Journal of Esthetic and Restorative Dentistry最新文献

{"title":"Is There Space for Resin Composite Restorations in a World of CAD-CAM and Digital Dentistry? Two-Year Follow-Up of Clinical Outcomes Using the Direct-Indirect Technique.","authors":"Andrés Dávila-Sánchez, Newton Fahl","doi":"10.1111/jerd.13430","DOIUrl":"https://doi.org/10.1111/jerd.13430","url":null,"abstract":"<p><strong>Objective: </strong>This clinical report seeks to elucidate the versatility and mid-term outcomes of the direct-indirect technique. It presents a comprehensive step-by-step protocol for restoring anterior dentition across various clinical scenarios in accordance with the principles of the polychromatic layering technique.</p><p><strong>Clinical considerations: </strong>This clinical report was divided into two phases. First, an urgent procedure due to the debonding of an interim restoration in tooth #10 was followed by crafting a direct-indirect veneer. Then, in the six-month follow-up appointment, a complete esthetic improvement in the anterior dentition (teeth #8, #9) with two techniques and different materials for each tooth was observed: In tooth #8, a direct incisal edge augmentation was performed, while in tooth #9, a thin contact lens-type direct-indirect fragment was created to improve the form of the tooth. The restorations were followed up for a 24-month mean, with the following criteria: Color, wear, adaptation, marginal discoloration, and integrity.</p><p><strong>Conclusions: </strong>The direct-indirect technique showed optimal clinical outcomes after a mid-term follow-up, making it an option to traditional direct veneering, ceramics, and CAD-CAM materials.</p><p><strong>Clinical significance: </strong>The direct-indirect technique amplifies the scope of resin composite restorations, providing optimal esthetic performance, broad indications, and mid-term longevity regardless of the selected restorative composite material or veneer type.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation of a Terminal Dentition Patient Using an Immediate Loading Protocol With a Virtual Patient-Assisted Workflow: A Case Report.","authors":"Panagiotis Ntovas, Piyarat Sirirattanagool, Praewvanit Asavanamuang, Lorenzo Tavelli, Maria Elisa Galarraga-Vinueza","doi":"10.1111/jerd.13451","DOIUrl":"https://doi.org/10.1111/jerd.13451","url":null,"abstract":"<p><strong>Objectives: </strong>To demonstrate the implementation of a digital workflow for the rehabilitation of a terminal dentition patient with complete-arch implant-supported prostheses.</p><p><strong>Clinical considerations: </strong>A virtual patient-oriented workflow can facilitate interdisciplinary treatment planning, improving the synergism between surgical and prosthetic procedures. Digital technologies assisted the acquisition of prosthetic information and optimized dental implant placement, provisional restoration fabrication, and delivery of definitive prostheses.</p><p><strong>Conclusions: </strong>Digital processing methods enable the integration of cutting-edge technological innovations, with fundamental prosthetic and surgical principles, to build individualized workflows for immediate implant placement and loading, aiming to provide improved patient care in comprehensive rehabilitation. To ensure predictable outcomes, a thorough diagnosis and data collection are needed for selecting the appropriate digital workflow, based on the latest scientific evidence.</p><p><strong>Clinical significance: </strong>For patients with terminal dentition, clinicians can integrate artificial intelligence (AI) driven applications to form a comprehensive treatment plan. The virtual treatment plan can then be transferred to clinical practice, enabling surgical and prosthetic interventions for complete-arch, immediate implant placement and loading through a digital workflow.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Limonene on the Bond Strength of a Universal Adhesive System to Caries-Affected Dentin.","authors":"Giulia Franc Liberatori, Eduardo José Soares, Rocio Geng Vivanco, Fernanda de Carvalho Panzeri Pires-de-Souza","doi":"10.1111/jerd.13452","DOIUrl":"https://doi.org/10.1111/jerd.13452","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effect of limonene (LIM) on the bond strength of a universal adhesive system in self-etch mode to caries-affected dentin (CAD).</p><p><strong>Materials and methods: </strong>Class I cavities were prepared in eighty sound human molars and divided into four groups (n = 20): Sound dentin (SD), SD + LIM (SD treated with LIM), CAD, and CAD + LIM (CAD treated with LIM). Following pH cycling, two layers of a universal adhesive system (Single Bond Universal, 3MESPE) were applied. After restoration (Filtek Z350, 3MESPE), samples were sectioned into 0.9 mm² sticks and stored in distilled water at 37°C for 24 h and 6 months. Subsequently, sticks were subjected to microtensile bond strength testing. Data were analyzed using 2-way ANOVA and Bonferroni's test (p < 0.05). Fracture patterns were examined under optical and scanning electron microscopes.