Journal of Extracellular Vesicles最新文献

{"title":"Correction to “Cell-engineered virus-mimetic nanovesicles for vaccination against enveloped viruses”","authors":"","doi":"10.1002/jev2.12452","DOIUrl":"10.1002/jev2.12452","url":null,"abstract":"<p>Han, C., Kim, S., Seo, Y., Lim, M., Kwon, Y., Yi, J., Oh, S.-I., Kang, M., Jeon, S. G., &amp; Park, J. (2024). Cell-engineered virus-mimetic nanovesicles for vaccination against enveloped viruses. Journal of Extracellular Vesicles, 13, e12438. https://doi.org/10.1002/jev2.12438</p><p>In the originally published article, the acknowledgements section was incorrect. The correct text is as follows:</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 5","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel multi-stage enrichment workflow and comprehensive characterization for HEK293F-derived extracellular vesicles","authors":"Nhan Vo,&nbsp;Chau Tran,&nbsp;Nam H. B. Tran,&nbsp;Nhat T. Nguyen,&nbsp;Thieu Nguyen,&nbsp;Duyen T. K. Ho,&nbsp;Diem D. N. Nguyen,&nbsp;Tran Pham,&nbsp;Tien Anh Nguyen,&nbsp;Hoa T. N. Phan,&nbsp;Hoai-Nghia Nguyen,&nbsp;Lan N. Tu","doi":"10.1002/jev2.12454","DOIUrl":"10.1002/jev2.12454","url":null,"abstract":"<p>Extracellular vesicles (EVs) are emerging as a promising drug delivery vehicle as they are biocompatible and capable of targeted delivery. However, clinical translation of EVs remains challenging due to the lack of standardized and scalable manufacturing protocols to consistently isolate small EVs (sEVs) with both high yield and high purity. The heterogenous nature of sEVs leading to unknown composition of biocargos causes further pushback due to safety concerns. In order to address these issues, we developed a robust quality-controlled multi-stage process to produce and isolate sEVs from human embryonic kidney HEK293F cells. We then compared different 2-step and 3-step workflows for eliminating protein impurities and cell-free nucleic acids to meet acceptable limits of regulatory authorities. Our results showed that sEV production was maximized when HEK293F cells were grown at high-density stationary phase in semi-continuous culture. The novel 3-step workflow combining tangential flow filtration, sucrose-cushion ultracentrifugation and bind-elute size-exclusion chromatography outperformed other methods in sEV purity while still preserved high yield and particle integrity. The purified HEK293F-derived sEVs were thoroughly characterized for identity including sub-population analysis, content profiling including proteomics and miRNA sequencing, and demonstrated excellent preclinical safety profile in both in-vitro and in-vivo testing. Our rigorous enrichment workflow and comprehensive characterization will help advance the development of EVs, particularly HEK293F-derived sEVs, to be safe and reliable drug carriers for therapeutic applications.</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 5","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles as human therapeutics: A scoping review of the literature","authors":"Clorinda Fusco,&nbsp;Giusy De Rosa,&nbsp;Ilaria Spatocco,&nbsp;Elisabetta Vitiello,&nbsp;Claudio Procaccini,&nbsp;Chiara Frigè,&nbsp;Valeria Pellegrini,&nbsp;Rosalba La Grotta,&nbsp;Roberto Furlan,&nbsp;Giuseppe Matarese,&nbsp;Francesco Prattichizzo,&nbsp;Paola de Candia","doi":"10.1002/jev2.12433","DOIUrl":"10.1002/jev2.12433","url":null,"abstract":"<p>Extracellular vesicles (EVs) are released by all cells and contribute to cell-to-cell communication. The capacity of EVs to target specific cells and to efficiently deliver a composite profile of functional molecules have led researchers around the world to hypothesize their potential as therapeutics. While studies of EV treatment in animal models are numerous, their actual clinical benefit in humans has more slowly started to be tested. In this scoping review, we searched PubMed and other databases up to 31 December 2023 and, starting from 13,567 records, we selected 40 pertinent published studies testing EVs as therapeutics in humans.</p><p>The analysis of those 40 studies shows that they are all small pilot trials with a large heterogeneity in terms of administration route and target disease. Moreover, the absence of a placebo control in most of the studies, the predominant local application of EV formulations and the inconsistent administration dose metric still impede comparison across studies and firm conclusions about EV safety and efficacy. On the other hand, the recording of some promising outcomes strongly calls out for well-designed larger studies to test EVs as an alternative approach to treat human diseases with no or few therapeutic options.