Journal of Health Economics and Outcomes Research最新文献

{"title":"Private Sector Hospitals' Response to Changes in Demand for Health Insurance in Arab Countries.","authors":"Vivian Nasiruddin","doi":"10.36469/001c.140416","DOIUrl":"10.36469/001c.140416","url":null,"abstract":"<p><p><b>Background:</b> Health insurance (HI) plays a vital role in providing health services, as it covers relevant healthcare costs to improve health outcomes. <b>Objectives:</b> The study aimed to analyze the extent to which private sector hospitals respond to changes in demand for HI in 3 Arab countries between 2006 and 2022. Methods: A structural equation model was used to evaluate the dynamic association between the variables. The study sample comprised the Kingdom of Saudi Arabia, the United Arab Emirates, and Jordan. <b>Results:</b> There were largely negative relationships between the demand for insurance and indicators of healthcare capacity, namely, the number of hospitals, hospital beds, and nurses. This suggests that publicly funded and organized healthcare systems limit private insurance demand. Furthermore, the panel vector autoregression Granger causality tests indicated a dynamic, 2-way Granger causal relationship between insurance demand and infrastructure. The policy implications of the study therefore suggest recommendations that healthcare planning be coordinated with insurance policy planning. <b>Discussion:</b> Regarding the number of hospitals, the coefficient for demand for HI was -0.169 (<i>P</i> = .032, indicating a negative but not significant relationship between HI and the number of hospitals. For beds, the coefficient for HI was 0.0000574 (<i>P</i> <  .001), suggesting a statistically significant negative relationship between HI and number of beds. Regarding the number of doctors, the coefficient for HI was -0.0000266 (<i>P</i>< .001), indicating a statistically significant negative relationship between HI and number of doctors. For the number of nurses, the coefficient for future insurance demand was -0.0000968 (<i>P</i> <  .001), reinforcing a negative relationship between HI and number of nurses. <b>Conclusions:</b> The study presents important insights into the intricate interplay between healthcare infrastructure and insurance demand in the private hospital markets of Saudi Arabia, the United Arab Emirates, and Jordan. These findings highlight the need for comprehensive health system planning in conjuction with insurance reforms, infrastructure development, and workforce reinforcement to maximize the sustainability and effectiveness of HI plans in the region.</p>","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"238-245"},"PeriodicalIF":2.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Pain Reduction and Functional Improvements Following a Noninvasive Biomechanical Intervention for Gait Rehabilitation on Healthcare Claims: An Observational Study.","authors":"William Vanderveer, Eric Freeman","doi":"10.36469/001c.140740","DOIUrl":"10.36469/001c.140740","url":null,"abstract":"<p><p><b>Background:</b> Musculoskeletal conditions substantially impact public health in the United States, affecting approximately 128 million adults and resulting in over $600 billion in annual socioeconomic costs. Low back pain and knee osteoarthritis are the most prevalent musculoskeletal disorders, with projections suggesting their incidence will increase markedly due to aging populations and rising obesity rates. <b>Objective:</b> The purpose of this study was to evaluate healthcare claims utilization (HCRU), clinical outcomes, and patient satisfaction for individuals with knee and back pain treated with a home-based, biomechanical intervention that aims to provide precision medicine for patients with musculoskeletal conditions. <b>Methods:</b> A retrospective analysis of claims data was conducted on 616 patients with knee and back pain who were treated with a noninvasive, home-based, biomechanical intervention (AposHealth) from October 2020 to October 2023. Eligibility was determined based on specific diagnostic