Journal of geriatric oncology最新文献

{"title":"Corticosteroid therapy in older adults with cancer: Expert recommendations from a task force of the International Society of Geriatric Oncology.","authors":"Rupert Bartsch, Daniel Aletaha, Thorsten Fuereder, Matti Aapro, Francois R Jornayvaz, Pierre-Olivier Lang, Denis Migliorini, Chantal Csajka, Marie-Bernadette Aretin, Vérène Dougoud-Chauvin","doi":"10.1016/j.jgo.2024.102077","DOIUrl":"https://doi.org/10.1016/j.jgo.2024.102077","url":null,"abstract":"<p><p>Corticosteroids are used frequently in oncology and many patients require short- or long-term corticosteroid therapy. General clinical guidelines and recommendations exist on the use of corticosteroids; however, evidence is lacking for recommendations on their appropriate use in older adult with cancer. Treatment of chemotherapy-induced nausea and vomiting (CINV) has dramatically improved over the last decade with 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists and neurokinin-1 (NK-1) receptor antagonists or a combination of both. However, corticosteroids continue to play an important role in the management of acute and delayed CINV prevention. While highly efficacious, the toxicity profile of corticosteroids must be considered, particularly in heterogeneous older patients with multiple comorbidities and polypharmacy. Guidance on corticosteroid-reducing/sparing strategies in this specific population is needed. This consensus, supported by the International Society of Geriatric Oncology, aims to provide evidence-based recommendations for the use of corticosteroid therapy in older adults with cancer.</p>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102077"},"PeriodicalIF":3.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of YOCAS©® yoga on cancer-related fatigue and quality of life in older (60+) vs. younger (≤ 59) cancer survivors: Secondary analysis of a nationwide, multicenter, phase 3 randomized controlled trial","authors":"Evelyn Arana-Chicas ,&nbsp;Po-Ju Lin ,&nbsp;Umang Gada ,&nbsp;Hongying Sun ,&nbsp;Alisha Chakrabarti ,&nbsp;Lindsey J. Mattick ,&nbsp;Katherine Rieth ,&nbsp;Christopher H. Chay ,&nbsp;Janet Ruzich ,&nbsp;Benjamin T. Esparaz ,&nbsp;Ana P. Cupertino ,&nbsp;Brian J. Altman ,&nbsp;Paula M. Vertino ,&nbsp;Supriya G. Mohile ,&nbsp;Karen M. Mustian","doi":"10.1016/j.jgo.2024.102076","DOIUrl":"10.1016/j.jgo.2024.102076","url":null,"abstract":"<div><h3>Introduction</h3><div>Older cancer survivors consistently express the need for interventions to reduce cancer-related fatigue (CRF) and maintain quality of life (QOL). Yoga is a promising treatment to address CRF and QOL. However, research comparing the efficacy of yoga for improving fatigue and QOL in older survivors (60+) vs. younger adult survivors (≤59)is limited. Our objective was to examine the effects of yoga on CRF and QOL in older survivors vs. younger survivors.</div></div><div><h3>Materials and Methods</h3><div>We conducted a secondary analysis of a nationwide, multicenter, phase 3 randomized controlled trial. For this study, participants who provided evaluable pre- and post-intervention data on the Functional Assessment for Chronic Illness Therapy-Fatigue (FACIT-F) and the Functional Assessment for Cancer Therapy-General (FACT-G) were eligible. The yoga intervention comprises gentle Hatha and Restorative Yoga and includes breathing exercises, physical alignment postures, and mindfulness.