Journal of immunoassay & immunochemistry最新文献_第2页

Adults with low opsonic natural antibody levels against Streptococcus pneumoniae show enhanced response to PPSV23 vaccination. 肺炎链球菌天然抗体水平低的成年人对接种 PPSV23 疫苗的反应增强。

Journal of immunoassay & immunochemistry Pub Date : 2025-01-02 Epub Date: 2024-11-19 DOI: 10.1080/15321819.2024.2430344

Sravani Dharmavaram, Geetha Nagaraj, Sundaresan Natesan, Manjula Subbanna, Ravikumar Kadahalli Lingegowda

{"title":"Adults with low opsonic natural antibody levels against Streptococcus pneumoniae show enhanced response to PPSV23 vaccination.","authors":"Sravani Dharmavaram, Geetha Nagaraj, Sundaresan Natesan, Manjula Subbanna, Ravikumar Kadahalli Lingegowda","doi":"10.1080/15321819.2024.2430344","DOIUrl":"10.1080/15321819.2024.2430344","url":null,"abstract":"Background: Pneumococcal diseases pose a significant public health concern globally, particularly among young children and the elderly. Vaccination plays a crucial role in their prevention. This study evaluated the functional immune responses to Pneumococcal polysaccharide vaccine serotypes in healthy Indian adults before and after administering a single dose of PPSV23 immunization.Methods: A total of 125 healthy participants aged 18-65 received the PPSV23 vaccine, and their pre- and post-immunization sera were analyzed by MOPA. Opsonic Index, Geometric mean OPA titers and fold increase for each serotype was calculated.Results: The highest baseline OPA GMTs were observed for serotypes 33F,17F,9N,20, and 6B. The lowest OPA GMTs were noted against types 1 and 12F. OPA GMTs post-vaccination increased significantly for all serotypes, with geometric mean fold rise (GMFR) ranging from 4.3 to 267.5. Participants with low pre-immunization OPA titers (<8 & <64) showed significant increases in OI fold raise across all tested serotypes post-vaccination. This robust immune response was consistent across serotypes, indicating highly effective seroconversion in individuals with low baseline antibody levels.Conclusion: The PPSV23 vaccine elicits a strong immunogenic response in individuals with low pre-immunization OPA titers, achieving substantial increases in opsonic index fold raise across various serotypes.","PeriodicalId":15990,"journal":{"name":"Journal of immunoassay & immunochemistry","volume":" ","pages":"29-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging therapies and innovations in vitiligo management: a comprehensive review. 白癜风治疗中的新兴疗法和创新：全面回顾。

Journal of immunoassay & immunochemistry Pub Date : 2025-01-02 Epub Date: 2024-10-06 DOI: 10.1080/15321819.2024.2412528

Manjusha Bhange, Sachin Kothawade, Darshan Telange, Vijaya Padwal

{"title":"Emerging therapies and innovations in vitiligo management: a comprehensive review.","authors":"Manjusha Bhange, Sachin Kothawade, Darshan Telange, Vijaya Padwal","doi":"10.1080/15321819.2024.2412528","DOIUrl":"10.1080/15321819.2024.2412528","url":null,"abstract":"Vitiligo is a common skin disorder where melanocytes, the cells that produce skin pigment, are destroyed by the immune system, leading to white patches on the skin and mucous membranes. This condition affects 0.4% to 2.0% of the global population, with a higher prevalence in females and often beginning in childhood. In India, about 1% of the population is affected, particularly in northern regions, with a higher incidence in females and links to other autoimmune diseases. This review examines recent progress in understanding vitiligo and its treatment. It focuses on the genetic, autoimmune, and environmental factors involved in the disease and highlights new therapies, such as targeted molecular treatments and advanced repigmentation methods. Current research shows that oxidative stress and genetic predispositions contribute to the autoimmune destruction of melanocytes. Novel drug delivery systems, including liposomes, nanoemulsions, and nanostructured lipid carriers, have improved treatment effectiveness. Clinical trials are exploring new treatments like Ruxolitinib cream and melanocyte transplantation, while teledermatology is becoming useful for managing patients. Vitiligo also poses a significant economic burden due to its impact on patients' quality of life. Continued research is essential to develop better, more accessible treatments and reduce the economic impact of vitiligo.","PeriodicalId":15990,"journal":{"name":"Journal of immunoassay & immunochemistry","volume":" ","pages":"1-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical interference of Burosumab therapy on intact fibroblast growth factor 23 (iFGF23) measurements using an immunoassay: preliminary evaluation. 使用免疫测定法分析布苏单抗疗法对完整成纤维细胞生长因子 23 (iFGF23) 测量的干扰：初步评估。

