Journal of geriatric oncology最新文献

{"title":"Treatment decision-making and quality of life versus length of life preferences of older patients with early stage cancer: A systematic review.","authors":"Charlene Martin, Jessica Banks, Nicolò Matteo Luca Battisti, Hilary Bekker, Adrian Edwards, Lynda Wyld, Jenna Morgan","doi":"10.1016/j.jgo.2025.102773","DOIUrl":"https://doi.org/10.1016/j.jgo.2025.102773","url":null,"abstract":"<p><strong>Introduction: </strong>To fully consider the preferences and information needs of older adults, cancer treatment decision-making discussions should take a patient-centred approach. Some older patients may place more value on maintaining quality of life over the continuation of life-prolonging treatments, even when the cancer is early-stage and potentially curable. Decision support tools can play a role in facilitating discussions around treatment trade-offs. The objective of this review is to examine the literature on the treatment decision-making preferences of patients aged 70 and older with early-stage, potentially curable, cancer.</p><p><strong>Materials and methods: </strong>MEDLINE OVID, CINAHAL, APA PsycINFO, Scopus, and Cochrane databases were systematically searched in January 2025. Published literature focusing on quality and length-of-life decision-making, and the use of decision support tools aimed towards older adults diagnosed with early-stage cancer, were included. Two authors performed full-text selection and quality appraisal. Data were synthesized according to themes, using the Framework Approach.</p><p><strong>Results: </strong>From 1476 screened records, a total of 14 studies were included. Five key themes were identified: Information needs; Treatment preferences; Trade-offs (treatments, quality and length-of-life); Decision-making involvement; Available decision support interventions.</p><p><strong>Discussion: </strong>Evidence suggests that older patients would benefit from receiving information about both quality and length-of-life when making cancer treatment decisions. Quality of life concerns including physical wellbeing, autonomy, and symptom burden were factors considered by patients. Decision support tools have the potential to assist in trade-off discussions, however, few have been developed to balance trade-offs between quality and length-of-life.</p><p><strong>Registration: </strong>PROSPERO: CRD42025626454.</p>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"102773"},"PeriodicalIF":2.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidelines to optimise ePROs monitoring for older patients under systemic cancer treatment from the French Society of Geriatric oncology (SoFOG) based on a delphi consensus","authors":"Poppy Evenden ,&nbsp;Mathilde Cancel ,&nbsp;Florian Correard ,&nbsp;Nicolas Bertrand ,&nbsp;Claire Falandry ,&nbsp;Loïc Mourey ,&nbsp;Anne-Laure Couderc ,&nbsp;Bérengère Beauplet ,&nbsp;on behalf the SoFOG (French Society of Geriatric Oncology)","doi":"10.1016/j.jgo.2025.102722","DOIUrl":"10.1016/j.jgo.2025.102722","url":null,"abstract":"<div><h3>Introduction</h3><div>Electronic patient-reported outcome (ePRO) monitoring improves cancer treatment completion, quality of life (QoL), and is now covered by several French National Health Insurances. Given that most patients diagnosed with cancer worldwide are aged 65 or over, we need to take into account patients' potential frailty (e.g., mobility and history of falls, comorbidities, polypharmacy, cognitive impairment) and its negative impact on cancer treatment outcomes. The aim of this study was to make recommendations to optimise ePRO monitoring in older patients treated for cancer.</div></div><div><h3>Materials and Methods</h3><div>This national Delphi method targeted patients with cancer aged ≥65 and/or their primary caregivers, as well as healthcare professionals (doctors, nurses, pharmacists) using ePROs developed for oncology. Ten recommendations were developed – using national and international guidelines as well as scientific literature – based on patients' profiles, ease of use, usefulness and satisfaction. The level of agreement with each recommendation was voted by each participant using a Likert scale. Recommendations could be modified after each round based on feedback to better reflect the needs regarding ePROs for older adults.</div></div><div><h3>Results</h3><div>Among the 221 participants at the first and the 148 at the second round, the majority of participants were aged ≥65 (94.1 % and 94.6 % respectively) and over 90 % of participants were patients (91 % and 93.2 % respectively). Males were predominant in both the first and second round (59.3 % and 62.2 % respectively). Of the 10 proposed recommendations, three reached a strong agreement and six a moderate agreement. There was no consensus on the recommendation to adapt telemonitoring to an age threshold.