Journal of geriatric oncology最新文献

{"title":"Response to Editorial, \"Comment on 'Effect of geriatric co-management on independence, quality of life, and severe toxicity in vulnerable older patients with cancer: Results of a randomized clinical trial'\".","authors":"Gabriele Ihorst, Barbara Deschler-Baier","doi":"10.1016/j.jgo.2026.102997","DOIUrl":"https://doi.org/10.1016/j.jgo.2026.102997","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102997"},"PeriodicalIF":2.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less treatment, but whose choice? Geriatric considerations in breast cancer care","authors":"Mohammad Shkokani , Louis John Koizia , Benjamin Howell Lole Harris","doi":"10.1016/j.jgo.2026.102931","DOIUrl":"10.1016/j.jgo.2026.102931","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 4","pages":"Article 102931"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Tolerability of immune checkpoint inhibitors for cancer treatment in frail, older patients\".","authors":"Mehmet Zahid Kocak","doi":"10.1016/j.jgo.2026.102984","DOIUrl":"https://doi.org/10.1016/j.jgo.2026.102984","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102984"},"PeriodicalIF":2.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' response to commentary on \"Causes of death in older patients with high-risk breast cancer: What are the most significant contributors?\"","authors":"Hong Li, Lovedeep Gondara, Caroline Speers, Caroline Lohrisch, Alan Nichol, Richard Musoke, Caroline Mariano","doi":"10.1016/j.jgo.2026.102974","DOIUrl":"https://doi.org/10.1016/j.jgo.2026.102974","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102974"},"PeriodicalIF":2.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength-based cachexia index with frailty in cancer survivors: Evidence from health and retirement study","authors":"Fan Zhang , Xinyue Yang , Yan Bai , Heng Yang","doi":"10.1016/j.jgo.2026.102937","DOIUrl":"10.1016/j.jgo.2026.102937","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 3","pages":"Article 102937"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world management and clinical outcomes of first line treatment of advanced renal cell carcinoma in older patients in Canada","authors":"Lauren Curry ,&nbsp;Sunita Ghosh ,&nbsp;Erica Arenovich ,&nbsp;Simon Tanguay ,&nbsp;Aly-Khan A. Lalani ,&nbsp;Daniel Yick Chin Heng ,&nbsp;Bimal Bhindi ,&nbsp;Naveen S. Basappa ,&nbsp;Jeffrey Graham ,&nbsp;Georg A. Bjarnason ,&nbsp;Rodney H. Breau ,&nbsp;Vincent Castonguay ,&nbsp;Denis Soulieres ,&nbsp;Frederic Pouliot ,&nbsp;Dominick Bosse ,&nbsp;Christian K. Kollmannsberger ,&nbsp;Antonio Finelli ,&nbsp;Nazanin Fallah-Rad ,&nbsp;Maryam Soleimani","doi":"10.1016/j.jgo.2026.102905","DOIUrl":"10.1016/j.jgo.2026.102905","url":null,"abstract":"<div><h3>Introduction</h3><div>There is a paucity of data with respect to optimal management of metastatic renal cell carcinoma (mRCC) in older patients. Real-world data may help close this knowledge gap and improve care in this understudied and growing patient population.</div></div><div><h3>Materials and methods</h3><div>The Canadian Kidney Cancer information system (CKCis) was utilized to identify patients with mRCC, categorizing them as either older (defined as age ≥ 75 years) or younger (age &lt; 75 years). Our primary objective was to identify if first line (1 L) mRCC management strategies differed by age. Secondary outcomes of interest were potential differences in treatment-related toxicities, overall survival (OS), progression free survival (PFS), and time to treatment discontinuation (TTD) by age.</div></div><div><h3>Results</h3><div>In total, 2585 patients were included (&lt;75 years of age <em>n</em> = 2205; ≥ 75 years of age <em>n</em> = 380). Baseline demographics were comparable between cohorts, though older patients more often had five or more comorbidities (95% vs. 67%, <em>p</em> &lt; 0.001) and more frequently had Karnofsky Performance Status ≤70% (19% vs. 13%, <em>p</em> = 0.002). Older patients underwent metastasectomy (15% vs. 24%, <em>p</em> &lt; 0.001) and cytoreductive nephrectomy less frequently (2% vs. 7%, <em>p</em> = 0.047), and were less likely to be enrolled in clinical trials (10% vs. 23%, <em>p</em> &lt; 0.001). Older patients received 1 L targeted monotherapy more frequently than immune checkpoint inhibitor (ICI)-based therapy in the post-ICI era (65% vs. 44%, <em>p</em> &lt; 0.001). Older patients did not experience more treatment-related toxicities from ICI-based therapy. Older patients experienced shorter OS when controlling for International mRCC Database Consortium (IMDC) classification, comorbidities, and histology (HR 1.25, 95% CI 1.1–1.4, <em>p</em> = 0.003) in the overall cohort.</div></div><div><h3>Discussion</h3><div>Patients ≥75 years of age received 1 L targeted monotherapy more frequently than those &lt;75 years of age, though when they received combination ICI-based therapy, they did not experience more treatment-related toxicities. Clinicians should individualize treatments for older patients not strictly based on age, but after discussion of available options in a patient-centered manner, considering comorbidities, disease burden, and patient preferences.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 3","pages":"Article 102905"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helping caregivers of older adults with cancer manage patient care: A qualitative analysis of healthcare professional perspectives","authors":"Ying Wang ,&nbsp;Maya Anand ,&nbsp;Kah Poh Loh ,&nbsp;AnnaLynn M. Williams ,&nbsp;Sally A. Norton ,&nbsp;Christopher L. Seplaki","doi":"10.1016/j.jgo.2026.102921","DOIUrl":"10.1016/j.jgo.2026.102921","url":null,"abstract":"<div><h3>Introduction</h3><div>Family and/or unpaid caregivers play an important role in managing care for older adults with cancer (aged ≥65 years). Despite the development of theoretical models that emphasize the need for medical teams to assess caregiver abilities and integrate this assessment into patient care plans, little is known about what specific caregiver abilities should be prioritized for assessment and how such assessments should be conducted.