criteria. The controls were 3576 patients with knee and back pain who were receiving the standard of care. HCRU, pain levels, functional disability, and patient satisfaction were captured. <b>Results:</b> Significant reductions in HCRU were noted, with significantly lower rates of minor and major surgeries compared with control groups. The economic analysis suggested substantial cost savings of approximately $9 million over 20 months, suggesting an 80% reduction in costs in those treated with the biomechanical intervention compared with controls. Pain levels decreased significantly by 32.5% and 57% at 3 and 6 months posttreatment for back pain, respectively. Patients with knee pain reported a significant decrease of 39% and 35% at 3 and 6 months, respectively. <b>Discussion:</b> The examined biomechanical intervention led to a significant reduction in pain and improvement in function, which presumably is a driving factor for a meaningful reduction in HCRU and potential cost savings. <b>Conclusions:</b> There is an urgent need for innovative strategies that alleviate the burden of musculoskeletal disorders on the healthcare system. The results of this study add to the evidence about the clinical effectiveness and cost-savings of this intervention in patients with knee and back pain, using real-world data.</p>","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"230-237"},"PeriodicalIF":2.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open Access to Antipsychotics in State Medicaid Programs: Effect on Healthcare Resource Utilization and Costs among Patients with Serious Mental Illness.","authors":"Rashmi Patel, Onur Baser, Heidi C Waters, Daniel Huang, Leigh Morrissey, Katarzyna Rodchenko, Gabriela Samayoa","doi":"10.36469/001c.137909","DOIUrl":"10.36469/001c.137909","url":null,"abstract":"<p><p><b>Background:</b> The restrictive consequences of Medicaid formulary restriction policies on antipsychotic medications may lead to higher healthcare utilization and costs among beneficiaries with serious mental illness (SMI). <b>Objectives:</b> This study compared outcomes among patients with SMI accessing antipsychotic medications through state Medicaid programs with open access (OA) policies (Michigan) vs 5 states without Medicaid OA policies (California, Colorado, Florida, Illinois, Wisconsin). <b>Methods:</b> A retrospective analysis was conducted using Kythera Labs Medicaid data (Jan. 1, 2016-Dec. 31, 2023). Outcomes were assessed for patients with SMI (>18 years of age, ≥1 antipsychotic medication claim during the identification period (Jan. 1, 2017-Dec. 31, 2022), ≥1 SMI claim in the 12-month baseline). Continuous medical and pharmacy benefits were required for 12 months pre- and post-index date. Outcomes included SMI-related hospital admissions, length of hospital stay, emergency department and outpatient visits, and associated costs. <b>Results:</b> A greater proportion of beneficiaries with SMI resided in Michigan than in the other states. After matching, significantly more antipsychotics users experienced SMI-related hospitalizations in California (18.25% vs 9.47%, P < .0001), Colorado (11.41% vs 7.33%, P  =.0004), Florida (19.70% vs 10.17%, P < .0001), Illinois (23.57% vs 8.79%, P < .0001), and Wisconsin (15.21% vs 10.02%, P = .0046) than in Michigan. Length of stay was lower in Michigan than in California, Colorado, and Illinois. Inpatient costs related to SMI were significantly lower in Michigan, yet pharmacy costs were higher. Total SMI-related costs were higher in all non-OA states than in Michigan, except Colorado. <b>Discussion:</b> State Medicaid programs without OA to antipsychotics were associated with higher rates of SMI-related resource utilization and costs vs Michigan. <b>Conclusions:</b> Policy makers should consider the potential downstream cost implications of restrictive access policies and evaluate whether OA could result in improved health outcomes for patients and savings for Medicaid programs.</p>","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"222-229"},"PeriodicalIF":2.