Journal of geriatric oncology最新文献

{"title":"From healthy aging to complex needs in older adults: Onco-geriatric insights from the EuGMS 2024 conference, a report from Young SIOG","authors":"Filippo M. Verri , Nicolás M. González-Senac , Chloé Herledan , Frederiek van den Bos , Nina R. Neuendorff","doi":"10.1016/j.jgo.2024.102156","DOIUrl":"10.1016/j.jgo.2024.102156","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 3","pages":"Article 102156"},"PeriodicalIF":3.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of enfortumab vedotin in older patients with metastatic urothelial carcinoma: A multicenter retrospective study","authors":"Tetsuya Shindo ,&nbsp;Kohei Hashimoto ,&nbsp;Toshiki Kenuka ,&nbsp;Shintaro Miyamoto ,&nbsp;Yoshiki Hiyama ,&nbsp;Fumimasa Fukuta ,&nbsp;Yasuharu Kunishima ,&nbsp;Manabu Okada ,&nbsp;Masanori Matsukawa ,&nbsp;Ryuichi Kato ,&nbsp;Masaya Senda ,&nbsp;Atsushi Wanifuchi ,&nbsp;Shunsuke Sato ,&nbsp;Ko Kobayashi ,&nbsp;Toshiaki Tanaka ,&nbsp;Naoya Masumori ,&nbsp;on behalf of the Sapporo Medical University Urologic Oncology Consortium","doi":"10.1016/j.jgo.2024.102183","DOIUrl":"10.1016/j.jgo.2024.102183","url":null,"abstract":"<div><h3>Introduction</h3><div>We aimed to evaluate the efficacy and safety of enfortumab vedotin therapy for a cohort of older Japanese patients with metastatic urothelial carcinoma compared to younger patients.</div></div><div><h3>Materials and Methods</h3><div>We retrospectively evaluated patients with metastatic urothelial carcinoma treated with enfortumab vedotin and recruited between April 2019 and February 2023. Older patients were defined as being ≥75 years old. Efficacy was evaluated by comparing overall survival, progression-free survival, and objective response rates between groups. Adverse events and relative dose intensity were also compared. Moreover, the prognostic factor for overall survival in the entire cohort was evaluated using multivariate analysis.</div></div><div><h3>Results</h3><div>Of the 57 patients treated with enfortumab vedotin, 37 were younger and 20 were older, (median ages of 67.6 and 79.2, respectively). Median overall survival in older and younger patients was 407 and 365 days, respectively (<em>P</em> = 0.48). The objective response rate was 60.0 % and 54 % (<em>P</em> = 0.68) and median progression-free survival 228 and 223 days in older and younger patients, respectively (<em>P</em> = 0.76). Adverse events were equivalent between groups except for liver dysfunction, which frequently occurred in younger patients. The dose intensity for the older and younger patients did not differ (65.7 % vs. 63.5 %, <em>P</em> = 0.37, respectively). In multivariate analysis, neutrophil-to-lymphocyte ratio of 3 or more was the only risk factor for worse overall survival in the entire cohort (<em>P</em> = 0.04).</div></div><div><h3>Discussion</h3><div>Our data demonstrated that enfortumab vedotin therapy can benefit older patients with metastatic urothelial carcinoma equivalent to younger patients without compromising safety profiles.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 2","pages":"Article 102183"},"PeriodicalIF":3.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant taxane-based chemotherapy treatment in older patients with early breast cancer: A pooled analysis of five phase III trials from the Hellenic Oncology Research Group","authors":"Oraianthi Fiste,&nbsp;Lambros Vamvakas,&nbsp;Panagiotis Katsaounis,&nbsp;Nikolaos Vardakis,&nbsp;Sofia Kallianteri,&nbsp;Vassilis Georgoulias,&nbsp;Athanasios Karampeazis","doi":"10.1016/j.jgo.2024.102184","DOIUrl":"10.1016/j.jgo.2024.102184","url":null,"abstract":"<div><h3>Introduction</h3><div>The use of taxanes in the adjuvant setting of early breast cancer (BC) confers survival benefits, however, their role in older patients merits further study. This retrospective pooled analysis of randomized controlled trials conducted by the Hellenic Oncology Research Group (HORG) aims to assess the efficacy and safety of taxane-based adjuvant chemotherapy in older women with BC.</div></div><div><h3>Materials and Methods</h3><div>Five phase III trials containing a taxane, conducted by HORG between 1995 and 2013, were included in a patient-data pooled analysis. The primary endpoint was disease-free survival (DFS) at three years, whereas secondary outcomes included overall survival (OS) at five years and toxicity.