Journal of geriatric oncology最新文献

{"title":"Corrigendum to “Representation of older adults in registrational trials associated with therapeutic approvals in diffuse large B-cell lymphoma” [Journal of Geriatric Oncology 16(6) (2025) 102264]","authors":"Ronit Juthani , Kelly Pugh , Nina Rosa Neuendorff , Pallawi Torka","doi":"10.1016/j.jgo.2025.102286","DOIUrl":"10.1016/j.jgo.2025.102286","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102286"},"PeriodicalIF":3.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representation of older adults in registrational trials associated with therapeutic approvals in diffuse large B-cell lymphoma","authors":"Ronit Juthani , Kelly Pugh , Nina Rosa Neuendorff , Pallawi Torka","doi":"10.1016/j.jgo.2025.102287","DOIUrl":"10.1016/j.jgo.2025.102287","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102287"},"PeriodicalIF":3.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of intraindividual variability in simple reaction time with balance and falls in older cancer survivors: A secondary analysis","authors":"Brendan L. McNeish ,&nbsp;C.M.S. Shores ,&nbsp;Sarah G. Bell ,&nbsp;Kim Dittus ,&nbsp;Jurdan Mossburg ,&nbsp;Nicholas Krant ,&nbsp;Jack A. Steinharter ,&nbsp;Kendall Feb ,&nbsp;Michael K. Hehir ,&nbsp;Mark S. Redfern ,&nbsp;Caterina Rosano ,&nbsp;James K. Richardson ,&nbsp;Noah Kolb","doi":"10.1016/j.jgo.2025.102288","DOIUrl":"10.1016/j.jgo.2025.102288","url":null,"abstract":"<div><h3>Introduction</h3><div>Intraindividual reaction time variability (IIRV) is associated with physical function and falls in older cancer-free adults but has been minimally studied in aging cancer survivors. The aims of this study were (a) to assess the association of IIRV with physical function and falls in chemotherapy-treated cancer survivors, (b) to determine if this relationship varied between middle-aged and older cancer survivors, and (c) to determine if any associations are independent of reaction response central tendency (i.e., total reaction accuracy) and locomotor impairment.</div></div><div><h3>Materials and Methods</h3><div>Fifty cancer survivors (<em>n</em> = 28 with age ≥ 65 years, 88 % female) post chemotherapy treatment were included in this cross-sectional study. Simple IIRV was defined as the standard deviation of simple reaction time from stick drop paradigm. Physical function was measured by time to complete five sit-to-stand (5STS), number of sit-to-stand repetitions in thirty seconds (STS30), and unipedal stance time (UST). Self-reported recurrent and injurious falls in the past year were recorded as secondary outcomes. Bivariate analyses were conducted between IIRV measures and physical function variables in middle-aged and older aged cancer survivors. Multivariable models were used to examine the associations of simple IIRV with UST and falls outcomes. Included covariates were age, total reaction accuracy, a measure of central reaction tendency, and presence of a locomotor risk factor (obesity or neuropathy).</div></div><div><h3>Results</h3><div>In older cancer survivors, Spearman correlations demonstrated significant relationships of simple IIRV with UST and STS30, but not STS. In multivariable models, the interaction of age ≥ 65 years with increasing levels of simple IIRV was independently associated with worse UST (B -0.919, 95 % CI -1.68, −0.159, <em>p</em> = 0.02), increased recurrent falls (OR 1.29, 95 % CI,1.04 1.61, p = 0.02), and injurious falls (OR 1.30, 95 % CI,1.04 1.63, p = 0.02).</div></div><div><h3>Discussion</h3><div>Simple IIRV was independently associated with balance and falls outcomes in older chemotherapy-treated cancer survivors. The relationship of IIRV to balance and falls did not extend to middle-aged cancer survivors, suggesting that IIRV may be of greater importance for cognitive motor control in older cancer survivors.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102288"},"PeriodicalIF":3.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: Technology ownership, use, and perceptions of web-based program design features for older adults prescribed oral anticancer medication [Journal of Geriatric Oncology, 16(2), (2025) 102190]","authors":"Victoria K. Marshall ,&nbsp;Melody N. Chavez ,&nbsp;Tina M. Mason ,&nbsp;Martine Extermann ,&nbsp;Lanie A. Simon ,&nbsp;Jay Ligatti ,&nbsp;Usha Menon ,&nbsp;Laura A. Szalacha","doi":"10.1016/j.jgo.2025.102281","DOIUrl":"10.1016/j.jgo.2025.102281","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalization due to adverse drug events in older adults with cancer, a retrospective analysis","authors":"Darren J. Walsh ,&nbsp;Laura J. Sahm ,&nbsp;Michelle O'Driscoll ,&nbsp;Bronagh Bolger ,&nbsp;Hitam Ameen ,&nbsp;Michelle Hannan ,&nbsp;Caitriona Goggin ,&nbsp;Anne M. Horgan","doi":"10.1016/j.jgo.2025.102283","DOIUrl":"10.1016/j.jgo.2025.102283","url":null,"abstract":"<div><h3>Introduction</h3><div>Geriatric oncology is a rapidly evolving field of practice, where comprehensive geriatric assessments (CGA) and multidisciplinary team (MDT) input have the potential to improve patient outcomes. Polypharmacy and potential drug interactions (PDI) have been associated with an increased risk of adverse outcomes in older adults with cancer, receiving systemic anti-cancer therapy (SACT). Our aim was to assess the incidence of unplanned hospitalization in older adults with cancer attending medical oncology outpatient clinics and to determine whether an unplanned hospitalization was potentially due to an adverse drug event (ADE).