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Upfront Treatment Patterns for Newly Initiated Patients With Pulmonary Arterial Hypertension in the United States.","authors":"Carly Paoli, Wenze Tang, Sumeet Panjabi, Ashwin Ravichandran","doi":"10.36469/001c.138006","DOIUrl":"10.36469/001c.138006","url":null,"abstract":"<p><p><b>Background:</b> The 2022 European Society of Cardiology/European Respiratory Society (ESC/ERS) pulmonary hypertension guidelines recommend initial combination of endothelin receptor antagonist (ERA) and phosphodiesterase type-5 inhibitor (PDE5i) in patients with pulmonary arterial hypertension (PAH) at low to intermediate risk without cardiopulmonary comorbidities. <b>Objective:</b> To examine US treatment patterns for newly diagnosed patients, including frequency of cardiopulmonary comorbidities. <b>Methods:</b> Treatment-naïve adults (≥18 years) initiating treatment, identified using claims data (IQVIA PharMetrics® Plus; April 2013-June 2023), were assigned dual therapy if initiating ERA/PDE5i within a treatment-determination period (3 months), or monotherapy if initiating ERA or PDE5i. Descriptive statistics captured 25th/75th percentiles, means (SD), and medians. <b>Results:</b> Of 2868 patients, 824 (28.7%) initiated dual therapy and 2044 (71.3%) monotherapy. In dual therapy, 461 (56.0%) initiated ERA first, 250 (30.3%) PDE5i first, and 113 (13.7%) both the same day. In monotherapy, 153 (7.5%) received ERA and 1891 (92.5%) PDE5i. For escalation to dual therapy, 330 (16.1%) monotherapy users initiated ERA (10.7%) or PDE5i (5.5%) during follow-up. Most had cardiopulmonary comorbidities (monotherapy: 86.8%; dual: 79.6%). Of the 824 on dual therapy, 20.4% started triple therapy during follow-up. Compared with monotherapy, dual therapy users were younger (54.9 vs 59.6 years) and mostly female (72.9% vs 60.9%). <b>Discussion:</b> This study found that in the United States, among newly diagnosed PAH patients, 71.3% initiated monotherapy and 28.7% dual therapy, with 16.1% of monotherapy patients eventually escalating to dual therapy. High rates of initial monotherapy may reflect the high proportion of patients with comorbidities and their possible intolerance of initial dual therapy. As these data mostly precede the 2022 guidelines, future research should include treatment post-guidelines, rationales behind decision making, differences between initial monotherapy and dual therapy users, and monotherapy overreliance and effects on morbidity and mortality. <b>Conclusions:</b> This analysis of real-world US treatment patterns for newly initiating PAH patients found low rates of upfront dual-therapy use with high rates of cardiopulmonary comorbidities.</p>","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"213-221"},"PeriodicalIF":2.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Costs and Consequences of Implementing an Optimization Process for Low-Complexity Emergency Care: The LINEA Program.","authors":"German Devia-Jaramillo, Nathalia Esmeral-Zuluaga, Juan Pablo Vargas-Gallo, Rafael Alfonso-Cristancho","doi":"10.36469/001c.130031","DOIUrl":"10.36469/001c.130031","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Introduction:&lt;/b&gt; Overcrowding is persistent in emergency departments (EDs) worldwide and can result in adverse patient outcomes and prolonged lengths of stay. Delays in care and unmet demand contribute to negative outcomes for patients awaiting treatment, including increased morbidity and mortality, prolonged hospital stays, and overall lower quality of medical care. Overcrowding in EDs not only diminishes patient satisfaction with the entire hospitalization experience, beyond the ED, but also significantly increases healthcare costs and contributes to a rise in medical errors. Therefore, developing strategies that optimize the limited resources available for emergency patient care, especially for those with low-complexity emergencies, is crucial. &lt;b&gt;Objective:&lt;/b&gt; To evaluate whether implementing a specific care strategy for patients