Journal of geriatric oncology最新文献

{"title":"Patterns of social support among older adults with cancer and associations with patient-reported outcomes: A latent class analysis","authors":"Jae-Yung Kwon ,&nbsp;Kelsey L. Johnson ,&nbsp;Kristen R. Haase ,&nbsp;Lorelei Newton ,&nbsp;Margaret Fitch ,&nbsp;Richard Sawatzky","doi":"10.1016/j.jgo.2024.102157","DOIUrl":"10.1016/j.jgo.2024.102157","url":null,"abstract":"<div><h3>Introduction</h3><div>Social support can play an important role in the care of older adults living with cancer. However, different patterns of social support, such as emotional, instrumental, informational, appraisal, and giving support need to be considered to facilitate adjustments to cancer. This study aimed to explore the distinct patterns of social support among older adults with cancer and examine the socio-demographic variables and patient-reported outcomes that may be associated with patterns of social support.</div></div><div><h3>Materials and Methods</h3><div>Data were used from 7,097 respondents from the Experience of Cancer Patients in Transition Study administered in 2016. Socio-demographic variables included sex, age, marital status, place of residence, and income, alongside patient-reported outcomes. Latent class analysis was used to identify distinct social support patterns. Multivariable multinomial regression models were then used to determine predictors of these latent classes.</div></div><div><h3>Results</h3><div>Three latent classes of social support were identified: “low,” “moderate,” and “high” emotional support. Having “high” emotional support did not necessarily mean patients had the highest levels of all social support attributes. For example, the “low” emotional support group exhibited the highest appraisal support (16 % of class members) and giving support (42 % of class members). While most socio-demographic variables were not significant predictors of the latent classes, statistically significant differences were found in emotional health.</div></div><div><h3>Discussion</h3><div>Assessing social support requires consideration of the different patterns of support, as the presence of one attribute (e.g., appraisal or giving support) does not ensure the coverage of others (e.g., emotional support). Comprehensive assessments of these varied support patterns are recommended to better address the psychological and emotional challenges associated with a cancer diagnosis and to inform subsequent interventions.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102157"},"PeriodicalIF":3.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential drug-drug interactions between cancer therapies and active antiretroviral treatments among Medicare-enrolled patients with cancer and HIV.","authors":"Jessica Y Islam, Xi Zhou, Christopher Baggett, Christine Jamjian, Anna Coghill, Gita Suneja, Jennifer L Lund","doi":"10.1016/j.jgo.2024.102158","DOIUrl":"https://doi.org/10.1016/j.jgo.2024.102158","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102158"},"PeriodicalIF":3.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing observational studies to estimate treatment effects in geriatric oncology: A closer look at confounding and its mitigation.","authors":"Nienke A de Glas, Sophie Pilleron, Esther Bastiaannet, Florence Canouï-Poitrine, Adolofo Gonzalez Serrano, Eva Culakova, Jennifer L Lund","doi":"10.1016/j.jgo.2024.102159","DOIUrl":"https://doi.org/10.1016/j.jgo.2024.102159","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102159"},"PeriodicalIF":3.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic and procedural challenges in transitioning patients with cancer to post-acute and long-term care facilities: A prospective mixed-methods study.","authors":"Oisharya Dasgupta, Nabiel Mir, Kunal Desai, Lauren J Gleason","doi":"10.1016/j.jgo.2024.102154","DOIUrl":"https://doi.org/10.1016/j.jgo.2024.102154","url":null,"abstract":"","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102154"},"PeriodicalIF":3.