Journal of geriatric oncology最新文献

{"title":"Effect of preoperative exercise on postoperative complications after colorectal cancer surgery in older people with low physical fitness: The CANOPTIPHYS randomised controlled trial","authors":"Johanna Danielsson ,&nbsp;Mikael Andersson ,&nbsp;Malin Nygren-Bonnier ,&nbsp;Anders Thorell ,&nbsp;Mattias Soop ,&nbsp;Christian Sturesson ,&nbsp;Monika Egenvall ,&nbsp;Elisabeth Rydwik","doi":"10.1016/j.jgo.2025.102280","DOIUrl":"10.1016/j.jgo.2025.102280","url":null,"abstract":"<div><h3>Introduction</h3><div>Preoperative exercise may decrease the risk of complications after major abdominal cancer surgery but the amount of time available for such interventions is limited. Our objective was to evaluate the effect of a short-term preoperative exercise program on postoperative outcomes in older patients with low physical fitness scheduled to undergo colorectal cancer surgery.</div></div><div><h3>Materials and Methods</h3><div>This was a randomised controlled, multicentre trial where patients scheduled for colorectal cancer surgery were considered for inclusion if they were ≥ 65 years of age and had low maximal walking speed. The intervention took place in participants' home environments and included inspiratory muscle training, aerobic training, and strength exercises for two to three weeks before surgery. Exercise was of high intensity and frequency, with at least six sessions supervised by a physiotherapist. Additionally, participants were instructed to perform unsupervised exercises, aiming for a total frequency of inspiratory muscle training twice daily, and aerobic and strength exercises five to six times per week. A control group underwent surgery without preoperative exercise. The primary endpoint was occurrence of any complications within 30 days after surgery. Secondary outcomes were postoperative length of hospital stay and discharge destination. Binary logistic regression and Mann-Whitney <em>U</em> test were used to analyse outcomes.</div></div><div><h3>Results</h3><div>A total of 51 patients were included in the intention-to-treat analysis and allocated to preoperative exercise (<em>n</em> = 27) or usual care (<em>n</em> = 24). The proportion of participants with at least one postoperative complication was 48.1 % in the intervention group and 62.5 % in the control group. There was no effect of preoperative exercise on the odds of developing postoperative complications (OR: 0.56, 95 % CI: 0.18–1.71) nor on discharge to another care facility instead of home (OR: 0.98, 95 % CI: 0.29–3.27). The median length of stay in nights was 5 (IQR: 4–6) for the intervention group and 5.5 (IQR: 4–7.8) for the control group (<em>p</em> = 0.55).</div></div><div><h3>Discussion</h3><div>In this study of older patients with low physical fitness awaiting colorectal cancer surgery, we could not demonstrate an influence of preoperative exercise on postoperative complications, discharge destination or length of hospital stay. These results should be interpreted with caution due to a small sample size.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102280"},"PeriodicalIF":3.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Hospitalization due to adverse drug events in older adults with cancer: A retrospective analysis” [Journal of Geriatric Oncology Volume 15(1) (2024) 101669]","authors":"Darren J. Walsh ,&nbsp;Laura J. Sahm ,&nbsp;Michelle O'Driscoll ,&nbsp;Bronagh Bolger ,&nbsp;Hitam Ameen ,&nbsp;Michelle Hannan ,&nbsp;Caitriona Goggin ,&nbsp;Anne M. Horgan","doi":"10.1016/j.jgo.2025.102282","DOIUrl":"10.1016/j.jgo.2025.102282","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102282"},"PeriodicalIF":3.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue, physical function, and the context of social vulnerability for older adults with cancer","authors":"Marielle Jensen-Battaglia ,&nbsp;Alan Delmerico ,&nbsp;Mostafa Mohamed ,&nbsp;Rachael Tylock ,&nbsp;Marie Flannery ,&nbsp;Brian L. Burnette ,&nbsp;Nisarg Desai ,&nbsp;Navin Anthony ,&nbsp;Karen Mustian ,&nbsp;Kah Poh Loh ,&nbsp;Supriya G. Mohile ,&nbsp;Christopher L. Seplaki ,&nbsp;Nikesha Gilmore","doi":"10.1016/j.jgo.2025.102284","DOIUrl":"10.1016/j.jgo.2025.102284","url":null,"abstract":"<div><h3>Introduction</h3><div>Older adults with cancer-related fatigue often experience impairments in their physical function. Social determinants of health (SDOH) at the individual and community level may mean some patients have fewer resources to deal with fatigue and are at greater risk for decline in physical function.