with low-complexity emergencies can effectively reduce costs and improve clinical outcomes and patient-reported experiences compared with standard care practices. &lt;b&gt;Methods:&lt;/b&gt; A cost-consequence model was employed to separately evaluate the costs and outcomes of each alternative. The cost and outcome analyses were applied to healthcare services using the database of a tertiary-level ED, analyzed from the perspective of the healthcare service provider over a 2-year time horizon. To assess the perspective of the healthcare provider institution, the cost-consequence analysis was conducted using a decision tree model. &lt;b&gt;Results:&lt;/b&gt; The study included 43 268 patients. No significant differences were found in demographic variables between groups. A significant difference was found in total length of stay in minutes between groups: minimum (median interquartile range [IQR]), 534 (456-644) vs 494 (364-719) (&lt;i&gt;P&lt;/i&gt; &lt; .001). In addition, there was an improvement in the NPS value from 44 to 53 throughout the ED, with 0.005% mortality in the study group and 0.07 in the control group (&lt;i&gt;P&lt;/i&gt; &lt; .001). Finally, a significant difference was documented in the mean billing per patient, with a median (IQR) of Col &lt;math&gt;&lt;mn&gt;255&lt;/mn&gt; &lt;mrow&gt;&lt;mo&gt; &lt;/mo&gt;&lt;/mrow&gt; &lt;mn&gt;903&lt;/mn&gt; &lt;mo&gt;(&lt;/mo&gt; &lt;mi&gt;C&lt;/mi&gt; &lt;mi&gt;o&lt;/mi&gt; &lt;mi&gt;l&lt;/mi&gt;&lt;/math&gt; 151 108-Col &lt;math&gt;&lt;mn&gt;658&lt;/mn&gt; &lt;mrow&gt;&lt;mo&gt; &lt;/mo&gt;&lt;/mrow&gt; &lt;mn&gt;585&lt;/mn&gt; &lt;mo&gt;)&lt;/mo&gt; &lt;mi&gt;v&lt;/mi&gt; &lt;mi&gt;s&lt;/mi&gt; &lt;mi&gt;t&lt;/mi&gt; &lt;mi&gt;h&lt;/mi&gt; &lt;mi&gt;e&lt;/mi&gt; &lt;mi&gt;c&lt;/mi&gt; &lt;mi&gt;o&lt;/mi&gt; &lt;mi&gt;m&lt;/mi&gt; &lt;mi&gt;p&lt;/mi&gt; &lt;mi&gt;a&lt;/mi&gt; &lt;mi&gt;r&lt;/mi&gt; &lt;mi&gt;i&lt;/mi&gt; &lt;mi&gt;s&lt;/mi&gt; &lt;mi&gt;o&lt;/mi&gt; &lt;mi&gt;n&lt;/mi&gt; &lt;mi&gt;g&lt;/mi&gt; &lt;mi&gt;r&lt;/mi&gt; &lt;mi&gt;o&lt;/mi&gt; &lt;mi&gt;u&lt;/mi&gt; &lt;mi&gt;p&lt;/mi&gt; &lt;mi&gt;a&lt;/mi&gt; &lt;mi&gt;n&lt;/mi&gt; &lt;mi&gt;d&lt;/mi&gt; &lt;mi&gt;C&lt;/mi&gt; &lt;mi&gt;o&lt;/mi&gt; &lt;mi&gt;l&lt;/mi&gt;&lt;/math&gt; 283 922 (Col &lt;math&gt;&lt;mn&gt;125&lt;/mn&gt; &lt;mrow&gt;&lt;mo&gt; &lt;/mo&gt;&lt;/mrow&gt; &lt;mn&gt;998&lt;/mn&gt; &lt;mo&gt;-&lt;/mo&gt; &lt;mi&gt;C&lt;/mi&gt; &lt;mi&gt;o&lt;/mi&gt; &lt;mi&gt;l&lt;/mi&gt;&lt;/math&gt; 776 097) (&lt;i&gt;P&lt;/i&gt; &lt; .018). &lt;b&gt;Conclusion:&lt;/b&gt; The implementation of a specialized unit for the care of patients with low-complexity emergencies within the ED has proven effective in improving total patient length of stay. This significantly contributes to reducing overcrowding, decreasing mortality, and reducing unmet ","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"207-212"},"PeriodicalIF":2.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Secondary Care System Burden of Glycogen Storage Disease Type Ia (GSDIa) Using the Hospital Episode Statistics Database.","authors":"Eliza Kruger, Shreena Giblin","doi":"10.36469/001c.137126","DOIUrl":"10.36469/001c.137126","url":null,"abstract":"<p><p><b>Background:</b> Glycogen storage disease type Ia (GSDIa) is a rare, inherited metabolic disorder characterized by a deficiency in glucose 6-phosphatase. People living with GSDIa are at high risk for clinical manifestations (including hypoglycemia and hepatomegaly) and clinical complications (including hyperlipidemia, stunted growth, liver adenomas, and renal failure). Evaluating symptom management and secondary care burdens is vital to understanding the patient experience and optimizing care pathways. <b>Objective:</b> We sought to quantify the number of patients with GSDIa within secondary care settings across England and to evaluate the burden of disease associated with living with GSDIa. <b>Methods:</b> This study utilized the United Kingdom Hospital Episode Statistics (HES) database across a 69-month time period (April 2015-December 2020) to investigate