Journal of geriatric oncology最新文献

{"title":"Feasibility and acceptability of a novel intervention to improve communication for older adults with dual diagnoses of dementia and cancer along with their care partners","authors":"A. Magnuson , A. Job , J. Bauer , J. Mortimer , E. Nguyen , S. Hryniv , H. D'Aurizio , N. Dukelow , L. Berkhof , R. Gelb , R. Epstein , B. Kluger , K. Heffner , M. Sohn , L. Wang , E. Ramsdale , S. Kadambi , K.P. Loh , M. Janelsins , S. Mohile","doi":"10.1016/j.jgo.2026.102887","DOIUrl":"10.1016/j.jgo.2026.102887","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102887"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survivorship care delivery for older patients with cancer: An evaluation of community oncology clinics enrolled in a nationwide trial in the United States","authors":"S. Mohile , K.P. Loh , A. Magnuson , M. Wells , C. Hoffman , R. Tylock , F. Stauffer , C. Braun-Inglis , J.O. Hopkins , M. Weiss , P.-J. Lin , S. Yilmaz , K. Mustian , M. Janelsins","doi":"10.1016/j.jgo.2026.102864","DOIUrl":"10.1016/j.jgo.2026.102864","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102864"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of neoadjuvant dual anti-HER2 therapy in older patients with HER2-positive breast cancer: A real-world retrospective analysis","authors":"L.S.J. Au , Y.N. Zhang , K. Yeung , K.L. Cheung , W.L. Chan","doi":"10.1016/j.jgo.2026.102883","DOIUrl":"10.1016/j.jgo.2026.102883","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102883"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric assessment in older patients with pancreatic cancer: Adding another piece to the puzzle","authors":"Giulia Giordano , Luca Mastrantoni , Giuseppe Ferdinando Colloca , Francesco Landi","doi":"10.1016/j.jgo.2026.102891","DOIUrl":"10.1016/j.jgo.2026.102891","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102891"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival prediction in older women with stage I-II breast cancer using decision tree-based machine learning","authors":"Hyuna Yoon ,&nbsp;Yeijin Kim ,&nbsp;Sola Han ,&nbsp;Hae Sun Suh ,&nbsp;Chanhyun Park","doi":"10.1016/j.jgo.2025.102828","DOIUrl":"10.1016/j.jgo.2025.102828","url":null,"abstract":"<div><h3>Introduction</h3><div>Predicting survival in older women with early breast cancer can guide personalized care and improve outcomes. Aging is an individualized process that influences tumor characteristics and survival, with cardiovascular disease (CVD) being the leading non-cancer cause of death due to cardiovascular risk factors. This study aimed to develop and validate machine learning (ML) models to predict all-cause, breast cancer-related, and CVD-related mortality in older women with stage I-II, hormone receptor-positive breast cancer at the U.S. population level. To address the heterogeneity associated with aging, we created separate models for two age groups (66–79 and ≥ 80 years).</div></div><div><h3>Materials and methods</h3><div>Using the 2006–2019 SEER–Medicare database, we identified women aged ≥66 years diagnosed with stage I–II breast cancer, representing early-stage invasive disease, who initiated adjuvant endocrine therapy (AET) between 2007 and 2009. The first date of AET use was defined as the index date. We assessed pre-existing comorbidities during the one year prior to the index date and followed patients for up to 10 years or until death. Outcomes included all-cause mortality, breast cancer-related mortality, and CVD-related mortality. We developed survival prediction models using the decision tree-based algorithms for the two age groups. Model performance was evaluated using the mean area under the receiver operating characteristic curve (AUROC), and model interpretability was enhanced using Shapley Additive Explanations.</div></div><div><h3>Results</h3><div>Among 10,104 women, all six models achieved a mean AUROC &gt;0.7 using the random survival forest algorithm (RSF), indicating strong predictive performance. For all-cause mortality, key predictors in both age groups included age, screenings for suspected conditions (abnormal findings without diagnosis), and congestive heart failure. Tumor size, cancer stage, and secondary malignancies were most predictive of breast cancer-related mortality, while congestive heart failure, heart valve disorders, and other ill-defined heart diseases were critical for CVD-related mortality.