Journal of Glaucoma最新文献

{"title":"Performance of Optic Disc Optical Coherence Tomography Normative Database in a Large, Diverse, Real-World Cohort.","authors":"Rithambara Ramachandran, Ming-Chen Lu, Leslie M Niziol, Maria A Woodward, Angela R Elam, Leroy Johnson, Martha Kershaw, David C Musch, Amanda Bicket, Denise John, Sarah Dougherty Wood, Amy Zhang, Jason Zhang, Joan O'Brien, Paula Anne Newman-Casey","doi":"10.1097/IJG.0000000000002545","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002545","url":null,"abstract":"<p><strong>Precis: </strong>Current optical coherence tomography normative sample data may not represent diverse human optic nerve anatomy to accurately classify all individuals with true glaucomatous optic neuropathy.</p><p><strong>Purpose: </strong>To compare optic nerve head (ONH) measurements between published values from an optical coherence tomography (OCT) normative database and a more diverse cohort of healthy individuals.</p><p><strong>Patients and methods: </strong>ONH parameters from healthy participants of the Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine (MI-SIGHT) program and the Topcon Maestro-1 normative cohort were compared. Chi-square tests compared MI-SIGHT retinal nerve fiber layer (RNFL) quadrant color-code labels with the expected distribution and multinomial logistic regression identified factors associated with label classifications.</p><p><strong>Results: </strong>1084 MI-SIGHT and 399 Topcon eyes were evaluated. The MI-SIGHT cohort was older (54 v 46 y), with more individuals identifying as Black (61% v 20%), less as Hispanic (4% v 18%), and spherical equivalents closer to plano (-0.6 v -1.2 diopters) compared to the Topcon cohort (all P<0.001). Black/African American MI-SIGHT participants had larger cup-to-disc ratios and cup volumes, while White MI-SIGHT participants had smaller ONH values, except for rim area and rim volume, compared to Topcon participants (all P<0.001). The MI-SIGHT cohort's RNFL color codes did not follow the expected distribution (P<0.05); more MI-SIGHT RNFL quadrant measurements were assigned as white (10.6% and 6.3% MI-SIGHT v 5% Topcon) and red codes (2.2% and 1.8% MI-SIGHT v <1% Topcon) than expected in the superior and inferior quadrants respectively.</p><p><strong>Conclusion: </strong>OCT normative databases should accurately reflect diverse populations to avoid misclassification by RNFL thickness color codes. Larger datasets should be leveraged to encompass the full spectrum of healthy optic nerve anatomy.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydipsia Induced Acute Angle-Closure Crisis.","authors":"Akash Maheshwari, Noor Laylani, Pamela Davila Siliezar, Andrew G Lee","doi":"10.1097/IJG.0000000000002546","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002546","url":null,"abstract":"<p><p>We present a case of Acute Angle-Closure Crisis (AACC) precipitated by primary transient psychogenic polydipsia; we believe that our case is the first of its kind to be reported. A 74-year-old male presented to the emergency department with altered mental status due to acute-onset hyponatremia. Six days after admission, the patient noticed painful loss of vision in his right eye and an ipsilateral headache lasting 10-15 minutes. Upon follow-up with his primary care physician several days later, a fixed, dilated right pupil was noted. On ophthalmologic evaluation in the ER the next day, the patient was found to have markedly elevated intraocular pressure (IOP) at 47 mm Hg in the right eye. He started topical brimonidine, dorzolamide 2%/timolol 0.5%, and latanoprost, and underwent phacoemulsification with placement of a posterior chamber intraocular lens (PCIOL) in the right eye. Several mechanisms of polydipsia induced AACC are proposed including choroidal expansion, increased sympathetic α-adrenergic tone, or differences in osmotic potential forces.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Capacity and Correlation of Optic Nerve Colorimetry with Structural Parameters in Primary Open-Angle Glaucoma.","authors":"Liseth Salazar-Quiñones, Yadhira Pérez-Quiñones, Haizea Etxabe-Ávila, José Ignacio Fernández-Vigo, Carmen Méndez-Hernández, Julián García-Feijóo","doi":"10.1097/IJG.0000000000002542","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002542","url":null,"abstract":"<p><strong>Prcis: </strong>The discriminant function of glaucoma, obtained by the Laguna ONhE colorimetric program, significantly correlates with the BMO-MRW. Furthermore, the diagnostic capacity was inferior to other structural tests in POAG patients.