Journal of Exotic Pet Medicine最新文献

{"title":"Literature Review","authors":"Jessica Robertson","doi":"10.1053/j.jepm.2023.08.006","DOIUrl":"https://doi.org/10.1053/j.jepm.2023.08.006","url":null,"abstract":"","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":"47 ","pages":"Page 47"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of spontaneous diabetes mellitus in a companion rat (Rattus norvegicus)","authors":"Julianne E. McCready ,&nbsp;Matthew R. Kornya ,&nbsp;Jessica Aymen ,&nbsp;Allison E. Dianis ,&nbsp;Trinita Barboza","doi":"10.1053/j.jepm.2023.08.003","DOIUrl":"10.1053/j.jepm.2023.08.003","url":null,"abstract":"<div><h3>Background</h3><p>Rats are a common model for diabetes mellitus in humans, but spontaneous diabetes in pet rats has not been described.</p></div><div><h3>Case Description</h3><p>A 1-year, 5-month-old, intact male domestic rat (<em>Rattus norvegicus</em><span><span><span>) was evaluated for polydipsia and weight loss. Diagnostics revealed glucosuria and </span>hyperglycemia<span><span> (414 mg/dL; normal 89–165 mg/dL) consistent with diabetes mellitus. Hypercholesteremia and elevated liver enzymes were also noted. Treatment with glipizide (0.5–1 mg/kg, orally, every 12 hours), metformin (50–150 mg/kg, orally, every 12 hours), and intermediate-acting porcine insulin (1–3 units, subcutaneously, every 12 hours) were ineffective at producing normoglycemia. Long-acting </span>glargine insulin (1 unit, subcutaneously, every 12 hours) resulted in improved body weight and longer periods of normoglycemia for 3 months. Eleven months after diagnosis, the rat presented with rapid weight loss and tail necrosis; euthanasia was elected. On histopathology of the pancreas, the few visible islets and lack of amyloid production was considered more consistent with insulin-dependent (type I) diabetes mellitus than insulin-independent (type II). Other </span></span>necropsy<span> findings included bronchopneumonia, radiculoneuropathy, skeletal muscle necrosis of the tail, and chronic renal disease.</span></span></p></div><div><h3>Conclusions and clinical relevance</h3><p>Although uncommon, diabetes mellitus should be considered in pet rats presenting with polydipsia, polyuria, and weight loss. Insulin therapy may be useful for treatment of diabetes mellitus in pet rats but requires careful monitoring and further evaluation.</p></div>","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":"47 ","pages":"Pages 48-52"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42409996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avian & Exotic News","authors":"","doi":"10.1053/j.jepm.2023.08.007","DOIUrl":"https://doi.org/10.1053/j.jepm.2023.08.007","url":null,"abstract":"","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":"47 ","pages":"Pages 53-54"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49867715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected abstracts from the literature","authors":"","doi":"10.1053/j.jepm.2023.08.008","DOIUrl":"https://doi.org/10.1053/j.jepm.2023.08.008","url":null,"abstract":"","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":"47 ","pages":"Pages 55-57"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49867716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystine and amino acid concentrations in the urine of pet ferrets (Mustela putorius furo)","authors":"Jonathan Stockman ,&nbsp;Shachar Malka ,&nbsp;Nicolle Lofgren ,&nbsp;Gina Vecere ,&nbsp;Karen Rosenthal ,&nbsp;Tara Piech ,&nbsp;Andrea Fascetti ,&nbsp;Jake Decker ,&nbsp;Janina A. Krumbeck ,&nbsp;Raphael Vanderstichel","doi":"10.1053/j.jepm.2023.03.003","DOIUrl":"10.1053/j.jepm.2023.03.003","url":null,"abstract":"<div><h3>Background</h3><p><span>The prevalence of cystine urolithiasis in domestic ferrets (</span><span><em>Mustela putorius</em><em> furo</em></span><span>) has increased dramatically in the past decade. Genetic mutations associated with a defect in the active resorption of cysteine (which is oxidized to cystine) and dibasic amino acids in the proximal renal tubules leading to cystinuria were described in several species; however, the etiology in ferrets is unknown. This study aimed to characterize cystinuria in pet ferrets.