown to be relatively robust to noisy edges.","PeriodicalId":160270,"journal":{"name":"Int. J. Knowl. Discov. Bioinform.","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131952313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exerting Cost-Sensitive and Feature Creation Algorithms for Coronary Artery Disease Diagnosis 应用成本敏感和特征创建算法进行冠状动脉疾病诊断

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/jkdb.2012010104

R. Alizadehsani, Mohammad Javad Hosseini, Reihane Boghrati, Asma Ghandeharioun, F. Khozeimeh, Z. Sani

引用次数: 38

K-NN Based Outlier Detection Technique on Intrusion Dataset 基于K-NN的入侵数据集离群点检测技术

Int. J. Knowl. Discov. Bioinform. Pub Date : 1900-01-01 DOI: 10.4018/IJKDB.2017010105

S. Sahu, S. K. Jena, Manish Verma

引用次数: 5