Journal of Esthetic and Restorative Dentistry最新文献

{"title":"Prognosis of Fragment Reattachment in Anterior Crown Fractures: A Retrospective Study.","authors":"Lisu Sung, Hyemin Ku, Yooseok Shin, Salma Swaid, Dohyun Kim, Byoung-Duck Roh","doi":"10.1111/jerd.13429","DOIUrl":"https://doi.org/10.1111/jerd.13429","url":null,"abstract":"<p><strong>Objective: </strong>Although several studies have compared fragment attachment with resin build-ups in anterior crown fractures, none have specifically investigated the outcome of reattached fragments. This retrospective study aimed to evaluate long-term outcomes of fragment reattachment in anterior crown fractures and determine the prognostic affecting their success.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed clinical records of patients who underwent fragment reattachment for crown fractures in anterior teeth (maxillary and mandibular central and lateral incisors) between 2008 and 2023. All procedures were performed by experienced professors and residents following a standardized protocol. Kaplan-Meier survival curves and Cox proportional hazards regression analyses were performed to evaluate fragment retention outcomes and identify potential prognostic factors.</p><p><strong>Results: </strong>Among 75 anterior crown fractures, the estimated fragment retention rates were 83.7% at 2 years, 75.2% at 5 years, and 56.4% at 10 years. Multivariate Cox regression analyses identified patient age and extent of crown fracture as significant factors affecting outcomes. The 5-year estimated fragment retention rates were 82.8% and 67.0% for uncomplicated and complicated crown fractures, respectively.</p><p><strong>Conclusions: </strong>Fragment reattachment remains a viable treatment option for anterior crown fractures. Treatment success decreased with patient age, and complicated crown fractures demonstrated lower retention rates than uncomplicated ones.</p><p><strong>Clinical significance: </strong>Fragment reattachment can provide predictable outcomes in anterior crown fractures when cases are carefully selected, particularly considering the patient's age and the type of crown fracture.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Universal Adhesive Systems With Nanoencapsulated Flavonoids Improve Long-Term Bonding to Caries-Affected Dentin.","authors":"Camila Falconi-Páez, Mayra Alejandra Nuñez Aldaz, Tobia Gastón Navarro, Claudia Carolina González-Vaca, Lucas Arrais Campos, Andres Davila-Sanchez, Cesar Augusto Galvão Arrais","doi":"10.1111/jerd.13426","DOIUrl":"https://doi.org/10.1111/jerd.13426","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the presence of nano-encapsulated flavonoids and their effect in universal adhesives on resin-dentin bond-strength (μTBS) and nanoleakage (NL) on artificial caries-affected dentin (CAD) after 24-h and 6 months of water storage (WS).</p><p><strong>Materials and methods: </strong>Artificial CAD was created on the occlusal dentin surfaces of 60 human third molars by a microbiological assay. Nanoencapsulated quercetin (Q) and naringin (N) were incorporated into Prime&Bond Universal (PBU; Dentsply-Sirona) and Single Bond Universal (SBU, 3M ESPE). The adhesive systems with and without (control) flavonoids were applied to the CAD surface, and a 4-mm resin composite block (TPH Spectrum, Dentsply Sirona) was built up and light-cured. Specimens were sectioned into resin-dentin beams (0.8 mm²). The hybrid layer (HL) was subjected to micro-Raman analysis to detect N and Q. The specimens were tested in tension in a universal testing machine at 0.5 mm/min. μTBS and NL tests were performed after 24-h and WS. μTBS and NL data were analyzed using a nonparametric three-way ANOVA test followed by Bonferroni's test (α = 5%).</p><p><strong>Results: </strong>Q and N were detected within the HL. N and Q nanocapsules increased μTBS and reduced NL values after WS. At 24 h, the PBU group showed higher NL values than the SBU group, and the values decreased after WS.</p><p><strong>Conclusions: </strong>Incorporating nanoencapsulated flavonoids may improve the longevity of universal bonding systems applied to CAD.</p><p><strong>Clinical relevance: </strong>Adhesive restorations incorporating nanoencapsulated quercetin or naringin might be a promising alternative for achieving long-term bonding stability.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Modified Coronally Advanced Tunnel Technique for Coverage of Mucosal Recessions at Dental Implants.","authors":"Anton Sculean, Georgios Nikou, Herbert Deppe, Edward P Allen, Raluca Cosgarea","doi":"10.1111/jerd.13423","DOIUrl":"https://doi.org/10.1111/jerd.13423","url":null,"abstract":"<p><strong>Objectives: </strong>To clinically evaluate the outcomes following surgical coverage of single peri-implant mucosal recessions in the aesthetic maxillary area by means of the modified coronally advanced tunnel (MCAT) and subepithelial connective tissue graft (SCTG).