</div></div><div><h3>Discussion</h3><div>As most of the participants were older patients, this consensus highlights their needs in terms of ePRO optimisation. Our guidelines propose a total of nine recommendations to be integrated by the ePRO monitoring systems.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"Article 102722"},"PeriodicalIF":2.7,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pragmatic randomized controlled trial of nurse-delivered brief Meaning Centered Psychotherapy at Home (MCP-H) for individuals with advanced cancer: Study protocol","authors":"Rebecca M. Saracino ,&nbsp;Ellen Y. Park ,&nbsp;Nicole Onorato ,&nbsp;Hayley Pessin ,&nbsp;Margaret McDonald ,&nbsp;Caraline Demirjian ,&nbsp;Elizabeth Schofield ,&nbsp;Barry Rosenfeld ,&nbsp;William Breitbart ,&nbsp;Allison J. Applebaum","doi":"10.1016/j.jgo.2025.102736","DOIUrl":"10.1016/j.jgo.2025.102736","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with advanced cancer are often confronted with existential distress that, when unaddressed, may lead to increased suffering and despair. Homebound individuals face compounded existential concerns and loss of meaning, as they must contend with loss of independence and declining opportunities for activities and social engagement. Thus, there is a need to develop strategies for delivering quality psychological interventions to homebound patients. In the United States, homecare agencies provide care to over 4.5 million patients annually, with nurses comprising over half of their employees. Given the size of this workforce and their frequent contact with homebound patients, we developed Meaning Centered Psychotherapy at Home (MCP-H) to be delivered by nurses to increase the reach of this evidence-based intervention to this population.</div></div><div><h3>Materials and Methods</h3><div>In Phase 1, nurse participants (<em>n</em> = 8–10) from VNS Health will be trained to deliver MCP-H. We will enroll 8–10 training case patients, each paired with one nurse interventionist, in a single-arm open pilot study to refine the intervention structure and procedures. In Phase 2, we will conduct a pilot randomized controlled trial to determine the feasibility, acceptability, and preliminary efficacy of MCP-H. Patients (<em>n</em> = 70) will be randomized to receive either MCP-H or treatment as usual.</div></div><div><h3>Discussion</h3><div>MCP-H has unique potential to increase the reach of mental health care to individuals receiving homecare, leveraging the existing infrastructure of a high-volume home health agency and nurses to address the unmet needs of these patients. If effective, it can be embedded in existing systems as a potentially widely disseminable approach to reaching historically underserved patient populations.</div><div>Trial Registration.</div><div>This study is registered under <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (ID <span><span>NCT05495737</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"Article 102736"},"PeriodicalIF":2.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From hospital to home: Strengthening the ERAS® 3.0 pathway in geriatric oncology","authors":"Fan Wu ,&nbsp;Jiaqi Cheng ,&nbsp;Rui Wu","doi":"10.1016/j.jgo.2025.102714","DOIUrl":"10.1016/j.jgo.2025.102714","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"Article 102714"},"PeriodicalIF":2.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of age and comorbidity on safety outcomes in phase 1 trial participants for metastatic solid malignancies","authors":"Adel Shahnam ,&nbsp;Nadia Hitchen ,&nbsp;Sathya Manoharan ,&nbsp;Thomas John ,&nbsp;Linda Mileshkin ,&nbsp;Benjamin Solomon ,&nbsp;Shahneen Sandhu ,&nbsp;Stephen J. Luen ,&nbsp;Jayesh Desai ,&nbsp;Ben Tran","doi":"10.1016/j.jgo.2025.102721","DOIUrl":"10.1016/j.jgo.2025.102721","url":null,"abstract":"<div><h3>Introduction</h3><div>The number of phase 1 clinical trials has been increasing globally over the past decade. However, patient recruitment remains skewed towards younger populations with older adults remaining underrepresented, limiting generalizability. Few studies have systematically examined the role of comorbidities as a determinant of safety outcomes in phase 1 trials. Thus, we aimed to investigate the impact of age and comorbidity on safety outcomes of phase 1 trial participants.