Journal of geriatric oncology最新文献

{"title":"Age and comorbidity in relation to treatment and survival outcomes in triple-negative breast cancer: A Swedish nationwide registry-based study","authors":"Jenny Nyqvist-Streng ,&nbsp;Josef Somi ,&nbsp;Jari Martikainen ,&nbsp;Maxim Olsson ,&nbsp;Khalil Helou ,&nbsp;Chaido Chamalidou ,&nbsp;Anikó Kovács ,&nbsp;Toshima Z. Parris","doi":"10.1016/j.jgo.2025.102255","DOIUrl":"10.1016/j.jgo.2025.102255","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with cancer and comorbidities often experience a longer time-to-diagnosis and significantly worse clinical outcomes. Here, we evaluate the association between age, Charlson Comorbidity Index (CCI), treatment given, and patient survival, thereby identifying common non-breast cancer-related causes of death in patients with triple-negative breast cancer (TNBC).</div></div><div><h3>Materials and Methods</h3><div>Population-based registry data were retrieved for patients diagnosed with primary invasive TNBC in Sweden between 2007 and 2021 (<em>n</em> = 7145). Multivariable Cox regression analyses were performed for disease-specific survival and overall survival was calculated using a landmark time set at six months post-diagnosis, the likely timeframe for treatment initiation. Multivariable logistic regression models were computed for age, comorbidity, and treatment. Weighted CCI (CCIw) was stratified into CCIw 0, CCIw 1–3, and CCIw 4–10.</div></div><div><h3>Results</h3><div>Approximately 42 % of patients were ≥ 65 years of age and 30 % had comorbidities (27 % CCIw 1–3 and 3 % CCIw 4–10). Two or more comorbidities were common in patients ≥65 years. Patients in the CCIw 4–10 group were significantly older (72 years vs. 68 years for CCIw 1–3 vs. 58 years for CCIw 0) and had locoregional spread and larger tumors. Individuals with comorbidities were less likely to receive neoadjuvant chemotherapy, breast-conserving surgery, or postoperative treatment, and had a higher risk of death due to non-breast cancer-related causes. Patients ≥75 years had a higher risk of breast cancer-related death up to eight years after the landmark time and death from other causes thereafter. Furthermore, older (≥75 years) and patients with comorbidities had the lowest five-year survival probabilities. Other neoplasms (26 %; e.g., lung, pancreas, and ovarian cancer) and cardiovascular disease (24 %) were the leading causes of non-breast-cancer-related death, particularly in patients ≥50 years of age.</div></div><div><h3>Discussion</h3><div>Patients with TNBC and comorbidities are less likely to receive specific treatment modalities and experience worse survival outcomes. Other malignant neoplasms are the leading cause of death for patients ≥50 years of age.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 5","pages":"Article 102255"},"PeriodicalIF":3.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary experience supporting older adults with breast cancer: Successes, challenges, and next steps for a program embedded in a breast oncology center","authors":"Madeleine Ling ,&nbsp;Karen Ruderman ,&nbsp;Sydney Simo ,&nbsp;Bonnie McGrath ,&nbsp;Craig Snow ,&nbsp;Kathryn Rigby ,&nbsp;Amal Arnaout ,&nbsp;Tammy T. Hshieh ,&nbsp;Christina Minami ,&nbsp;Rachel A. Freedman","doi":"10.1016/j.jgo.2025.102243","DOIUrl":"10.1016/j.jgo.2025.102243","url":null,"abstract":"<div><h3>Introduction</h3><div>Older adults diagnosed with cancer often have functional vulnerability and increased risk for treatment-related toxicity and poor outcomes, with emergent clinical strategies to mitigate these risks. The geriatric assessment (GA) is a widely recommended platform in the clinic to help inform treatment decisions and toxicity risk and initiate referrals, but incorporating the GA into busy clinical practice remains challenging.