</div></div><div><h3>Materials and Methods</h3><div>We analyzed patients age ≥ 70 with advanced cancer and ≥ 1 aging-related impairment who were starting new treatment regimens with a high risk of toxicity in a nationwide cluster-randomized clinical trial (<span><span>NCT02054741</span><svg><path></path></svg></span>, UG1CA189961). Patient-Reported Outcome Common Terminology Criteria for Adverse Events (PROC-CTCAE) fatigue severity (0–4 points) was collected at baseline, Short Physical Performance Battery (SPPB, a measure of physical function, 0–12 points) at baseline, 4–6 weeks, 3 months, and 6 months. SDOH in the county where patients lived were measured by the Social Vulnerability Index (SVI, a measure reflecting community vulnerability, 0 to 1, higher = worse). We estimated adjusted relative risk (RR) of ≥1 point SPPB decline at 4–6 weeks associated with baseline fatigue. In exploratory analyses we estimated: (1) this association at 3 and 6 months, (2) moderation of this association by SVI.</div></div><div><h3>Results</h3><div>Out of 718 patients, we analyzed 600 with SPPB assessed at ≥1 follow up timepoint. Half reported fatigue that was moderate or greater, and 38.8 % declined in SPPB by 4–6 weeks. Mean SVI was 0.42 (SD 0.23). Greater fatigue was associated with increased risk of SPPB decline at 4–6 weeks (RR 1.21; 95 % CI 1.09, 1.34, <em>p</em> &lt; 0.001), but not 3 or 6 months. The association at 4–6 weeks was not significantly different for patients living in areas with the least vulnerable quartile of SVI (RR 1.27, 95 % CI 1.05, 1.53) vs. the most vulnerable (RR 1.22, 95 % CI 0.91, 1.65; <em>p</em> = 0.85).</div></div><div><h3>Discussion</h3><div>Fatigue is associated with decline in physical function among older adults with advanced cancer and does not vary by social vulnerability. These results emphasize the importance of assessing and managing fatigue in this population.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102284"},"PeriodicalIF":3.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal assessment of functional independence of older adults after lung cancer surgery: Final results of the JCOG1710A prospective cohort study","authors":"Tomonori Mizutani ,&nbsp;Hidefumi Takei ,&nbsp;Hideo Kunitoh ,&nbsp;Masashi Wakabayashi ,&nbsp;Yuta Sekino ,&nbsp;Masahiro Tsuboi ,&nbsp;Norihiko Ikeda ,&nbsp;Hisao Asamura ,&nbsp;Morihito Okada ,&nbsp;Makoto Takahama ,&nbsp;Yasuhisa Ohde ,&nbsp;Jiro Okami ,&nbsp;Satoshi Shiono ,&nbsp;Keijyu Aokage ,&nbsp;Shun-ichi Watanabe ,&nbsp;on behalf of the Lung Cancer Surgical Study Group of the Japan Clinical Oncology Group, Japan","doi":"10.1016/j.jgo.2025.102268","DOIUrl":"10.1016/j.jgo.2025.102268","url":null,"abstract":"<div><h3>Introduction</h3><div>We previously reported the results of a prospective observational study evaluating activities of daily living (ADL) at six months after curative surgical resection in patients aged ≥75 years with non-small cell lung cancer (NSCLC). In this manuscript, we report the 24-month longitudinal ADL outcomes in this population, providing important data to support treatment decision-making and to identify risk factors for long-term functional decline.</div></div><div><h3>Materials and Methods</h3><div>This is a prospective, multi-institutional observational cohort study conducted in Japan. We evaluated patients aged ≥75 years who underwent curative surgery for stage 0–III NSCLC. ADL were evaluated at 6, 12, and 24 months postoperatively using the Tokyo Metropolitan Institute of Gerontology Index of Competence (TMIG-IC)<u>,</u> which encompasses dimensions of instrumental activities of daily living. We defined ADL deterioration as a decline of ≥3 points or missing data and performed multivariable analyses for ADL deterioration.</div></div><div><h3>Results</h3><div>The follow-up data of 876 patients were available for a median of 24.2 months. At 6, 12, and 24 months postoperatively, the proportion of patients with ADL deterioration was 11.0 %, 10.3 %, and 12.6 %, respectively. Multivariable analysis revealed that factors such as poor performance status, low G8 score, undergoing segmentectomy instead of wedge resection, and surgery duration &lt;3 h were associated with ADL deterioration after six months. Conversely, a low G8 score was sole factor associated with a decline in the TMIG-IC score after 24 months. Multivariable analysis demonstrated that at six months, segmentectomy was significantly associated with more ADL deterioration compared with wedge resection, with an odds ratio (OR) of 4.96 (95 % confidence interval [CI]: 1.88–13.07). However, segmentectomy and wedge resection showed no significant difference at 24 months (OR: 0.92, 95 % CI: 0.40–2.10).