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of healthcare professionals' attitudes in treatment decision-making for older adults with cancer: A scoping review.","authors":"India Pinker, Lisa Wetzlmair-Kephart, Allini Mafra da Costa, Sophie Pilleron","doi":"10.1016/j.jgo.2024.102151","DOIUrl":"https://doi.org/10.1016/j.jgo.2024.102151","url":null,"abstract":"<p><strong>Introduction: </strong>The global population of older adults with cancer is increasing, presenting care challenges caused by comorbidity, polypharmacy, and frailty. In response to these complexities, healthcare professionals (HCPs) rely on their own attitudes to a larger extent due to limitations in the treatment evidence for this population. This scoping review aims to explore and describe the attitudes of HCPs in the context of treatment decision-making for older adults with cancer.</p><p><strong>Materials and methods: </strong>We conducted a scoping review on HCP attitudes or subjective inclinations in the treatment decision-making process for older adults with cancer. PubMed, Embase, Medline, and EBSCO CINAHL Complete were searched using predefined inclusion criteria. A two-step screening process was implemented, conducted by two-reviewer teams.</p><p><strong>Results: </strong>From 5161 de-duplicated references, 21 studies were retained for analysis (nine qualitative, six quantitative, five mixed methods). Five patterns were observed, highlighting how HCP attitudes can shape consultation dynamics, influence the interpretation of patient factors such as age and comorbidities, and impact communication with older patients. Additionally, HCP background profession and practice environment emerged as influential in shaping both attitudes and decision-making processes.</p><p><strong>Discussion: </strong>This scoping review describes the role of HCP attitudes in communicating treatment options with older adults with cancer. It suggests the importance of considering the role of attitudes in decision-making when developing educational resources for geriatric-centred communication skills to support shared decision-making practices in the cancer treatment of older adults.</p>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102151"},"PeriodicalIF":3.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Start low, go slow,\" a strategy to tailor treatment dosing in older or vulnerable adults with advanced solid cancer: A systematic review and meta-analysis.","authors":"Gabriel Aleixo, Tej Patel, Julianne Ani, Will J Ferrell, Efrat Dotan, Samuel U Takvorian, Grant R Williams, Ravi B Parikh, Ramy Sedhom","doi":"10.1016/j.jgo.2024.102153","DOIUrl":"https://doi.org/10.1016/j.jgo.2024.102153","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The use of standard-dose cancer treatment can result in a decline in the functional abilities of older adults with cancer. The \"start-low, go-slow\" (SLGS) strategy involves initiating cancer treatment at lower-than-standard doses in selected patients who are vulnerable to excess toxicity and escalating based on tolerance. We performed a systematic review and meta-analysis to assess the available data and the effectiveness of the SLGS strategy in the treatment of cancer in older adults with incurable solid cancer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;The review was registered with PROSPERO. Two independent reviewers (GA and TP) conducted a comprehensive search across multiple databases (PubMed/Medline, Journal of Geriatric Oncology, American Society of Clinical Oncology abstracts, and EMBASE) of prospective studies involving patients with solid tumors who received SLGS. SLGS was defined as starting cancer therapy with a lower than standard dose and dose-escalating, if possible. The main objective of this study was to evaluate overall survival (OS) in patients treated with the SLGS strategy. Secondary objectives were to analyze treatment discontinuation and toxicity in patients treated with the SLGS strategy. Additionally, we aimed to compile a comprehensive report on studies employing the SLGS strategy in solid oncology. We utilized a random-effects meta-analysis model to consider the diversity among patient populations with different cancer stages, types, and treatments. Two researchers independently employed the Newcastle-Ottawa Quality (NOQ) assessment for cohort analysis to evaluate the methodological quality and standard of outcomes reporting in the included studies. The quality of evidence was appraised using the Grading recommendations assessment, development and evaluation GRADE summary of findings tool.