</div></div><div><h3>Materials and Methods</h3><div>To promote a consistent approach in conducting the GA and connecting older adults with relevant resources and services while acknowledging the specific care needs for those with breast cancer, our National Cancer Institute-designated center launched the Program for Older Adults with Breast Cancer (OABC) in May 2022, embedded within the Breast Oncology Center. The OABC coordinator offers approached patients an introduction to program services and an opportunity to undergo the GA. The coordinator uses the GA responses to facilitate appropriate geriatrics and supportive care referrals, with recommendations and utilization of services tracked in the program database. We report the initial findings from systematic GA administration within a high-volume breast cancer program.</div></div><div><h3>Results</h3><div>From 2022 to 2024, 362 patients were approached to enroll in OABC; 108 completed a GA. Overall, 32.1 % were aged 70–75 and 10 % were aged ≥86, and most (2/3) had non-metastatic disease. Approximately 30 % were hospitalized in the year before enrollment, 19 % had recent falls, and the majority reported having social supports for emotional and physical needs (&gt;65 % for each). Based on the GA (<em>n</em> = 108), the most frequently recommended services were geriatrics (67 %) and social work (36 %). However, only 60 % of patients who completed the GA agreed to one or more referrals to any of the recommended supportive care services.</div></div><div><h3>Discussion</h3><div>OABC systematically reaches patients at high risk for aging-relevant needs. Coordination of services was successful, but patient declines for geriatrics and supportive resources referrals were common despite having dedicated program staff. Further efforts will increase uptake of the GA and these important services.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 5","pages":"Article 102243"},"PeriodicalIF":3.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three lessons from “The Fox and the Grapes” to inform precision oncology in the older adult","authors":"Gabriel Aleixo ,&nbsp;Teja Voruganti ,&nbsp;Ramy Sedhom","doi":"10.1016/j.jgo.2025.102186","DOIUrl":"10.1016/j.jgo.2025.102186","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 4","pages":"Article 102186"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the status of online social support for older adults with cancer: A scoping review","authors":"Fei Liu ,&nbsp;Sophie Pilleron ,&nbsp;India Pinker","doi":"10.1016/j.jgo.2024.102182","DOIUrl":"10.1016/j.jgo.2024.102182","url":null,"abstract":"<div><h3>Introduction</h3><div>The number of new cancer cases among older adults is rising, yet their social support needs remain unmet due to diminishing social networks with age. Since the COVID-19 pandemic, online technologies have provided increased opportunities for social support for this demographic via digital platforms such as online peer support groups, online communities, and chat rooms. This scoping review explores the current state of the use of online social support for older adults with cancer.</div></div><div><h3>Materials and Methods</h3><div>This scoping review was based on the Arksey and O'Malley methodological framework with the extension proposed by Levac and colleagues. The protocol was registered on Open Science Framework (OSF). PubMed, Elsevier Embase (including Medline), and EBSCO CINAHL Complete were searched to identify eligible studies. The review findings were presented in a narrative synthesis.</div></div><div><h3>Results</h3><div>Out of 6542 references, we included three studies. Two studies investigated older patients' preferences for different types of peer support through surveys and questionnaires, and the third examined the feasibility of an online platform for older women with breast cancer. Barriers identified include a lower interest and familiarity, sense of involvement, and emotional impact of a new diagnosis. However, factors such as socio-demographic characteristics and positive motivation for using online peer support act as facilitators.