</div></div><div><h3>Materials and Methods</h3><div>We identified patients who attended a medical oncology outpatient appointment from January 1st to March 31st, 2018. Medical records were examined to identify any unplanned hospital admissions between the clinic visit date and three and six months after initial clinic visit. Incidences of unplanned hospitalization were assessed to determine if an ADE potentially occurred.</div></div><div><h3>Results</h3><div>Data collected from 174 patients were analyzed. Over half (57 %) were female, median age was 75 years and 53 % had a favorable performance status. The most common malignancies were gastrointestinal (GI) at 31 % (<em>n</em> = 54), breast 29 % (<em>n</em> = 51), and genitourinary 22 % (<em>n</em> = 37). Seventy-two percent had advanced disease (Stage III/IV) and 61 % had systemic therapy (SACT and hormonal therapy). Polypharmacy (≥5 medications) was observed in 77 % of patients. The total number of admissions at six months was 99, with 55 % of these potentially due to an ADE. On multivariate analysis performance status (<em>p</em> ≤0.001), monochemotherapy (<em>p</em> = 0.012), polychemotherapy (<em>p</em> ≤0.001) and radiotherapy (<em>p</em> = 0.048), were independent predictors of unplanned hospitalization. Monochemotherapy (<em>p</em> = 0.039), and polychemotherapy (p ≤0.001) were independent predictors of unplanned hospitalization due to ADE on multivariate analysis.</div></div><div><h3>Discussion</h3><div>We observed that older adults with cancer have a high risk of unplanned hospitalization due to ADE. Medication review as part of a CGA in newly diagnosed older adults with cancer by a clinical pharmacist is recommended. This may identify opportunities to avoid medications that could potentially lead to unplanned hospitalization.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102283"},"PeriodicalIF":3.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial disparities in longitudinal frailty state transitions among older cancer survivors","authors":"Hannah N. Lee ,&nbsp;Anna G. Kuzma ,&nbsp;Heidi D. Klepin ,&nbsp;Emilie D. Duchesneau","doi":"10.1016/j.jgo.2025.102277","DOIUrl":"10.1016/j.jgo.2025.102277","url":null,"abstract":"<div><h3>Introduction</h3><div>Black older patients with cancer are at high risk of frailty during cancer treatment, yet racial disparities in long-term frailty state transitions during the survivorship phase are understudied.</div></div><div><h3>Materials and Methods</h3><div>We conducted a longitudinal analysis of older cancer survivors (≥65 years) using rounds 1–9 (2011–2019) of the National Health and Aging Trends Study. A multistate Markov model assessed one-year transitions across Fried frailty phenotypes states (robust, prefrail, frail) and death, stratified by self-reported race (Black vs. non-Black).</div></div><div><h3>Results</h3><div>Among 1303 survivors, 55 % were female, 24 % Black, and 76 % non-Black. Black survivors were less likely to remain robust (50 % vs. 57 %), more likely to stay frail (46 % vs. 39 %), more likely to die, and more likely to transition to poorer frailty states (e.g., robust to prefrail or frail) than non-Black survivors.</div></div><div><h3>Discussion</h3><div>Black older cancer survivors experience poorer frailty trajectories than non-Black counterparts, highlighting the need for targeted survivorship care to improve long-term outcomes.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102277"},"PeriodicalIF":3.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing frailty in patients with relapsed/refractory multiple myeloma: A comparison between the patient-reported frailty phenotype and the International Myeloma Working Group frailty index","authors":"Daniela Krepper ,&nbsp;Francesco Sparano ,&nbsp;Johannes M. Giesinger ,&nbsp;Gianluca Gaidano ,&nbsp;Pasquale Niscola ,&nbsp;Katia Codeluppi ,&nbsp;Elisabetta Antonioli ,&nbsp;Catello Califano ,&nbsp;Lajos Floro ,&nbsp;Ombretta Annibali ,&nbsp;Claudio Fozza ,&nbsp;Agostino Tafuri ,&nbsp;Patrizio Mazza ,&nbsp;Leonardo Potenza ,&nbsp;Marco Vignetti ,&nbsp;Michele Cavo ,&nbsp;Maria Teresa Petrucci ,&nbsp;Fabio Efficace","doi":"10.1016/j.jgo.2025.102266","DOIUrl":"10.1016/j.jgo.2025.102266","url":null,"abstract":"<div><h3>Introduction</h3><div>The International Myeloma Working Group Frailty Index (IMWG FI) is one of the most used frailty assessment tools in patients with multiple myeloma (MM). A patient-centered frailty tool based on patient-reported outcomes (PROs) has been recently proposed for patients with relapsed/refractory MM (RRMM): the Patient-Reported Frailty Phenotype (PRFP). This cross-sectional analysis aimed to replicate the PRFP within a real-world setting and to describe health-related quality of life (HRQoL) profiles based on this new patient-centered frailty classification.