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The systematic search identified a total of 12,690 articles. Thirteen studies met criteria for inclusion in the systematic review, totaling 8546 patients. Twelve studies evaluated OS. However, only five studies focused solely on older adults, and the studies involved different types of cancer without following a specific pattern. In meta-analysis of survival among three studies, patients who underwent the SLGS approach had lower mortality (hazar ratio 0.91, 95 % confidence interval [CI] 0.85-0.98, p = 0.01, i2 = 0 %). Toxicity ranged from 5 % to 89 % across studies; SLGS had lower grade 3 and 4 toxicity compared to the standard dose (six studies, meta-analysis relative risk 0.86, 95 % CI 0.75-0.98, p &lt; 0.02, i2 = 30 %). Treatment discontinuation was not different for SLGS vs. standard dose (seven studies, meta-analysis RR 0.96, 95 % CI 0.87-1.05, p = 0.37 i2 = 50 %).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;This systematic review and meta-analysis suggests that a SLGS approach to systemic therapy dosing may reduce toxicity without affecting survival among older patients w","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":" ","pages":"102153"},"PeriodicalIF":3.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric determinants of curative radiotherapy scheme choice for older adults with breast cancer treatment compliance and tolerance: Results from the GERABEL study","authors":"Elisabeth Daguenet ,&nbsp;Emmanuel Chamorey ,&nbsp;Omar Jmour ,&nbsp;Grégoire Pigné ,&nbsp;Caroline Chung Kim Yuen ,&nbsp;Emilie Gadéa ,&nbsp;Elodie Guillaume ,&nbsp;Claire Bosacki ,&nbsp;Blandine De Lavigerie ,&nbsp;Rachid Laassami ,&nbsp;Nicolas Magné","doi":"10.1016/j.jgo.2024.102147","DOIUrl":"10.1016/j.jgo.2024.102147","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronological and functional aging complicates care in older patients, and therapeutic decisions need to consider individual needs to minimise morbidity and mortality. Therapeutic decisions should be guided by a multidisciplinary geriatric assessment, allowing a complete assessment of physical and functional performance. In this context, the GERABEL study aimed to orientate the irradiation strategy based on a detailed oncogeriatric assessment in women more than 70 years old with breast cancer.</div></div><div><h3>Materials and Methods</h3><div>This was a multicentre clinical trial conducted between January 2017 and June 2021. The oncogeriatric assessment comprised seven questionnaires (activities of daily living [ADL], instrumental ADL, Mini-Mental State Examination, mini Geriatric Depression Scale, Mini-Nutritional Assessment, Cumulative Illness Rating Scale-Geriatric, and Timed Up and Go) to determine a predictive score. Irradiation regimen was assigned according to oncogeriatric score: normofractionated – NF (score range, 160–200), hypofractionated – HF (score range, 159–120), or high-dose hypofractionated – HDHF (score ≤ 119). Endpoints were the overall tolerance to treatment, using the oncogeriatric score as a proxy at six months post-treatment, and compliance.</div></div><div><h3>Results</h3><div>After oncogeriatric assessment at baseline, 177 patients were treated with a NF regimen, 24 with a HF regimen, and four with a HDHF regimen. Tolerance was excellent in the three groups, as no decrease of more than 20 % in the oncogeriatric score was noted at six months post-treatment. More generally, 68 % and 73 % of patients reported an improvement of the oncogeriatric score at two months and six months post-treatment, respectively. Only four treatment interruptions were observed and quality-of-life was well-conserved. In the hypo fractionated groups, short-term toxicities were not increased and no impact was noted on compliance.</div></div><div><h3>Discussion</h3><div>Decision-making guidance for irradiation schemes in breast cancer according to oncogeriatric determinants was successful in older patients, who tolerated treatment well and, overall, had a preserved general condition.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102147"},"PeriodicalIF":3.