Journal of Heart and Lung Transplantation最新文献

{"title":"Heart transplantation in Ukraine during wartime: A retrospective cohort study of standard vs marginal donor heart transplantation outcomes","authors":"Borys Todurov MD, PhD ,&nbsp;Sofia Chaikovska MD, PhD ,&nbsp;Gavrylo Kovtun MD, PhD ,&nbsp;Mykola Melnyk MD ,&nbsp;Igor Kuzmych MD ,&nbsp;Teryn Roberts PhD ,&nbsp;Andriy Batchinsky MD ,&nbsp;Serhii Sudakevych MD, PhD","doi":"10.1016/j.healun.2025.07.001","DOIUrl":"10.1016/j.healun.2025.07.001","url":null,"abstract":"<div><h3>Background</h3><div>Heart transplantation (HTx) is the gold standard for end-stage heart failure treatment, yet donor shortages limit its availability. In Ukraine, legislative reforms in 2019 spurred HTx growth, but the ongoing war halted progress and disrupted logistics. This study evaluates outcomes of orthotopic HTx, focusing on use of marginal donor hearts to expand the traditional donor pool.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of 106 consecutive HTx cases at the Heart Institute of the Ministry of Health of Ukraine from December 2019 to October 2024. Data included donor and recipient characteristics, surgical details, complications, and survival. Marginal donors were defined by criteria such as age &gt;55 years, ischemic time &gt;240 minutes, or weight mismatch. Outcomes were compared between standard (<em>n</em> = 67) and marginal (<em>n</em> = 39) donor groups using Kaplan-Meier survival analysis and nonparametric tests.</div></div><div><h3>Results</h3><div>Median donor and recipient age were 47 and 48.5 years, respectively; 36.7% of donors were marginal. Median ischemic time was 80 minutes, similar between groups (<em>p</em> = 0.554). Postoperative complications (e.g., primary graft dysfunction, 10.4%) and survival (1-year: 87.7%, 2-year: 86.7%) showed no significant differences between groups (log-rank <em>p</em> = 0.709). Marginal donors increased the donor pool by ∼40%.</div></div><div><h3>Conclusions</h3><div>Utilizing marginal donor hearts in Ukraine’s HTx program expanded organ availability without compromising outcomes, offering a viable strategy amidst war-related challenges.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 11","pages":"Pages 1728-1734"},"PeriodicalIF":6.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National utilization and outcomes of heart transplantation using ex situ machine perfusion","authors":"Armaan F. Akbar BS ,&nbsp;Alice L. Zhou MS ,&nbsp;Jessica M. Ruck MD, PhD ,&nbsp;Chetan Pasrija MD,&nbsp;Antonio Polanco MD,&nbsp;Ahmet Kilic MD","doi":"10.1016/j.healun.2025.06.032","DOIUrl":"10.1016/j.healun.2025.06.032","url":null,"abstract":"<div><h3>Background</h3><div>In recent years, machine perfusion (MP) for heart transplantation has been increasingly adopted in the United States. However, pragmatic national studies on the utilization and outcomes of this practice are lacking.</div></div><div><h3>Methods</h3><div>Adult (≥18 years) heart recipients transplanted between October 18, 2018 and September 30, 2023 in the United Network for Organ Sharing database were included. We compared outcomes of MP and non-MP transplants among donation after brain death (DBD) and circulatory death (DCD) donors. We used Cox regression to evaluate survival at 30 days and 1 year post-transplant.</div></div><div><h3>Results</h3><div>Of 13,500 DBD transplants, 403 (3.0%) utilized MP. Donors of MP vs non-MP grafts were older (34 vs 32 years, <em>p</em> = 0.003) and traveled longer distances to the recipient center (478 vs 228 nautical miles, <em>p</em> &lt; 0.001). Recipients of MP vs non-MP DBD grafts had increased risk of predischarge dialysis (adjusted odds ratio (aOR) 1.33 [95% confidence interval (CI): 1.01-1.75], <em>p</em> = 0.04) and predischarge stroke (aOR 1.66 [95% CI: 1.08-2.55], <em>p</em> = 0.02), but similar hazards of mortality at 30 days (adjusted hazard ratio (aHR) 1.01 [95% CI: 0.54-1.86], <em>p</em> = 0.99) and 1 year (aHR 0.98 [95% CI: 0.66-1.43], <em>p</em> = 0.90). Of 976 DCD transplants, 633 (64.9%) utilized MP. Recipients of MP vs non-MP DCD grafts had similar risks of dialysis (aOR 1.19 [95% CI: 0.82-1.72], <em>p</em> = 0.36) and stroke (aOR 1.68 [95% CI: 0.82-3.49, <em>p</em> = 0.16), and similar hazard of 30-day (aHR 1.62 [95% CI: 0.67-3.94], <em>p</em> = 0.28), and 1-year mortality (aHR 0.91 [95% CI: 0.54-1.54], <em>p</em> = 0.73).</div></div><div><h3>Conclusions</h3><div>MP use in heart transplantation was associated with favorable outcomes, suggesting it has the potential to increase donor heart utilization, particularly for donors with long projected ischemic times.