</div></div><div><h3>Results</h3><div>A total of 3,026 randomized patients, of whom 701 (23 %) were ≥ 65 years old (median age 69 years; range 65–80), were included in the analysis. No statistically significant heterogeneity in survival was observed between older and younger patients. Within the cohort of older patients, taxane-based regimens were superior to 5-fluorouracil, epirubicin, and cyclophosphamide (FE₇₅C) regimen in terms of three-year DFS (92.02 % vs 77.17 %; <em>p</em> &lt; 0.001) and five-year OS (94.38 % vs 72.64 %; <em>p</em> &lt; 0.001), respectively. A higher number of older patients discontinued treatment compared to younger patients (5.7 % vs 2.9 %; <em>p</em> &lt; 0.001), mainly due to toxicity (3.4 % vs 1.8 %; <em>p</em> = 0.01). The incidence of grade 3–4 neutropenia (35.4 % vs 29.8 %; <em>p</em> = 0.006) and thrombocytopenia (0.8 % vs 0.3 %; <em>p</em> = 0.049) was higher for patients aged ≥65 years compared to those aged &lt;65 years; however, there was no difference in terms of febrile neutropenia and non-hematologic toxicity.</div></div><div><h3>Discussion</h3><div>Taxane-based adjuvant chemotherapy offers significant survival benefits in older patients with BC, similar to younger patients, yet with increased toxicity.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 2","pages":"Article 102184"},"PeriodicalIF":3.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric Assessment-driven INterventions among Hospitalized older adults with cancer (GAIN-HOSP), a prospective pilot study","authors":"Leana Cabrera Chien,&nbsp;Can-Lan Sun,&nbsp;Heeyoung Kim,&nbsp;Carolina Uranga,&nbsp;Enrique Soto-Perez-de-Celis,&nbsp;Peggy Burhenn,&nbsp;Kemeberly Charles,&nbsp;Jessica Vazquez,&nbsp;Elsa Roberts,&nbsp;Wai Yu (Kim),&nbsp;Jae Y. Kim,&nbsp;Clayton Lau,&nbsp;Stephen Sentovich,&nbsp;Tanya B. Dorff,&nbsp;Mina S. Sedrak,&nbsp;Vani Katheria,&nbsp;Arti Hurria,&nbsp;William Dale,&nbsp;Daneng Li","doi":"10.1016/j.jgo.2024.102063","DOIUrl":"10.1016/j.jgo.2024.102063","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102063"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The care of older patients with cancer across the United Kingdom in 2024: A narrative review by the International Society of Geriatric Oncology UK Country Group","authors":"Fabio Gomes ,&nbsp;Naomi Farrington ,&nbsp;Jessica Pearce ,&nbsp;Daniel Swinson ,&nbsp;Jenny Welford ,&nbsp;Alastair Greystoke ,&nbsp;Mark Baxter ,&nbsp;Alana G. Brown-Kerr ,&nbsp;Lynda Wyld ,&nbsp;Jenna Morgan ,&nbsp;Nicolò Matteo Luca Battisti ,&nbsp;Anne Barrell ,&nbsp;David Cobben ,&nbsp;Anthea Cree ,&nbsp;Mark Johnston ,&nbsp;Kirsty Colquhoun ,&nbsp;Iain Phillips ,&nbsp;Jemima Smith ,&nbsp;Simon Stapley ,&nbsp;Lisa Lyons ,&nbsp;Kwok-Leung Cheung","doi":"10.1016/j.jgo.2024.102133","DOIUrl":"10.1016/j.jgo.2024.102133","url":null,"abstract":"<div><div>The worldwide population is ageing, alongside an increase in cancer incidence rates. Over the past 10 years, there has been huge progress in the field of oncology with earlier diagnosis and an expansion of treatment options, leading to a growing number of older people living with cancer. That has meant that caring for older patients with cancer is now part of day-to-day oncology practices. This cohort often has geriatric syndromes and a higher prevalence of frailty and complex needs and preparing our clinical services to optimise care for these patients is essential. Whilst it is widely accepted that comprehensive geriatric assessments are of benefit to patients, only a small proportion of patients can access these through specialised teams during their cancer care. In the past few years there has been significant progress in this field throughout the United Kingdom (UK). The goal of this review is to inform other health care systems how to learn from what has been done in the UK. This paper provides an update from our previous review in 2020, detailing the new services being implemented and made available to patients and an expansion in the number of new pilot teams and research projects/trials throughout the four nations of the UK.