National Health Service (NHS) resource use and GSDIa mortality. <b>Results:</b> Patients (N = 943) with GSDIa were identified. Frequent manifestations included anemia (n = 421; 45%), hypoglycemia (n = 185; 20%), and hepatomegaly (n = 152; 16%). On average, patients had a total of 8 events/year, including 2 elective events, 2 nonelective emergencies, 1 outpatient visit, and 3 daycase visits. In the entire HES population, there was approximately 1 (~60% elective, ~40% nonelective) event/year. The highest total number of events across the entire patient journey tracked within the HES occurred with adolescents (12-17 years) who had an average of 28.5 events. Average length of stay was greatest in the pediatric infantile (0-2 years) population with 4.6 days and 3.4 days for nonelective and elective events, respectively. When benchmarked against the general population, patients with GSDIa had a mortality rate of 4.3%, compared with 0.9% for the entire HES population. The average age at mortality was 14.3 years lower for patients with GSDIa vs the entire HES population (63.7 years vs 78.0 years). <b>Discussion:</b> This study demonstrates high burden associated with GSDIa. Complications are a key driver of NHS resource use. Mortality associated with GSDIa in hospitalized patients is higher than the general population. <b>Conclusions:</b> GSDIa imposes a large burden on the healthcare system. There is a clear unmet need for patients with GSDIa, and complications are a substantial driver of resource use and burden of disease.</p>","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"201-206"},"PeriodicalIF":2.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Digital Navigation on Screening Adherence With the Multi-Target Stool DNA Test.","authors":"Mallik Greene, Timo Pew, A Burak Ozbay, John B Kisiel, A Mark Fendrick, Paul Limburg","doi":"10.36469/001c.133939","DOIUrl":"https://doi.org/10.36469/001c.133939","url":null,"abstract":"<p><p><b>Background:</b> Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second leading cause of cancer-related deaths in the United States. Screening can prevent CRC by detecting advanced precancerous lesions. Adherence to screening is crucial in reducing CRC disease burden; however, there is limited research on the impact of digital outreach screening uptake and adherence. <b>Objective:</b> This study evaluated the impact of different digital outreach channels on patient adherence to CRC screening with a multi-target stool DNA (mt-sDNA) test in a real-world setting. Methods: Patients were individuals aged 45 to 85 years with a valid mt-sDNA test order from Exact Sciences Laboratories, LLC (Jan. 1, 2023-Sept. 23, 2023). All patients received letters and phone calls; some received short message service (SMS), email, or both. Adherence and time to test return were compared across digital outreach categories stratified by patient characteristics. Multivariable regression evaluated the association of digital outreach methods with adherence and time to test return. <b>Results:</b> Among 2 425 308 patients (43.5% between 50 and 64 years, 58.2% female), digital SMS only (62.7%) was the most common outreach method. Overall adherence was 70.1%, with highest adherence in the digital SMS-plus-email group (72.9%). Mean time to test return from shipment of mt-sDNA kit to receipt of valid test was 25.8 days. In adjusted analyses, patients receiving digital SMS plus email had the highest odds of test return (odds ratio, 1.75; 95% confidence interval [CI], 1.73-1.78; <i>P</i><.001) and had return times 8.7% shorter than the no-digital-outreach group (95% CI, 8.2-9.2; <i>P</i><.001). <b>Discussion:</b> Among nationally insured individuals within the recommended age range for CRC screening, overall adherence to the mt-sDNA test was in the 70s, with the highest rates in the digital (SMS and email) outreach group and the lowest in the no-digital-outreach group. <b>Conclusions:</b> These findings highlight the importance of multichannel navigation in facilitating completion of CRC screening with the mt-sDNA test.