</p><p><strong>Materials and methods: </strong>Eleven systemically healthy non-smoking patients (8 females) each presenting a single peri-implant mucosal recession in the anterior maxillary region were consecutively treated with MCAT in conjunction with SCTG. In all cases, the facial recession was associated with an impaired aesthetic appearance. Before reconstructive surgery and at 12 months postoperatively, clinical and aesthetic parameters were assessed. The primary outcome variable was the mean mucosal recession coverage (MRC).</p><p><strong>Results: </strong>Healing was uneventful in all cases. At 12 months, statistically significant (p < 0.05) recession coverage (MRC 94.71%) and improvement of aesthetics (pink aesthetic score) was obtained at all implants. Complete RC was obtained in 10 out of the 11 patients (90.9%). The treatment was associated with a statistically significant gain of keratinized and attached mucosa (p < 0.05).</p><p><strong>Conclusion: </strong>The present results demonstrate that single peri-implant mucosal recessions in the maxillary aesthetic area can be successfully treated with MCAT and SCTG.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse Torque and Wear of Internal Connections of Metal-Based Abutments Under Cyclic Loading.","authors":"Daher Antonio Queiroz, Mariana Itaborai Moreira Freitas, Kaden Thomas Ockey, Damian Jaewhan Lee, Fengyuan Zheng","doi":"10.1111/jerd.13425","DOIUrl":"https://doi.org/10.1111/jerd.13425","url":null,"abstract":"<p><strong>Objective: </strong>Evaluate the reverse torque values and wear of internal connections caused by metal-based zirconia abutments under cyclic loading.</p><p><strong>Material and methods: </strong>Thirty implants were divided into three groups (n = 10), based on connection systems: Interference-fit cone-screw (Cortical Master Flash MI Fit-MTA and Cortical Master Flash MI RP-MTB), and Internal hexagon (Cortical Titanium Master Connect AR-IH). Metal-based zirconia abutments were tightened into the implant, and zirconia crowns were bonded using resin cement. All specimens underwent cyclic loading at 300 N and 9 Hz for 1,000,000 cycles. Reverse torques were assessed postloading, and wear was analyzed using scanning electron microscopy (SEM). Statistical analysis employed one-way ANOVA for reverse torque and wear values, with significant differences assessed via the Tukey test (α = 0.05).</p><p><strong>Results: </strong>Significant differences in reverse torque values were found among groups: MTA (24.9 N), MTB (24.1 N), and IH (14.4 N). The IH group showed higher mean wear values on the tension side (121.0) and compression side (112.6), with a wear difference of 8.4.</p><p><strong>Conclusion: </strong>The interference-fit cone-screw abutments demonstrated significantly reduced torque loss and morphology after cyclic loading, reflecting enhanced performance.</p><p><strong>Clinical significance: </strong>Although the stability of the metal base zirconia abutments to the implants was accurate, clinicians should be cautious about torque loss and more wear when using internal hexagon connections.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-Printed Ultra-Thin Non-Prep Lithium Disilicate Veneers: A Proof-of-Concept Clinical Case.","authors":"Alexey Unkovskiy, Florian Beuer, Jeremias Hey, Daniel Bomze, Franziska Schmidt","doi":"10.1111/jerd.13427","DOIUrl":"https://doi.org/10.1111/jerd.13427","url":null,"abstract":"<p><strong>Objective: </strong>To test the clinical application of LCM-printed lithium disilicate veneers.</p><p><strong>Clinical considerations: </strong>A female patient with tooth wear was scanned with intraoral scanner (Prime Scan, Dentsply Sirona). The six non-prep veneers were designed (DentalCAD, Exocad) and printed from lithium disilicate with an LCM-printer with the thickness of 0.1-0.2 mm (CeraFab System S65 Medical, Lithoz GmbH). The green parts after printing were cleaned of the excess slurry and debindered in a furnace (Nabertherm, Lilienthal) until 430°C with a dwell time of 5 h to remove all polymeric binder. The resulting parts were sintered in an oven (Programat P510, Ivoclar Vivadent AG) at a temperature of 900°C. The supports were removed with a dental technician handpiece (Perfecta 900, W & H). The final restorations were stained (e-max Ceram, Ivoclar Vivadent AG) by a master dental technician.</p><p><strong>Conclusions: </strong>The six LCM-printed ultra-thin non-prep lithium disilicate veneers were tried-in on the patient using a try-in glycerin gel (Ivoclar Vivadent, Schaan, Lichtenstein) and demonstrated excellent fit and esthetics. LCM technology enabled the production of ultra-thin non-prep lithium disilicate veneers with layer thicknesses of down to 0.1 mm.</p><p><strong>Clinical significance: </strong>The 3D-printing of ultra-thin non-prep veneers is technically feasible and provides an adequate clinical outcome. Additive manufacturing of ultra-thin non-prep lithium disilicate veneers may pose a valid alternative to conventional and subtractive manufacturing.