Journal of immunoassay & immunochemistry Pub Date : 2025-01-02 Epub Date: 2024-11-04 DOI: 10.1080/15321819.2024.2422098

Vincenzo Brescia, Roberto Lovero, Antonietta Fontana, Francesca Di Serio, Marica Colella, Vincenza Carbone, Marika Giliberti, Maria Grazia Perrone, Antonio Scilimati, Raffaele Palmirotta

{"title":"Analytical interference of Burosumab therapy on intact fibroblast growth factor 23 (iFGF23) measurements using an immunoassay: preliminary evaluation.","authors":"Vincenzo Brescia, Roberto Lovero, Antonietta Fontana, Francesca Di Serio, Marica Colella, Vincenza Carbone, Marika Giliberti, Maria Grazia Perrone, Antonio Scilimati, Raffaele Palmirotta","doi":"10.1080/15321819.2024.2422098","DOIUrl":"10.1080/15321819.2024.2422098","url":null,"abstract":"Our study evaluated the possible interference of Burosumab (human recombinant monoclonal antibody directed against N-terminal domain of FGF23) on the immunoassay of intact FGF23 (iFGF23) with the Liaison XL. The analytical method uses three different antibodies, one of which directed against the N-terminal portion of FGF23. The evaluation of the method accuracy involved the fully automated execution of a dilution test on EDTA plasma from 5 subjects who had not received any monoclonal antibody (mAb), 20 EDTA plasma from patients treated with Burosumab, and 2 EDTA plasma from subjects who had not received any mAb in witch an adequate volume of Burosumab had been added in vitro. One sample with specific diluent (LIAISON® FGF 23) with an adequate volume of Burosumab had been added in vitro. The dilution assay provided highly inaccurate iFGF23 results in samples with therapeutic concentrations of Burosumab and in samples with concentrations below the LoQ (6.5 pg/mL). The addition of Burosumab to the diluent did not produce any analytical interference. Dissociation of iFGF23 from the mAb-target complex in diluted sample could explain the loss of accuracy in the iFGF23 immunoassay using the Liaison XL analyzer. Burosumab could be an interferent in immunoassay procedures of iFGF23.","PeriodicalId":15990,"journal":{"name":"Journal of immunoassay & immunochemistry","volume":" ","pages":"89-105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of diagnostic performances of Pro-neurotensin and Heart-type fatty acid binding protein as reliable biomarkers for cardiovascular diseases. 评估前神经紧张素和心脏型脂肪酸结合蛋白作为心血管疾病可靠生物标记物的诊断性能。

Journal of immunoassay & immunochemistry Pub Date : 2025-01-02 Epub Date: 2024-11-26 DOI: 10.1080/15321819.2024.2430332

Ahmed Shaker Elzantout, Amal Ahmed Mohamed, Manar Selim Fouda, Gamil Karam Mohamed, George Ghaly Girgis, Nesreen Hamdy Mahmoud, Mohamed Abdel Kader Elian, Mariana Victor Philips, Rasha Mohamed, Mohamed Moustafa Omran

{"title":"Evaluation of diagnostic performances of Pro-neurotensin and Heart-type fatty acid binding protein as reliable biomarkers for cardiovascular diseases.","authors":"Ahmed Shaker Elzantout, Amal Ahmed Mohamed, Manar Selim Fouda, Gamil Karam Mohamed, George Ghaly Girgis, Nesreen Hamdy Mahmoud, Mohamed Abdel Kader Elian, Mariana Victor Philips, Rasha Mohamed, Mohamed Moustafa Omran","doi":"10.1080/15321819.2024.2430332","DOIUrl":"10.1080/15321819.2024.2430332","url":null,"abstract":"Aim: In 2019, cardiovascular diseases accounted for 32% of global deaths. So, early detection of cardiac disorders is crucial. The study aimed to examine the suitability of Pro-neurotensin and Heart-type fatty acid binding protein as dependable biomarkers for cardiac patients with Heart failure as a primary diagnosis.Methodology: The prospective study involved 204 Egyptian volunteers (100 cardiac patients and 104 controls) enrolled from El-Sahel Teaching Hospital in Cairo, Egypt, between October 2022 and May 2023. Inclusion criteria included a high risk of cardiovascular events with symptoms like a fast or irregular pulse, shortness of breath, and fatigue. Exclusion criteria included asymptomatic individuals, cognitive disorders, and psychiatric conditions. The Research Ethics Committee approved the protocol. The consultant conducted a clinical examination of all patients and assessed their heart state. Serum ProNT and H-FABP were detected using a kit for the sandwich ELISA technique.Results: ProNT and H-FABP were significantly elevated in patients compared to controls with p < 0.001. Demonstrated sensitivity of 81% and 84%, with a specificity of 89% and 91%, respectively.Conclusion: Elevated ProNT and H-FABP levels are associated with severe CVDs, suggesting their potential as diagnostic biomarkers for patients, specifically those with heart failure, as a primary characteristic.","PeriodicalId":15990,"journal":{"name":"Journal of immunoassay & immunochemistry","volume":" ","pages":"49-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Further evidence of antibodies against Crimean-Congo haemorrhagic fever virus in different livestock species in Nigeria. 尼日利亚不同牲畜物种中克里米亚-刚果出血热病毒抗体的进一步证据。