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 11","pages":"Pages 1714-1724"},"PeriodicalIF":6.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revitalizing donor organs: The potential of mitochondrial transplantation in heart and lung transplantation","authors":"Aybuke Celik ,&nbsp;Sandra Lindstedt ,&nbsp;David C. McGiffin ,&nbsp;Jacky Y. Suen ,&nbsp;John F. Fraser ,&nbsp;Pedro J. del Nido ,&nbsp;Sitaram M. Emani ,&nbsp;James D. McCully","doi":"10.1016/j.healun.2025.07.002","DOIUrl":"10.1016/j.healun.2025.07.002","url":null,"abstract":"<div><div>Heart and lung transplantation remain the primary treatments for end-stage organ failure; yet organ shortages and ischemia-reperfusion injury (IRI) limit their success. Extended criteria donors (ECDs) have expanded the donor pool; however, prolonged cold ischemia times increase the risk of primary graft dysfunction (PGD). Static cold storage (SCS), the standard organ preservation method, is suboptimal, leading to mitochondrial dysfunction, ATP depletion, and oxidative stress. Recent advancements in organ storage show promise in maintaining graft viability. Mitochondria are key regulators of cellular homeostasis, and their dysfunction exacerbates IRI, contributing to inflammation and graft failure. Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy to restore cellular bioenergetics, reduce oxidative stress, and improve graft function. Further research is needed to optimize MTx protocols and integrate them into current preservation techniques to enhance transplant success and long-term graft survival.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 10","pages":"Pages 1648-1658"},"PeriodicalIF":6.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACUTE PULMONARY EMBOLISM IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION, TWO CLINICAL CASES","authors":"A.-M. Claveau ,&nbsp;M.J. Eisenberg ,&nbsp;A.O. Abualsaud","doi":"10.1016/j.healun.2024.04.022","DOIUrl":"10.1016/j.healun.2024.04.022","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S22"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF PRECEDING BALLOON PULMONARY ANGIOPLASTY BEFORE PULMONARY ENDARTERECTOMY FOR HIGH-RISK CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENTS","authors":"J. Yamashita ,&nbsp;R. Ito ,&nbsp;S. Suzuki ,&nbsp;K. Satomi ,&nbsp;Y. Shimahara","doi":"10.1016/j.healun.2024.04.031","DOIUrl":"10.1016/j.healun.2024.04.031","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S25"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MICROCIRCULATORY RESISTANCE IN THE RIGHT CORONARY ARTERY OF PATIENTS WITH CTEPH","authors":"I.M. Lang,&nbsp;C. Gerges,&nbsp;M. Stojanovic","doi":"10.1016/j.healun.2024.04.009","DOIUrl":"10.1016/j.healun.2024.04.009","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S16"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INITIAL CHARACTERISTICS OF PATIENTS WITH AND WITHOUT RESIDUAL PULMONARY HYPERTENSION AFTER PULMONARY THROMBOENDARTERECTOMY","authors":"S. Gratsianskaya,&nbsp;Z. Valieva,&nbsp;K. Mershin,&nbsp;T. Martynyuk","doi":"10.1016/j.healun.2024.04.038","DOIUrl":"10.1016/j.healun.2024.04.038","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S28"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARISON OF THE RESPONSE TO SELECTIVE PULMONARY VASODILATOR IN CTEPH PATIENTS WITH OR WITHOUT MYELOPROLIFERATIVE NEOPLASM","authors":"M. Hirose ,&nbsp;S. Adachi ,&nbsp;Y. Nakano ,&nbsp;I. Nishiyama ,&nbsp;T. Adachi ,&nbsp;H. Kondo ,&nbsp;T. Murohara","doi":"10.1016/j.healun.2024.04.028","DOIUrl":"10.1016/j.healun.2024.04.028","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S24"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAME DAY DISCHARGE FOLLOWING BALLOON PULMONARY ARTERY ANGIOPLASTY","authors":"S. Bartolome,&nbsp;T. Shah,&nbsp;J. Chidester,&nbsp;T. Koshy","doi":"10.1016/j.healun.2024.04.050","DOIUrl":"10.1016/j.healun.2024.04.050","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S33"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDENTIFICATION OF POTENTIAL PATHOGENIC GENES FUNCTIONING IN THE DEVELOPMENT FROM PE TO CTEPH BY INTEGRATED BIOINFORMATICS ANALYSIS AND MACHINE LEARNING","authors":"Y. Li ,&nbsp;X. Li ,&nbsp;J. Liu ,&nbsp;S. Ma ,&nbsp;Z. Zhai ,&nbsp;W. Xie ,&nbsp;C. Wang","doi":"10.1016/j.healun.2024.04.008","DOIUrl":"10.1016/j.healun.2024.04.008","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Pages S15-S16"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}