</div></div><div><h3>Discussion</h3><div>This scoping review is the first to examine the literature on online social support specifically for older adults with cancer, revealing a paucity of research. Further research is required to understand the potential need and interest in online social support for this population, especially as technology becomes more integrated into daily life post-COVID.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 4","pages":"Article 102182"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of clinical judgement versus geriatric assessment with course of treatment in older patients with cancer","authors":"Ellen R.M. Scheepers ,&nbsp;Inez C. van Walree ,&nbsp;N. Bartels ,&nbsp;Frederiek van den Bos ,&nbsp;Lieke H. van Huis-Tanja ,&nbsp;Marije E. Hamaker","doi":"10.1016/j.jgo.2025.102245","DOIUrl":"10.1016/j.jgo.2025.102245","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 5","pages":"Article 102245"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of p16(INK4a), a biomarker of cellular senescence, with receipt of therapy and frailty status among adults with plasma cell disorders","authors":"Christopher E. Jensen ,&nbsp;Allison M. Deal ,&nbsp;Shweta Srikanth ,&nbsp;Kirsten A. Nyrop ,&nbsp;Natalia Mitin ,&nbsp;Matthew R. LeBlanc ,&nbsp;Hyman B. Muss ,&nbsp;Samuel M. Rubinstein ,&nbsp;Sascha A. Tuchman ,&nbsp;Eben I. Lichtman","doi":"10.1016/j.jgo.2024.102174","DOIUrl":"10.1016/j.jgo.2024.102174","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 4","pages":"Article 102174"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening interprofessional and interdisciplinary collaboration in geriatric oncology initiatives: An adapted World Café at the 2024 International Society of Geriatric Oncology (SIOG) Annual Conference, a joint initiative of the SIOG Nursing, Allied Health, and Scientists Interest Group and the Canadian Association of Nurses in Oncology (CANO) Oncology and Aging Special Interest Group","authors":"Fay J. Strohschein ,&nbsp;Sophie Pilleron ,&nbsp;Manon Lemonde ,&nbsp;Fay Bennie ,&nbsp;Kristen R. Haase ,&nbsp;Michelle Hannan ,&nbsp;Caitríona Barrett ,&nbsp;Cassandra Vonnes ,&nbsp;Susie Monginot ,&nbsp;Vanya Slavova-Boneva ,&nbsp;Martine Puts","doi":"10.1016/j.jgo.2025.102238","DOIUrl":"10.1016/j.jgo.2025.102238","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 4","pages":"Article 102238"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing quality of life in older adults with cancer: Outcomes of a 12-week supervised remote exercise intervention","authors":"Paulo Gustavo Bergerot ,&nbsp;Cristiane Decat Bergerot ,&nbsp;Jonas Ribeiro Gomes Silva ,&nbsp;Marcos V.S. Franca ,&nbsp;Jasmin Hundal ,&nbsp;William Hiromi Fuzita ,&nbsp;Paulo Sergio Lages ,&nbsp;Gabriel dos Anjos ,&nbsp;Andressa Cardoso de Azeredo ,&nbsp;Carolina Bezerra Patriota ,&nbsp;Marco Murilo Buso ,&nbsp;Errol J. Philip ,&nbsp;Kathryn H. Schmitz ,&nbsp;Narjust Florez ,&nbsp;Enrique Soto-Perez-de-Celis","doi":"10.1016/j.jgo.2025.102244","DOIUrl":"10.1016/j.jgo.2025.102244","url":null,"abstract":"<div><h3>Introduction</h3><div>Exercise in oncology improves health outcomes in patients with cancer. Remote programs offer a promising alternative to in-person sessions, overcoming barriers such as mobility, geography, and treatment-related fatigue. This study assessed the impact of a 12-week supervised remote exercise program on health-related quality of life (HRQOL) as the primary endpoint, and feasibility and acceptability as secondary outcomes in older patients (65+ years) undergoing systemic treatment in Brazil.</div></div><div><h3>Materials and Methods</h3><div>This is a pilot, single-arm trial (June 2023 to January 2024) of a 12-week remote exercise program for older adults. Participants received individualized aerobic, resistance, and mobility exercises, completed at home. The program was facilitated through WhatsApp® and the Vedius platform for real-time monitoring and support. Patients were assessed using the Functional Assessment of Cancer Therapy – General and the Edmonton Symptom Assessment System. Linear mixed models were employed. Adherence was measured by the completion percentage of prescribed exercises, and acceptability was assessed via a satisfaction question.