</p><p><strong>Results: </strong>After 24 h, SD + LIM showed lower bond strength than CAD but remained higher than CAD + LIM. CAD + LIM exhibited the lowest bond strength, regardless of aging. In SD + LIM, widened dentinal tubules were observed, accompanied by resin tags. In CAD + LIM, disorganized and unprotected collagen fibrils were identified, with fewer resin tags.</p><p><strong>Conclusions: </strong>Limonene decreased the bond strength of the universal adhesive system in self-etch mode to caries-affected dentin.</p><p><strong>Clinical significance: </strong>Limonene as a pretreatment in self-etch adhesive protocols shows potential for enhancing the durability of adhesive restorations on sound dentin. However, its use on caries-affected dentin could compromise adhesion, highlighting the need for careful consideration when applying it to compromised substrates.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Pink Esthetic Score for Single Implants in the Esthetic Zone Using Intraoral Scanning Data: A Proof-of-Concept Study.","authors":"Ziang Wu, Guanyu Su, Xinbo Yu, Lijuan Ye, Feng Wang, Chun Xu","doi":"10.1111/jerd.13445","DOIUrl":"https://doi.org/10.1111/jerd.13445","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the feasibility of esthetic assessments based on intraoral scanning data using pink and white esthetic scores (PES/WES).</p><p><strong>Materials and methods: </strong>Thirty samples with both intraoral photographs and scanning data were collected and rated by two observers with excellent consistency independently. PES includes seven variables, and WES includes five. The maximum scores were 14 and 10, respectively.</p><p><strong>Results: </strong>The mean PES/WES was 10.60 ± 1.69 and 8.50 ± 1.28 for photographs and 10.97 ± 1.69 and 8.40 ± 1.25 for scanning data. No significant difference was observed between the two sample types. The alveolar process variable had significantly higher scores, while the soft-tissue color variable had significantly lower scores based on intraoral photographs compared to scanning.</p><p><strong>Conclusions: </strong>Intraoral scanning could be a method for the esthetic evaluation of single implant-supported restorations using PES/WES. The use of three-dimensional imaging enables the precise assessment of esthetic outcomes, paving the way for improvements in the digital workflow of implant dentistry. However, the limitations of color and texture reproducibility should be noted.</p><p><strong>Clinical significance: </strong>Intraoral scanning data can be used for esthetic evaluation, and reliable results could be achieved with the application of scanning.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Color Match of Single-Shade Versus Multi-Shade Resin Composites: A Systematic Review With Meta-Analysis.","authors":"Eleonora Forabosco, Uros Josic, Ugo Consolo, Luigi Generali, Carlo D'Alessandro, Lorenzo Breschi, Vittorio Checchi","doi":"10.1111/jerd.13444","DOIUrl":"https://doi.org/10.1111/jerd.13444","url":null,"abstract":"<p><strong>Objective: </strong>To address the following PICOS question: Can single-shade resin composites achieve a color match comparable to multi-shade composites in tooth restoration?</p><p><strong>Materials and methods: </strong>A comprehensive search was conducted across multiple electronic databases to identify in vitro and clinical studies evaluating the color match in tooth restoration, in terms of CIELAB (ΔE_ab) and/or CIEDE2000 (ΔE₀₀) color differences metrics, using single-shade and multi-shade composites. The risk of bias was assessed using the Quality Assessment Tool For In Vitro Studies (QUIN Tool), while the revised Cochrane Collaboration's tool (RoB 2) was employed for randomized controlled clinical trials (RCTs). Meta-analyses were performed using RevMan to compare ΔE_ab and ΔE₀₀ values between single-shade and multi-shade composites (p < 0.05).</p><p><strong>Results: </strong>After initial screening, 15 in vitro studies and 4 RCTs met the inclusion criteria for qualitative synthesis, with 8 in vitro studies selected for quantitative analysis. The majority of in vitro studies were classified as medium risk of bias, while RCTs were ranked as low risk of bias. Meta-analyses performed on in vitro studies revealed that single-shade composites exhibited statistically significant higher color differences with the surrounding tooth structure compared to multi-shade composites, for both ΔE_ab and ΔE₀₀ (p < 0.05). However, RCTs usually reported promising outcomes for single-shade materials.</p><p><strong>Conclusions: </strong>This systematic review concluded that multi-shade composites provide a more accurate color match between tooth and direct restoration than single-shade materials when evaluated by instrumental analysis in laboratory settings.</p><p><strong>Clinical significance: </strong>Multi-shade composites exhibit superior color match properties in laboratory studies. However, single-shade composites are a promising alternative when observed visually in clinical settings.