Journal of immunoassay & immunochemistry Pub Date : 2025-01-02 Epub Date: 2024-11-11 DOI: 10.1080/15321819.2024.2426146

Chinonyerem Chinyere, Ismaila Shittu, Ndudim Ogo, Adeyinka Adedeji, Aliyu Sada, Vakuru Columba, Hussaini Ularamu, Chika Nwosuh, Clement Meseko

引用次数: 0

Rotavirus-specific-IgA and cytokines responses in Ascaris lumbricoides-infected preschool-aged Nigerian children following rotavirus vaccination. 尼日利亚学龄前蛔虫感染儿童接种轮状病毒疫苗后的轮状病毒特异性-IgA 和细胞因子反应。

Journal of immunoassay & immunochemistry Pub Date : 2025-01-02 Epub Date: 2024-11-12 DOI: 10.1080/15321819.2024.2426147

Kazeem Sanjo Akinwande, Paul Akinniyi Akinduti, OlatunbosunGaniyu Arinola

{"title":"Rotavirus-specific-IgA and cytokines responses in Ascaris lumbricoides-infected preschool-aged Nigerian children following rotavirus vaccination.","authors":"Kazeem Sanjo Akinwande, Paul Akinniyi Akinduti, OlatunbosunGaniyu Arinola","doi":"10.1080/15321819.2024.2426147","DOIUrl":"10.1080/15321819.2024.2426147","url":null,"abstract":"Rotavirus diarrhea and Ascaris lumbricoides (Al) infection increase intestinal morbidity and were associated with altered immune responses that compromise the vaccine efficacy in children. The serum level of rotavirus specific IgA (RV-IgA) and cytokine profiles in A. lumbricoides (AI) infected preschool-aged Nigerian children were estimated following oral rotavirus vaccination. Nineteen of the 149 preschool-aged children (aged 6 to 60 months) with Ascaris lumbricoides infection paired with age and sex-matched helminth - free children were administered with oral rotavirus vaccine after intestinal helminth screening using stool sample concentration technique. Separated sera from 3 mL venous blood samples were collected and estimated for cytokines (IFN-γ, TNF-α, IL-4, IL-8 IL-6, IL-10) and RV-IgA before and three weeks after rotavirus vaccination using Enzyme Linked Immunosorbent Assay. IFN-γ, IL-8, IL-4 were significantly lower at post-vaccination in Al-infected children compared with pre-vaccination. Serum IL-10 was significantly higher at post-vaccination in both Al-infected children and helminth-free controls, compared with pre-vaccination levels (p < 0.05). Pre-vaccination IL-8 and IL-6 were significantly higher in Ascaris lumbricoides-infected children, while the post-vaccination IL-8 was significantly higher in Ascaris lumbricoides-infected compared with control. At post-vaccination period, RV-IgA level was lower in Al-infected children and significantly higher in helminth - free control group compared to pre-vaccination RV-IgA level. Ascaris lumbricoides infection contributed to down-regulation of some cytokines and antibody responses to oral rotavirus vaccine.","PeriodicalId":15990,"journal":{"name":"Journal of immunoassay & immunochemistry","volume":" ","pages":"75-88"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pilot study of interferon-induced helicase and glutamate decarboxylase gene polymorphism with autoimmune thyroid disease. 干扰素诱导解旋酶和谷氨酸脱羧酶基因多态性与自身免疫性甲状腺疾病的初步研究。

Journal of immunoassay & immunochemistry Pub Date : 2025-01-02 Epub Date: 2024-12-05 DOI: 10.1080/15321819.2024.2435856

Sherin Sobhy Elnaidany, Abdlhamid Abdo Esmail, Enas Sobhy Zahran, Maram Fathi, Shimaa Kamal Zewain