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dementia on functional decline in patients with non-small cell lung cancer at discharge from acute care hospitals: A retrospective cohort study","authors":"Kayo Hirooka ,&nbsp;Yasuyuki Okumura ,&nbsp;Jun Hamano ,&nbsp;Junko Nozato ,&nbsp;Sakiko Fukui ,&nbsp;Asao Ogawa","doi":"10.1016/j.jgo.2024.102150","DOIUrl":"10.1016/j.jgo.2024.102150","url":null,"abstract":"<div><h3>Introduction</h3><div>Hospital admissions often result in functional decline for patients with dementia, yet evidence on the impact of cancer treatments in this population during hospitalization is limited. We aimed to examine the association between dementia and functional decline after cancer treatment in patients with non-small cell lung cancer (NSCLC).</div></div><div><h3>Materials and Methods</h3><div>A total of 30,213 patients aged 65 years or older hospitalized for NSCLC treatment, from a dataset of 366 acute care hospitals in Japan, were eligible for this study. The primary outcome was activities of daily living (ADL) at discharge, assessed using the Barthel Index, with a total score ranging from 0 to 100, and the secondary outcome was the length of hospital stay. We conducted causal mediation analysis by cancer treatment within a counterfactual framework using the g-formula approach with direct counterfactual imputation. Bias-corrected and adjusted bootstrapped 95 % confidence intervals (CIs) were calculated based on 100 bootstrap samples. Dementia status served as the exposure, ADL scores at admission as the mediator, and ADL scores at discharge as the outcome. Covariates measured at admission were used to adjust for dementia status. Subgroup analyses were performed by treatment group including surgery.</div></div><div><h3>Results</h3><div>Compared with patients with NSCLC who did not have dementia, those with dementia exhibited lower ADLs at discharge across most cancer treatments, regardless of ADL scores at admission. Patients with dementia who underwent chemotherapy had prolonged hospital stays of 2.90 days longer (95 % CI, 1.27 to 4.52) and lower ADL scores at discharge than their counterparts without dementia (−9.77 [95 % CI, −12.55 to −7.00]). Similarly, patients with dementia who received radiotherapy experienced lower ADL scores at discharge compared with those without dementia (−15.06 [95 % CI, −19.59 to −10.54]), with no difference in the length of hospital stay (−0.54 [95 % CI, −2.84 to 1.75] days). Similar findings were observed from the total effects after adjusting for potential confounders.</div></div><div><h3>Discussion</h3><div>Patients with comorbid cancer and dementia consistently displayed lower ADL scores at discharge following various cancer treatments. Understanding the effects of dementia on functional decline may aid in making optimal treatment choices for inpatient care for patients with NSCLC.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102150"},"PeriodicalIF":3.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of geriatric assessment and Geriatric 8-based targeted interventions on quality of life in older adults with cancer","authors":"Jia Li Low ,&nbsp;Angela Pang ,&nbsp;Joseph Cheng ,&nbsp;Alex Ng ,&nbsp;Tai Bee Choo ,&nbsp;Ng Yean Shin ,&nbsp;Jeremy Tey ,&nbsp;Francis Ho ,&nbsp;Matthew Chen ,&nbsp;Nesaretnam Barr Kumarakulasinghe","doi":"10.1016/j.jgo.2024.102149","DOIUrl":"10.1016/j.jgo.2024.102149","url":null,"abstract":"<div><h3>Introduction</h3><div>Both Geriatric-8 (G8) and geriatric assessment (GA) assess frailty and facilitate providing appropriate interventions as recommended by the International Society for Geriatric Oncology. The main objective of this study is to evaluate the impact of G8 and GA-based interventions on the quality of life (QOL) of older adults with cancer.</div></div><div><h3>Materials and Methods</h3><div>This is a prospective study of patients with cancer aged ≥70 y. A G8, GA, and a European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) was performed at study entry. Targeted interventions were offered. After three months, a follow-up EORTC QLQ-C30 was repeated for patients who required interventions. The study's primary outcome measure was a comparison of pre-and post-geriatric intervention EORTC QLQ-C30 scores.