</div></div><div><h3>Results</h3><div>Of 48 patients approached, 41 enrolled (median age 70 years, 56.1 % female). Significant improvements were observed in HRQOL (baseline: 83.2; post-intervention: 94.4, <em>P</em> = 0.001). Symptom reductions included pain (1.6 to 0.7, <em>P</em> = 0.001), fatigue (3.8 to 1.3, P = 0.001), nausea (0.8 to 0.2, <em>P</em> = 0.01), depression (2.6 to 0.8, P = 0.001), anxiety (3.2 to 1.2, P = 0.001), and drowsiness (1.8 to 0.4, P = 0.001). Notably, 87.8 % of patients adhered to the prescribed exercise program, and reported high satisfaction, particularly with its convenience and flexibility.</div></div><div><h3>Discussion</h3><div>A 12-week remote exercise program is feasible and acceptable for older patients with cancer. High adherence and satisfaction suggest that remote exercise interventions can improve HRQOL and symptom management, offering a low-cost, accessible solution for cancer care in resource-limited settings. Future studies should explore long-term outcomes and integrate exercise with other supportive care services.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 5","pages":"Article 102244"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Factors affecting advance care planning in older adults with cancer” – Avenues for future research","authors":"Vincent E.S. Allott ,&nbsp;Benjamin H.L. Harris ,&nbsp;Michael B. Fertleman ,&nbsp;Louis J. Koizia","doi":"10.1016/j.jgo.2025.102242","DOIUrl":"10.1016/j.jgo.2025.102242","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 5","pages":"Article 102242"},"PeriodicalIF":3.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Will evidence-based patient-centred care meet the future inter-generational needs of older adults with cancer? A diverse perspective","authors":"Raymond Gardner ,&nbsp;Beverly Canin ,&nbsp;Kah Poh Loh ,&nbsp;Chuck O'Shea ,&nbsp;Martine Puts ,&nbsp;Siri Rostoft ,&nbsp;Sushmita Sen ,&nbsp;Christopher Steer ,&nbsp;Susan Brill ,&nbsp;Antonella Cardone ,&nbsp;William Dale ,&nbsp;Barbara Ewals ,&nbsp;Martine Extermann ,&nbsp;Theodora Karnakis ,&nbsp;Romeo Marcaida ,&nbsp;Nicole Saur ,&nbsp;Grant Williams ,&nbsp;Nicolò Matteo Luca Battisti","doi":"10.1016/j.jgo.2025.102241","DOIUrl":"10.1016/j.jgo.2025.102241","url":null,"abstract":"<div><div>The introduction of evidence-based patient-centred care (EBPCC) into the cancer treatment pathway requires older adults with cancer and their support networks to actively participate in the decision-making process. EBPCC is a combination of evidence-based practice (EBP) and patient-centred care (PCC). EBPCC is a healthcare approach that focuses on the needs and preferences of the patient. However, the increasingly complex nature of cancer treatment options, the heterogeneity of older adults, and the probability of comorbidities can make it a complicated and difficult task for older adults with cancer to process these options, evaluate the information presented, and determine their preferred treatment pathway.</div><div>EBPCC can effectively facilitate shared decision-making in the clinic for older adults with cancer but may not fulfil the healthcare expectations of all older adults. Older adult patients newly diagnosed with cancer may expect a more holistic approach to their care, with emphasis on ‘what matters most for the patient?’</div><div>In this paper, we consider EBPCC and its effectiveness in building active collaboration between clinicians and older adults with cancer. We examine EBPCC from both clinician and patient perspectives and reflect on the extent that heterogeneity, comorbidities, and generational characteristics influence these perspectives. We then evaluate the cancer clinical pathway for its preparedness to meet the future needs of this heterogenous population.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 5","pages":"Article 102241"},"PeriodicalIF":3.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}