</p><p><strong>Purpose: </strong>To evaluate the diagnostic capability for glaucoma and the correlation between peripapillary and macular parameters using spectral domain optical coherence tomography (SD-OCT) and optic nerve head hemoglobin (OHN Hb) levels assessed by the Laguna ONhE® software using colorimetric analysis.</p><p><strong>Methods: </strong>This cross-sectional study included 112 eyes from 112 primary open-angle glaucoma (POAG) patients and 112 eyes from 112 healthy controls. The peripapillary analysis included standard peripapillary retinal nerve fiber layer (pRNFL), Bruch's membrane opening-minimum ring width (BMO-MRW), and peripapillary RNFL thickness measured with the Glaucoma Module Premium Edition program (RNFLT). The macular analysis assessed the ganglion cell layer (GCL), inner plexiform layer (IPL), macular RNFL (mRNFL), total retina, ganglion cell complex (GCC), and the GCL-IPL complex. The Laguna ONhE program evaluated ONH Hb levels and the glaucoma discriminant function (GDF). Pearson correlation was used to analyze the relationships between variables, and the area under the curve (AUC) was calculated.</p><p><strong>Results: </strong>Significant differences in AUC were found between GDF (0.80) and RNFLT global (G) (0.91), BMO-MRW G (0.89), and outer-temporal GCL (0.88). BMO-MRW showed the strongest correlation with the Laguna ONhE parameters (r from 0.271 to 0.682). Additionally, a significant correlation was observed between the temporal-inferior sector of ONH Hb and the inferior macular sector (r=0.40-0.56 for GCL-IPL) (P<0.05 for all).</p><p><strong>Conclusions: </strong>GDF demonstrated lower diagnostic capacity compared to other structural tests. BMO-MRW showed the strongest correlation with the Laguna ONhE parameters, and a significant relationship was identified between the temporal-inferior sector ONH Hb and the inferior macular region.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Glaucoma Surgery on Corneal Graft Survival After Keratoplasty: A Systematic Review and Meta-Analysis.","authors":"Abdelrahman M Tawfik, Rawan A Kasem, Zeyad M Wesh, Sara M Abo Daif, Abdulla Aly Elmansoury, Raouf Korish, Mohammad Bazzazeh, Kai-Yang Chen, Alaa Ramadan, Almoatazbellah A Attalla, Nada M GabAllah","doi":"10.1097/IJG.0000000000002540","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002540","url":null,"abstract":"<p><strong>Precis: </strong>Glaucoma surgery impacts corneal graft survival differently by procedure type, with GDDs being most effective at reducing intraocular pressure. However, graft survival rates are comparable across trabeculectomy, CPC, and GDDs. Trabeculectomy improves visual acuity best but often requires additional interventions.</p><p><strong>Purpose: </strong>To investigate the impact of different glaucoma procedures on corneal graft survival and corneal endothelium health.</p><p><strong>Methods: </strong>We searched PubMed, Cochrane Library, Scopus, and Web of Science, to identify eligible studies. Studies were included based on predetermined criteria. The primary outcome was corneal graft survival, and secondary outcomes included intraocular pressure (IOP) control, visual acuity, antiglaucoma medications, additional glaucoma surgery, and postoperative complications. Meta-analyses were conducted using random-effects models, and heterogeneity was assessed using the (I2) test.</p><p><strong>Results: </strong>Our results included 27 studies involving 905 patients were analyzed. However, there were no randomized comparative studies. The overall proportion of corneal graft survival at last follow-up was 66.4%, with the three subgroups of trabeculectomy, cyclophotocoagulation (CPC), and Glaucoma drainage devices (GDD) showing similar survival rates of 66.6%, 64.8%, and 65.6%, respectively. Short term graft survival (6 months) was similar across groups, however 2-year survival favoured trabeculectomy. GDDs were the most effective in reducing IOP with an average reduction of 21.4 mmHg compared to 18.9 mmHg for trabeculectomy and 14.8 mmHg for CPC. CPC yielded the best improvement in visual acuity reported as BCVA. GDD required the fewest postoperative antiglaucoma medications. Trabeculectomy had the highest proportion of patients needing additional surgery for glaucoma. The most common complications were hypotony, uveitis and tube obstruction.