Journal of GlaucomaPub Date : 2025-01-01Epub Date: 2024-06-28DOI: 10.1097/IJG.0000000000002455
Bonnie B Huang, Angelo P Tanna
{"title":"Association of Social Determinants of Health With the Likelihood of Treatment With Laser Trabeculoplasty in a US Database.","authors":"Bonnie B Huang, Angelo P Tanna","doi":"10.1097/IJG.0000000000002455","DOIUrl":"10.1097/IJG.0000000000002455","url":null,"abstract":"<p><strong>Prcis: </strong>Among 1861 adults with ocular hypertension or mild or moderate primary open angle glaucoma, those with Medicaid or no insurance had a statistically significantly lower likelihood of receiving laser trabeculoplasty compared with those with other insurance.</p><p><strong>Purpose: </strong>To determine whether social determinants of health are associated with undergoing treatment with laser trabeculoplasty (LTP) among individuals with ocular hypertension (OHT) or mild or moderate primary open angle glaucoma (POAG).</p><p><strong>Methods: </strong>In this cross-sectional study, we included patients with OHT or mild or moderate POAG from the National Institutes of Health All of Us Research Program, a diverse US nationwide data set. Logistic regression was performed to study the association between LTP treatment status and 7 covariates (diagnosis severity, age, gender, race/ethnicity, income, insurance status, and education).</p><p><strong>Results: </strong>A total of 1861 subjects were included (median age of 72 y). In univariable logistic regression, diagnosis severity, older age, higher income, and insurance (non-Medicaid) were associated with LTP treatment. On multivariable logistic regression models, those with mild POAG (OR, 3.49; 95% CI: 2.12-5.87) and moderate POAG [OR, 7.15 (4.49-11.8)] were still more likely than OHT patients to have received LTP. Moreover, compared with participants with Medicaid or no insurance, participants with other insurance (eg, employer-provided, Medicare) were still more likely to have received LTP [OR, 2.24 (1.08-5.29)]. There was no significant difference in the LTP treatment likelihood based on race/ethnicity.</p><p><strong>Conclusions: </strong>After controlling for confounders, the likelihood of receiving LTP appears to be driven primarily by insurance rather than income or race/ethnicity. Potential reasons for decreased utilization of LTP among Medicaid patients include higher rates of declining the procedure, or LTP may have been offered less frequently due to Medicaid's lower levels of reimbursement and longer reimbursement delays.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"47-54"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2025-01-01Epub Date: 2024-07-15DOI: 10.1097/IJG.0000000000002461
Mehmet Cuneyt Ozmen, Burak Acar, Betul Seher Uysal
{"title":"Wipe-Out Following Gonioscopy-Assisted Transluminal Trabeculotomy Combined With Phacoemulsification.","authors":"Mehmet Cuneyt Ozmen, Burak Acar, Betul Seher Uysal","doi":"10.1097/IJG.0000000000002461","DOIUrl":"10.1097/IJG.0000000000002461","url":null,"abstract":"<p><strong>Prcis: </strong>We report a case of a 62-year-old male patient who developed a wipe-out phenomenon after uncomplicated gonioscopy-assisted transluminal trabeculotomy combined with cataract surgery.</p><p><strong>Abstract: </strong>A 62-year-old male patient with a diagnosis of pseudo-exfoliation and open angle glaucoma underwent uncomplicated gonioscopy-assisted transluminal trabeculotomy (GATT) combined with phacoemulsification surgery due to advanced glaucomatous damage and high intraocular pressure. Postoperative decrease in visual acuity and central visual field deterioration suggested a wipe-out phenomenon. Although the wipe-out phenomenon has been reported after other surgeries in patients with advanced glaucoma, as far as we know, this is the first report of a wipe-out phenomenon secondary to GATT combined with phacoemulsification surgery. This complication, which can lead to severe vision loss, should be considered before the surgical decision.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"58-60"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor: Reliability of Visual Field Testing in a Telehealth Setting Using a Head-Mounted Device: A Pilot Study.","authors":"Kainat Chaudhary, Monica Gandhi, Suneeta Dubey, Julie Pegu","doi":"10.1097/IJG.0000000000002501","DOIUrl":"10.1097/IJG.0000000000002501","url":null,"abstract":"","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e1"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2025-01-01Epub Date: 2024-07-15DOI: 10.1097/IJG.0000000000002463