</div></div><div><h3>Discussion</h3><div>Among patients aged ≥75 years undergoing lung cancer surgery, approximately 10 % experienced a decline in ADL at six months postoperatively; however, the proportion remained stable thereafter, suggesting no further functional deterioration. Short-term ADL tended to be preserved with wedge resection, but this advantage diminished over time. The insights from this study are also expected to inform patient decision-making regarding treatment strategy.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102268"},"PeriodicalIF":3.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life's Crucial 9 and its influence on frailty and survival in patients with cancer: Insights from NHANES","authors":"Zheling Chen ,&nbsp;Xiuxiu Qiu ,&nbsp;Qi Gao","doi":"10.1016/j.jgo.2025.102276","DOIUrl":"10.1016/j.jgo.2025.102276","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to examine the effect of Life's Crucial 9 (LC9), a comprehensive health measure, on frailty status and its association with all-cause, cancer-related, and non-cancer-related mortality in patients with cancer.</div></div><div><h3>Materials and Methods</h3><div>A prospective cohort study was conducted with 2466 patients with cancer aged 20 years or older (weighted population: 16,222,181) from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. The LC9 score was calculated by averaging the Life's Essential 8 (LE8) and depression scores, which reflect psychological well-being. Multivariable logistic regression models were used to examine the relationship between LC9 and frailty in patients with cancer, while Cox proportional hazards models evaluated the associations between LC9 and all-cause, cancer-specific, and non-cancer mortality.</div></div><div><h3>Results</h3><div>At baseline, 664 deaths were recorded among the 2466 patients with cancer, including 229 from cancer, 138 from heart disease, and 297 from other causes. Higher LC9 scores were linked to a lower risk of frailty and reduced hazard ratios for all-cause and non-cancer mortality, but not for cancer-specific mortality, compared to those with lower scores. Kaplan-Meier survival curves stratified by LC9 quartiles showed that participants in the highest quartile (Q4) had significantly lower risks of death from all causes (<em>P</em> &lt; 0.001), cancer-specific causes (<em>P</em> = 0.01), and non-cancer causes (<em>P</em> &lt; 0.001).</div></div><div><h3>Discussion</h3><div>In patients with cancer in the United States, higher LC9 scores were independently associated with reduced risks of frailty, all-cause mortality, and non-cancer-related mortality. This health measure may serve as an effective secondary prevention strategy to mitigate mortality in this population.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102276"},"PeriodicalIF":3.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurse navigation for older adults with cancer: A scoping review","authors":"Madison Ban ,&nbsp;Kayoung Lee ,&nbsp;Ailsa C. Sirois ,&nbsp;Martine Puts ,&nbsp;Kristen R. Haase","doi":"10.1016/j.jgo.2025.102267","DOIUrl":"10.1016/j.jgo.2025.102267","url":null,"abstract":"<div><h3>Introduction</h3><div>Nurse navigation is important in cancer care, with prior studies indicating improvements in quality of life and symptom management. We sought to understand the scope of literature on nurse navigation for older adults with cancer. Specifically, we aimed to understand the characteristics, roles, and services nurse navigators provide for older adults with cancer.</div></div><div><h3>Materials and Methods</h3><div>Using the updated Arksey and O'Malley scoping review method, we conducted a scoping review of the literature with searches in PubMed, CINAHL, Embase, and Cochrane. Two reviewers independently screened studies following the inclusion and exclusion criteria. We included studies: (1) published between 2000 and 2024 in English;(2) with participants with cancer aged ≥60 years or mean or median age ≥ 60 years, or a sub-group analysis of those aged ≥60; and (3) navigation provided by a nurse. We excluded grey literature and studies on nurse navigation in cancer screening.</div></div><div><h3>Results</h3><div>Our search and citation screening yielded 1291 and 748 studies, respectively, of which we screened 1528 titles/abstracts and 257 full-text articles. We identified 29 studies meeting inclusion criteria which describe nurse navigation for older adults with cancer addressing several outcomes including patient experience, satisfaction, and timeliness. About half (14/29) of the included studies addressed older adults specifically.