</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 5","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140910811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches”","authors":"","doi":"10.1002/jev2.12451","DOIUrl":"10.1002/jev2.12451","url":null,"abstract":"<p>Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A., Nieuwland, R., … Witwer, K. W. (2024). Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. <i>Journal of Extracellular Vesicles</i>, 13, e12404. https://doi.org/10.1002/jev2.12404</p><p>In the originally published article, Gisela D'Angelo was omitted from the MISEV Consortium. They have been added to the online version of the article. We apologize for this error.</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 5","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140898448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head-to-head comparison of relevant cell sources of small extracellular vesicles for cardiac repair: Superiority of embryonic stem cells","authors":"Hernán González-King,&nbsp;Patricia G. Rodrigues,&nbsp;Tamsin Albery,&nbsp;Benyapa Tangruksa,&nbsp;Ramya Gurrapu,&nbsp;Andreia M. Silva,&nbsp;Gentian Musa,&nbsp;Dominika Kardasz,&nbsp;Kai Liu,&nbsp;Bengt Kull,&nbsp;Karin Åvall,&nbsp;Katarina Rydén-Markinhuhta,&nbsp;Tania Incitti,&nbsp;Nitin Sharma,&nbsp;Cecilia Graneli,&nbsp;Hadi Valadi,&nbsp;Kasparas Petkevicius,&nbsp;Miguel Carracedo,&nbsp;Sandra Tejedor,&nbsp;Alena Ivanova,&nbsp;Sepideh Heydarkhan-Hagvall,&nbsp;Phillipe Menasché,&nbsp;Jane Synnergren,&nbsp;Niek Dekker,&nbsp;Qing-Dong Wang,&nbsp;Karin Jennbacken","doi":"10.1002/jev2.12445","DOIUrl":"https://doi.org/10.1002/jev2.12445","url":null,"abstract":"<p>Small extracellular vesicles (sEV) derived from various cell sources have been demonstrated to enhance cardiac function in preclinical models of myocardial infarction (MI). The aim of this study was to compare different sources of sEV for cardiac repair and determine the most effective one, which nowadays remains limited. We comprehensively assessed the efficacy of sEV obtained from human primary bone marrow mesenchymal stromal cells (BM-MSC), human immortalized MSC (hTERT-MSC), human embryonic stem cells (ESC), ESC-derived cardiac progenitor cells (CPC), human ESC-derived cardiomyocytes (CM), and human primary ventricular cardiac fibroblasts (VCF), in in vitro models of cardiac repair. ESC-derived sEV (ESC-sEV) exhibited the best pro-angiogenic and anti-fibrotic effects in vitro. Then, we evaluated the functionality of the sEV with the most promising performances in vitro, in a murine model of MI-reperfusion injury (IRI) and analysed their RNA and protein compositions. In vivo, ESC-sEV provided the most favourable outcome after MI by reducing adverse cardiac remodelling through down-regulating fibrosis and increasing angiogenesis. Furthermore, transcriptomic, and proteomic characterizations of sEV derived from hTERT-MSC, ESC, and CPC revealed factors in ESC-sEV that potentially drove the observed functions. In conclusion, ESC-sEV holds great promise as a cell-free treatment for promoting cardiac repair following MI.</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 5","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermotolerance in S. cerevisiae as a model to study extracellular vesicle biology","authors":"Curtis John Logan,&nbsp;Claire C. Staton,&nbsp;Joshua Thomas Oliver,&nbsp;Jeff Bouffard,&nbsp;Thomas David Daniel Kazmirchuk,&nbsp;Melissa Magi,&nbsp;Christopher Leonard Brett","doi":"10.1002/jev2.12431","DOIUrl":"https://doi.org/10.1002/jev2.12431","url":null,"abstract":"<p>The budding yeast <i>Saccharomyces cerevisiae</i> is a proven model organism for elucidating conserved eukaryotic biology, but to date its extracellular vesicle (EV) biology is understudied. Here, we show yeast transmit information through the extracellular medium that increases survival when confronted with heat stress and demonstrate the EV-enriched samples mediate this thermotolerance transfer. These samples contain vesicle-like particles that are exosome-sized and disrupting exosome biogenesis by targeting endosomal sorting complexes required for transport (ESCRT) machinery inhibits thermotolerance transfer. We find that Bro1, the yeast ortholog of the human exosome biomarker ALIX, is present in EV samples, and use Bro1 tagged with green fluorescent protein (GFP) to track EV release and uptake by endocytosis. Proteomics analysis reveals that heat shock protein 70 (HSP70) family proteins are enriched in EV samples that provide thermotolerance. We confirm the presence of the HSP70 ortholog stress-seventy subunit A2 (Ssa2) in EV samples and find that mutant yeast cells lacking SSA2 produce EVs but they fail to transfer thermotolerance. We conclude that Ssa2 within exosomes shared between yeast cells contributes to thermotolerance. Through this work, we advance <i>Saccharomyces cerevisiae</i> as an emerging model organism for elucidating molecular details of eukaryotic EV biology and establish a role for exosomes in heat stress and proteostasis that seems to be evolutionarily conserved.