Rithambara Ramachandran, Patrice M Hicks, Ming-Chen Lu, Leslie M Niziol, Maria A Woodward, Angela R Elam, Leroy Johnson, Martha Kershaw, David C Musch, Amanda Bicket, Denise John, Olivia J Killeen, Paula Anne Newman-Casey
{"title":"Neighborhood Poverty and Clinic Attendance in the Michigan Screening and Intervention for Glaucoma and Eye Health Through Telemedicine Program.","authors":"Rithambara Ramachandran, Patrice M Hicks, Ming-Chen Lu, Leslie M Niziol, Maria A Woodward, Angela R Elam, Leroy Johnson, Martha Kershaw, David C Musch, Amanda Bicket, Denise John, Olivia J Killeen, Paula Anne Newman-Casey","doi":"10.1097/IJG.0000000000002463","DOIUrl":"10.1097/IJG.0000000000002463","url":null,"abstract":"<p><strong>Prcis: </strong>Higher neighborhood-level poverty is associated with greater odds of missing a free eye disease screening appointment, underscoring the importance of community-based interventions to address upstream social determinants of health.</p><p><strong>Purpose: </strong>To investigate the association between neighborhood-level characteristics and attendance for a free eye disease screening.</p><p><strong>Methods: </strong>The MI-SIGHT program is conducted in 2 community clinics in Southeastern Michigan. Participant-level demographics were extracted from electronic health records. Neighborhood-level characteristics, including Area Deprivation Index (ADI), median household income (HHI), percent of households with >30% rent burden, percent of households without vehicles, percent of households in subsidized housing, and energy burden, were obtained from the Wisconsin Neighborhood Atlas and the United States census. Logistic regression was used to model the probability of clinic visit attendance, which was the main outcome measure.</p><p><strong>Results: </strong>One thousand four hundred thirty-one participants were scheduled for screening appointments between July 2020 and November 2021, with a no-show rate of 23%. Individuals lived an average of 7.7 miles from each clinic (SD=8.1) and in neighborhoods with a mean ADI of 6.8 (SD=3.2, 1-10 scale, where 10 is the most deprived). After adjusting for age, sex, race, and ethnicity, participants from neighborhoods with higher deprivation were more likely to have missed clinic visits. For example, there was an 8% higher odds of missed clinic visits for every 1-point increase in ADI (odds ratio, OR=1.08, P =0.020) and an 18% higher odds of a missed visit with every 10% increase in households without a vehicle (OR=1.18, P =0.013).</p><p><strong>Conclusions: </strong>Higher neighborhood-level poverty was associated with greater odds of missing a free eye disease screening appointment after adjusting for individual characteristics. Increased neighborhood-level resources are likely needed to bolster engagement in preventive eye care.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"30-38"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2025-01-01Epub Date: 2024-08-15DOI: 10.1097/IJG.0000000000002486
Yousaf Jamal Mahsood, Ali Hassan Nasir, Hira Wakil, Saima Farooq