</p>","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"191-200"},"PeriodicalIF":2.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic Evaluation of Population-Level Chronic Kidney Disease Interventions in the UK National Health Service.","authors":"George Agathangelou, Matthew Graham-Brown, Aisling C McMahon, George Xydopoulos, Larisa Gofman, Jacob Jaffe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p><b>Background:</b> Chronic kidney disease (CKD) affects 13% of the global population, is predicted to be the fifth leading cause of premature death by 2040, and is associated with increased risk of cardiovascular disease and acute cardiovascular events. With an aging population and rising diabetes rates, the prevalence of CKD is expected to escalate in the United Kingdom, leading to substantial healthcare costs. When patients reach end-stage kidney disease, interventions such as dialysis and transplantation are required. Dialysis is not only extremely costly but is also associated with a diminished quality of life and significantly elevated mortality. <b>Objectives:</b> This study assesses the cost-effectiveness of several population-level interventions designed to manage CKD, including its progression to end-stage kidney disease. <b>Methods:</b> A population-level Markov model was developed to evaluate the cost-effectiveness and population health impacts of 4 key interventions, individually and combined: (1) early/improved diagnosis, (2) enhanced CKD management, (3) increased use of SGLT-2 inhibitors, and (4) higher rates of pre-emptive live donor transplantation. The model incorporates both NHS direct costs and broader economic impacts, with a 10-year horizon and quarterly cycles. Two scenarios were analyzed: a base case (based on disease progression probabilities) and a constrained case (where growth in the number of patients receiving dialysis and transplantation is limited to historical rates observed in the UK National Health Service). <b>Results:</b> All interventions demonstrated cost-effectiveness, with the combined approach preventing 10 351 deaths and yielding 48 381 quality-adjusted life-years (QALYs) at a cost of £7675 per QALY in the base case scenario. In the constrained scenario, the combined interventions demonstrated cost-effectiveness, preventing 10 026 deaths and yielding 47 514 QALYs at a cost of £22 767 per QALY. <b>Conclusions:</b> The results demonstrate the cost-effectiveness of population level interventions for management of CKD, and the significant burden of dialysis, with avoidance of progression to dialysis a key driver of QALY gains and cost offsets.</p>","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"184-190"},"PeriodicalIF":2.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Resource Utilization and Costs Related to Falls and Fractures Among People With Type 2 Diabetes Receiving Basal Insulin: The FRAGILE Study.","authors":"Guillermo E Umpierrez, Elizabeth K Pogge, Xuan Li, Ronald Preblick, Jasvinder Gill, Naushira Pandya","doi":"10.36469/001c.133274","DOIUrl":"https://doi.org/10.36469/001c.133274","url":null,"abstract":"<p><p><b>Background:</b> The association between falls or fall-related fractures and hypoglycemia in people with type 2 diabetes is well established. Insulin treatment is associated with an increased risk of hypoglycemia, which is compounded in people of older age, but the risk is lower with longer-acting vs intermediate- or long-acting basal insulin analogs. <b>Objective:</b> To examine healthcare resource utilization and costs related to falls/fractures in people with type 2 diabetes treated with the longer-acting basal insulin Gla-300 (insulin glargine 300 U/mL) vs long-acting basal insulins (insulin glargine 100 U/mL or insulin detemir)/neutral protamine Hagedorn (NPH). <b>Methods:</b> This retrospective study of Optum's de-identified Clinformatics® Data Mart Database compared data for people aged 50 years or older with at least 1 prescription claim for basal insulin (excluding insulin degludec) between April 1, 