</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 5","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12431","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140844858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to article pagination in the Journal of Extracellular Vesicles","authors":"","doi":"10.1002/jev2.12443","DOIUrl":"https://doi.org/10.1002/jev2.12443","url":null,"abstract":"&lt;p&gt;The following articles in the Journal of Extracellular Vesicles contained an error in pagination. The “e” was left out of the eLocator pagination code. The pagination has been updated in each article. We apologize for this error.&lt;/p&gt;&lt;p&gt;(2024), Correction to Heat inactivation of foetal bovine serum performed after EV-depletion influences the proteome of cell-derived extracellular vesicles. J Extracell Vesicles., 13: e12411. https://doi.org/10.1002/jev2.12411&lt;/p&gt;&lt;p&gt;Chen, Z., Luo, L., Ye, T., Zhou, J., Niu, X., Yuan, J., Yuan, T., Fu, D., Li, H., Li, Q., &amp; Wang, Y. (2024). Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. Journal of Extracellular Vesicles, 13, e12409. https://doi.org/10.1002/jev2.12409&lt;/p&gt;&lt;p&gt;Gao, Y., Mi, N., Wu, W., Zhao, Y., Fan, F., Liao, W., Ming, Y., Guan, W., &amp; Bai, C. (2024). Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis. Journal of Extracellular Vesicles, 13, e12410. https://doi.org/10.1002/jev2.12410&lt;/p&gt;&lt;p&gt;Hansen, A. S., Jensen, L. S., Gammelgaard, K. R., Ryttersgaard, K. G., Krapp, C., Just, J., Jønsson, K. L., Jensen, P. B., Boesen, T., Johannsen, M., Etzerodt, A., Deleuran, B. W., &amp; Jakobsen, M. R. (2023). T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy. Journal of Extracellular Vesicles, 12, e12350. https://doi.org/10.1002/jev2.12350&lt;/p&gt;&lt;p&gt;Klemetti, M. M., Pettersson, A. B. V., Ahmad Khan, A., Ermini, L., Porter, T. R., Litvack, M. L., Alahari, S., Zamudio, S., Illsley, N. P., Röst, H., Post, M., &amp; Caniggia, I. (2024). Lipid profile of circulating placental extracellular vesicles during pregnancy identifies foetal growth restriction risk. Journal of Extracellular Vesicles, 13, e12413. https://doi.org/10.1002/jev2.12413&lt;/p&gt;&lt;p&gt;Kyykallio, H., Faria, A. V. S., Hartman, R., Capra, J., Rilla, K., &amp; Siljander, P. R.-M. (2022). A quick pipeline for the isolation of 3D cell culture-derived extracellular vesicles. Journal of Extracellular Vesicles, 11, e12273. https://doi.org/10.1002/jev2.12273&lt;/p&gt;&lt;p&gt;Lötvall, J. (2024), Publishing the MISEV guidelines; The editorial process. J Extracell Vesicles., 13: e12415. https://doi.org/10.1002/jev2.12415&lt;/p&gt;&lt;p&gt;Phu, T. A., Ng, M., Vu, N. K., Gao, A. S., &amp; Raffai, R. L. (2023). ApoE expression in macrophages communicates immunometabolic signaling that controls hyperlipidemia-driven hematopoiesis &amp; inflammation via extracellular vesicles. Journal of Extracellular Vesicles, 12, e12345. https://doi.org/10.1002/jev2.12345&lt;/p&gt;&lt;p&gt;Schöne, N., Kemper, M., Menck, K., Evers, G., Krekeler, C., Schulze, A. B., Lenz, G., Wardelmann, E., Binder, C., &amp; Bleckmann, A. (2024). PD-L1 on large extracellular vesicles is a predictive biomarker for therapy response in tissue PD-L1-low and -negative patients with non-small cell lung cancer. Journal of Extracellular Vesicl","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 5","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140818960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exhaled breath condensate contains extracellular vesicles (EVs) that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed","authors":"Megan I. Mitchell,&nbsp;Iddo Z. Ben-Dov,&nbsp;Kenny Ye,&nbsp;Christina Liu,&nbsp;Miao Shi,&nbsp;Ali Sadoughi,&nbsp;Chirag Shah,&nbsp;Taha Siddiqui,&nbsp;Aham Okorozo,&nbsp;Martin Gutierrez,&nbsp;Rashmi Unawane,&nbsp;Lisa Biamonte,&nbsp;Kaushal Parihk,&nbsp;Simon Spivack,&nbsp;Olivier Loudig","doi":"10.1002/jev2.12440","DOIUrl":"https://doi.org/10.1002/jev2.12440","url":null,"abstract":"<p>Lung diseases, including lung cancer, are rising causes of global mortality. Despite novel imaging technologies and the development of biomarker assays, the detection of lung cancer remains a significant challenge. However, the lung communicates directly with the external environment and releases aerosolized droplets during normal tidal respiration, which can be collected, stored and analzsed as exhaled breath condensate (EBC). A few studies have suggested that EBC contains extracellular vesicles (EVs) whose microRNA (miRNA) cargos