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Submucous Alveolar Cleft With Hard- and Soft-Tissue Reconstruction in the Aesthetic Zone: A Case Report.","authors":"Li Niu, Yujia Wang, Cancan Zu, Junjie Zhao, Yuanyuan Ouyang, Shengwei Zhong, Lang Lei, Houxuan Li","doi":"10.1111/jerd.13440","DOIUrl":"https://doi.org/10.1111/jerd.13440","url":null,"abstract":"<p><strong>Objective: </strong>This case report offers information on accurate diagnostic and soft- and hard-tissue reconstruction periodontal surgery deal with \"black triangles\" in the aesthetic zone of anterior teeth caused by submucous alveolar cleft, which is rare and easily overlooked.</p><p><strong>Clinical considerations: </strong>Vertical and horizontal bone augmentation was conducted via guided tissue regeneration and alveolar bone grafting (ABG) at the cleft site where favorable bone grafting conditions were absent. A customized, vascularized interpositional periosteal-connective tissue (VIP-CT) flap was applied as the barrier membrane to maintain the stability of bone replacement graft and provide soft-tissue foundation for gingival papilla growth. Adjustment on the contact point position of the anterior teeth and the shapes of crowns induced growth of the gingival papillae with resin restoration. The radiological and clinical parameters, and smiling photographs demonstrated a satisfactory treatment outcome.</p><p><strong>Conclusions: </strong>When the inflammation and local alveolar bone destruction in the anterior area are disproportionate, submucous alveolar cleft should be considered a potential etiology. Surgical treatment combined with resin restoration substantially improved the affected area.</p><p><strong>Clinical significance: </strong>The hard- and soft-tissue defects can be improved through ABG and VIP-CT flap in a single surgery.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Printed Provisional Removable Partial Denture Designed Using Virtual Patient for a Road Traffic Accident Victim.","authors":"Lucas Cavalcante de Sousa, Míria Rafaelli Souza Curinga, Cecília Santos Galvão, Walter Yu Hang Lam, Adriana da Fonte Porto Carreiro","doi":"10.1111/jerd.13446","DOIUrl":"https://doi.org/10.1111/jerd.13446","url":null,"abstract":"<p><strong>Objective: </strong>Provisional removable partial denture (RPD) preserves esthetic and functional parameters until definitive treatment. This clinical report presents a 19-year-old victim of a road traffic accident who lost the maxillary right central and lateral incisors.</p><p><strong>Clinical considerations: </strong>A 3D printed maxillary provisional RPD planned using a virtual patient was provided until the patient could undergo implant-supported rehabilitation. Intraoral and facial scans were conducted, and the images were integrated into a dental software program for digital prosthetic planning. The provisional RPD was designed considering the facial parameters, then 3D printed, characterized, and delivered to the patient.</p><p><strong>Conclusions: </strong>The 3D printed provisional RPD demonstrated satisfactory esthetic and functional outcomes, offering a faster and more predictable alternative compared to the conventional method.</p><p><strong>Clinical significance: </strong>Using virtual patients to design 3D printed provisional removable partial dentures can enhance the predictability of treatment, especially in the esthetic area.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Gaps in Clinical Research on Tooth Bleaching: A Bibliometric Analysis of Studies Published From 2001 to 2024.","authors":"Walessa Alana Bragança Aragão, Victória Santos Chemelo, Wallacy Watson Pereira Melo, José Lucas Gomes-Moura, Sandro Cordeiro Loretto, Marcelo Figueiredo Lobato, Renata Duarte de Souza-Rodrigues, Alessandra Reis, Alessandro Dourado Loguercio, Rafael Rodrigues Lima","doi":"10.1111/jerd.13434","DOIUrl":"https://doi.org/10.1111/jerd.13434","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this bibliometric review is to address the main trends and development in dental whitening throughout the 21st century, as well as to identify knowledge gaps on the subject.</p><p><strong>Method: </strong>A search was conducted in the Web of Science Core Collection database and information was extracted regarding the journal, authors, keywords, year of publication, number of citations, country, continent of the corresponding author. After reading the articles, data such as study design, type of bleaching technique, types of light sources used with the bleaching, occurrence of tooth sensitivity, and tooth color change analysis method were extracted.</p><p><strong>Results: </strong>The journal with the largest number of publications was \"Operative dentistry\" (n = 61), and the authors with the most articles were Loguercio AD (n = 82) and Reis A (n = 76). The productions are concentrated in Brazil, with emphasis on the State University Ponta Grossa. Most of the articles are randomized clinical studies that used the in-office bleaching technique with 35% hydrogen peroxide.