</div></div><div><h3>Materials and methods</h3><div>In this interpretive description qualitative study, we conducted individual, semi-structured interviews with healthcare professionals (HCPs) who are involved in caring for older adults with cancer. All participants were recruited from a single large academic medical center between June and September 2024. The interviews focused on: (1) the caregiver abilities of interest to HCPs, (2) how HCPs assess these abilities, and (3) how HCPs respond to caregiver-reported deficits in these abilities. All interviews were audio-recorded and transcribed. Two analysts analyzed the transcripts using inductive thematic analysis and open coding.</div></div><div><h3>Results</h3><div>We interviewed 19 HCPs from diverse specialties (mean age: 45 ± 1.7 years, 90% female, 90% White). HCPs expressed interest in various caregiver abilities, including physical or functional capacity, cognitive function, medical knowledge and skills, emotional ability to cope with cancer diagnosis, financial ability (e.g., accessing medications), and availability. HCPs reported assessing caregiver abilities based on interactions with caregivers or using informal direct questions. They also reported several challenges in this assessment such as time limitations in clinical settings and ambiguity regarding their responsibility in evaluating caregiver abilities. When responding to deficits in caregivers' abilities, HCPs usually encourage caregivers to seek available social support or connect them with relevant resources. If caregivers need to develop specific caregiving skills, HCPs use more deliberate methods (e.g., a teach-back approach) to evaluate their abilities and provide direct support, including helping simplify caregiving tasks, providing necessary supplies or equipment, and offering various learning methods.</div></div><div><h3>Discussion</h3><div>We did not identify a systematic approach among HCPs to assessing these abilities. Given HCP-reported challenges in this assessment, our study highlights the need for a formal caregiver ability assessment to identify caregiver challenges and inform patient care plan development.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 3","pages":"Article 102921"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Important aspects of care and priorities of older patients with cancer: The PRIORITY multicenter cohort study","authors":"Thomas Grellety ,&nbsp;Carine Bellera ,&nbsp;Coralie Cantarel ,&nbsp;Cécile Mertens ,&nbsp;Mathilde Cabart ,&nbsp;Guilhem Roubaud ,&nbsp;Marie-Claude Chantecaille ,&nbsp;Hervé Desclos ,&nbsp;Corinne Souyris ,&nbsp;Patrick Bouchaert ,&nbsp;Emmanuelle Bourbouloux ,&nbsp;Catherine Terret ,&nbsp;Cécile Delattre ,&nbsp;Laurent Cany ,&nbsp;Caroline Lalet ,&nbsp;Simone Mathoulin-Pelissier ,&nbsp;Pierre Soubeyran ,&nbsp;Camille Chakiba-Brugere","doi":"10.1016/j.jgo.2025.102812","DOIUrl":"10.1016/j.jgo.2025.102812","url":null,"abstract":"<div><h3>Introduction</h3><div>Data on treatment preferences in older cancer patients are lacking. We aimed to identify their priorities.</div></div><div><h3>Materials and Methods</h3><div>We conducted a multicenter prospective cohort study on patients with cancer aged ≥70 and 18–69, initiating first medical treatment. Patients and physicians prioritized eight aspects of care: treatment efficacy, life expectancy, autonomy, daily tasks, social activities, treatment burden, toxicity, and economic burden via self-completed questionnaires. The primary endpoint was the priorities of older patients.</div></div><div><h3>Results</h3><div>We included 233 older and 100 younger patients at eight sites. In the older patient cohort, median age was 79 (min-max: 70–97), breast cancer represented 34 % (<em>N</em> = 78) and lung 12 % (<em>N</em> = 27). Metastatic setting concerned 45 % of the patients. The most frequently rated top priority at treatment initiation was treatment efficacy in both older (73 %) and younger cohorts (79 %), followed by autonomy in the older cohort (13 %) and life expectancy in the younger cohort (14 %). Treatment efficacy was almost systematically cited in the top four priorities for both older (94 %) and younger patients (96 %), followed by autonomy (86 %) for older and life expectancy (82 %) for younger patients. These priorities were stable (&gt;70 %) between initiation and three months for each cohort. Agreement rate for prioritization of aspects of care between older patients and physicians was 87 % for treatment efficacy and 64 % for autonomy.</div></div><div><h3>Discussion</h3><div>Autonomy was the second most cited priority among older patients, yet many physicians failed to recognize this, potentially affecting treatment decisions. These findings highlight the need for shared decision-making to align treatment choices with patient expectations.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 3","pages":"Article 102812"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The transition to person-centered care: Putting patient priorities at the heart of decision-making","authors":"Suzanne Festen","doi":"10.1016/j.jgo.2026.102904","DOIUrl":"10.1016/j.jgo.2026.102904","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 3","pages":"Article 102904"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: What nutritional interventions can effectively treat sarcopenia in older adults with cancer? A systematic review","authors":"Erkan Topkan ,&nbsp;Ugur Selek","doi":"10.1016/j.jgo.2026.102942","DOIUrl":"10.1016/j.jgo.2026.102942","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"17 3","pages":"Article 102942"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}