{"title":"A pilot study of interferon-induced helicase and glutamate decarboxylase gene polymorphism with autoimmune thyroid disease.","authors":"Sherin Sobhy Elnaidany, Abdlhamid Abdo Esmail, Enas Sobhy Zahran, Maram Fathi, Shimaa Kamal Zewain","doi":"10.1080/15321819.2024.2435856","DOIUrl":"10.1080/15321819.2024.2435856","url":null,"abstract":"Background: Numerous genes are involved in immune system modulation, and their polymorphisms may contribute to developing autoimmune disorders. Genetic variation contributes significantly to disease susceptibility to autoimmune thyroid disease (AITD).Objectives: This work aims to investigate the role of single-nucleotide polymorphisms (SNPs) of interferon induced with helicase C domain 1 (IFIH1) rs1990760 and glutamate decarboxylase (GAD) rs769404 in AITD development.Methods: The study had 330 participants, including 153 cases of Hashimoto's thyroiditis (HT), 77 cases of Graves' disease (GD), and 100 healthy controls. All subjects underwent medical history assessment and clinical evaluation. Tests were conducted using real-time PCR, including genotyping of IFIH1 (rs1990760) and GAD (rs769404) via an allele discrimination assay.Results: Most patients with AITD were females. About 18.3% of HT cases and 15.6% of GD cases have a positive family history of thyroid disease. A significant statistical difference was observed between AITD cases and control regarding IFIH1 (rs1990760) and GAD (rs769404) gene polymorphism. Moreover, GD patients, HT patients, and the control group showed increased CT and TT alleles in patients compared to those in controls.Conclusion: IFIH1 and GAD polymorphisms are involved in AITDs (HT and GD) development and are associated with some clinical presentations. HT and GD cases had a positive family history of thyroid disease. There was a significant statistical difference between AITD cases and control regarding IFIH1 (rs1990760) and GAD (rs769404) gene polymorphism.","PeriodicalId":15990,"journal":{"name":"Journal of immunoassay & immunochemistry","volume":" ","pages":"106-121"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of SHMT2 and NDUFA4L2 gene expression and UCA1 levels in Egyptian patients with bladder cancer. SHMT2和NDUFA4L2基因表达和UCA1水平在埃及膀胱癌患者中的作用

Journal of immunoassay & immunochemistry Pub Date : 2025-01-01 Epub Date: 2025-07-14 DOI: 10.1080/15321819.2025.2533800

Eman A E Badr, Yostena Mekhail, Khaled S A Hassan, Mohamed F A Assar

{"title":"The role of SHMT2 and NDUFA4L2 gene expression and UCA1 levels in Egyptian patients with bladder cancer.","authors":"Eman A E Badr, Yostena Mekhail, Khaled S A Hassan, Mohamed F A Assar","doi":"10.1080/15321819.2025.2533800","DOIUrl":"10.1080/15321819.2025.2533800","url":null,"abstract":"Bladder Cancer (BC) has a significant burden, with poor survival rates in advanced cases. This case-controlled study aimed to identify genes having diagnostic and prognostic value. Seventy patients with BC and 70 healthy individuals were included. Real-time PCR was used to quantify the expression of the SHMT2 and NDUFA4L2 genes, and UCA1 levels. Results showed that SHMT2, NDUFA4L2, and UCA1 were significantly upregulated in patients compared to the control group (p < 0.001). The area under the receiver operating characteristic curve (ROC) analysis showed that AUC was 0.995 (95% CI = 0.989-1, p < 0.001), 0.994 (95% CI = 0.987-1, p < 0.001) and 0.977 (95% CI = 0.958-0.996, p < 0.001) for UCA1, SHMT2, and NDUFA4L2, respectively with high diagnostic sensitivity and specificity. Additionally, the high expression of SHMT2 and the high level of UCA1 were correlated with histological grade (p < 0.001and 0.001, respectively) and with CT tumor size (p = 0.005 and 0.001, respectively). In univariate COX regression analysis, SHMT2 and UCA1 were poor prognostic (p = 0.003 and 0.001, respectively). Furthermore, in the multivariate analysis, UCA1 was independent poor prognostic factor (p =0.037). Thus, SHMT2, NDUFA4L2, and UCA1 could be promising diagnostic and prognostic biomarkers and a novel therapeutic target.","PeriodicalId":15990,"journal":{"name":"Journal of immunoassay & immunochemistry","volume":" ","pages":"435-449"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroprevalence and associated risk factors of Newcastle disease in guinea fowls in the Upper East region of Ghana. 加纳上东部地区珍珠鸡新城疫血清流行率及相关危险因素