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102133"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional impact of cancer from a patient's perspective","authors":"Ann Pennella","doi":"10.1016/j.jgo.2024.102155","DOIUrl":"10.1016/j.jgo.2024.102155","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102155"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric assessment in older adults with metastatic breast cancer: A pilot study","authors":"Kaitlyn Kwok ,&nbsp;Bryn Rahusaar Routledge ,&nbsp;Kristen Haase ,&nbsp;Gregory Arbour ,&nbsp;Tracy Zhang ,&nbsp;Janet Kow ,&nbsp;Stephen Chia ,&nbsp;Caroline Mariano","doi":"10.1016/j.jgo.2024.102131","DOIUrl":"10.1016/j.jgo.2024.102131","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102131"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of lifestyle interventions on sarcopenia in advanced colorectal cancer: A systematic review","authors":"David Burke ,&nbsp;Malcolm Brown ,&nbsp;Conor O'Neill ,&nbsp;Helen G. Coleman ,&nbsp;Tilman Kuhn ,&nbsp;Sabrina Schlesinger ,&nbsp;Gillian Prue ,&nbsp;Vicky Coyle","doi":"10.1016/j.jgo.2024.102143","DOIUrl":"10.1016/j.jgo.2024.102143","url":null,"abstract":"<div><h3>Introduction</h3><div>Sarcopenia is a common syndrome in older patients with advanced colorectal cancer that is worsened during standard-of-care chemotherapy and is associated with increased chemotherapy toxicity, impaired quality of life, and poorer survival independent of cancer stage or chemotherapy response. Physical activity and nutrition interventions have been shown to support muscle mass in patients recovering from treatment for early-stage colorectal cancer. The aim of this present review was to evaluate the effect of physical activity and nutritional interventions on sarcopenia in patients with advanced colorectal cancer.</div></div><div><h3>Materials and Methods</h3><div>We performed a systematic literature review of studies investigating the impact of physical activity and nutritional interventions on muscle mass in patients with advanced colorectal cancer. Relevant key words were searched in appropriate databases through December 2022. Review procedures were performed in line with guidelines from the Cochrane Handbook for systematic reviews and Synthesis Without Meta-analysis (SWiM) guidelines.</div></div><div><h3>Results</h3><div>Twelve studies were identified with 1461 participants of which 587 had advanced colorectal cancer. Eight studies were randomised controlled trials (RCTs). Only two studies exclusively reported on the population with advanced colorectal cancer. Physical activity and nutritional interventions explored were heterogenous. Studies reporting an improvement in muscle mass utilised protein supplementation (one study), moderate intensity aerobic exercise (one study), and assisted resistance training (two studies). However, only a small number of participants with advanced colorectal cancer were included in these studies. Risk of bias was moderate to high for most studies. Recruitment to physical activity interventions was often low although adherence to supervised interventions was high. Physical activity and nutritional interventions across studies were safe.</div></div><div><h3>Discussion</h3><div>A small number of studies with limited sample size and moderate-to-high risk of bias suggest that assisted resistance training and supported protein intake improve muscle mass in participants with cancer. However, there is currently sparse evidence for the effect of physical activity and nutritional interventions on sarcopenia in the setting of advanced and incurable colorectal cancer. Given the impact of sarcopenia in this population, further research in this area is warranted.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102143"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age disparities in clinical trials of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with high grade serous ovarian cancer: A wake up call to improving outcomes in older patients","authors":"Omali Pitiyarachchi ,&nbsp;Michael Friedlander","doi":"10.1016/j.jgo.2024.102152","DOIUrl":"10.1016/j.jgo.2024.102152","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102152"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“I have a doctor that handles all the other stuff.” Perceptions of older adults with cancer about discussing aging-related conditions with their oncologists","authors":"Sindhuja Kadambi ,&nbsp;Lee Kehoe ,&nbsp;Megan Wells ,&nbsp;Amita Patil ,&nbsp;Lianlian Lei ,&nbsp;Marquita Wenonah Lewis-Thames ,&nbsp;Anna Job ,&nbsp;Yingzi Zhang PhD ,&nbsp;Marie Flannery ,&nbsp;Nikesha Gilmore ,&nbsp;Victor G. Vogel ,&nbsp;Tony Philip ,&nbsp;Judith O. Hopkins ,&nbsp;Mary Whitehead ,&nbsp;Allison Magnuson ,&nbsp;Supriya Mohile ,&nbsp;Sally A. Norton","doi":"10.1016/j.jgo.2024.102065","DOIUrl":"10.1016/j.jgo.2024.102065","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102065"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}