</span></p></div><div><h3>Methods</h3><p><span>Urine samples were aseptically acquired from 27 domestic client-owned ferrets with known dietary and medical histories. The samples underwent a routine urinalysis and microscopic evaluation. Urine aliquots were deproteinized with 6% sulfosalicylic acid and analyzed for amino acid concentrations by </span>ion exchange chromatography.</p></div><div><h3>Results</h3><p>Urine cystine concentrations ranged from 8 to 2486 nmol/mL (median 243; SD 540.02). Principal component analyses revealed correlations among urinary<span><span> amino acid concentrations, which were explained mostly by three components. Analyses revealed significant correlations between cystine and citrulline, </span>ornithine, and lysine concentrations. Linear regression revealed a negative correlation between age and urinary cystine concentrations and no significant correlation between cystinuria and diet or treats.</span></p></div><div><h3>Conclusions and clinical relevance</h3><p>This is the 1^st description of urine amino acid analysis in a cohort of pet ferrets. The detected correlations between cystine, ornithine, and citrulline could indicate that the pathology responsible for cystine urolithiasis in ferrets is like in other species. Result may indicate young ferrets are at increased risk of cystine urolithiasis Further research is needed to evaluate the possible association between diet and cystinuria.</p></div>","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":"47 ","pages":"Pages 59-64"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44904668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics and innocuity of a single dose of intravenous, intramuscular, and subcutaneous methadone in the domestic rabbit (Oryctolagus cuniculus)","authors":"Julie Pujol ,&nbsp;Claire Vergneau-Grosset ,&nbsp;Francis Beaudry ,&nbsp;Fleur Gaudette ,&nbsp;Annabelle Vigneault ,&nbsp;Inga-Catalina Cruz Benedetti","doi":"10.1053/j.jepm.2023.08.001","DOIUrl":"https://doi.org/10.1053/j.jepm.2023.08.001","url":null,"abstract":"<div><h3>Background</h3><p><span>This study describes the pharmacokinetics<span> and adverse effects of methadone in six healthy female New Zealand white rabbits (</span></span><span><em>Oryctolagus cuniculus</em></span>).</p></div><div><h3>Methods</h3><p>In a randomized crossover study, methadone was administered at 0.3 mg/kg intravenously (IV), 0.6 mg/kg intramuscularly (IM), and 1 mg/kg subcutaneously (SC), with 10-day washout periods. The same catheter was used for IV methadone administration and blood sampling. Plasma methadone concentrations were determined by high-performance liquid chromatography-mass spectrometry immediately before and up to 24 hours after drug administration. Respiratory rates and sedation scores were assessed at each timepoint. Food and water intake, stool, and urine outputs were quantified.</p></div><div><h3>Results</h3><p>For IV, IM, and SC routes, the median elimination half-life was 2.3, 3.4, and 5.8, hours, respectively. Median clearance was 1.5 L/h/kg and the volume of distribution was 4.1 L/kg for the IV route. Median bioavailability for IM and SC was 21.5% and 18.0% respectively. Median maximum plasma concentrations were 41.8 and 26.4 ng/mL at 0.2 and 0.4 hours after IM and SC administration, respectively. High interindividual variability was noted. At the doses tested, methadone did not cause sedation. Water intake was decreased immediately after, and food intake was decreased two days after methadone administration. No effects were noted on urine, fecal production, and respiratory rate.</p></div><div><h3>Conclusions and clinical relevance</h3><p>At the doses administered, IV reached higher methadone plasmatic concentrations, followed by IM and SC. However, results obtained for the IV should be confirmed in future studies using different catheters for drug administration and blood collection. The minimum effective plasma concentration of methadone is unknown in rabbits; caution should therefore be used when extrapolating from other species. Further studies are warranted to evaluate the pharmacodynamics of methadone in rabbits.