Meng-Han Tsai , Jorge Cortes , Elinita Pollard , Marlo Vernon , Yanbin Dong , Kenneth J. Vega , Steven S. Coughlin
{"title":"在佐治亚州一个服务不足的社区,结直肠癌诊断后年龄相关的生存差异:一项回顾性队列分析","authors":"Meng-Han Tsai , Jorge Cortes , Elinita Pollard , Marlo Vernon , Yanbin Dong , Kenneth J. Vega , Steven S. Coughlin","doi":"10.1016/j.jgo.2025.102318","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Limited studies have examined disparities regarding age at diagnosis and 5-year overall survival (OS) following colorectal cancer (CRC) diagnosis within medically underserved areas in Georgia. The study aim was to examine this association and determine key factors of 5-year survival within four age groups in Augusta-Richmond County, Georgia.</div></div><div><h3>Materials and Methods</h3><div>We conducted a retrospective cohort analysis using 2012–2022 data from an institutional cancer registry linked with medical records and billing data from a single cancer center in Georgia. Multivariable Cox proportional hazard regression models were used.</div></div><div><h3>Results</h3><div>Among 839 patients with CRC, 5-year survival rates were lowest among patients aged 70+ years (54.9 % vs. 63.4 % for 60–69 years, 67.2 % for 50–59 years, and 67.4 % for 18–49 years) (<em>p</em> < 0.001). Patients with CRC with a late stage at diagnosis were associated with increased risk of death by 2 to 7 times (18–49 years: HR, 5.45; 95 % CI, 2.28–10.55; 50–59 years: HR, 6.72; 95 % CI, 4.08–11.06; 60–69 years: HR, 5.98; 95 % CI, 3.92–9.10; 70+ years: HR, 2.21; 95 % CI, 1.41–3.46). Further, 50–59-year-old former smokers had an increased risk of death (HR, 2.16; 95 % CI, 1.11–4.20). Patients aged 60–69 years and living in persistent poverty areas also had an increased risk of death (HR, 1.85; 95 % CI, 1.20–2.85).</div></div><div><h3>Discussion</h3><div>Advanced diagnoses were associated with a greater risk of mortality regardless of age group. Former smokers and those living in persistent poverty areas were also linked to increased mortality for 50–59 and 60–69 age groups, respectively. Improving equitable access to screening facilities/ cancer treatment resources and promoting healthy lifestyles are critical.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 7","pages":"Article 102318"},"PeriodicalIF":3.0000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age-related disparities in survival following colorectal cancer diagnosis in an underserved community in Georgia: A retrospective cohort analysis\",\"authors\":\"Meng-Han Tsai , Jorge Cortes , Elinita Pollard , Marlo Vernon , Yanbin Dong , Kenneth J. Vega , Steven S. Coughlin\",\"doi\":\"10.1016/j.jgo.2025.102318\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Limited studies have examined disparities regarding age at diagnosis and 5-year overall survival (OS) following colorectal cancer (CRC) diagnosis within medically underserved areas in Georgia. The study aim was to examine this association and determine key factors of 5-year survival within four age groups in Augusta-Richmond County, Georgia.</div></div><div><h3>Materials and Methods</h3><div>We conducted a retrospective cohort analysis using 2012–2022 data from an institutional cancer registry linked with medical records and billing data from a single cancer center in Georgia. Multivariable Cox proportional hazard regression models were used.</div></div><div><h3>Results</h3><div>Among 839 patients with CRC, 5-year survival rates were lowest among patients aged 70+ years (54.9 % vs. 63.4 % for 60–69 years, 67.2 % for 50–59 years, and 67.4 % for 18–49 years) (<em>p</em> < 0.001). Patients with CRC with a late stage at diagnosis were associated with increased risk of death by 2 to 7 times (18–49 years: HR, 5.45; 95 % CI, 2.28–10.55; 50–59 years: HR, 6.72; 95 % CI, 4.08–11.06; 60–69 years: HR, 5.98; 95 % CI, 3.92–9.10; 70+ years: HR, 2.21; 95 % CI, 1.41–3.46). Further, 50–59-year-old former smokers had an increased risk of death (HR, 2.16; 95 % CI, 1.11–4.20). Patients aged 60–69 years and living in persistent poverty areas also had an increased risk of death (HR, 1.85; 95 % CI, 1.20–2.85).</div></div><div><h3>Discussion</h3><div>Advanced diagnoses were associated with a greater risk of mortality regardless of age group. Former smokers and those living in persistent poverty areas were also linked to increased mortality for 50–59 and 60–69 age groups, respectively. Improving equitable access to screening facilities/ cancer treatment resources and promoting healthy lifestyles are critical.</div></div>\",\"PeriodicalId\":15943,\"journal\":{\"name\":\"Journal of geriatric oncology\",\"volume\":\"16 7\",\"pages\":\"Article 102318\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of geriatric oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1879406825001341\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of geriatric oncology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1879406825001341","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Age-related disparities in survival following colorectal cancer diagnosis in an underserved community in Georgia: A retrospective cohort analysis
Introduction
Limited studies have examined disparities regarding age at diagnosis and 5-year overall survival (OS) following colorectal cancer (CRC) diagnosis within medically underserved areas in Georgia. The study aim was to examine this association and determine key factors of 5-year survival within four age groups in Augusta-Richmond County, Georgia.
Materials and Methods
We conducted a retrospective cohort analysis using 2012–2022 data from an institutional cancer registry linked with medical records and billing data from a single cancer center in Georgia. Multivariable Cox proportional hazard regression models were used.
Results
Among 839 patients with CRC, 5-year survival rates were lowest among patients aged 70+ years (54.9 % vs. 63.4 % for 60–69 years, 67.2 % for 50–59 years, and 67.4 % for 18–49 years) (p < 0.001). Patients with CRC with a late stage at diagnosis were associated with increased risk of death by 2 to 7 times (18–49 years: HR, 5.45; 95 % CI, 2.28–10.55; 50–59 years: HR, 6.72; 95 % CI, 4.08–11.06; 60–69 years: HR, 5.98; 95 % CI, 3.92–9.10; 70+ years: HR, 2.21; 95 % CI, 1.41–3.46). Further, 50–59-year-old former smokers had an increased risk of death (HR, 2.16; 95 % CI, 1.11–4.20). Patients aged 60–69 years and living in persistent poverty areas also had an increased risk of death (HR, 1.85; 95 % CI, 1.20–2.85).
Discussion
Advanced diagnoses were associated with a greater risk of mortality regardless of age group. Former smokers and those living in persistent poverty areas were also linked to increased mortality for 50–59 and 60–69 age groups, respectively. Improving equitable access to screening facilities/ cancer treatment resources and promoting healthy lifestyles are critical.
期刊介绍:
The Journal of Geriatric Oncology is an international, multidisciplinary journal which is focused on advancing research in the treatment and survivorship issues of older adults with cancer, as well as literature relevant to education and policy development in geriatric oncology.
The journal welcomes the submission of manuscripts in the following categories:
• Original research articles
• Review articles
• Clinical trials
• Education and training articles
• Short communications
• Perspectives
• Meeting reports
• Letters to the Editor.