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Scissor Bite Case Treatment With Moving Teeth Through Maxillary Sinus.","authors":"Sang-Hoon Lee, Jae Hyun Park, Hee-Sun Huh, Jae-Hyung Yu, Dong-Hwa Chung","doi":"10.1111/jerd.13424","DOIUrl":"https://doi.org/10.1111/jerd.13424","url":null,"abstract":"<p><strong>Objective: </strong>This case report demonstrates the orthodontic treatment to correct a severe scissor bite and occlusal disharmony in a 26-year-old female patient, including the use of temporary anchorage devices (TADs) and fixed orthodontic appliances.</p><p><strong>Clinical considerations: </strong>Severe scissor bite is associated with vertical problems, such as molar extrusion. For orthodontic treatment, interradicular TADs were used to intrude the extruded molars, control the inclination of molars, correct dental midline, and improve dental relationships.</p><p><strong>Conclusions: </strong>This treatment not only achieved successful correction of the scissor bite but also provided adequate occlusion function and improved facial esthetics.</p><p><strong>Clinical significance: </strong>TADs provided an effective orthodontic force system to correct the scissor bite. In severe scissor bite cases, a significant amount of maxillary molar intrusion is required, which can increase the risk of moving teeth through the maxillary sinus. Using CBCT images could help in treatment planning for the three-dimensional movement of teeth during the orthodontic treatment.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interdisciplinary Approach to Retreatment of a Full-Mouth Rehabilitation: Horizontal Preparations, Vertical Dimension of Occlusion Increase, and Mucogingival Surgery in a Tetracycline-Stained Dentition.","authors":"Alfonso Gil, Belén Morón-Conejo, Mónica Bonfanti, Francisco Martínez-Rus, Guillermo Pradies","doi":"10.1111/jerd.13416","DOIUrl":"https://doi.org/10.1111/jerd.13416","url":null,"abstract":"<p><strong>Objective: </strong>This case report presents the interdisciplinary retreatment of a patient with a worn full-mouth rehabilitation using defect-oriented restorations, horizontal preparations, and vertical dimension of occlusion (VDO) increase.</p><p><strong>Clinical considerations: </strong>A 58-year-old woman with a previous full-mouth rehabilitation presented with worn dentition, loss of VDO, and reduced posterior support. Examination revealed signs of parafunctional habits, tetracycline-stained teeth, and compromised aesthetics with exposed discolored teeth and open embrasure spaces. Additionally, the veneers showed wear and ceramic chipping. The retreatment started with a diagnostic phase, including a wax-up and mock-up to guide the treatment plan. Mucogingival surgery was performed to correct gingival recession according to the restorative margins established by the mock-up. The full-mouth rehabilitation involved increasing the VDO through anterior crowns and veneers, posterior overlays, and dental implant restoration. Horizontal chamfer preparations ensured sufficient thickness for the ceramic material, allowing for durable adhesive restorations.</p><p><strong>Conclusions: </strong>The interdisciplinary approach, combining diagnostic, surgical, and prosthetic phases, enabled the successful retreatment of this complex case, restoring function and aesthetics. A 2-year follow-up confirmed the stability and positive outcomes of the rehabilitated dentition.</p><p><strong>Clinical significance: </strong>This interdisciplinary approach provides an effective strategy for managing complex full-mouth rehabilitations, integrating aesthetics, function, and periodontal health through defect-oriented preparation techniques.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Plaque Detectors on the Color Stability of Two Types of Restorative Materials.","authors":"Claudia Mazzitelli, Gaetano Paolone, Uros Josic, Edoardo Mancuso, Alessandro Vichi, Ginevra Pastremoli, Annalisa Mazzoni, Lorenzo Breschi, Tatjana Maravic","doi":"10.1111/jerd.13420","DOIUrl":"https://doi.org/10.1111/jerd.13420","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the color stability of a one-shade resin-based composite material (RC) and a glass-ionomer cement (GIC) after staining with plaque detectors (PDs) with different formulations and delivery forms.</p><p><strong>Materials and methods: </strong>Rectangular-shaped specimens (7 × 3 × 2 mm) were produced with RC (Venus Diamond One, Kulzer) and GIC (Fujy IX GP, GC) (n = 30). Further, the following PDs were used on the specimens: (1) tablets (T; Plaq-Search, TePe); (2) mouthwash (M; Plaque Agent, Miradent); and (3) light-curing liquid (L; Plaque test, Ivoclar). The PDs were removed with dedicated toothbrushes (T₁) and the specimens were repolished (T₂). The protocol was repeated after 1 week of storage in artificial saliva (staining-T₃ and repolishing-T₄). Color measurement were performed at baseline (T₀) and all testing times (T₁-T₄) using a recently introduced digital colorimeter (SmartColor, Smart Vision). Color changes (ΔE_ab) compared to T₀ were automatically recorded by the digital instrument. The data were statistically analyzed (p < 0.05).