</div></div><div><h3>Results</h3><div>Two hundred thirty patients were accrued. Median age was 74 y (range:70–90). Based on the GA, 11 % were classified as frail, 58 % as pre-frail, and 31 % as fit. A total of 79 % had a G8 scores ≤14. Patients who were pre-frail, frail, and those with G8 ≤ 14 had lower baseline EORTC QLQ-C30 function scores and higher EORTC QLQ-C30 symptom scores (<em>p</em> &lt; 0.05). They also had significantly shorter overall survival (OS) compared to fit patients or those with G8 &gt; 14. (hazard ratio: 2.54 95 % CI 1.46–4.43, <em>p</em> = 0.001 for frail vs fit patients; 1.72 95 % CI 1.18–2.53, <em>p</em> = 0.005 for pre-frail vs fit patients; 1.51 95 % CI 1.05–2.18, <em>p</em> = 0.03 for G8 ≤ 14 vs &gt;14). Geriatric oncology (GO) interventions were suggested for 144 patients with 104 patients completing a second EORTC QLQ-C30. These patients reported significant improvements in the EORTC emotional and social functioning domains (mean difference + 4.6, <em>p</em> &lt; 0.001 and + 12.3 <em>p</em> &lt; 0.001, respectively), a significant reduction in the EORTC symptom scale of pain, insomnia, constipation, and financial difficulties (mean difference − 5.8 <em>p</em> = 0.003, −8.3 <em>p</em> &lt; 0.001, −9.0 <em>p</em> &lt; 0.001, and − 6 <em>p</em> = 0.01), with no significant deterioration in other QOL domains.</div></div><div><h3>Discussion</h3><div>GA-based targeted interventions delivered by a multidisciplinary GO service improved multiple QOL domains in older adult patients undergoing cancer treatment.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102149"},"PeriodicalIF":3.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive ability of the Cancer and Aging Research Group chemotherapy toxicity calculator in hematologic malignancy","authors":"Ashley E. Rosko ,&nbsp;Ying Huang ,&nbsp;Sarah A. Wall ,&nbsp;Alice Mims ,&nbsp;Jennifer Woyach ,&nbsp;Carolyn Presley ,&nbsp;Nicole O. Williams ,&nbsp;Erin Stevens ,&nbsp;Claire J. Han ,&nbsp;Diane Von Ah ,&nbsp;Nowshin Islam ,&nbsp;Jessica L. Krok-Schoen ,&nbsp;Christin E. Burd ,&nbsp;Michelle J. Naughton","doi":"10.1016/j.jgo.2024.102144","DOIUrl":"10.1016/j.jgo.2024.102144","url":null,"abstract":"<div><h3>Introduction</h3><div>Chemotherapy toxicity tools are rarely studied in patients with hematologic malignancy (HM). The primary aim of this pilot study was to determine the predictive ability of the Cancer and Aging Research Group (CARG) chemo-toxicity calculator in estimating grade 3–5 toxicity in patients with HM.</div></div><div><h3>Materials and Methods</h3><div>Patients 60 years and older with HM were prospectively evaluated using the CARG chemo-toxicity calculator. Discrimination and calibration were checked by applying the published model in our data. Additionally, a full geriatric assessment (GA), the Short Physical Performance Battery (SPPB), and health related quality of life (HRQoL) were captured longitudinally at the start of treatment and at end of study. Secondary aims explored the association of GA metrics with chemo-related toxicities and survival.</div></div><div><h3>Results</h3><div>One hundred forty-five patients were approached, 118 patients consented, and 97 patients were evaluable. Most patients were newly diagnosed (<em>n</em> = 91). The median CARG score was 9 (range 4–18). The CARG score was not validated in our cohort of older patients with HM, with area under the receiver operation characteristic curve being 0.53 (95 % CI: 0.41–0.65). In multivariable analysis, after controlling for disease type, risk factors associated with grade 3–5 toxicity included living alone (hazard ratio [HR] 4.24, 95 %CI: 2.07–8.68, <em>p</em> &lt; 0.001), increase in body mass index (HR 1.06, 95 %CI: 1.01–1.12, <em>p</em> = 0.03) and a higher social activities score (HR 1.27, 95 %CI: 1.06–1.51, <em>p</em> = 0.01). In multivariable analysis of overall survival, the only prognostic factor was an objective marker of physical function (SPPB score HR = 0.85, 95 %CI:0.78–0.93, <em>p</em> &lt; 0.001).</div></div><div><h3>Discussion</h3><div>The CARG chemo-toxicity calculator was not predictive of grade 3–5 toxicity in patients with hematologic malignancy. The SPPB was associated with overall survival in multivariable analysis, suggesting future use as an objective biomarker in HM. We also report a comprehensive trajectory of function, QoL, psychosocial well-being, and cognition among older adults with HM. The predictive accuracy of the CARG chemo-toxicity calculator may be affected by the diverse range of HM treatment options that are not traditional chemotherapy.</div></div>","PeriodicalId":15943,"journal":{"name":"Journal of geriatric oncology","volume":"16 1","pages":"Article 102144"},"PeriodicalIF":3.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}