</div></div><div><h3>Discussion</h3><div>Nurse navigation shows promise in bridging critical gaps in the care of older adults with cancer. Our findings highlight the need for further evidence about models of care and development of practice-guiding documents to enhance the effectiveness of nurse navigation for older adults with cancer.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102267"},"PeriodicalIF":3.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of geriatric assessment on decision-making for adjuvant chemotherapy in older patients with breast cancer","authors":"Ines B. Menjak ,&nbsp;Khloe Campos ,&nbsp;Nazia Hossain ,&nbsp;Liying Zhang ,&nbsp;Rajin Mehta ,&nbsp;Maureen Trudeau","doi":"10.1016/j.jgo.2025.102260","DOIUrl":"10.1016/j.jgo.2025.102260","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102260"},"PeriodicalIF":3.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive characterization of the real-world perioperative morbidity of radical cystectomy in older adults","authors":"Boris Gershman ,&nbsp;John Ernandez ,&nbsp;Sumedh Kaul ,&nbsp;Agustin Perez-Londono ,&nbsp;Aaron Fleishman ,&nbsp;Ruslan Korets ,&nbsp;Peter Chang ,&nbsp;Andrew A. Wagner ,&nbsp;Simon Kim ,&nbsp;Joaquim Bellmunt ,&nbsp;Nima Aghdam ,&nbsp;Dae Kim ,&nbsp;Ellen P. McCarthy ,&nbsp;Aria F. Olumi","doi":"10.1016/j.jgo.2025.102265","DOIUrl":"10.1016/j.jgo.2025.102265","url":null,"abstract":"<div><h3>Introduction</h3><div>The perioperative morbidity of radical cystectomy (RC) is a critical factor for optimal decision-making in older adults with bladder cancer (BC). However, existing literature is dated and does not focus on older adults. We aimed to examine the real-world, perioperative morbidity of RC among older adults with BC.</div></div><div><h3>Materials and Methods</h3><div>We identified 6041 patients aged 66–89 years diagnosed with T_anyN_anycM0 urothelial bladder cancer from 2000 to 2017 who underwent RC in SEER-Medicare. Rates of perioperative morbidity and healthy days at home (HDAH) were examined using Medicare claims. The associations between baseline characteristics and each outcome were evaluated using logistic regression and negative binomial regression.</div></div><div><h3>Results</h3><div>The perioperative morbidity of RC is substantial, with 3859 (64 %) patients experiencing a complication during hospitalization or one requiring care utilization post-discharge. A total of 1764 (29 %) patients required ER evaluation within 90 days of surgery, and 2637 (44 %) were readmitted to the hospital. The median number of HDAH was 78 (interquartile range 66–82). Adjusted multivariable analyses demonstrated that a higher Charlson Comorbidity Index (CCI) and higher census tract poverty level were associated with increased risk of 90-day inpatient readmission, while older age, Black race, higher CCI, and lower annual hospital RC volume were associated with increased risk of 90-day complications.</div></div><div><h3>Discussion</h3><div>The real-world perioperative morbidity of RC in older adults is substantial and even greater than reported in prior institutional studies, with 44 % of patients requiring hospital-based care within 90 days of surgery. These observations inform clinical counseling of older adults with bladder cancer.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102265"},"PeriodicalIF":3.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to make recommendations on dosing for older adults receiving systemic cancer treatment – A holistic and pragmatic approach to decision-making with a focus on colorectal cancer","authors":"Gabor Liposits ,&nbsp;Konstantinos Christofyllakis ,&nbsp;Luca Tondulli ,&nbsp;Mostafa R. Mohamed","doi":"10.1016/j.jgo.2025.102262","DOIUrl":"10.1016/j.jgo.2025.102262","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102262"},"PeriodicalIF":3.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Representation of older adults in registrational trials associated with therapeutic approvals in diffuse large B-cell lymphoma","authors":"Ronit Juthani ,&nbsp;Kelly Pugh ,&nbsp;Nina Rosa Neuendorff ,&nbsp;Pallawi Torka","doi":"10.1016/j.jgo.2025.102264","DOIUrl":"10.1016/j.jgo.2025.102264","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 6","pages":"Article 102264"},"PeriodicalIF":3.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}