</p><p><strong>Conclusion: </strong>There were no significant differences in corneal graft survival rates among various glaucoma surgical techniques, but these findings must be interpreted with caution due to the limitations of primary research. GDDs effectively reduced IOP and minimized the need for antiglaucoma medications. Trabeculectomy may be associated with the greatest visual acuity improvement but may carry a higher likelihood of requiring further glaucoma surgery.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schlemm's Bidirectional Fluid Wave and Luminal Blood Reflux as Novel Intra-Operative Signs Confirming Optimal Placement of the iStent.","authors":"Bryan Chin Hou Ang, Bjorn Kaijun Betzler, Sheng Yang Lim","doi":"10.1097/IJG.0000000000002539","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002539","url":null,"abstract":"<p><strong>Purpose: </strong>Trabecular micro-bypass devices (TBDs) such as the iStent series (Glaukos Corporation, Laguna Hills, CA), are effective in reducing intraocular pressure (IOP). However, precise placement of TBDs is crucial in achieving surgical efficacy, as device malpositioning may lead to suboptimal IOP reduction. We demonstrate two novel intra-operative signs to aid confirmation of accurate iStent placement, without reliance on imaging technologies.</p><p><strong>Methods: </strong>Surgical technique report with video accompaniment.</p><p><strong>Surgical technique: </strong>Two intra-operative clinical signs which confirm optimal iStent placement are described: (1) Luminal Blood Reflux - achieved by gently decompressing the anterior chamber, with or without flushing of the stent lumen with balanced salt solution (BSS), thereby confirming stent positioning in the Schlemm's Canal (SC). (2) Schlemm's Bidirectional Fluid Wave (SBFW) - observable when flushing with BSS, suggesting fluid movement in the canal segments adjacent to the iStent device, thereby confirming stent patency and positioning in the SC.</p><p><strong>Conclusion: </strong>The identified signs are useful, feasible and reproducible indicators of accurate iStent placement. Future studies may evaluate the application of these confirmatory manoeuvres in diverse clinical contexts and further establish correlation with clinical outcomes.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Goniotomy for Childhood Glaucoma Secondary to Uveitis: Long-term Outcomes.","authors":"Tiki Ewing, Natalia Correa, Sharon Armarnik, Christopher J Lyons","doi":"10.1097/IJG.0000000000002538","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002538","url":null,"abstract":"<p><strong>Precis: </strong>Goniotomy is effective in managing intraocular pressure in childhood glaucoma secondary to uveitis with cumulative probability of success 0.94 after 1 year and 0.77 after 5 years.</p><p><strong>Objective: </strong>To evaluate the long-term success of goniotomy for childhood glaucoma secondary to chronic uveitis.</p><p><strong>Methods: </strong>Retrospective chart review of all children treated with goniotomy for this indication from 2001 to 2023. Post operative success was defined as IOP ≥ 6 and ≤ 21 mmHg after 1 or 2 goniotomies, without the need for further surgical intervention or sight-threatening complication.</p><p><strong>Results: </strong>31 eyes of 21 patients were included. Mean age at first goniotomy was 10.3 years (range 6.6- 15.7 years) with uveitis diagnosed on average 4.7 years earlier. Mean pre-operative IOP was 28.8 mmHg, on a median of 4 topical agents. Mean follow-up post-goniotomy was 6.8 years (Median 5.7 years) and average post operative IOP at 1, 5 and 8 years post-operatively was 15.9, 15.2 and 15.6 mmHg respectively. At most recent follow-up, 24 eyes (77.4%) were a surgical success. Of these, 5 (21%) needed a second goniotomy to achieve this, and 5 (21%) needed anti-glaucoma drops to maintain IOP ≤21 mmHg (two of these were cases who also underwent a second goniotomy). There were no major complications including loss of inflammatory control.