</div></div><div><h3>Discussion</h3><div>We developed ML-based survival models across outcomes and age group using the decision tree-based algorithms to predict mortality in older women with stage I-II breast cancer. RSF demonstrated the best performance, with age, screenings for suspected conditions, and congestive heart failure consistently emerging as key predictors. Targeting these factors may enhance cardio-oncology care.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102828"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an older adult-centred cancer program at an academic centre in Ontario, Canada: Initial steps and early successes","authors":"Taleen Haddad ,&nbsp;Karen Misquitta ,&nbsp;Shaila J. Merchant","doi":"10.1016/j.jgo.2025.102838","DOIUrl":"10.1016/j.jgo.2025.102838","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102838"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity cluster trajectories across the care continuum in older women with breast cancer initiating adjuvant endocrine therapy","authors":"Sola Han ,&nbsp;Hyejoong M. Lee ,&nbsp;Chanhyun Park","doi":"10.1016/j.jgo.2026.102852","DOIUrl":"10.1016/j.jgo.2026.102852","url":null,"abstract":"<div><h3>Introduction</h3><div>With the growing population of older breast cancer survivors, understanding how chronic comorbidities evolve across treatment and toward the end-of-life (EOL) is increasingly important. We aimed to characterize temporal and EOL patterns of comorbidity clusters before and after adjuvant endocrine therapy (AET) among women aged 66–79 years and ≥ 80 years with breast cancer.</div></div><div><h3>Materials and methods</h3><div>We used the 2016–2019 SEER-Medicare data to identify women aged ≥66 years who initiated AET in 2017. Eligible patients had hormone receptor–positive, stage I–III breast cancer diagnosed within one year prior to AET initiation (index date). Comorbidities were defined using Clinical Classifications Software Refined (CCSR) codes. To identify comorbidity patterns, we applied agglomerative hierarchical clustering using Jaccard's dissimilarity index and Ward's minimum variance method to the top 50 CCSR categories across four periods: pre-index, post–year 1, post–year 2, and EOL.</div></div><div><h3>Results</h3><div>We identified 11,551 women, of whom 11,050 were alive at the end of follow-up and 501 died during follow-up. Among the patients who were alive, more than 50% had ≥2 chronic conditions across the observation windows. Cardiovascular diseases and their associated risk factors showed the largest increase over time. The most consistent and prevalent cluster across post–year 1, post–year 2, and EOL was “cardiovascular and pulmonary diseases,” including hypertension, coronary atherosclerosis, with additional respiratory and kidney-related conditions emerging near EOL.</div></div><div><h3>Discussion</h3><div>Comorbidity clustering was common and persisted across observation windows, with cardiovascular and related conditions prominent and expanding near EOL. These patterns highlight the need for integrated cardio-oncology and geriatric co-management to address the complex care needs of older women receiving AET.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102852"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncogeriatric assessment: Expert consensus recommendations in Chile","authors":"Rocío Quilodrán Loyola ,&nbsp;Gabriel Martínez Fuentes ,&nbsp;Isidora Jiménez Álvarez ,&nbsp;Evangelina Röling ,&nbsp;Gonzalo Navarrete Hernández","doi":"10.1016/j.jgo.2026.102847","DOIUrl":"10.1016/j.jgo.2026.102847","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102847"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One voice for radiotherapy: Addressing inequities in radiotherapy utilization for older adults","authors":"Penny Mackenzie ,&nbsp;Geoff Delaney ,&nbsp;Lucinda Morris ,&nbsp;Anita O'Donovan","doi":"10.1016/j.jgo.2026.102899","DOIUrl":"10.1016/j.jgo.2026.102899","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102899"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and post-radiation therapy quality of life in geriatric cancer patients","authors":"R. Agrawal ,&nbsp;J. Banerjee ,&nbsp;M. Bhowmik ,&nbsp;N. Aggarwal","doi":"10.1016/j.jgo.2026.102885","DOIUrl":"10.1016/j.jgo.2026.102885","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 2","pages":"Article 102885"},"PeriodicalIF":2.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147449167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}