{"title":"Compliance With International Council of Ophthalmology Guidelines for Glaucoma Eye Care in Pakistan.","authors":"Yousaf Jamal Mahsood, Ali Hassan Nasir, Hira Wakil, Saima Farooq","doi":"10.1097/IJG.0000000000002486","DOIUrl":"10.1097/IJG.0000000000002486","url":null,"abstract":"<p><strong>Prcis: </strong>This study demonstrated that the compliance levels with International Council of Ophthalmology (ICO) Guidelines for glaucoma eye care were low for all the elements in both public and private health care settings.</p><p><strong>Purpose: </strong>To determine the compliance with the ICO guidelines for glaucoma eye care among Pakistani ophthalmologists and to compare differences among ophthalmologists practicing in public and private health care settings.</p><p><strong>Materials and methods: </strong>This was a retrospective chart review, and the records were reviewed according to ICO guidelines. The ICO recommends that each patient with glaucoma be evaluated for 19 items from 3 elements which are history, examination, and investigations. Mean compliance was recorded for each of the 3 elements. The compliance of each item was also checked and then a compared between the 2 settings, that is, public and private health care settings.</p><p><strong>Results: </strong>A total of 394 records were analyzed, with a mean age of 51.9±14.9 years and 232 (58.9%) male patients. Most records were from private settings 339 (86%), and primary open angle glaucoma 163 (41.4%) was the most common diagnosis. Compliance was low for all elements; history (31.8%), examination (61.3%), and investigation (6%). Pupil reaction differed significantly between the 2 groups ( P =0.001).</p><p><strong>Conclusion: </strong>Pakistan's ophthalmologists, whether in public or private health care settings, lack knowledge of ICO guidelines for glaucoma eye care. This study emphasizes the importance of implementing these guidelines in the general ophthalmology curriculum.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"25-29"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2025-01-01Epub Date: 2024-08-29DOI: 10.1097/IJG.0000000000002489
Dong Kyun Han, Eun Ji Lee, Tae-Woo Kim
{"title":"Bilateral Normal Tension Glaucoma in a Healthy Child Without Myopia.","authors":"Dong Kyun Han, Eun Ji Lee, Tae-Woo Kim","doi":"10.1097/IJG.0000000000002489","DOIUrl":"10.1097/IJG.0000000000002489","url":null,"abstract":"","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"55-57"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2025-01-01Epub Date: 2024-08-28DOI: 10.1097/IJG.0000000000002491
Nurit Mathalone, Or Ben-Shaul, Olga Podkovyrin, Chen Lux, Orna Geyer
{"title":"The Impact of Femtosecond Laser on Intraocular Pressure With Cataract Surgery in Healthy Eyes.","authors":"Nurit Mathalone, Or Ben-Shaul, Olga Podkovyrin, Chen Lux, Orna Geyer","doi":"10.1097/IJG.0000000000002491","DOIUrl":"10.1097/IJG.0000000000002491","url":null,"abstract":"<p><strong>Prcis: </strong>Femtosecond laser-assisted cataract surgery (FLACS) leads to an increase in intraocular pressure (IOP) during the procedure and subsequent IOP reduction after surgery, with greater magnitude in eyes with higher preoperative IOP.</p><p><strong>Purpose: </strong>To evaluate the effect of FLACS using the LDVZ8 laser on IOP during and after surgery, and to compare the IOP-lowering effect of FLACS and conventional phacoemulsification cataract surgery (CPCS).</p><p><strong>Patients and methods: </strong>This prospective cohort study enrolled 395 healthy eyes (395 patients) scheduled for FLACS (n=245) and CPCS (n=150). FLACS was performed using the LDVZ8 laser. During FLACS, IOP was assessed before and immediately after docking. IOP reduction during a 6-month postoperative period was evaluated following FLACS and CPCS. Multivariate analyses were performed.</p><p><strong>Results: </strong>The mean IOP increase after docking was 2.3±4.1 mm Hg ( P <0.0001); the maximum increase was 17.6 mm Hg, peak of 38 mm Hg. Sixty-one eyes (25.1%) demonstrated an increase of ≥5 mm Hg and 10 (3.7%) showed an increase of ≥10 mm Hg; predocking IOP was associated with an IOP increase of ≥5 mm Hg ( P =0.029). IOP reduction over 6 months postsurgery was similar for FLACS and CPCS ( P >0.05), -1.33±3.12 mm Hg for FLACS ( P <0.001) and -1.4±2.87 mm Hg for CPCS ( P <0.001). Preoperative IOP correlated statistically significantly with IOP reduction in both FLACS (β -0.742, P <0.001) and CPCS (β -0.743, P <0.001).</p><p><strong>Conclusions: </strong>Although the LDVZ8 laser procedure causes an increase in IOP in some healthy eyes, a subsequent decrease in IOP is observed after FLACS. The IOP-lowering effect of FLACS is similar to CPCS and tends to be more pronounced in eyes with higher preoperative IOP. Eyes with higher preoperative IOP are prone to IOP elevation during FLACS, a critical consideration for glaucoma patients.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"19-24"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Journal of GlaucomaPub Date : 2025-01-01Epub Date: 2024-08-13DOI: 10.1097/IJG.0000000000002480