</div></div><div><h3>Materials and Methods</h3><div>This analysis was based on baseline data from a multi-center prospective observational study that included adult patients with RRMM. Frailty was assessed using the IMWG FI, and HRQoL was evaluated with the EORTC QLQ-C30 and its myeloma module (QLQ-MY20). For this analysis, the PRFP was also calculated, and Cohen's kappa was computed to examine the agreement between the two frailty assessment approaches. Descriptive statistics were used to investigate the HRQoL profiles of patients classified as frail, pre-frail, and fit.</div></div><div><h3>Results</h3><div>Five hundred eleven patients were enrolled. The median age was 69.8 years, and 44 % were female. According to IMWG FI and PRFP, 24.5 % and 25.1 % of patients were classified as frail, with a weighted Cohen's kappa of 0.27, indicating fair agreement. Frail patients, as classified by the PRFP, reported higher treatment side effects, disease symptoms, and worse future perspectives and body image compared to pre-frail and fit patients.</div></div><div><h3>Discussion</h3><div>Current findings suggest that the PRFP may be a valuable tool to assess frailty in patients with RRMM. However, further prospective studies are needed to better understand the value of PROs in a more accurate assessment of frailty in the RRMM setting.</div><div>Trial registration: <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>: <span><span>NCT03190525</span><svg><path></path></svg></span></div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102266"},"PeriodicalIF":3.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How oncologists assess and consider cognition in clinical decision-making with older adults","authors":"Romy Van Rickstal ,&nbsp;Lieve Van den Block ,&nbsp;Lore Decoster ,&nbsp;Christine Ritchie ,&nbsp;Alys Wyn Griffiths ,&nbsp;Joni Gilissen","doi":"10.1016/j.jgo.2025.102204","DOIUrl":"10.1016/j.jgo.2025.102204","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 5","pages":"Article 102204"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticosteroid therapy in older adults with cancer: Expert recommendations from a task force of the International Society of Geriatric Oncology","authors":"Rupert Bartsch ,&nbsp;Daniel Aletaha ,&nbsp;Thorsten Fuereder ,&nbsp;Matti Aapro ,&nbsp;Francois R. Jornayvaz ,&nbsp;Pierre-Olivier Lang ,&nbsp;Denis Migliorini ,&nbsp;Chantal Csajka ,&nbsp;Marie-Bernadette Aretin ,&nbsp;Tanya M Wildes ,&nbsp;Vérène Dougoud-Chauvin","doi":"10.1016/j.jgo.2024.102077","DOIUrl":"10.1016/j.jgo.2024.102077","url":null,"abstract":"<div><div>Corticosteroids are used frequently in oncology and many patients require short- or long-term corticosteroid therapy. General clinical guidelines and recommendations exist on the use of corticosteroids; however, evidence is lacking for recommendations on their appropriate use in older adult with cancer.</div><div>Treatment of chemotherapy-induced nausea and vomiting (CINV) has dramatically improved over the last decade with 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists and neurokinin-1 (NK−1) receptor antagonists or a combination of both. However, corticosteroids continue to play an important role in the management of acute and delayed CINV prevention. While highly efficacious, the toxicity profile of corticosteroids must be considered, particularly in heterogeneous older patients with multiple comorbidities and polypharmacy.</div><div>Guidance on corticosteroid-reducing/sparing strategies in this specific population is needed. This consensus, supported by the International Society of Geriatric Oncology, aims to provide evidence-based recommendations for the use of corticosteroid therapy in older adults with cancer.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 5","pages":"Article 102077"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes in older patients presenting to a radiation oncology clinic based on an electronic health record-based frailty index","authors":"Ryan T. Hughes,&nbsp;Niema B. Razavian,&nbsp;Claire M. Lanier,&nbsp;Michael K. Farris","doi":"10.1016/j.jgo.2025.102192","DOIUrl":"10.1016/j.jgo.2025.102192","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 5","pages":"Article 102192"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}