</p></div>","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":"47 ","pages":"Pages 41-46"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49901407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clostridium perfringens type A-associated disseminated necrogranulomas in a red-eyed crocodile skink (Tribolonotus gracilis)","authors":"Imogen L. Payne ,&nbsp;Rowena Killick ,&nbsp;Asia Bell ,&nbsp;Andrew F. Rich","doi":"10.1053/j.jepm.2023.08.005","DOIUrl":"10.1053/j.jepm.2023.08.005","url":null,"abstract":"","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":"47 ","pages":"Pages 39-40"},"PeriodicalIF":0.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48240016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population pharmacokinetics of single dose oral pimobendan in the ferret (Mustela putorius furo)","authors":"Megan L. Cabot ,&nbsp;Mark G. Papich ,&nbsp;Tara M. Harrison ,&nbsp;Andrea E. Thomson ,&nbsp;Teresa DeFrancesco ,&nbsp;Sarah M. Ozawa","doi":"10.1053/j.jepm.2023.09.002","DOIUrl":"10.1053/j.jepm.2023.09.002","url":null,"abstract":"<div><h3>Background</h3><p><span>Therapeutic options and dosing recommendations for congestive heart failure in the domestic ferret are currently extrapolated from domestic dogs and </span>cats<span>. The goal of this study was to determine the pharmacokinetics of oral pimobendan in the domestic ferret.</span></p></div><div><h3>Methods</h3><p>Twelve domestic ferrets were administered a single dose (average 0.4 mg/kg) of pimobendan in a commercially available, chewable, meat-flavored tablet formulation. High-performance liquid chromatography and fluorescence detection were used to measure pimobendan and the metabolite O-desmethylpimobendan (ODMP) in plasma samples collected at 0, 0.25, 0.5, 1, 2, 4, 6, 9, and 12 hours after administration using a sparse sampling protocol.</p></div><div><h3>Results</h3><p>Pharmacokinetic parameters for pimobendan and ODMP were as follows: peak plasma concentration, 14.29 ng/mL and 16.88 ng/mL; time to peak plasma concentration, 1.69 hours and 1.97 hours; area under the curve, 129.87 ng*h/mL and 190.97 ng*h/mL; and elimination half-life, 4.97 hours and 6.32 hours, respectively. No adverse events were noted.</p></div><div><h3>Conclusions and clinical relevance</h3><p>A single dose of oral pimobendan in ferrets reached concentrations higher than that reported for dogs by the manufacturer and similar to peak plasma concentrations correlated with a therapeutic effect in healthy dogs in a separate study. Individual variability was high and plasma concentrations in at least half of the ferrets remained at or below the lower limit of quantification throughout the duration of the study. Additional studies are needed to characterize the pharmacodynamics, oral bioavailability, and duration of action to facilitate dosing recommendations for pimobendan in the domestic ferret.</p></div>","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":"48 ","pages":"Pages 1-5"},"PeriodicalIF":0.5,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135638301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics and innocuity of a single dose of intravenous, intramuscular and subcutaneous methadone in domestic rabbit","authors":"Julie Pujol, C. Vergneau-Grosset, F. Beaudry, F. Gaudette, Annabelle Vigneault, Inga-Catalina Cruz Benedetti","doi":"10.1053/j.jepm.2023.08.001","DOIUrl":"https://doi.org/10.1053/j.jepm.2023.08.001","url":null,"abstract":"","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41983310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthetic effects of dexmedomidine-ketamine sedation followed by isoflurane induction and maintenance in the Saker falcon (Falco cherrug)","authors":"Eugenio Gaudio, Cristiano Franceschinis, Peter McKinney, P. Azmanis","doi":"10.1053/j.jepm.2023.07.004","DOIUrl":"https://doi.org/10.1053/j.jepm.2023.07.004","url":null,"abstract":"","PeriodicalId":15801,"journal":{"name":"Journal of Exotic Pet Medicine","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47673126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}