may be useful for evaluating different lung conditions, but the cellular origin of these EVs remains unknown. In this study, we used nanoparticle tracking, transmission electron microscopy, Western blot analyses and super resolution nanoimaging (ONi) to detect and validate the identity of exhaled EVs (exh-EVs). Using our customizable antibody-purification assay, EV-CATCHER, we initially determined that exh-EVs can be selectively enriched from EBC using antibodies against three tetraspanins (CD9, CD63 and CD81). Using ONi we also revealed that some exh-EVs harbour lung-specific proteins expressed in bronchiolar Clara cells (Clara Cell Secretory Protein [CCSP]) and Alveolar Type II cells (Surfactant protein C [SFTPC]). When conducting miRNA next generation sequencing (NGS) of airway samples collected at five different anatomic levels (i.e., mouth rinse, mouth wash, bronchial brush, bronchoalveolar lavage [BAL] and EBC) from 18 subjects, we determined that miRNA profiles of exh-EVs clustered closely to those of BAL EVs but not to those of other airway samples. When comparing the miRNA profiles of EVs purified from matched BAL and EBC samples with our three tetraspanins EV-CATCHER assay, we captured significant miRNA expression differences associated with smoking, asthma and lung tumor status of our subjects, which were also reproducibly detected in EVs selectively purified with our anti-CCSP/SFTPC EV-CATCHER assay from the same samples, but that confirmed their lung tissue origin. Our findings underscore that enriching exh-EV subpopulations from EBC allows non-invasive sampling of EVs produced by lung tissues.</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 4","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-engineered virus-mimetic nanovesicles for vaccination against enveloped viruses","authors":"Chungmin Han,&nbsp;Suyeon Kim,&nbsp;Youngjoo Seo,&nbsp;Minyeob Lim,&nbsp;Yongmin Kwon,&nbsp;Johan Yi,&nbsp;Seung-Ik Oh,&nbsp;Minsu Kang,&nbsp;Seong Gyu Jeon,&nbsp;Jaesung Park","doi":"10.1002/jev2.12438","DOIUrl":"https://doi.org/10.1002/jev2.12438","url":null,"abstract":"<p>Enveloped viruses pose a significant threat to human health, as evidenced by the recent COVID-19 pandemic. Although current vaccine strategies have proven effective in preventing viral infections, the development of innovative vaccine technologies is crucial to fortify our defences against future pandemics. In this study, we introduce a novel platform called cell-engineered virus-mimetic nanovesicles (VNVs) and demonstrate their potential as a vaccine for targeting enveloped viruses. VNVs are generated by extruding plasma membrane-derived blebs through nanoscale membrane filters. These VNVs closely resemble enveloped viruses and extracellular vesicles (EVs) in size and morphology, being densely packed with plasma membrane contents and devoid of materials from other membranous organelles. Due to these properties, VNVs express viral membrane antigens more extensively and homogeneously than EVs expressing the same antigen. In this study, we produced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) VNVs expressing the SARS-CoV-2 Spike glycoprotein (S) on their surfaces and assessed their preclinical efficacy as a COVID-19 vaccine in experimental animals. The administration of VNVs successfully stimulated the production of S-specific antibodies both systemically and locally, and immune cells isolated from vaccinated mice displayed cytokine responses to S stimulation.</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 4","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140641859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis”","authors":"","doi":"10.1002/jev2.12441","DOIUrl":"https://doi.org/10.1002/jev2.12441","url":null,"abstract":"<p>Gao Y., Mi N., Wu W., Zhao Y., Fan F., Liao W., Ming Y., Guan W., &amp; Bai C. (2024). Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis. Journal of Extracellular Vesicles, 13, e12410. https://doi.org/10.1002/jev2.12410</p><p>In the originally published article, there was an error in the address of author Weijun Guan. The correct address is as follows:</p><p>Weijun Guan</p><p>Institute of Animal Sciences, Chinese Academy of Agricultural Sciences</p><p>Yuanmingyuan West Road, Haidian District</p><p>Beijing 100193, R.P. China</p><p>Email: <span>[email protected]</span></p><p>This information has been updated in the online version of the article.</p><p>We apologize for this error.</p>","PeriodicalId":15811,"journal":{"name":"Journal of Extracellular Vesicles","volume":"13 4","pages":""},"PeriodicalIF":16.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jev2.12441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140632081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}