</div></div><div><h3>Results</h3><div>Of the 177 participants included in the study, 30.1 % were aged 60+ and 69.9 % were aged ≤59. More younger participants had breast cancer (82.0 % vs. 59.2 %. <em>p</em> = 0.009), surgery (98.9 % vs. 77.8 %, <em>p</em> &lt; 0.001), and chemotherapy (80.5 % vs. 55.6 %, <em>p</em> = 0.001). There were no differences in the cancer stage (66.1 % stage I or II). There were statistically significant and clinically meaningful within-group improvements from baseline to post-intervention in CRF for participants aged ≤59 and participants aged 60+ (4.0 ± 0.7, <em>p</em> &lt; 0.001 vs. 3.1 ± 1.0, <em>p</em> = 0.003). Both age groups also demonstrated improvements in QOL (3.2 ± 0.8, <em>p</em> &lt; 0.001 vs. 2.1 ± 1.2, <em>p</em> = 0.078), physical (1.6 ± 0.3, <em>p</em> &lt; 0.001 vs. 0.8 ± 0.5, <em>p</em> = 0.084), functional (0.7 ± 0.3, <em>p</em> = 0.048 vs. 1.0 ± 0.5, <em>p</em> = 0.037), and emotional well-being. There were no significant between-group differences between the age groups. Most younger and older participants reported that yoga helped improve their sleep quality (92.8 % vs 88.5 %) and they would recommend it to other survivors (98.2 % vs 90.4 %).</div></div><div><h3>Discussion</h3><div>Older cancer survivors who undergo gentle Hatha and restorative yoga performed two to three times per week for four weeks at a low to moderate level of intensity have similar improvements in CRF and QOL compared to participants aged ≤59. For older survivors experiencing these toxicities, it is reasonable for clinicians to prescribe yoga.</div><div><span><span><strong>ClinicalTrials.gov</strong></span><svg><path></path></svg></span> <strong>identifier</strong>: <span><span>NCT00397930</span><svg><path></path></svg></span></div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"15 8","pages":"Article 102076"},"PeriodicalIF":3.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIOG2024-2-OA-016 Association between adiposity and overall survival in older adults with newly diagnosed gastrointestinal (GI) malignancies","authors":"S. Maheshwari,&nbsp;D. Hess,&nbsp;A. Tucker,&nbsp;C. Ubersax,&nbsp;G.R. Williams,&nbsp;S. Bhatia,&nbsp;S. Giri","doi":"10.1016/j.jgo.2024.101886","DOIUrl":"10.1016/j.jgo.2024.101886","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"15 7","pages":"Article 101886"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIOG2024-3-P-068 Feasibility of a telehealth-based clinical trial evaluating Memory and Attention Adaptation Training-Geriatrics (MAAT-G) to address symptoms of Cancer Related Cognitive Decline (CRCD) in older adults","authors":"K. Kyi,&nbsp;L. Berkhof,&nbsp;J. Bauer,&nbsp;M. Sohn,&nbsp;L. Wang,&nbsp;J. Mortimer,&nbsp;S. Hryniv,&nbsp;G. DiGiovanni,&nbsp;L. Mustian,&nbsp;V. Targia,&nbsp;T. Lloyd,&nbsp;T. Winslow,&nbsp;S. Kadambi,&nbsp;M. Anand,&nbsp;L. Mattick,&nbsp;L. Kehoe,&nbsp;K.P. Loh,&nbsp;S. Mohile,&nbsp;M. Janelsins,&nbsp;A. Magnuson","doi":"10.1016/j.jgo.2024.101930","DOIUrl":"10.1016/j.jgo.2024.101930","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"15 7","pages":"Article 101930"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIOG2024-1-OA-001 Randomized phase II study of Gemcitabine/Nab-Paclitaxel compared with 5-Fluorouracil/Leucovorin/Liposomal Irinotecan in older patients with treatment-naïve metastatic pancreatic cancer (GIANT EA2186)","authors":"E. Dotan,&nbsp;P. Catalano,&nbsp;L. Lenchik,&nbsp;R. Boutin,&nbsp;X. Yao,&nbsp;J.P. Ohr,&nbsp;K.