Factors Associated With Lamina Cribrosa Microvasculature Determined Through Swept-Source Optical Coherence Tomography Angiography.

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Journal of Glaucoma Pub Date : 2025-04-01 Epub Date: 2024-12-19 DOI:10.1097/IJG.0000000000002531
Jooyoung Yoon, Kyung Rim Sung, Jin Yeong Lee, Joong Won Shin, Joon Mo Kim
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Abstract

Prcis: The lamina cribrosa (LC) microvasculature reduction was associated with the posterior deformation of LC, as well as the functional deterioration, in all spectrums of open angle glaucoma.

Objective: To investigate the factors associated with the lamina cribrosa vessel density (LCVD) determined through swept-source optical coherence tomography angiography.

Materials and methods: The optic nerve head (ONH) scan was obtained using swept-source optical coherence tomography angiography (PLEX Elite 9000; Carl Zeiss Meditec, Inc.). The lamina cribrosa curvature index (LCCI) was assessed using seven horizontal B-scan images across the ONH. The LCVD was calculated from the segmented layer at the level of LC. Primary open angle glaucoma (POAG) eyes were categorized into 2 groups according to the visual field mean deviation (VF MD; mild to moderate [≥ -12 dB] and advanced [< -12 dB]). The factors associated with the LCVD were evaluated using linear regression analysis.

Results: A total of 127 POAG and 43 healthy eyes were included. POAG eyes showed a significantly thinner circumpapillary retinal nerve fiber layer and macular ganglion cell inner plexiform layer, lower LCVD, and greater LCCI compared with healthy eyes (all P < 0.05). In the mild to moderate group, lower LCVD was associated with worse VF MD, thinner circumpapillary retinal nerve fiber layer and macular ganglion cell inner plexiform layer, and greater LCCI (all P < 0.05). In the advanced group, the LCVD was associated with VF MD and LCCI (both P < 0.05). A greater LCVD was correlated with a greater LCCI in the healthy group ( P = 0.045).

Conclusions: Reduced LCVD was associated with an increased LCCI in all spectrums of POAG. LC deformation may affect the ONH microvasculature in glaucoma.

通过扫源光学相干断层扫描血管造影术确定的颅底薄层微血管相关因素
结论:在开角型青光眼的所有频谱中,筛板微血管减少与筛板后部变形以及功能恶化有关。目的:探讨扫描源光学相干断层扫描血管造影(SS-OCTA)测定筛板血管密度(LCVD)的相关因素。材料和方法:视神经头(ONH)扫描采用SS-OCTA (PLEX Elite 9000);卡尔蔡司医疗科技公司,都柏林,CA, USA)。通过7张横贯ONH的水平b扫描图像评估筛板曲率指数(LCCI)。从筛板(LC)水平的分节层计算LCVD。根据视野平均偏差(VF MD)将原发性开角型青光眼(POAG)分为轻度至中度[≥-12 dB]和晚期[< -12 dB]两组。使用线性回归分析评估与LCVD相关的因素。结果:共纳入POAG 127只眼,健康眼43只眼。与健康眼相比,POAG眼的视网膜乳头周围神经纤维层(cpRNFL)和黄斑神经节细胞内丛状层(mGCIPL)明显变薄,LCVD降低,LCCI增大(所有p)。结论:在POAG的所有频谱中,LCVD降低与LCCI升高相关。青光眼LC变形可能影响ONH微血管。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Glaucoma
Journal of Glaucoma 医学-眼科学
CiteScore
4.20
自引率
10.00%
发文量
330
审稿时长
4-8 weeks
期刊介绍: The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.
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