2015, and April 30, 2021, who initiated Gla-300 insulin (basal insulin-naive) or transitioned to Gla-300 from a different basal insulin (basal insulin-switch). Cohorts were propensity score-matched. The primary outcome was fall/fracture-related hospitalization and emergency department visit events (per 100 person-years of follow-up [P100PYFU]). The association between fall/fracture events and hypoglycemia and costs were secondary outcomes. Outcomes were compared using 95% confidence intervals of rate and other ratios; no statistical inference was performed. <b>Results:</b> Fall/fracture-related hospitalization (2.88 vs 3.33 P100PYFU) and emergency department visit events (5.28 vs 5.95 P100PYFU) were numerically lower in people who initiated basal insulin with Gla-300 vs long-acting basal insulins/NPH, and in those who switched to Gla-300 vs long-acting basal insulins/NPH (2.54 vs 3.38 and 4.48 vs 5.21 P100PYFU, respectively). People with vs without hypoglycemia experienced more falls/fractures, regardless of whether initiating basal insulin or switching basal insulin treatment. Costs tended to be lower for people who switched to Gla-300; however, low event rates caused variability. <b>Conclusions:</b> The results of this study suggest that there is a positive correlation between fall/fracture events and hypoglycemia in people with type 2 diabetes and also, that fall/fracture-related healthcare resource utilization was numerically lower in people who initiated basal insulin with Gla-300 vs long-acting basal insulins/NPH, and in those who switched to Gla-300 vs long-acting basal insulins/NPH.</p>","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"171-183"},"PeriodicalIF":2.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Burden of Adult X-Linked Hypophosphatemia on Carers and Family Members: A Mixed-Methods Study.","authors":"Elina Matter, Claire Lawrence, Oliver Gardiner, Victoria Hayes, Gillian Logan, Ben Johnson, Andrew Lloyd","doi":"10.36469/001c.133860","DOIUrl":"https://doi.org/10.36469/001c.133860","url":null,"abstract":"<p><p><b>Introduction:</b> X-linked hypophosphatemia (XLH) is a rare, genetic disorder that severely impacts the health-related quality of life (HRQoL) of people living with the condition. This impact can also extend to carers and family members, described as a \"spillover effect.\" Measurement of spillover effects can lead to greater understanding of disease burden and potentially to more equitable decision-making regarding adoption of treatments by health technology assessment (HTA) bodies. This study aimed to explore spillover effects among carers and family members of adults with XLH. <b>Methods:</b> This cross-sectional, mixed-methods study included carers and family members of adults diagnosed with XLH in the United Kingdom. Quantitative data included a background questionnaire, the EQ-5D-5L, and the Work Productivity and Activity Impairment Questionnaire (WPAI). Qualitative data were gathered through semi-structured interviews. <b>Results:</b> Twenty carers or family members of adults with XLH completed the study. Four (20%) had an XLH diagnosis themselves. Mean (SD) EQ-5D utility was 0.66 (0.33) for the total sample, and 0.20 (0.31) and 0.77 (0.21) for participants with and without a personal diagnosis of XLH, respectively. The WPAI activity impairment was 42% and overall work impairment was 28%. Interviews revealed 6 areas of participants' lives impacted by XLH: emotional wellbeing, daily activities, work, finances, social lives and relationships, and physical impacts. <b>Conclusion:</b> Findings of this study indicate a substantial health-related quality-of-life and productivity burden for carers and family members of adults with XLH. The magnitude of this burden highlights the importance of incorporating such spillover effects in HTAs and broader rare disease policies.</p>","PeriodicalId":16012,"journal":{"name":"Journal of Health Economics and Outcomes Research","volume":"12 1","pages":"162-170"},"PeriodicalIF":2.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}