Kaela N Acuff, Bharanidharan Radha Saseendrakumar, Robert N Weinreb, Sally L Baxter
{"title":"Assessment of Missing Data on Glaucoma Severity Among Participants in the NIH All of Us Research Program of the United States.","authors":"Kaela N Acuff, Bharanidharan Radha Saseendrakumar, Robert N Weinreb, Sally L Baxter","doi":"10.1097/IJG.0000000000002480","DOIUrl":"10.1097/IJG.0000000000002480","url":null,"abstract":"<p><strong>Prcis: </strong>There were statistically significant differences across multiple socioeconomic characteristics and self-reported barriers to care among primary glaucoma patients with severity staging data versus those missing this data in the NIH All of Us database.</p><p><strong>Purpose: </strong>To characterize missing data among glaucoma patients within All of Us .</p><p><strong>Materials and methods: </strong>We used diagnosis codes to define cohorts of primary glaucoma patients with and without severity staging specified. Descriptive analyses were conducted by presence of disease severity stage. Analysis of missing data was conducted using a set intersection plot and the Little Test of Missing Completely at Random. T tests were performed to evaluate differences.</p><p><strong>Results: </strong>Of 2982 participants, 1714 (57%) did not have glaucoma severity stage specified, and 11 of 23 analyzed variables had missing data. The Little Test indicated data was not missing completely at random ( P <0.001). Significant differences existed between the 2 cohorts with respect to age, age of first glaucoma diagnosis, gender, ethnicity, education, income, insurance, history of glaucoma surgery and medication use, and answers regarding the ability to afford eyeglasses and having seen an eye care provider in the last 12 months (all P- values ≤0.01).</p><p><strong>Conclusion: </strong>There were significant differences between glaucoma participants with glaucoma severity stage specified versus those with unstaged disease across multiple socioeconomic characteristics and self-reported barriers to care. Glaucoma severity staging data was not missing completely at random. The unstaged cohort included higher rates of multiple underrepresented communities, which may potentially contribute to bias in ophthalmology research as participants from vulnerable populations may be disproportionately excluded from electronic health records or claims data studies where diagnosis codes with severity/staging levels are used to examine risk factors for disease, progression, and treatment efficacy.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"39-46"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic Variants Associated With a History of Glaucoma Surgery in Japanese Patients With Primary Open Angle Glaucoma.","authors":"Fumihiko Mabuchi, Nakako Tanaka-Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Zentaro Yamagata, Kenji Kashiwagi","doi":"10.1097/IJG.0000000000002510","DOIUrl":"10.1097/IJG.0000000000002510","url":null,"abstract":"<p><strong>Prcis: </strong>The genetic risk score (GRS) of genetic variants associated with intraocular pressure (IOP) elevation, but not those associated with optic nerve vulnerability, was associated with a history of glaucoma surgery in Japanese patients with primary open angle glaucoma (POAG).</p><p><strong>Objective: </strong>To investigate genetic variants associated with a history of glaucoma surgery in Japanese patients with POAG.