Journal of immunoassay & immunochemistry Pub Date : 2025-01-01 Epub Date: 2025-06-12 DOI: 10.1080/15321819.2025.2518206

Albert Agyapong Tweneboah, Sherry Ama Mawuko Johnson, Patrick Mensah Amponsah, Derrick Adu Asare, Benjamin Obukowho Emikpe

{"title":"Seroprevalence and associated risk factors of Newcastle disease in guinea fowls in the Upper East region of Ghana.","authors":"Albert Agyapong Tweneboah, Sherry Ama Mawuko Johnson, Patrick Mensah Amponsah, Derrick Adu Asare, Benjamin Obukowho Emikpe","doi":"10.1080/15321819.2025.2518206","DOIUrl":"10.1080/15321819.2025.2518206","url":null,"abstract":"Newcastle Disease (ND) is a major constraint to poultry production in sub-Saharan Africa. However, information on Newcastle disease in guinea fowls is scant in Ghana. This study seeks to detect circulating antibodies against ND and the risk factors for occurrence in guinea fowls in the Upper East region of Ghana. Sera was obtained from guinea fowls from households, live bird markets, and slaughter points in different locations in the Upper East region. The sera were evaluated for antibodies against Newcastle disease using the Haemagglutination Inhibition (HI) test. Questionnaire was administered to the farmers to assess risk factors such as vaccination status, management system, and contact with wild birds. Almost half, 213/431 (49.4%, 95% CI = 44.6-54.2) of the guinea fowls were seropositive. The seroprevalence was 46.2% in live bird markets, 36.63% in households, and 52.7% at slaughter points. A seroprevalence of 49.7% was observed in adults and 45.7% growers. There was a 53.4% prevalence in males and 43.9% in females. Antibodies to ND were found circulating in guinea fowls in the Upper East region. We recommend that guinea fowls be made an important component element in the ND surveillance for an effective monitoring and control in the region.","PeriodicalId":15990,"journal":{"name":"Journal of immunoassay & immunochemistry","volume":" ","pages":"403-418"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CXCR4 expression in immunohistochemistry of gastrointestinal neuroendocrine neoplasms: a meta-analysis. CXCR4在胃肠道神经内分泌肿瘤免疫组织化学中的表达：一项meta分析。

Journal of immunoassay & immunochemistry Pub Date : 2025-01-01 Epub Date: 2025-03-24 DOI: 10.1080/15321819.2025.2482642

Changlong Ruan, Jiajia Zhang, Yingying Liao, Yujie Hang, Yuan Dong, Hanfeng Shi, Xiaoya Wang

{"title":"CXCR4 expression in immunohistochemistry of gastrointestinal neuroendocrine neoplasms: a meta-analysis.","authors":"Changlong Ruan, Jiajia Zhang, Yingying Liao, Yujie Hang, Yuan Dong, Hanfeng Shi, Xiaoya Wang","doi":"10.1080/15321819.2025.2482642","DOIUrl":"10.1080/15321819.2025.2482642","url":null,"abstract":"Objective: C-X-C chemokine receptor type 4 (CXCR4) is significantly associated with the development of various malignant tumors. This meta-analysis aims to investigate the expression of CXCR4 in the immunohistochemistry of gastrointestinal neuroendocrine neoplasms (GI-NENs).Methods: A comprehensive literature search regarding gastrointestinal neuroendocrine neoplasms and CXCR4 was conducted using PubMed,Web of Science, and the Cochrane Library, with a cut off date of June 30, 2024.Two researchers independently screened the literature according to inclusion and exclusion criteria and assessed study quality using the Newcastle-OttawaScale. Meta-analysis was performed using Stata version 17.0. The pooled positive rate was employed to evaluate the expression of CXCR4 in the immunohistochemistry of GI-NENs.Results: A total of eight studies involving 501 patients were included in this research. The immunohistochemical analysis revealed positive CXCR4 expression in 174 patients. The meta-analysis calculated and summarized the combined positive rate (R: 0.41; 95% CI = 0.21-0.60, p = 0.00), indicating that the differences were statistically significant.Conclusion: CXCR4 is highly expressed in the immunohistochemistry of GI-NENs, which may provide some evidence for the therapeutic application of CXCR4 antagonists in treating neuroendocrine neoplasms.","PeriodicalId":15990,"journal":{"name":"Journal of immunoassay & immunochemistry","volume":" ","pages":"209-217"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0