</div></div><div><h3>Materials and Methods</h3><div>This retrospective analysis examined electronic health records of patients aged ≥18 years enrolled in phase 1 trials for metastatic solid malignancies between January 2020 and May 2023. Patients were stratified into two age groups (&lt;70 years vs. ≥70 years). Patients were classified as comorbid if they had Charlson Comorbidity Index (CCI) ≥3, Elixhauser Comorbidity Index (ECI) ≥4, or modified Elixhauser Comorbidity Index (mECI) &gt;12. Eastern Cooperative Oncology Group (ECOG) performance status was also evaluated. Logistic regression models assessed associations between age, comorbidity, and safety outcomes: serious adverse events (SAE), dose-limiting toxicities (DLT), dose reductions/interruptions (DR/DI), cessation of treatment due to toxicity (COTT), and grade 3–5 toxicities.</div></div><div><h3>Results</h3><div>We included 229 patients, of whom 51 (22%) were aged ≥70 years. Among them, 79 (34%) experienced an SAE, 109 (48%) had DR/DI, 34 (15%) had COTT, 17 (7%) had DLT, and 99 (43%) developed grade 3–5 adverse events. Age was not significantly associated with a higher likelihood of adverse safety outcomes. However, patients with ECI ≥4 had significantly higher likelihood of SAE than those with ECI &lt;4 (50% vs. 31%, <em>p</em> = 0.04, OR: 2.18, 95% CI: 1.08–4.44). Patients with ECOG ≥1 had higher likelihood of SAE than those with ECOG 0 (42% vs. 29%, <em>p</em> = 0.06, OR: 1.75, 95% CI: 1.01–3.05, <em>p</em> = 0.05). Patients with ECOG ≥1 had significantly higher likelihood of grade 3–5 adverse events than those with ECOG 0 (52% vs. 36%, <em>p</em> = 0.03, OR: 1.89, 95% CI: 1.11–3.23, <em>p</em> = 0.02). Other comorbidity indices were not significantly associated with safety outcomes.</div></div><div><h3>Discussion</h3><div>Age alone was not associated with safety outcomes in phase 1 clinical trials for metastatic solid malignancies. Instead, comorbidity burden and ECOG performance status were predictors of adverse events in our cohort of patients.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"Article 102721"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Singaporean multi-disciplinary team's quest to deliver precision medicine in older adults with hematological malignancy","authors":"Hiu Kwan To ,&nbsp;Lawrence Cheng Kiat Ng ,&nbsp;Mui Fong Chong ,&nbsp;Si Jie Khoo ,&nbsp;Rachel Qiao Ming Ng","doi":"10.1016/j.jgo.2025.102720","DOIUrl":"10.1016/j.jgo.2025.102720","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"Article 102720"},"PeriodicalIF":2.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying and prioritizing treatment values and tailored question prompts for older adults with advanced cancer: A concept mapping study","authors":"Amy C. Cole ,&nbsp;Angela M. Stover ,&nbsp;Lisa Vizer ,&nbsp;Fei Yu ,&nbsp;Andy J. King ,&nbsp;Lukasz Mazur ,&nbsp;Daniel R. Richardson","doi":"10.1016/j.jgo.2025.102717","DOIUrl":"10.1016/j.jgo.2025.102717","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"Article 102717"},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERAS® 3.0 protocol: Response to letter to the editor","authors":"Elna A. Dalsgaard ,&nbsp;Troels G. Dolin ,&nbsp;Cecilia M. Lund ,&nbsp;Jakob Lykke ,&nbsp;Tina Munk ,&nbsp;Anders Vinther ,&nbsp;Jacob Rosenberg","doi":"10.1016/j.jgo.2025.102718","DOIUrl":"10.1016/j.jgo.2025.102718","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"Article 102718"},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation for sarcopenia as part of comprehensive geriatric assessment in older adults with cancer: Secondary analysis of a prospective clinical dataset","authors":"Sophie Lightbody ,&nbsp;Pascale Ashman ,&nbsp;Adibah Badrin ,&nbsp;Michelle Brennan ,&nbsp;Sarah Compton ,&nbsp;Katie Emblen-Jarrett ,&nbsp;Rose Evans ,&nbsp;Tania Kalsi ,&nbsp;Danielle Harari ,&nbsp;James Maguire ,&nbsp;Stephanie Moore ,&nbsp;Clare Nottage ,&nbsp;Prashant Patel ,&nbsp;Karen Stoner ,&nbsp;Carly Welch","doi":"10.1016/j.jgo.2025.102361","DOIUrl":"10.1016/j.jgo.2025.102361","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"Article 102361"},"PeriodicalIF":2.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice variations in geriatric assessment for patients with head and neck cancer in the Netherlands: A nationwide analysis","authors":"B. Vincenzoni Padovan ,&nbsp;L.A. van der Velden ,&nbsp;J.A.U. Hardillo ,&nbsp;S.L. van Egmond ,&nbsp;A. Hoeben ,&nbsp;S.E.J. Eerenstein ,&nbsp;Y. Schoon ,&nbsp;R. de Bree ,&nbsp;B.J. de Kleijn ,&nbsp;A.J.M. van Bemmel ,&nbsp;R.J. Sedee ,&nbsp;A. Vesseur ,&nbsp;R.E. Plaat ,&nbsp;S. Festen ,&nbsp;G.B. Halmos","doi":"10.1016/j.jgo.2025.102715","DOIUrl":"10.1016/j.jgo.2025.102715","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 8","pages":"Article 102715"},"PeriodicalIF":2.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}