-H. Lim,&nbsp;N. Vijayvergia,&nbsp;S.R. Chandana,&nbsp;A. Kalyan,&nbsp;R.F. Dunne,&nbsp;D.B. Zhen,&nbsp;D. Li,&nbsp;M.A. Simon,&nbsp;J. Berlin,&nbsp;L.I. Wagner,&nbsp;P.J. O'Dwyer","doi":"10.1016/j.jgo.2024.101845","DOIUrl":"10.1016/j.jgo.2024.101845","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"15 7","pages":"Article 101845"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIOG2024-1-OA-003 A randomized pilot study of memory and attention adaptation training-geriatrics (MAAT-G) To mitigate cancer related cognitive decline (CRCD) symptoms in older women with breast cancer","authors":"A. Magnuson,&nbsp;J.M. Kelly,&nbsp;H. D'Aurizio,&nbsp;R. Ferguson,&nbsp;J. Bauer,&nbsp;J. Mortimer,&nbsp;L. Berkhof,&nbsp;S. Hryniv,&nbsp;G. DiGiovanni,&nbsp;M. Sohn,&nbsp;L. Wang,&nbsp;L. Mustian,&nbsp;V. Targia,&nbsp;G. Morrow,&nbsp;H. Klepin,&nbsp;F.V. Lin,&nbsp;E. Culakova,&nbsp;M. Wittink,&nbsp;L. DeCaporale-Ryan,&nbsp;K. Scioli,&nbsp;M. Janelsins","doi":"10.1016/j.jgo.2024.101847","DOIUrl":"10.1016/j.jgo.2024.101847","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"15 7","pages":"Article 101847"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIOG2024-3-OA-027 What matters most to healthy older adults in treatment decision making: a discrete choice experiment","authors":"V.C. Hanewinkel,&nbsp;H. van der Wal-Huisman,&nbsp;S. Festen,&nbsp;R.C. Schuurman,&nbsp;G.L. van Leeuwen,&nbsp;M.A. Kooijman,&nbsp;M.J. Nogarede,&nbsp;B.L. van Leeuwen,&nbsp;D. Brandenbarg","doi":"10.1016/j.jgo.2024.101911","DOIUrl":"10.1016/j.jgo.2024.101911","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"15 7","pages":"Article 101911"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIOG2024-3-OA-023 Machine learning (ML) analysis of the association of concurrent medication use and comorbidities (CM) with overall survival in senior prostate cancer patients","authors":"M. Extermann,&nbsp;E. Carranza,&nbsp;V.L. Williams,&nbsp;M. Sehovic,&nbsp;R. Geiss,&nbsp;I.M. El Naqa,&nbsp;T. Thieu","doi":"10.1016/j.jgo.2024.101907","DOIUrl":"10.1016/j.jgo.2024.101907","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"15 7","pages":"Article 101907"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIOG2024-3-OA-024 DIFPAD-Onco, a nurse district screening of frailty's older adult with cancer at home","authors":"S. Basti,&nbsp;P. Le Bon,&nbsp;F. Gouabault,&nbsp;M. Bauval,&nbsp;V. Sevestre,&nbsp;C. Quinton,&nbsp;O. Serrée,&nbsp;A. Briant,&nbsp;F. Clères,&nbsp;B. Beauplet","doi":"10.1016/j.jgo.2024.101908","DOIUrl":"10.1016/j.jgo.2024.101908","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"15 7","pages":"Article 101908"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIOG2024-1-P-012 Emergence of APIS BREAST CANCER SUBTYPING KIT as a viable RNA-based risk-stratification tool in older BC patients. Results from a Swiss Cohort","authors":"E.D. Chiru,&nbsp;S. Rollinson,&nbsp;A. Gasior,&nbsp;J. Gorniak,&nbsp;C. Kurzeder,&nbsp;S. Münst,&nbsp;M. Matter,&nbsp;M. Javier-Gonzalez,&nbsp;A. Voss,&nbsp;M. Vetter","doi":"10.1016/j.jgo.2024.101863","DOIUrl":"10.1016/j.jgo.2024.101863","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"15 7","pages":"Article 101863"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}