</p><p><strong>Results: </strong>The type of PD, the polishing procedure and their interactions influenced the color stability of both restorative materials (p < 0.05). Particularly, after the second PDs application, M and L produced the highest color changes (p < 0.05), with GIC showing higher color variability than RC. Although repolishing reduced the color changes of RC (p < 0.05), it could not reestablish the initial color of GIC, irrespective of the PD used (p < 0.05). Except for RC associated with T, all materials exhibited discoloration above the clinical perceptibility (1.77) and acceptability (2.66) thresholds.</p><p><strong>Conclusions: </strong>The influence of PDs on the color stability of RC and GIC was material-dependent. GIC showed higher color instability than RC. Repolishing could not reestablish the original color of GIC and only attenuated the color changes of the one-shade RC. The newly introduced digital colorimeter was an important tool to standardize and simplify color measurement evaluations.</p><p><strong>Clinical significance: </strong>PDs can pose a potential risk to the color stability of restorative materials. Dental practitioners should be careful when recommending the frequency of at-home application of PDs, taking into consideration the material properties and the position of the restorations of each patient.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Fixed Prosthodontics: A Narrative Review.","authors":"Mariam Margvelashvili-Malament, Van Thompson, Kenneth A Malament","doi":"10.1111/jerd.13422","DOIUrl":"https://doi.org/10.1111/jerd.13422","url":null,"abstract":"<p><strong>Objective: </strong>Minimally invasive dentistry is being widely practiced. The center stone is to be as conservative as possible to minimize unnecessary removal of healthy tooth structure. In prosthodontics the patients have generalized and combined nature of diseases. This narrative literature review analyzed available evidence on minimally invasive treatment protocols in fixed prosthodontics and raised awareness on the importance of longevity of treatments and secondary prevention.</p><p><strong>Overview: </strong>The long-term clinical survival of ceramic and resin composite materials was reviewed. Loss of tooth vitality after prosthodontic treatment was also explored. And finally, treatment options for patients with severe wear were examined. The search of the literature resulted in evidence of superior survival of ceramic restorations over resin composites. The literature is also clear that ceramic partial coverage inlay and onlay restorations have excellent long-term clinical performance in posterior dentition. Glass ceramic lithium disilicate showed to be an adequate material not only for anterior but also for posterior dentition, including the patients with severe wear.</p><p><strong>Conclusions: </strong>Minimally invasive dentistry as applied in fixed prosthodontics needs updates in its concepts to account for secondary prevention and longevity of chosen treatment techniques.</p><p><strong>Clinical significance: </strong>This narrative review article critically reviews available evidence on long-term clinical performance of minimally invasive and traditional treatment concepts and materials in fixed prosthodontics. Awareness is raised for secondary prevention and longevity of chosen treatments.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Twist on Injection Molding: Injecting Conventional Resin Composites.","authors":"Marcos A Vargas, Robert Margeas","doi":"10.1111/jerd.13410","DOIUrl":"https://doi.org/10.1111/jerd.13410","url":null,"abstract":"<p><strong>Purpose: </strong>This article presents a different approach to injectable techniques. This technique uses conventional viscosity materials to achieve maximum strength and esthetics.</p><p><strong>Clinical considerations: </strong>The use of high-viscosity material which has the strongest physical properties is desirable since failure of anterior resin composite has been described as fracture and recurrent decay. By incorporating changes to the conventional injection technique, heating and making bigger access wholes on the matrix allows the utilization of higher conventional viscosity materials.</p><p><strong>Conclusions: </strong>The use of higher viscosity materials while using injectable techniques is possible by heating and providing a bigger access entrance to composite resin compules.</p>","PeriodicalId":15988,"journal":{"name":"Journal of Esthetic and Restorative Dentistry","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}