</p><p><strong>Methods: </strong>Japanese patients with POAG (n = 468), including normal tension glaucoma (n = 246) and high tension glaucoma (n = 222), and control subjects (n = 246) were genotyped for 22 genetic variants predisposing to POAG, which can be classified into those associated with IOP elevation (IOP-related genetic variants) and optic nerve vulnerability independent of IOP (optic nerve-related genetic variants). The unweighted and weighted GRSs of 17 IOP-related, 5 optic nerve-related, and all 22 genetic variants were calculated, and the association between the GRS and a history of glaucoma surgery was evaluated.</p><p><strong>Results: </strong>There was a significant association (odds ratio 1.13 per unweighted GRS, 95% CI: 1.03 to 1.24, P = 0.0093) between IOP-related unweighted GRS and a history of glaucoma surgery. A significant association (odds ratio 1.09 per 0.1 weighted GRS, 95% CI: 1.04 to 1.14, P = 0.00022) was also found between IOP-related weighted GRS and a history of glaucoma surgery. The IOP-related GRS was positively correlated with the need for glaucoma surgery. The mean of IOP-related unweighted and weighted GRS in patients with POAG with a history of glaucoma surgery were significantly higher ( P = 0.013 and P = 0.00031, respectively) than those in patients with POAG without a history of glaucoma surgery.</p><p><strong>Conclusions: </strong>IOP-related, but not optic nerve-related, genetic variants were associated with a history of glaucoma surgery in Japanese patients with POAG. These results indicate that IOP elevation induced by IOP-related genetic variants rather than optic nerve vulnerability induced by optic nerve-related genetic variants may play an important role in requiring glaucoma surgery.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"7-12"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harsha L Rao, Srilakshmi Dasari, Narendra K Puttaiah, Zia S Pradhan, Sasan Moghimi, Kaweh Mansouri, Carroll Ab Webers, Robert N Weinreb
{"title":"Optical Microangiography and Progressive Retinal Nerve Fiber Layer Loss in Primary Angle-closure Glaucoma.","authors":"Harsha L Rao, Srilakshmi Dasari, Narendra K Puttaiah, Zia S Pradhan, Sasan Moghimi, Kaweh Mansouri, Carroll Ab Webers, Robert N Weinreb","doi":"10.1097/IJG.0000000000002524","DOIUrl":"10.1097/IJG.0000000000002524","url":null,"abstract":"<p><strong>Precis: </strong>Younger patient age (coefficient: 0.10, P=0.04) and greater peak IOP during follow-up (coefficient: -0.14, P=0.03), but not baseline optical microangiography parameters, were significantly associated with a faster rate of RNFL loss in mild-moderate PACG.</p><p><strong>Purpose: </strong>To evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary angle-closure glaucoma (PACG).</p><p><strong>Methods: </strong>In a prospective study, 45 eyes of 30 PACG patients (86 hemifields) with mild to moderate functional damage were longitudinally studied for at least 2 years and with a minimum of 3 optical coherence tomography (OCT) examinations. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, gender, presence of systemic diseases, central corneal thickness, mean, peak and fluctuation of intraocular pressure during follow-up), baseline hemifield mean deviation (MD) and baseline OMAG (quadrant peripapillary and macular perfusion density [PD]) on the rate of RNFL change was evaluated using linear mixed models.</p><p><strong>Results: </strong>Average (±SD) hemifield MD, RNFL thickness, peripapillary PD and macular PD of the analyzed quadrants at baseline were -6.0±3.4 dB, 89±21 µm, 40.1±3.5% and 29.6±10.3%, respectively. Rate of quadrant RNFL change was -2.5±1.7 µm/year. Multivariate mixed models showed that younger patient age (coefficient: 0.10, P=0.04) and higher peak IOP during follow-up (coefficient: -0.14, P=0.03) were significantly associated with a faster rate of RNFL loss.</p><p><strong>Conclusions: </strong>Younger patient age and greater peak IOP during follow-up were significantly associated with a faster rate of RNFL loss in PACG patients with mild to moderate severity of functional damage. None of the OMAG parameters at baseline were associated with RNFL thinning suggesting a limited role of OCTA imaging in predicting structural progression in mild-moderate PACG.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}