</p><p><strong>Conclusion: </strong>We confirm that this quick, safe, conjunctival sparing primary approach is safe and effective in this context, and early success rates are usually maintained in the long-term. If stable inflammatory control can be achieved pre-operatively, we recommend it as first line treatment for children with childhood glaucoma secondary to uveitis.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multi-Centred Study.","authors":"Karl Mercieca, Matthew Azzopardi, Neeru A Vallabh, Cristina Cristian, Verena Prokosch, Vincent Dubois, Christopher Hemmerdinger, Stefano De Cillà, Divya Mathews, Andre Mermoud, Matthias C Grieshaber, Gordana Sunaric Mégevand, Nitin Anand, Alessandro Rabiolo","doi":"10.1097/IJG.0000000000002535","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002535","url":null,"abstract":"<p><strong>Prcis: </strong>Deep sclerectomy (DS) and canaloplasty provide better intraocular pressure (IOP) control than viscocanalostomy. DS required less glaucoma medications but more interventions to reach target IOP.</p><p><strong>Purpose: </strong>To compare real-world outcomes of three non-penetrating glaucoma surgery (NPGS) techniques.</p><p><strong>Methods: </strong>Retrospective, cohort study of consecutive patients undergoing canaloplasty (CP), deep sclerectomy (DS), and viscocanalostomy (VC), across nine European glaucoma units. Four intraocular pressure (IOP) criteria were used to define success at 2-year follow-up: (A)IOP≤21 mmHg and ≥20% reduction; (B)IOP≤18 mmHg and ≥20% reduction; (C)IOP≤15 mmHg and ≥25% reduction; (D)IOP≤12 mmHg and ≥30% reduction. Secondary outcomes included IOP control, BCVA, number of medications over time, risk factors for failure, complications, and post-operative interventions. Success was distinguished as qualified or complete, if reached with or without antiglaucoma medications, respectively.</p><p><strong>Results: </strong>600 eyes (545 patients) undergoing standalone CP (201 eyes), DS (200 eyes), and VC (199 eyes) were included. Qualified success rates of CP, DS, and VP at 24 months were, respectively: (Criterion A) 85.1%, 67.6% and 64.6%; (Criterion B) 85.1%, 66.1% and 58.6%; (Criterion C) 76.6%, 55.5% and 39.0%; (Criterion D) 27.7%, 28.5% and 22.1%. Success rates were significantly different across the three techniques (P=0.04 or below), except for complete success according to criterion A (P=0.07). Mean IOP(±SD) reduced from 25.2(±6.9), 20.5(±6.7), and 22.7(±7.2)mmHg pre-operatively to 13.1(±3.1), 12.9(±4.5), and 14.7(±4.6)mmHg at post-operative year 2 in the CP, DS, and VC groups respectively (P<0.001 between pre-operative and post-operative time points for all groups).</p><p><strong>Conclusions: </strong>All three NPGS provide sustained IOP reduction, but DS and CP provide better success rates and IOP control. Success rates were low for the most stringent cut-offs, suggesting that other techniques such as trabeculectomy may be indicated when a very low target IOP is demanded.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slow-Coagulation Transscleral Cyclophotocoagulation in Pseudoexfoliation Glaucoma.","authors":"Mohamed M Khodeiry, Ramsey Yusuf, Christopher A Dorizas, Abdelrahman M Elhusseiny, Mohamed S Sayed, Merry Ruan, Richard K Lee","doi":"10.1097/IJG.0000000000002534","DOIUrl":"https://doi.org/10.1097/IJG.0000000000002534","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the outcomes of slow-coagulation transscleral cyclophotocoagulation (SC-TSCPC) in pseudoexfoliation glaucoma (PXG).</p><p><strong>Methods: </strong>A single-center, retrospective non-comparative study including consecutive patients with medically uncontrolled PXG who underwent SC-TSCPC (1250-milliwatt power and 4-second duration). The primary outcome measure was surgical success (defined as intraocular pressure (IOP) between 6 - 21 mmHg with ≥20% reduction compared to baseline and no need for further glaucoma surgeries or development of vision-threatening complications). Success was considered qualified when achieved with additional glaucoma medications and complete when achieved without additional glaucoma medications. The secondary outcomes included IOP, glaucoma medication numbers, visual acuity, and postoperative complications at 1 and 2 years after laser treatment.