</p><p><strong>Conclusion: </strong>Our results show that the most recent studies used light sources such as a violet LED during whitening; however, more studies are needed to prove the benefits in relation to color change and reduction of tooth sensitivity.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Properties and Behavior of Additively Manufactured Provisional Fixed Dental Prostheses: A Systematic Review on 3D Printing Orientations Relative to Applied Materials and Postprocessing.","authors":"Mohammed Ahmed Alghauli, Shahad Almutairi, Sarah Almuzaini, Rola Aljohani, Waad Aljohani, Ahmed Yaseen Alqutaibi","doi":"10.1111/jerd.13435","DOIUrl":"https://doi.org/10.1111/jerd.13435","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review aimed to assess the influence of printing orientations alone and with other parameters, such as applied material and postprocessing, on the physical-mechanical properties and mechanical behavior of provisional fixed dental prostheses (FDPs).</p><p><strong>Materials and methods: </strong>A comprehensive search of websites such as PubMed, Scopus, Web of Science, and Cochrane was conducted in July 2024. Adhering to PRISMA 2020 guidelines, the studies that investigated the impact of printing orientations on the physical and mechanical properties were included in this review. The modified CONSORT statement was utilized for the risk of bias assessment. A total of 24 records were included; the main build-up angles were horizontal, oblique, and vertical (0°, 45°, and 90°), and other angles such as 30° and 150° were also reported. The data focused on the impact of orientation on 3D-printed products from different materials, applying various postcuring times and artificial aging. Horizontally printed specimens exhibited significantly superior mechanical properties and behavior compared with other angles, while vertically printed specimens displayed the lowest results. Additionally, the material type, amount, and type of fillers and postcuring had the most substantial impacts; zirconia fillers showed more enhanced strength compared to silica fillers, and the mechanical behavior was enhanced with postcuring time of up to 120 min. Optical properties were more related to the materials and technology applied than to printing directions. Polishing of the products enhances surface quality and removes differences from various orientations. Resin specimens exhibited a high susceptibility to staining, irrespective of printing orientation. Furthermore, aging significantly influenced the mechanical properties, gloss, and surface quality of the specimens.</p><p><strong>Conclusions: </strong>To achieve high-quality provisional FDPs, it is essential to select a horizontal orientation. Careful selection of materials is necessary, as well as adherence to optimal printing parameters. 3D-printed resin may not yet be suitable for permanent rehabilitation; however, it is appropriate for short- and long-term temporization.</p><p><strong>Clinical significance: </strong>The production of dental parts is shifting to additive manufacturing; it is crucial to understand the impact of various parameters on the physical and mechanical behavior of dental parts, particularly provisional restorations, to ensure their durable clinical service.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Coloring Pigments on the Properties of Dental Zirconia-A Systematic Review and Meta-Analysis.","authors":"Sivaranjani Gali, Zulekha Patel, Y N Akanksha, Vineetha Karuveetil","doi":"10.1111/jerd.13441","DOIUrl":"10.1111/jerd.13441","url":null,"abstract":"<p><strong>Objectives: </strong>The effect of pigmentation on color, aging behavior, and mechanical properties of zirconia is debated. The purpose of the paper is to conduct a systematic review and meta-analysis of the studies that evaluated the effect of coloring pigments on the properties of zirconia.</p><p><strong>Data sources: </strong>A systematic electronic search was conducted using MEDLINE, Scopus, Cochrane Central, and EBSCO Host. A platform-specific search strategy was employed, using MeSH keywords and text words.</p><p><strong>Study selection: </strong>The inclusion criteria were in vitro experimental studies that synthesized coloring pigments and evaluated their effect on zirconia. Case reports, narrative reviews, and systematic reviews were excluded. Commercially available pre-shaded zirconia, coloring liquids, and staining or glazing systems were not considered. Two investigators independently evaluated the risk of bias using modified CONSORT. Meta-analysis employed a random-effects model and assessed heterogeneity with the I-square test and continuous data with the inverse variance test.</p><p><strong>Conclusions: </strong>Transitional metal oxides are used in pre-shaded blocks and rare earth metals in coloring liquids. These pigments can alter grain size and lattice parameters, increase porosity, reduce translucency, improve aging resistance, and affect zirconia's hardness, fracture toughness, and flexural strength. They demonstrated no effect on gingival fibroblast proliferation, indicating their cytocompatibility.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}