</p><p><strong>Results: </strong>This study included 48 eyes of 48 patients. The median age of study participants was 87.5 years, with a median follow-up duration of 24.0 months. The qualified success for a single SC-TCPC treatment at 1 and 2 years was 58.3% and 47.9%, respectively. Cumulative qualified success (>1 SC-TSCPC) was 64.6% at 1 year and 56.2% at 2 years. Complete surgical success after a single SC-TSCPC was 45.8% at 1 year and 33.3% at 2 years, increased to 50.0% at 1 year and 39.6% at 2 years after >1 SC-TSCPC. After SC-TSCPC treatment, the mean IOP decreased from 29.2±10.3 mmHg on 3.7±1.0 medications pre-treatment to 14.3±6.43 mmHg on 2.6±1.3 medications at the final follow-up visit (P<0.001). Seven eyes (14.6%) had SC-TSCPC retreatment, and two eyes (4.2%) required incisional glaucoma surgeries. Reported postoperative complications included: decreased visual acuity in 9 (18.8%) eyes, iridocyclitis in 5 (10.4%) eyes, hyphema in 5 (10.4%) eyes, cystoid macular edema in 2 (4.2%) eyes, and transient hypotony in 2 (4.2%) eyes.</p><p><strong>Conclusions: </strong>SC-TSCPC is an effective, relatively safe, and repeatable surgical treatment option in PXG. Further prospective investigations are suggested to confirm these findings.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Intermittent Fasting and Glaucoma.","authors":"Marlow Schulz, Leona Ding, Shu Feng, Andrew Chen, Philip P Chen, Karine D Bojikian","doi":"10.1097/IJG.0000000000002515","DOIUrl":"10.1097/IJG.0000000000002515","url":null,"abstract":"<p><strong>Prcis: </strong>Intermittent fasting was not associated with a decreased risk of glaucoma diagnosis overall.</p><p><strong>Objective: </strong>To examine the association between intermittent fasting (\"breakfast skipping\") and glaucoma in the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Patients and methods: </strong>Retrospective, cross-sectional study of adult participants of the 2005-2008 NHANES aged 40 years and older. Intermittent fasting was defined as skipping breakfast on both days of the NHANES dietary interview. Glaucoma was defined by (1) self-reported glaucoma diagnosis, (2) cup-to-disc (CDR) ≥0.6 in at least one eye, and (3) possible, probable, or definite glaucoma based on clinical judgment of retinal imaging of individuals with CDR ≥0.6 in at least one eye. Covariates included age, sex, race/ethnicity, body mass index, blood pressure, and waist circumference. χ 2 and Fisher exact test were used for categorical variables and the t test for continuous variables. All data were weighted based on the NHANES multistage sampling design.</p><p><strong>Results: </strong>The population included 7081 individuals 40 years or older, of whom 946 (13.4%) reported skipping breakfast on both interview days; 482 (6.8%) individuals self-reported glaucoma diagnosis, 549 (7.8%) individuals had glaucoma based on CDR ≥0.6, and 343 (6.0%) individuals had glaucoma based on clinical judgment. Diagnosis of glaucoma by all definitions was associated with older age and black or Latinx/Hispanic ethnicity ( P = 0.004) but was not associated with intermittent fasting status ( P = 0.151).</p><p><strong>Conclusions: </strong>In the 2005-2008 NHANES population, intermittent fasting, defined as breakfast skipping, was not associated with decreased risk of glaucoma diagnosis overall. Further studies are needed to examine the potential effects of intermittent fasting on glaucoma risk.</p>","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"1-6"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: Fixed High Energy Versus Standard Titrated Energy Settings for Selective Laser Trabeculoplasty.","authors":"Boonkit Purt, David T Danielson, Sean J Jin, Anthony R Cox, Ruston L Hess, Won I Kim","doi":"10.1097/IJG.0000000000002506","DOIUrl":"10.1097/IJG.0000000000002506","url":null,"abstract":"","PeriodicalId":15938,"journal":{"name":"Journal of Glaucoma","volume":" ","pages":"e2-e3"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}